Nutrient-Induced Cellular Mechanisms of Gut Hormone Secretion

L-Cell Differentiation Is Induced by Bile Acids Through GPBAR1 and Paracrine GLP-1 and Serotonin Signaling

(2020) Mari Lilith Lund et al.   DIABETES

Super-resolution microscopy compatible fluorescent probes reveal endogenous glucagon-like peptide-1 receptor distribution and dynamics

(2020) Julia Ast et al.   Nature Communications

Selective stimulation of colonic L cells improves metabolic outcomes in mice

(2020) Jo E. Lewis et al.   DIABETOLOGIA

Effects of L-Phenylalanine on Energy Intake and Glycaemia—Impacts on Appetite Perceptions, Gastrointestinal Hormones and Gastric Emptying in Healthy Males

(2020) Penelope C. E. Fitzgerald et al.   Nutrients

Labeling and Characterization of Human GLP-1-Secreting L-cells in Primary Ileal Organoid Culture

(2020) Deborah A. Goldspink et al.   Cell Reports

Intestine-selective reduction of Gcg expression reveals the importance of the distal gut for GLP-1 secretion

(2020) Brandon L. Panaro et al.   Molecular Metabolism

High-Resolution mRNA and Secretome Atlas of Human Enteroendocrine Cells

(2020) Joep Beumer et al.   CELL

Adenosine triphosphate is co-secreted with glucagon-like peptide-1 to modulate intestinal enterocytes and afferent neurons

(2019) Van B. Lu et al.   Nature Communications

Effects of combined GIP and GLP-1 infusion on energy intake, appetite and energy expenditure in overweight/obese individuals: a randomised, crossover study

(2019) Natasha C. Bergmann et al.   DIABETOLOGIA

Comparison of Human and Murine Enteroendocrine Cells by Transcriptomic and Peptidomic Profiling

(2019) Geoffrey P. Roberts et al.   DIABETES

Bile acids drive colonic secretion of glucagon-like-peptide 1 and peptide-YY in rodents

(2019) Charlotte Bayer Christiansen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Effects of intraduodenal administration of lauric acid and L-tryptophan, alone and combined, on gut hormones, pyloric pressures, and energy intake in healthy men

(2019) Christina McVeay et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

An Atlas of Vagal Sensory Neurons and Their Molecular Specialization

(2019) Jussi Kupari et al.   Cell Reports

The Discovery and Development of Liraglutide and Semaglutide

(2019) Lotte Bjerre Knudsen et al.   Frontiers in Endocrinology

Paracrine Crosstalk between Intestinal L- and D-cells Controls Secretion of Glucagon-Like Peptide-1 in mice

(2019) Sara L. Jepsen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Expression patterns of l-amino acid receptors in the murine STC-1 enteroendocrine cell line

(2019) Hongxia Wang et al.   CELL AND TISSUE RESEARCH

Glucose-Dependent Insulinotropic Polypeptide Receptor-Expressing Cells in the Hypothalamus Regulate Food Intake

(2019) Alice E. Adriaenssens et al.   Cell Metabolism

Efficacy, safety, and mechanistic insights of cotadutide a dual receptor glucagon-like peptide-1 and glucagon agonist

(2019) Victoria E R Parker et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Circulating but not faecal short-chain fatty acids are related to insulin sensitivity, lipolysis and GLP-1 concentrations in humans

(2019) Mattea Müller et al.   Scientific Reports

The impact of short-chain fatty acids on GLP-1 and PYY secretion from the isolated perfused rat colon

(2018) Charlotte Bayer Christiansen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Taste sensitivity to a mixture of monosodium glutamate and inosine 5′-monophosphate by mice lacking both subunits of the T1R1+T1R3 amino acid receptor

(2018) Ginger D. Blonde et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Enteroendocrine cells switch hormone expression along the crypt-to-villus BMP signalling gradient

(2018) Joep Beumer et al.   NATURE CELL BIOLOGY

Microbial regulation of the L cell transcriptome

(2018) Tulika Arora et al.   Scientific Reports

Bile acids are important direct and indirect regulators of the secretion of appetite- and metabolism-regulating hormones from the gut and pancreas

