Journal
JOURNAL OF ALZHEIMERS DISEASE
Volume 61, Issue 1, Pages 209-219Publisher
IOS PRESS
DOI: 10.3233/JAD-170554
Keywords
Alzheimer's disease; phospholipids; fatty acids; temporal cortex; polyunsaturated fatty acids
Categories
Funding
- Colciencias [111554531478]
- Advanced Microscopy Unit
- Group of Neuroscience of Antioquia, University of Antioquia
- NSF [MCB 0455318, 0920663, DBI 0521587]
- NSF EPSCoR [EPS-0236913]
- State of Kansas through the Kansas Technology Enterprise Corporation
- Kansas State University
- K-INBRE (NIH from the INBRE program of the National Center for Research Resources) [P20 RR16475]
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Lipids are considered important factors in the pathogenesis of Alzheimer's disease (AD). In this study, we realized a comparative analysis of the phospholipid profile and phospholipid composition of the temporal cortex from E280A-familiar AD(FAD), sporadicAD(SAD), and healthy human brains. Findings showed a significant decrease of lysophosphatidylcholine and phosphatidylethanolamine formed by low levels of polyunsaturated fatty acids (20 : 4, 22 : 6) in AD brains. However, phosphatidylethanolamine-ceramide and phosphoglycerol were significantly increased in SAD, conformed by high levels of (18 : 0/18 : 1) and (30/32/36 : 0/1/2), respectively. Together, the findings suggest a deficiency in lysophosphacholine and phosphatidylethanolamine, and alteration in the balance between poly-and unsaturated fatty acids in both types of AD, and a differential pattern of phospholipid profile and fatty acid composition between E280A FAD and SAD human brains.
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