Extracellular Vesicles From 3xTg-AD Mouse and Alzheimer’s Disease Patient Astrocytes Impair Neuroglial and Vascular Components

Altered Waste Disposal System in Aging and Alzheimer’s Disease: Focus on Astrocytic Aquaporin-4

(2020) Marta Valenza et al.   Frontiers in Pharmacology

Immortalised Hippocampal Astrocytes from 3xTG-AD Mice Fail to Support BBB Integrity In Vitro: Role of Extracellular Vesicles in Glial-Endothelial Communication

(2020) Karolina Kriaučiūnaitė et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Alzheimer’s disease brain-derived extracellular vesicles spread tau pathology in interneurons

(2020) Zhi Ruan et al.   BRAIN

Astrocyte Signaling in the Neurovascular Unit After Central Nervous System Injury

(2019) Lena Huang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Extracellular Vesicles Secreted by Astroglial Cells Transport Apolipoprotein D to Neurons and Mediate Neuronal Survival Upon Oxidative Stress

(2019) Raquel Pascua-Maestro et al.   Frontiers in Cellular Neuroscience

Insufficient glutamine synthetase activity during synaptogenesis causes spatial memory impairment in adult mice

(2019) Hyeonwi Son et al.   Scientific Reports

Neuroimmune Crosstalk through Extracellular Vesicles in Health and Disease

(2019) Jean-Christophe Delpech et al.   TRENDS IN NEUROSCIENCES

Propagation of Tau via Extracellular Vesicles

(2019) Mar Pérez et al.   Frontiers in Neuroscience

Extracellular Vesicles Isolated from Familial Alzheimer’s Disease Neuronal Cultures Induce Aberrant Tau Phosphorylation in the Wild-Type Mouse Brain

(2019) Brent Aulston et al.   JOURNAL OF ALZHEIMERS DISEASE

Proteomic Profiling of Extracellular Vesicles Isolated From Cerebrospinal Fluid of Former National Football League Players at Risk for Chronic Traumatic Encephalopathy

(2019) Satoshi Muraoka et al.   Frontiers in Neuroscience

Activated human astrocyte-derived extracellular vesicles modulate neuronal uptake, differentiation and firing

(2019) Yang You et al.   Journal of Extracellular Vesicles

Glia-to-neuron transfer of miRNAs via extracellular vesicles: a new mechanism underlying inflammation-induced synaptic alterations

(2018) Ilaria Prada et al.   ACTA NEUROPATHOLOGICA

High complement levels in astrocyte-derived exosomes of Alzheimer disease

(2018) Edward J. Goetzl et al.   ANNALS OF NEUROLOGY

Transcriptional remodeling in primary hippocampal astrocytes from an Alzheimer’s disease mouse model

(2018) F Ruffinatti et al.   Current Alzheimer Research

TGF-β2 and TGF-β3 from cultured β-amyloid-treated or 3xTg-AD-derived astrocytes may mediate astrocyte-neuron communication

(2018) Laura Tapella et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Inflammation leads to distinct populations of extracellular vesicles from microglia

(2018) Yiyi Yang et al.   Journal of Neuroinflammation

Recovery of Neurovascular Unit Integrity by CDK5-KD Astrocyte Transplantation in a Global Cerebral Ischemia Model

(2018) Andrea Becerra-Calixto et al.   MOLECULAR NEUROBIOLOGY

Shedding light on the cell biology of extracellular vesicles

(2018) Guillaume van Niel et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Blood–brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders

(2018) Melanie D. Sweeney et al.   Nature Reviews Neurology

Palmitoylethanolamide Dampens Reactive Astrogliosis and Improves Neuronal Trophic Support in a Triple Transgenic Model of Alzheimer’s Disease: In Vitro and In Vivo Evidence

(2018) Maria Rosanna Bronzuoli et al.   Oxidative Medicine and Cellular Longevity

Focusing on claudin-5: A promising candidate in the regulation of BBB to treat ischemic stroke