(2018) Rune E. Kuhre et al.   Molecular Metabolism

Mechanistic insights into the detection of free fatty and bile acids by ileal glucagon-like peptide-1 secreting cells

(2018) Deborah A. Goldspink et al.   Molecular Metabolism

Profiling of G protein-coupled receptors in vagal afferents reveals novel gut-to-brain sensing mechanisms

(2018) Kristoffer L. Egerod et al.   Molecular Metabolism

Gut carbohydrate inhibits GIP secretion via a microbiota/SCFA/FFAR3 pathway

(2018) Eun Young Lee et al.   JOURNAL OF ENDOCRINOLOGY

A gut-brain neural circuit for nutrient sensory transduction

(2018) Melanie Maya Kaelberer et al.   SCIENCE

SCFAs strongly stimulate PYY production in human enteroendocrine cells

(2018) P. Larraufie et al.   Scientific Reports

Co-storage and release of insulin-like peptide-5, glucagon-like peptide-1 and peptideYY from murine and human colonic enteroendocrine cells

(2018) Lawrence J. Billing et al.   Molecular Metabolism

Preproglucagon Neurons in the Nucleus of the Solitary Tract Are the Main Source of Brain GLP-1, Mediate Stress-Induced Hypophagia, and Limit Unusually Large Intakes of Food

(2018) Marie K. Holt et al.   DIABETES

Efficacy and safety of LY3298176, a novel dual GIP and GLP-1 receptor agonist, in patients with type 2 diabetes: a randomised, placebo-controlled and active comparator-controlled phase 2 trial

(2018) Juan Pablo Frias et al.   LANCET

The aromatic amino acid sensor GPR142 controls metabolism through balanced regulation of pancreatic and gut hormones

(2018) Olga Rudenko et al.   Molecular Metabolism

Optimized GIP analogs promote body weight lowering in mice through GIPR agonism not antagonism

(2018) Piotr A. Mroz et al.   Molecular Metabolism

LY3298176, a novel dual GIP and GLP-1 receptor agonist for the treatment of type 2 diabetes mellitus: From discovery to clinical proof of concept

(2018) Tamer Coskun et al.   Molecular Metabolism

Long-Chain Free Fatty Acid Receptor GPR120 Mediates Oil-Induced GIP Secretion Through CCK in Male Mice

(2017) Akiko Sankoda et al.   ENDOCRINOLOGY

Costorage of Enteroendocrine Hormones Evaluated at the Cell and Subcellular Levels in Male Mice

(2017) Linda J. Fothergill et al.   ENDOCRINOLOGY

Glucagon-Like Peptide-1 Inhibits Prandial Gastrointestinal Motility Through Myenteric Neuronal Mechanisms in Humans

(2017) Md Abdul Halim et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

A single-cell survey of the small intestinal epithelium

(2017) Adam L. Haber et al.   NATURE

Sweet Taste Receptor Activation in the Gut Is of Limited Importance for Glucose-Stimulated GLP-1 and GIP Secretion

(2017) Monika Saltiel et al.   Nutrients

GPR119, a Major Enteroendocrine Sensor of Dietary Triglyceride Metabolites Coacting in Synergy With FFA1 (GPR40)

(2016) Jeppe H. Ekberg et al.   ENDOCRINOLOGY

Neurotensin Is Coexpressed, Coreleased, and Acts Together With GLP-1 and PYY in Enteroendocrine Control of Metabolism

(2016) Kaare V. Grunddal et al.   ENDOCRINOLOGY

A Novel Allosteric Activator of Free Fatty Acid 2 Receptor Displays Unique Gi-functional Bias

(2016) Daniele Bolognini et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Serum fatty acid and lipoprotein subclass concentrations and their associations in prepubertal healthy Norwegian children

(2016) Tarja Rajalahti et al.   Metabolomics

Effects of peripherally administered cholecystokinin-8 and secretin on feeding/drinking and oxytocin-mRFP1 fluorescence in transgenic rats

(2016) Yasuhito Motojima et al.   NEUROSCIENCE RESEARCH

Signalling pathways involved in the detection of peptones by murine small intestinal enteroendocrine L-cells

(2016) Ramona Pais et al.   PEPTIDES

Lipid derivatives activate GPR119 and trigger GLP-1 secretion in primary murine L-cells

