Article
Biochemistry & Molecular Biology
Penjai Thongnuanjan, Sirima Soodvilai, Somsak Fongsupa, Natechanok Thipboonchoo, Napason Chabang, Bamroong Munyoo, Patoomratana Tuchinda, Sunhapas Soodvilai
Summary: This study revealed that the derivative DD-218 of panduratin A has the potential to protect against CDDP-induced nephrotoxicity by modulating various cellular mechanisms, making it a promising adjuvant therapy for patients receiving CDDP.
Article
Anatomy & Morphology
Xin Yan, Dayu Tian, Rui Peng, Lei Chen, Qingling He, Qin Zhou, Qianyin Li
Summary: This study reveals the role of TTC36, a chaperone for heat shock protein 70, in acute kidney injury. The down-regulation of TTC36 is negatively correlated with the severity of kidney injury, and it protects renal tubular cells from cisplatin-induced apoptosis by maintaining mitochondrial potential and expression of mitochondrial autophagy-related genes.
Article
Biochemistry & Molecular Biology
Theodoros Eleftheriadis, Georgios Pissas, Spyridon Golfinopoulos, Maria Efthymiadi, Vassilios Liakopoulos, Ioannis Stefanidis
Summary: Inhibition of malate dehydrogenase-2 (MDH-2) protects renal cells from death or senescence caused by ischemia-reperfusion injury. MDH-2 inhibition reduces oxidative stress and inflammation, and maintains cell proliferation capacity.
Article
Chemistry, Medicinal
Ningning Li, Xianghua Liu, Yanfei Lei, Baoying Wang, Zhenzhen Li
Summary: This study found that melatonin could alleviate cisplatin-induced cell damage through upregulation of PPAR alpha/FAO.
CHEMICAL RESEARCH IN TOXICOLOGY
(2022)
Article
Pharmacology & Pharmacy
Binbin Cui, Xiying Hou, Mengjun Liu, Qing Li, Chao Yu, Shenglei Zhang, Yi Wang, Jun Wang, Shougang Zhuang, Feng Liu
Summary: This study reveals that SMYD2 plays a critical role in cisplatin-induced acute kidney injury. The specific inhibitor AZ505 suppresses SMYD2 expression, improving kidney function and reducing kidney damage. AZ505 exerts its protective effects through mechanisms including reducing cell injury and apoptosis, inhibiting inflammation, and promoting cell proliferation.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cell Biology
Chunyun Zhang, Yingjie Guan, Jianan Zou, Xu Yang, Georgia Bayliss, Shougang Zhuang
Summary: This study reveals the role of MLL1 in acute kidney injury (AKI) induced by cisplatin. The inhibition of the MLL1/WDR5 complex using MM102 improved renal function, attenuated tubular injury and apoptosis, and suppressed the phosphorylation of p53 and the decrease of E-cadherin expression. MM102 also effectively inhibited the DNA damage response triggered by cisplatin.
CELL DEATH & DISEASE
(2022)
Article
Urology & Nephrology
Weiwei Shen, Nan Jia, Jinhua Miao, Shuangqin Chen, Shan Zhou, Ping Meng, Xuefeng Zhou, Lan Tang, Lili Zhou
Summary: Penicilliumin B has shown protective effects against cisplatin-induced renal tubular cell apoptosis by enhancing autophagic flux and promoting the activation of multiple autophagy-related proteins. Additionally, Penicilliumin B triggered AMPK phosphorylation, indicating its potential as an AMPK activator for protection against kidney injury.
Article
Biochemistry & Molecular Biology
Qisheng Lin, Shu Li, Haijiao Jin, Hong Cai, Xuying Zhu, Yuanting Yang, Jingkui Wu, Chaojun Qi, Xinghua Shao, Jialin Li, Kaiqi Zhang, Wenyan Zhou, Minfang Zhang, Jiayi Cheng, Leyi Gu, Shan Mou, Zhaohui Ni
Summary: This study investigated the mechanism by which mitophagy protects against ferroptosis in cisplatin-induced acute kidney injury. The results showed aggravated iron accumulation, lipid peroxidation, and ferroptosis in mice lacking BNIP3, Pink1, or Park2. Additionally, the synthetic antioxidant ferroptosis inhibitor, Ferrstatin-1, rescued the effects of mitophagy inhibition.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Article
Plant Sciences
Meng-ya Zhang, Li-juan Ma, Ling Jiang, Li Gao, Xian Wang, Yue-bo Huang, Xiang-ming Qi, Yong-gui Wu, Xue-qi Liu
Summary: Paeonia lactiflora Pall, also known as Bai Shao, has been used in Chinese Medicine for thousands of years and has anti-inflammatory, sedative, analgesic, and other pharmacological effects. Paeoniflorin, the main active ingredient in Paeonia lactiflora Pall, has been found to have therapeutic effects on various kidney diseases.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Haoyu Shi, Hao Qi, Dongdong Xie, Jiayi Zhuang, Huiyue Qi, Yingbo Dai, Jiaqing Wu
Summary: Acute kidney injury (AKI) is a common clinical condition caused by sepsis and ischemia reperfusion (IR) injury. Impairment of function in renal tubular cells leads to renal tubular structural changes and ultimately AKI. In this study, we identified Acyl-CoA Synthetase Family Member 2 (ACSF2) as a target gene for its high specific expression in renal tubular cells and location in mitochondria. Silencing ACSF2 enhanced mitophagy, restored mitochondrial function, and protected against IR-induced AKI, suggesting ACSF2 as a potential therapeutic target.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Oncology
Ling Wang, Xiang Gao, Xiaojing Tang, Jing Xu, Jie Zhou, Lin Li, Yun Zou, Ming Wu, Lin Xu, Pinglan Lin, Dongsheng Yao, Qing Wu, Yuan Zhou, Chaoyang Ye, Dongping Chen
Summary: This study reveals the role of SENP1 in acute kidney injury (AKI) and demonstrates that it provides kidney protection through regulating cell apoptosis and HIF-1 alpha expression. This finding is important for understanding the pathogenesis of AKI and identifying potential therapeutic targets for its treatment.
