Clustering of transcriptional profiles identifies changes to insulin signaling as an early event in a mouse model of Alzheimer’s disease

A commentary on studies presenting projections of the future prevalence of dementia

(2013) Sam Norton et al.   BMC PUBLIC HEALTH

Insulin and IGF-1 signalling: longevity, protein homoeostasis and Alzheimer's disease

(2012) Cora O'Neill et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Brain Insulin Resistance and Deficiency as Therapeutic Targets in Alzheimers Disease

(2012) Suzanne M. de la Monte   Current Alzheimer Research

Radiation treatment inhibits monocyte entry into the optic nerve head and prevents neuronal damage in a mouse model of glaucoma

(2012) Gareth R. Howell et al.   JOURNAL OF CLINICAL INVESTIGATION

Amyloid-related imaging abnormalities in patients with Alzheimer's disease treated with bapineuzumab: a retrospective analysis

(2012) Reisa Sperling et al.   LANCET NEUROLOGY

The Age-related Gliosis and Accompanying Deficit in Spatial Learning are Unaffected by Dimebon

(2012) Thelma R. Cowley et al.   NEUROCHEMICAL RESEARCH

Obesity, Insulin Resistance, and Alzheimer's Disease

(2012) Kerry L. Hildreth et al.   Obesity

What the halted phase III γ-secretase inhibitor trial may (or may not) be telling us

(2011) Nina F. Schor   ANNALS OF NEUROLOGY

Modelling early responses to neurodegenerative mutations in mice

(2011) Jonathan Gilley et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Ankyrin repeat and SOCS box containing protein 4 (Asb-4) colocalizes with insulin receptor substrate 4 (IRS4) in the hypothalamic neurons and mediates IRS4 degradation

(2011) Ji-Yao Li et al.   BMC NEUROSCIENCE

Molecular clustering identifies complement and endothelin induction as early events in a mouse model of glaucoma

(2011) Gareth R. Howell et al.   JOURNAL OF CLINICAL INVESTIGATION

Neuronal activity regulates the regional vulnerability to amyloid-β deposition

(2011) Adam W Bero et al.   NATURE NEUROSCIENCE

The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics

(2011) Eric Karran et al.   NATURE REVIEWS DRUG DISCOVERY

APOE4 is associated with greater atrophy of the hippocampal formation in Alzheimer's disease

(2011) Michela Pievani et al.   NEUROIMAGE

Alzheimer disease biomarkers are associated with body mass index

(2011) E. D. Vidoni et al.   NEUROLOGY

Alzheimer's failure raises questions about disease-modifying strategies

(2010) Andy Extance   NATURE REVIEWS DRUG DISCOVERY

The design of barriers in the hypothalamus allows the median eminence and the arcuate nucleus to enjoy private milieus: The former opens to the portal blood and the latter to the cerebrospinal fluid

(2010) Esteban M. Rodríguez et al.   PEPTIDES

Review: Obesity and Alzheimer’s Disease: A Link Between Body Weight and Cognitive Function in Old Age

(2009) Ebrahim K. Naderali et al.   American Journal of Alzheimers Disease and Other Dementias

Deletion of Irs2 reduces amyloid deposition and rescues behavioural deficits in APP transgenic mice

(2009) Richard Killick et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

TopHat: discovering splice junctions with RNA-Seq

(2009) Cole Trapnell et al.   BIOINFORMATICS

Reduced IGF-1 Signaling Delays Age-Associated Proteotoxicity in Mice

(2009) Ehud Cohen et al.   CELL

Brain-Endocrine Interactions: A Microvascular Route in the Mediobasal Hypothalamus

(2009) Philippe Ciofi et al.   ENDOCRINOLOGY

Impact of reduced insulin-like growth factor-1/insulin signaling on aging in mammals: novel findings

(2008) Andrzej Bartke   AGING CELL

Rapid appearance and local toxicity of amyloid-β plaques in a mouse model of Alzheimer’s disease

(2008) Melanie Meyer-Luehmann et al.   NATURE