(2016) Catherine E. Moss et al.   PEPTIDES

Insulin-like peptide 5 is a microbially regulated peptide that promotes hepatic glucose production

(2016) Ying Shiuan Lee et al.   Molecular Metabolism

GPR142 Controls Tryptophan-Induced Insulin and Incretin Hormone Secretion to Improve Glucose Metabolism

(2016) Hua V. Lin et al.   PLoS One

Potentiation of Glucose-stimulated Insulin Secretion by the GPR40–PLC–TRPC Pathway in Pancreatic β-Cells

(2016) Hodaka Yamada et al.   Scientific Reports

Incretin mimetics: a novel therapeutic option for patients with type 2 diabetes – a review

(2016) Filip Krag Knop et al.   Diabetes Metabolic Syndrome and Obesity-Targets and Therapy

Species-specific action of (Pro3)GIP - a full agonist at human GIP receptors, but a partial agonist and competitive antagonist at rat and mouse GIP receptors

(2015) A H Sparre-Ulrich et al.   BRITISH JOURNAL OF PHARMACOLOGY

Selective FFA2 Agonism Appears to Act via Intestinal PYY to Reduce Transit and Food Intake but Does Not Improve Glucose Tolerance in Mouse Models

(2015) Sarah Forbes et al.   DIABETES

Bile Acids Trigger GLP-1 Release Predominantly by Accessing Basolaterally Located G Protein–Coupled Bile Acid Receptors

(2015) Cheryl A. Brighton et al.   ENDOCRINOLOGY

A Transcriptome-Led Exploration of Molecular Mechanisms Regulating Somatostatin-Producing D-Cells in the Gastric Epithelium

(2015) Alice Adriaenssens et al.   ENDOCRINOLOGY

Free Fatty Acid Receptor GPR120 Is Highly Expressed in Enteroendocrine K Cells of the Upper Small Intestine and Has a Critical Role in GIP Secretion After Fat Ingestion

(2015) Kanako Iwasaki et al.   ENDOCRINOLOGY

Antagonism of gastric inhibitory polypeptide (GIP) by palmitoylation of GIP analogues with N- and C-terminal modifications improves obesity and metabolic control in high fat fed mice

(2015) V. Pathak et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Expression of the short chain fatty acid receptor GPR41/FFAR3 in autonomic and somatic sensory ganglia

(2015) M.K. Nøhr et al.   NEUROSCIENCE

Farnesoid X receptor inhibits glucagon-like peptide-1 production by enteroendocrine L cells

(2015) Mohamed-Sami Trabelsi et al.   Nature Communications

Fructose induces glucose-dependent insulinotropic polypeptide, glucagon-like peptide-1 and insulin secretion: Role of adenosine triphosphate-sensitive K+channels

(2015) Yusuke Seino et al.   Journal of Diabetes Investigation

GPR40 (FFAR1) – Combined Gs and Gq signaling in vitro is associated with robust incretin secretagogue action ex vivo and in vivo

(2015) Maria Hauge et al.   Molecular Metabolism

Distribution and characterisation of Glucagon-like peptide-1 receptor expressing cells in the mouse brain

(2015) Simon C. Cork et al.   Molecular Metabolism

Mice lacking neutral amino acid transporter B0AT1 (Slc6a19) have elevated levels of FGF21 and GLP-1 and improved glycaemic control

(2015) Yang Jiang et al.   Molecular Metabolism

Fructose stimulates GLP-1 but not GIP secretion in mice, rats, and humans

(2014) Rune E. Kuhre et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Oral administration of osteocalcin improves glucose utilization by stimulating glucagon-like peptide-1 secretion

(2014) Akiko Mizokami et al.   BONE

Molecular Mechanisms of Glucose-Stimulated GLP-1 Secretion From Perfused Rat Small Intestine

(2014) Rune E. Kuhre et al.   DIABETES

GPR120 (FFAR4) is preferentially expressed in pancreatic delta cells and regulates somatostatin secretion from murine islets of Langerhans

