GPR142 Controls Tryptophan-Induced Insulin and Incretin Hormone Secretion to Improve Glucose Metabolism

GPR142 Agonists Stimulate Glucose-Dependent Insulin Secretion via Gq-Dependent Signaling

(2016) Jingru Wang et al.   PLoS One

Novel Observations From Next-Generation RNA Sequencing of Highly Purified Human Adult and Fetal Islet Cell Subsets

(2015) David M. Blodgett et al.   DIABETES

Incretin-based medications for type 2 diabetes: an overview of reviews

(2015) J.-M. Gamble et al.   DIABETES OBESITY & METABOLISM

Efficacy and safety of fasiglifam (TAK-875), a G protein-coupled receptor 40 agonist, in Japanese patients with type 2 diabetes inadequately controlled by diet and exercise: a randomized, double-blind, placebo-controlled, phase III trial

(2015) K. Kaku et al.   DIABETES OBESITY & METABOLISM

Gut chemosensing mechanisms

(2015) Arianna Psichas et al.   JOURNAL OF CLINICAL INVESTIGATION

Activation of the gut calcium-sensing receptor by peptide agonists reduces rapid elevation of plasma glucose in response to oral glucose load in rats

(2014) Maya Muramatsu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Incretin, insulinotropic and glucose-lowering effects of whey protein pre-load in type 2 diabetes: a randomised clinical trial

(2014) Daniela Jakubowicz et al.   DIABETOLOGIA

RNA-Seq Analysis of Enteroendocrine Cells Reveals a Role for FABP5 in the Control of GIP Secretion

(2014) Cesar A. Sommer et al.   MOLECULAR ENDOCRINOLOGY

Free Fatty Acids-Sensing G Protein-Coupled Receptors in Drug Targeting and Therapeutics

(2013) Tomo Yonezawa et al.   CURRENT MEDICINAL CHEMISTRY

Lack of GPR40/FFAR1does not induce diabetes even under insulin resistance condition

(2013) K. Matsuda-Nagasumi et al.   DIABETES OBESITY & METABOLISM

Oligopeptides stimulate glucagon-like peptide-1 secretion in mice through proton-coupled uptake and the calcium-sensing receptor

(2013) Eleftheria Diakogiannaki et al.   DIABETOLOGIA

An atlas and functional analysis of G-protein coupled receptors in human islets of Langerhans

(2013) Stefan Amisten et al.   PHARMACOLOGY & THERAPEUTICS

Potent and Orally Bioavailable GPR142 Agonists as Novel Insulin Secretagogues for the Treatment of Type 2 Diabetes

(2013) Narihiro Toda et al.   ACS Medicinal Chemistry Letters

Seven transmembrane G protein-coupled receptor repertoire of gastric ghrelin cells

(2013) Maja S. Engelstoft et al.   Molecular Metabolism

Discovery and optimization of a novel series of GPR142 agonists for the treatment of type 2 diabetes mellitus

(2012) Mike Lizarzaburu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The regulation of K- and L-cell activity by GLUT2 and the calcium-sensing receptor CasR in rat small intestine

(2012) Oliver J. Mace et al.   JOURNAL OF PHYSIOLOGY-LONDON

The extracellular calcium-sensing receptor is required for cholecystokinin secretion in response to l-phenylalanine in acutely isolated intestinal I cells

(2011) Alice P. Liou et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Glucose-Dependent Insulinotropic Polypeptide: A Bifunctional Glucose-Dependent Regulator of Glucagon and Insulin Secretion in Humans

(2011) M. Christensen et al.   DIABETES

Regulation of glucagon secretion by incretins

(2011) J. J. Holst et al.   DIABETES OBESITY & METABOLISM

Monitoring Gq-coupled receptor response through inositol phosphate quantification with the IP-One assay

(2011) Eric Trinquet et al.   Expert Opinion on Drug Discovery

Amino acids stimulate cholecystokinin release through the Ca2+-sensing receptor

(2010) Yu Wang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

GIP and GLP-1, the two incretin hormones: Similarities and differences

(2010) Yutaka Seino et al.   Journal of Diabetes Investigation

Anatomical Profiling of G Protein-Coupled Receptor Expression

(2008) Jean B. Regard et al.   CELL

Lack of FFAR1/GPR40 Does Not Protect Mice From High-Fat Diet-Induced Metabolic Disease

(2008) H. Lan et al.   DIABETES