(2018) Jianjun Lv et al.   PROGRESS IN NEUROBIOLOGY

Extracellular Vesicles: Multimodal Envoys in Neural Maintenance and Repair

(2018) Mea M. Holm et al.   TRENDS IN NEUROSCIENCES

TNFα and IL-1β modify the miRNA cargo of astrocyte shed extracellular vesicles to regulate neurotrophic signaling in neurons

(2018) Amrita Datta Chaudhuri et al.   Cell Death & Disease

Potential Involvement of Platelet-Derived Microparticles and Microparticles Forming Immune Complexes during Monocyte Activation in Patients with Systemic Lupus Erythematosus

(2018) Catalina Burbano et al.   Frontiers in Immunology

Platelet-derived microparticles generated in vitro resemble circulating vesicles of patients with rheumatoid arthritis and activate monocytes

(2018) Juan Villar-Vesga et al.   CELLULAR IMMUNOLOGY

Astrocytes and microglia: Models and tools

(2018) Kevin A. Guttenplan et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Astrocytes and the TGF-β1 Pathway in the Healthy and Diseased Brain: a Double-Edged Sword

(2018) Luan Pereira Diniz et al.   MOLECULAR NEUROBIOLOGY

Specificities of secretion and uptake of exosomes and other extracellular vesicles for cell-to-cell communication

(2018) Mathilde Mathieu et al.   NATURE CELL BIOLOGY

Neuro-Immune Hemostasis: Homeostasis and Diseases in the Central Nervous System

(2018) Ciro De Luca et al.   Frontiers in Cellular Neuroscience

Multicellular Crosstalk Between Exosomes and the Neurovascular Unit After Cerebral Ischemia. Therapeutic Implications

(2018) Ana-Maria Zagrean et al.   Frontiers in Neuroscience

Molecular Mechanisms of Synaptotoxicity and Neuroinflammation in Alzheimer’s Disease

(2018) Mikael Marttinen et al.   Frontiers in Neuroscience

Alzheimer's disease

(2017) C. A. Lane et al.   EUROPEAN JOURNAL OF NEUROLOGY

Reactive Astrocytes: Production, Function, and Therapeutic Potential

(2017) Shane A. Liddelow et al.   IMMUNITY

Differential Pattern of Phospholipid Profile in the Temporal Cortex from E280A-Familiar and Sporadic Alzheimer’s Disease Brains

(2017) Javier Gustavo Villamil-Ortiz et al.   JOURNAL OF ALZHEIMERS DISEASE

Astrocyte Transforming Growth Factor Beta 1 Protects Synapses against Aβ Oligomers in Alzheimer's Disease Model

(2017) Luan Pereira Diniz et al.   JOURNAL OF NEUROSCIENCE

Cerebral blood flow regulation and neurovascular dysfunction in Alzheimer disease

(2017) Kassandra Kisler et al.   NATURE REVIEWS NEUROSCIENCE

Human Astrocyte Maturation Captured in 3D Cerebral Cortical Spheroids Derived from Pluripotent Stem Cells

(2017) Steven A. Sloan et al.   NEURON

The Neurovascular Unit Coming of Age: A Journey through Neurovascular Coupling in Health and Disease

(2017) Costantino Iadecola   NEURON

Cell Biology of Astrocyte-Synapse Interactions

(2017) Nicola J. Allen et al.   NEURON

Astrocyte-shed extracellular vesicles regulate the peripheral leukocyte response to inflammatory brain lesions

(2017) Alex M. Dickens et al.   Science Signaling

White Matter Repair After Extracellular Vesicles Administration in an Experimental Animal Model of Subcortical Stroke

(2017) Laura Otero-Ortega et al.   Scientific Reports

Primary Cell Culture of Live Neurosurgically Resected Aged Adult Human Brain Cells and Single Cell Transcriptomics

(2017) Jennifer M. Spaethling et al.   Cell Reports

Association of Perivascular Localization of Aquaporin-4 With Cognition and Alzheimer Disease in Aging Brains

(2017) Douglas M. Zeppenfeld et al.   JAMA Neurology

Astrocyte-shed extracellular vesicles regulate the peripheral leukocyte response to inflammatory brain lesions