(2014) Virginia M. Stone et al.   DIABETOLOGIA

Duodenal CCK Cells from Male Mice Express Multiple Hormones Including Ghrelin

(2014) Alexandros G. Sykaras et al.   ENDOCRINOLOGY

The short chain fatty acid propionate stimulates GLP-1 and PYY secretion via free fatty acid receptor 2 in rodents

(2014) A Psichas et al.   INTERNATIONAL JOURNAL OF OBESITY

Effects of Intraduodenal Infusion of L-Tryptophan on ad Libitum Eating, Antropyloroduodenal Motility, Glycemia, Insulinemia, and Gut Peptide Secretion in Healthy Men

(2014) Robert E. Steinert et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

The Role of SGLT1 and GLUT2 in Intestinal Glucose Transport and Sensing

(2014) Pia V. Röder et al.   PLoS One

An Enteroendocrine Cell – Enteric Glia Connection Revealed by 3D Electron Microscopy

(2014) Diego V. Bohórquez et al.   PLoS One

Insulin-like peptide 5 is an orexigenic gastrointestinal hormone

(2014) J. Grosse et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nucleus accumbens GLP-1 receptors influence meal size and palatability

(2013) Amanda M. Dossat et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

The food intake-suppressive effects of glucagon-like peptide-1 receptor signaling in the ventral tegmental area are mediated by AMPA/kainate receptors

(2013) Elizabeth G. Mietlicki-Baase et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Endogenous PYY and GLP-1 mediatel-glutamine responses in intestinal mucosa

(2013) S Joshi et al.   BRITISH JOURNAL OF PHARMACOLOGY

Microbial Modulation of Energy Availability in the Colon Regulates Intestinal Transit

(2013) Anita Wichmann et al.   Cell Host & Microbe

Exaggerated Glucagon-Like Peptide 1 Response Is Important for Improved β-Cell Function and Glucose Tolerance After Roux-en-Y Gastric Bypass in Patients With Type 2 Diabetes

(2013) Nils B. Jørgensen et al.   DIABETES

Identification and Characterization of GLP-1 Receptor-Expressing Cells Using a New Transgenic Mouse Model

(2013) P. Richards et al.   DIABETES

Generation of L Cells in Mouse and Human Small Intestine Organoids

(2013) N. Petersen et al.   DIABETES

Effects of Intraduodenal Glutamine on Incretin Hormone and Insulin Release, the Glycemic Response to an Intraduodenal Glucose Infusion, and Antropyloroduodenal Motility in Health and Type 2 Diabetes

(2013) J. Chang et al.   DIABETES CARE

Co-localisation and secretion of glucagon-like peptide 1 and peptide YY from primary cultured human L cells

(2013) A. M. Habib et al.   DIABETOLOGIA

Oligopeptides stimulate glucagon-like peptide-1 secretion in mice through proton-coupled uptake and the calcium-sensing receptor

(2013) Eleftheria Diakogiannaki et al.   DIABETOLOGIA

GPR41/FFAR3 and GPR43/FFAR2 as Cosensors for Short-Chain Fatty Acids in Enteroendocrine Cells vs FFAR3 in Enteric Neurons and FFAR2 in Enteric Leukocytes

(2013) Mark K. Nøhr et al.   ENDOCRINOLOGY

Incretin hormones and the satiation signal

(2013) J J Holst   INTERNATIONAL JOURNAL OF OBESITY

 -Hydroxybutyrate Modulates N-Type Calcium Channels in Rat Sympathetic Neurons by Acting as an Agonist for the G-Protein-Coupled Receptor FFA3

(2013) Y.-J. Won et al.   JOURNAL OF NEUROSCIENCE

Vagal Afferent Mediates the Anorectic Effect of Peripheral Secretin

(2013) Jessica Y. S. Chu et al.   PLoS One

Unimolecular Dual Incretins Maximize Metabolic Benefits in Rodents, Monkeys, and Humans

(2013) B. Finan et al.   Science Translational Medicine

Seven transmembrane G protein-coupled receptor repertoire of gastric ghrelin cells

(2013) Maja S. Engelstoft et al.   Molecular Metabolism

Effects of JNJ-38431055, a novel GPR119 receptor agonist, in randomized, double-blind, placebo-controlled studies in subjects with type 2 diabetes

(2012) L. B. Katz et al.   DIABETES OBESITY & METABOLISM

Effects of rectal administration of taurocholic acid on glucagon-like peptide-1 and peptide YY secretion in healthy humans

(2012) T. Wu et al.   DIABETES OBESITY & METABOLISM

Predominant role of active versus facilitative glucose transport for glucagon-like peptide-1 secretion

(2012) H. E. Parker et al.   DIABETOLOGIA

Multiligand Specificity and Wide Tissue Expression of GPRC6A Reveals New Endocrine Networks

(2012) Min Pi et al.   ENDOCRINOLOGY

A Major Lineage of Enteroendocrine Cells Coexpress CCK, Secretin, GIP, GLP-1, PYY, and Neurotensin but Not Somatostatin

(2012) Kristoffer L. Egerod et al.   ENDOCRINOLOGY

Overlap of Endocrine Hormone Expression in the Mouse Intestine Revealed by Transcriptional Profiling and Flow Cytometry

(2012) Abdella M. Habib et al.   ENDOCRINOLOGY

The G Protein-coupled Receptor Family C Group 6 Subtype A (GPRC6A) Receptor Is Involved in Amino Acid-induced Glucagon-like Peptide-1 Secretion from GLUTag Cells

(2012) Manami Oya et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Glucagon-Like Peptide 1 (GLP-1) Analogue, Exendin-4, Decreases the Rewarding Value of Food: A New Role for Mesolimbic GLP-1 Receptors

(2012) S. L. Dickson et al.   JOURNAL OF NEUROSCIENCE

The regulation of K- and L-cell activity by GLUT2 and the calcium-sensing receptor CasR in rat small intestine

(2012) Oliver J. Mace et al.   JOURNAL OF PHYSIOLOGY-LONDON

Chylomicron Formation and Secretion is Required for Lipid-Stimulated Release of Incretins GLP-1 and GIP

(2012) Wendell J. Lu et al.   LIPIDS

The Glucagon Receptor Is Involved in Mediating the Body Weight-Lowering Effects of Oxyntomodulin

(2012) Jennifer R. Kosinski et al.   Obesity

GIP-Overexpressing Mice Demonstrate Reduced Diet-Induced Obesity and Steatosis, and Improved Glucose Homeostasis

(2012) Su-Jin Kim et al.   PLoS One

TRPM5 is critical for linoleic acid-induced CCK secretion from the enteroendocrine cell line, STC-1

(2011) Bhavik P. Shah et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

The role of the gut sweet taste receptor in regulating GLP-1, PYY, and CCK release in humans

(2011) A. C. Gerspach et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

The extracellular calcium-sensing receptor is required for cholecystokinin secretion in response to l-phenylalanine in acutely isolated intestinal I cells

(2011) Alice P. Liou et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Molecular mechanisms underlying bile acid-stimulated glucagon-like peptide-1 secretion

(2011) HE Parker et al.   BRITISH JOURNAL OF PHARMACOLOGY

Administration of an acylated GLP-1 and GIP preparation provides added beneficial glucose-lowering and insulinotropic actions over single incretins in mice with Type 2 diabetes and obesity

(2011) Victor A. Gault et al.   CLINICAL SCIENCE

Na+-D-glucose Cotransporter SGLT1 is Pivotal for Intestinal Glucose Absorption and Glucose-Dependent Incretin Secretion

(2011) V. Gorboulev et al.   DIABETES

Short-Chain Fatty Acids Stimulate Glucagon-Like Peptide-1 Secretion via the G-Protein-Coupled Receptor FFAR2

(2011) G. Tolhurst et al.   DIABETES

Effects of short-term therapy with glibenclamide and repaglinide on incretin hormones and oxidative damage associated with postprandial hyperglycaemia in people with type 2 diabetes mellitus

(2011) J.W. Stephens et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Glutamine Triggers and Potentiates Glucagon-Like Peptide-1 Secretion by Raising Cytosolic Ca2+and cAMP

(2011) Gwen Tolhurst et al.   ENDOCRINOLOGY

Comparative expression of hexose transporters (SGLT1, GLUT1, GLUT2 and GLUT5) throughout the mouse gastrointestinal tract