(2017) Alex M. Dickens et al.   Science Signaling

Involvement of Astrocytes in Alzheimer’s Disease from a Neuroinflammatory and Oxidative Stress Perspective

(2017) Rodrigo E. González-Reyes et al.   Frontiers in Molecular Neuroscience

Translation in astrocyte distal processes sets molecular heterogeneity at the gliovascular interface

(2017) Anne- Cécile Boulay et al.   Cell Discovery

Immunoregulation at the gliovascular unit in the healthy brain: A focus on Connexin 43

(2016) Anne-Cécile Boulay et al.   BRAIN BEHAVIOR AND IMMUNITY

CDK5 downregulation enhances synaptic plasticity

(2016) Rafael Andrés Posada-Duque et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Astrocytes as secretory cells of the central nervous system: idiosyncrasies of vesicular secretion

(2016) A. Verkhratsky et al.   EMBO JOURNAL

Pivotal role of glutamine synthetase in ammonia detoxification

(2016) Theodorus B.M. Hakvoort et al.   HEPATOLOGY

Appearance of claudin-5+ leukocytes in the central nervous system during neuroinflammation: a novel role for endothelial-derived extracellular vesicles

(2016) Debayon Paul et al.   Journal of Neuroinflammation

Transfer of mitochondria from astrocytes to neurons after stroke

(2016) Kazuhide Hayakawa et al.   NATURE

Astrocytes mediate neurovascular signaling to capillary pericytes but not to arterioles

(2016) Anusha Mishra et al.   NATURE NEUROSCIENCE

Functional diversity of astrocytes in neural circuit regulation

(2016) Lucile Ben Haim et al.   NATURE REVIEWS NEUROSCIENCE

Astrocytes from old Alzheimer's disease mice are impaired in Aβ uptake and in neuroprotection

(2016) Tal Iram et al.   NEUROBIOLOGY OF DISEASE

Purification and Characterization of Progenitor and Mature Human Astrocytes Reveals Transcriptional and Functional Differences with Mouse

(2016) Ye Zhang et al.   NEURON

Microglia–blood vessel interactions: a double-edged sword in brain pathologies

(2015) Nevenka Dudvarski Stankovic et al.   ACTA NEUROPATHOLOGICA

Increased cerebrospinal fluid calpain activity and microparticle levels in Alzheimer's disease

(2015) Christoph Laske et al.   Alzheimers & Dementia

Perisynaptic astroglial processes: dynamic processors of neuronal information

(2015) Grégory Ghézali et al.   Brain Structure & Function

Establishment and Dysfunction of the Blood-Brain Barrier

(2015) Zhen Zhao et al.   CELL

Expression of familial Alzheimer disease presenilin 1 gene attenuates vesicle traffic and reduces peptide secretion in cultured astrocytes devoid of pathologic tissue environment

(2015) Matjaž Stenovec et al.   GLIA

CDK5 knockdown in astrocytes provide neuroprotection as a trophic source via Rac1

(2015) Rafael Andrés Posada-Duque et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Astrocyte heterogeneity in the brain: from development to disease

(2015) Clarissa Schitine et al.   Frontiers in Cellular Neuroscience

The neurovascular unit - concept review

(2014) V. Muoio et al.   Acta Physiologica

The overlap between vascular disease and Alzheimer’s disease - lessons from pathology

(2014) Johannes Attems et al.   BMC Medicine

Structural and Functional Plasticity of Astrocyte Processes and Dendritic Spine Interactions

(2014) A. Perez-Alvarez et al.   JOURNAL OF NEUROSCIENCE

Extracellular vesicles as modulators of cell-to-cell communication in the healthy and diseased brain

(2014) D. M. Pegtel et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Microparticles: A New Perspective in Central Nervous System Disorders

(2014) Stephanie M. Schindler et al.   Biomed Research International

Alzheimer's Prevention Initiative Colombia registry in the PSEN1 E280A mutation kindred

(2013) Francisco Lopera et al.   Alzheimers & Dementia

TANGO: a generic tool for high-throughput 3D image analysis for studying nuclear organization

(2013) Jean Ollion et al.   BIOINFORMATICS

Microglia convert aggregated amyloid-β into neurotoxic forms through the shedding of microvesicles