(2011) Tohru Yoshikawa et al.   HISTOCHEMISTRY AND CELL BIOLOGY

2-Oleoyl Glycerol Is a GPR119 Agonist and Signals GLP-1 Release in Humans

(2011) Katrine B. Hansen et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Diet-induced adaptation of vagal afferent function

(2011) Stephen Kentish et al.   JOURNAL OF PHYSIOLOGY-LONDON

The Lipid-Sensor Candidates CD36 and GPR120 Are Differentially Regulated by Dietary Lipids in Mouse Taste Buds: Impact on Spontaneous Fat Preference

(2011) Céline Martin et al.   PLoS One

Apical CD36 immunolocalization in human and porcine taste buds from circumvallate and foliate papillae

(2010) Peter J. Simons et al.   ACTA HISTOCHEMICA

The effect of gastric inhibitory polypeptide on intestinal glucose absorption and intestinal motility in mice

(2010) Eiichi Ogawa et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Effect of the artificial sweetener, sucralose, on small intestinal glucose absorption in healthy human subjects

(2010) Jing Ma et al.   BRITISH JOURNAL OF NUTRITION

Leptin Directly Depolarizes Preproglucagon Neurons in the Nucleus Tractus Solitarius

(2010) Kazunari Hisadome et al.   DIABETES

Xenin-25 Potentiates Glucose-dependent Insulinotropic Polypeptide Action via a Novel Cholinergic Relay Mechanism

(2010) Burton M. Wice et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Extracellular calcium sensing receptor stimulation in human colonic epithelial cells induces intracellular calcium oscillations and proliferation inhibition

(2010) Osvaldo Rey et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Vagal afferent innervation of the proximal gastrointestinal tract mucosa: Chemoreceptor and mechanoreceptor architecture

(2010) Terry L. Powley et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Characterization of basal pseudopod-like processes in ileal and colonic PYY cells

(2010) Diego V. Bohórquez et al.   JOURNAL OF MOLECULAR HISTOLOGY

Absence of Evidence of Translocation of GLUT2 to the Apical Membrane of Enterocytes in Everted Intestinal Sleeves

(2010) Jeffrey S. Scow et al.   JOURNAL OF SURGICAL RESEARCH

Differential incretin effects of GIP and GLP-1 on gastric emptying, appetite, and insulin-glucose homeostasis

(2010) T. Edholm et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Expression and function of the bile acid receptor GpBAR1 (TGR5) in the murine enteric nervous system

(2010) D. P. Poole et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Central and Peripheral Administration of Secretin Inhibits Food Intake in Mice through the Activation of the Melanocortin System

(2010) Carrie Yuen Yee Cheng et al.   NEUROPSYCHOPHARMACOLOGY

Taste signaling elements expressed in gut enteroendocrine cells regulate nutrient-responsive secretion of gut hormones

(2009) Zaza Kokrashvili et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Luminal l-glutamate enhances duodenal mucosal defense mechanisms via multiple glutamate receptors in rats

(2009) Yasutada Akiba et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Role of MGAT2 and DGAT1 in the release of gut peptides after triglyceride ingestion

(2009) Mayumi Okawa et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Expression of short-chain fatty acid receptor GPR41 in the human colon

(2009) Hideaki Tazoe et al.   BIOMEDICAL RESEARCH-TOKYO

TGR5-Mediated Bile Acid Sensing Controls Glucose Homeostasis

(2009) Charles Thomas et al.   Cell Metabolism

Glucagon-Like Peptide 1/Glucagon Receptor Dual Agonism Reverses Obesity in Mice

(2009) A. Pocai et al.   DIABETES

GPR119 Is Essential for Oleoylethanolamide-Induced Glucagon-Like Peptide-1 Secretion From the Intestinal Enteroendocrine L-Cell

(2009) L. M. Lauffer et al.   DIABETES

Coingestion of Acylglycerols Differentially Affects Glucose-Induced Insulin Secretion via Glucose-Dependent Insulinotropic Polypeptide in C57BL/6J Mice

(2009) Akira Shimotoyodome et al.   ENDOCRINOLOGY

Role of Fat Hydrolysis in Regulating Glucagon-Like Peptide-1 Secretion

(2009) Svetlana Beglinger et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

The calcium-sensing receptor couples to Gαs and regulates PTHrP and ACTH secretion in pituitary cells

(2009) Ramanaiah Mamillapalli et al.   JOURNAL OF ENDOCRINOLOGY

GPR119 is required for physiological regulation of glucagon-like peptide-1 secretion but not for metabolic homeostasis

(2009) Hong Lan et al.   JOURNAL OF ENDOCRINOLOGY

Effects of liraglutide in the treatment of obesity: a randomised, double-blind, placebo-controlled study

(2009) Arne Astrup et al.   LANCET

N-Oleoyldopamine Enhances Glucose Homeostasis through the Activation of GPR119

(2009) Zhi-Liang Chu et al.   MOLECULAR ENDOCRINOLOGY

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

(2009) Toshiro Sato et al.   NATURE

GLP-1 regulates gastroduodenal motility involving cholinergic pathways

(2009) j. schirra et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Receptor-mediated activation of gastric vagal afferents by glucagon-like peptide-1 in the rat

(2009) v. bucinskaite et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Role of neurotensin receptor 1 in the regulation of food intake by neuromedins and neuromedin-related peptides

(2009) Eun Ran Kim et al.   NEUROSCIENCE LETTERS

Peripheral and Central Administration of Xenin and Neurotensin Suppress Food Intake in Rodents

(2009) Jennifer H. Cooke et al.   Obesity

Oral glutamine increases circulating glucagon-like peptide 1, glucagon, and insulin concentrations in lean, obese, and type 2 diabetic subjects

(2008) Jerry R Greenfield et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Dietary resistant starch upregulates total GLP-1 and PYY in a sustained day-long manner through fermentation in rodents

(2008) June Zhou et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Incretin release from gut is acutely enhanced by sugar but not by sweeteners in vivo

(2008) Yukihiro Fujita et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Orlistat accelerates gastric emptying and attenuates GIP release in healthy subjects

(2008) Feruze Yılmaz Enç et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

The Lipid Messenger OEA Links Dietary Fat Intake to Satiety

(2008) Gary J. Schwartz et al.   Cell Metabolism

Glucose Sensing in L Cells: A Primary Cell Study

(2008) Frank Reimann et al.   Cell Metabolism

Gpr40 Is Expressed in Enteroendocrine Cells and Mediates Free Fatty Acid Stimulation of Incretin Secretion

(2008) S. Edfalk et al.   DIABETES

Glucokinase, the pancreatic glucose sensor, is not the gut glucose sensor

(2008) R. Murphy et al.   DIABETOLOGIA

Nutrient-dependent secretion of glucose-dependent insulinotropic polypeptide from primary murine K cells

(2008) H. E. Parker et al.   DIABETOLOGIA

A Role for Intestinal Endocrine Cell-Expressed G Protein-Coupled Receptor 119 in Glycemic Control by Enhancing Glucagon-Like Peptide-1 and Glucose-Dependent Insulinotropic Peptide Release

(2008) Zhi-Liang Chu et al.   ENDOCRINOLOGY

Evidence that Intestinal Glucagon-Like Peptide-1 Plays a Physiological Role in Satiety

(2008) Diana L. Williams et al.   ENDOCRINOLOGY

CD36 Mediates Both Cellular Uptake of Very Long Chain Fatty Acids and Their Intestinal Absorption in Mice

(2008) Victor A. Drover et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeted Ablation of Glucose-dependent Insulinotropic Polypeptide-producing Cells in Transgenic Mice Reduces Obesity and Insulin Resistance Induced by a High Fat Diet

(2008) Matthew C. Althage et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Orlistat Inhibition of Intestinal Lipase Acutely Increases Appetite and Attenuates Postprandial Glucagon-Like Peptide-1-(7–36)-Amide-1, Cholecystokinin, and Peptide YY Concentrations

(2008) Mark Ellrichmann et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Cloning and characterization of the rat free fatty acid receptor GPR120: in vivo effect of the natural ligand on GLP-1 secretion and proliferation of pancreatic β cells

(2008) Toshiki Tanaka et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

The incretin hormones GIP and GLP-1 in diabetic rats: effects on insulin secretion and small bowel motility

(2008) t. edholm et al.   NEUROGASTROENTEROLOGY AND MOTILITY