(2013) P Joshi et al.   CELL DEATH AND DIFFERENTIATION

Glial influence on the blood brain barrier

(2013) Jorge Ivan Alvarez et al.   GLIA

Mutant Copper-Zinc Superoxide Dismutase (SOD1) Induces Protein Secretion Pathway Alterations and Exosome Release in Astrocytes

(2013) Manuela Basso et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Development, maintenance and disruption of the blood-brain barrier

(2013) Birgit Obermeier et al.   NATURE MEDICINE

Emerging roles of astrocytes in neural circuit development

(2013) Laura E. Clarke et al.   NATURE REVIEWS NEUROSCIENCE

The Pathobiology of Vascular Dementia

(2013) Costantino Iadecola   NEURON

Extracellular vesicles as mediators of neuron-glia communication

(2013) Carsten Frühbeis et al.   Frontiers in Cellular Neuroscience

Amyloid-β and Alzheimer’s disease type pathology differentially affects the calcium signalling toolkit in astrocytes from different brain regions

(2013) A A Grolla et al.   Cell Death & Disease

Deficiency in Mural Vascular Cells Coincides with Blood-Brain Barrier Disruption in Alzheimer's Disease

(2012) Jesse D. Sengillo et al.   BRAIN PATHOLOGY

The exposure of autoantigens by microparticles underlies the formation of potent inflammatory components: the microparticle-associated immune complexes

(2012) Nathalie Cloutier et al.   EMBO Molecular Medicine

Transient acidification and subsequent proinflammatory cytokine stimulation of astrocytes induce distinct activation phenotypes

(2012) Nicole A. Renner et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The vascular factor in Alzheimer's disease: A study in Golgi technique and electron microscopy

(2012) Stavros J. Baloyannis et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Early Astrocytic Atrophy in the Entorhinal Cortex of a Triple Transgenic Animal Model of Alzheimer's Disease

(2011) Chia-Yu Yeh et al.   ASN Neuro

Age-dependent decrease in glutamine synthetase expression in the hippocampal astroglia of the triple transgenic Alzheimer's disease mouse model: mechanism for deficient glutamatergic transmission?

(2011) Markel Olabarria et al.   Molecular Neurodegeneration

Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders

(2011) Berislav V. Zlokovic   NATURE REVIEWS NEUROSCIENCE

Amyloid Triggers Extensive Cerebral Angiogenesis Causing Blood Brain Barrier Permeability and Hypervascularity in Alzheimer's Disease

(2011) Kaan E. Biron et al.   PLoS One

Assisted morphogenesis: glial control of dendrite shapes

(2010) Carl Procko et al.   CURRENT OPINION IN CELL BIOLOGY

The perivascular astroglial sheath provides a complete covering of the brain microvessels: An electron microscopic 3D reconstruction

(2010) Thomas Misje Mathiisen et al.   GLIA

Actin in dendritic spines: connecting dynamics to function

(2010) Pirta Hotulainen et al.   JOURNAL OF CELL BIOLOGY

Alzheimer's Disease

(2010) Henry W. Querfurth et al.   NEW ENGLAND JOURNAL OF MEDICINE

Astrocytes: biology and pathology

(2009) Michael V. Sofroniew et al.   ACTA NEUROPATHOLOGICA

Acid sphingomyelinase activity triggers microparticle release from glial cells

(2009) Fabio Bianco et al.   EMBO JOURNAL

Structure and function of the blood–brain barrier

(2009) N. Joan Abbott et al.   NEUROBIOLOGY OF DISEASE

Increased levels of circulating microparticles in primary Sjögren's syndrome, systemic lupus erythematosus and rheumatoid arthritis and relation with disease activity

(2009) Jérémie Sellam et al.   ARTHRITIS RESEARCH & THERAPY

Genome-Wide Association Studies in Alzheimer Disease

(2008) Stephen C. Waring et al.   ARCHIVES OF NEUROLOGY

Dysfunctional Cell-Cell Signaling in the Neurovascular Unit as a Paradigm for Central Nervous System Disease

(2008) S. Guo et al.   STROKE