EXPERIMENTAL CELL RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Xinhui Liu, Liwen Gao, Xi Huang, Ruyu Deng, Shanshan Wu, Yu Peng, Jiandong Lu
Summary: Huangqi-Danshen decoction (HDD) was found to have a protective effect against cisplatin-induced acute kidney injury (AKI) and could suppress apoptosis, inflammation, and oxidative stress in the kidney. The modulation of NAD+ biosynthesis may contribute to these effects.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Xing-Qiang Dong, Li-Kai Chu, Xu Cao, Qian-Wei Xiong, Yi-Ming Mao, Ching-Hsien Chen, Yun-Li Bi, Jun Liu, Xiang-Ming Yan
Summary: Cisplatin induces renal tubular cell apoptosis and ferroptosis by disrupting glutathione metabolism, leading to acute renal dysfunction and eventual chronic kidney diseases.
Article
Cell Biology
Cheol Ho Park, Bin Lee, Myeonggil Han, Woo Joong Rhee, Man Sup Kwak, Tae-Hyun Yoo, Jeon-Soo Shin
Summary: Canagliflozin protects against cisplatin-induced AKI by activating AMPK and autophagy in renal proximal tubular cells.
CELL DEATH DISCOVERY
(2022)
Article
Medical Laboratory Technology
Bingyao Liu, Linlin Zhang, Hang Yang, Xinyu Chen, Hongting Zheng, Xiaoyu Liao
Summary: Reduced expression of SIK2 contributes to renal tubular injury and fibrosis in diabetic kidney disease (DKD). SIK2 overexpression reduces ER stress-mediated tubular epithelial apoptosis by inhibiting p300's histone acetyltransferase activity. Restoring SIK2 in tubules alleviates tubular and interstitial impairments in DKD mice, suggesting that SIK2 is a potential therapeutic target for DKD.
TRANSLATIONAL RESEARCH
(2023)
Article
Computer Science, Information Systems
Wei Su, Xueqiao Wang, Ge Chen, Yongguang Yu, Tarik Hadzibeganovic
INFORMATION SCIENCES
(2020)
Article
Polymer Science
Jiaxiong Li, Bo Song, Dong An, Yanjuan Ren, Jinho Hah, Xueqiao Wang, Rong Zhang, Kyoung-sik Moon, Ching-Ping Wong
Summary: In this study, highly conductive polysulfide (PS)/Ag composite with a high electrical conductivity of 10(6) S m(-1) was prepared through two thermal treatment methods. Chemical and thermal analyses revealed that the coordination of sulfide components on Ag surfaces plays a key role in blocking electron tunneling pathways, affecting the conductivity of the composite.
JOURNAL OF APPLIED POLYMER SCIENCE
(2021)
Article
Gastroenterology & Hepatology
Zhemin Shen, Xueqiao Wang, Zili Zhen, Yao Wang, Peilong Sun
Summary: The study found an association between metabolic syndrome and the occurrence of acute pancreatitis, with a higher incidence rate of metabolic syndrome in investigated AP patients compared to controls. Multivariate regression analysis showed a significant association between smoking, alcohol consumption history, biliary stones, total cholesterol, triglyceride, hyperglycaemia, apolipoprotein A, and the occurrence of AP.
BMC GASTROENTEROLOGY
(2021)
Article
Medicine, Research & Experimental
Chengyu Wang, Xueqiao Wang, Angxuan Han, Yuhao Wang, Hui Jiang
Summary: The study investigated the significance of the S100P-RAGE axis in the progression of nasopharyngeal carcinoma (NPC), revealing that this axis promotes NPC progression and activates certain signaling pathways. Therapeutic strategies targeting S100P-RAGE may hold promise for NPC treatment.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Shifeng Zhao, Xueqiao Wang, Xiaoqing Zheng, Xiu Liang, Zhigang Wang, Juanlian Zhang, Xudong Zhao, Shougang Zhuang, Qiuhui Pan, Fenyong Sun, Wenjun Shang, Jonathan Barasch, Andong Qiu
Summary: Iron deficiency is identified as a risk factor for nephrotoxic intrinsic acute kidney injury (iAKI), exacerbating damage by increasing catalytic iron species. Targeting specific iron types may be a strategy to mitigate diverse forms of kidney injury in patients.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Medical Laboratory Technology
Ji-wen Fan, Lin Yan, Xue-qiao Wang, Ya-mei Li, Yang-juan Bai, Xiao-qi Ou, Zheng-li Wan, Yi Li
Summary: This study explored the association between PD-1(+)CXCR5(+) follicular helper CD8(+) T cells and renal allograft dysfunction in kidney transplant recipients, indicating that these cells could be a promising biomarker for distinguishing different types of allograft rejection.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2022)
Letter
Computer Science, Information Systems
Wei Su, Xue-Qiao Wang, Ge Chen, Kai Shen
SCIENCE CHINA-INFORMATION SCIENCES
(2022)
Article
Microbiology
Xinyu Zhou, Mingjuan Gu, Lin Zhu, Di Wu, Miaomiao Yang, Yajie Gao, Xueqiao Wang, Chunling Bai, Zhuying Wei, Lei Yang, Guangpeng Li
Summary: Myostatin gene-edited cattle showed similar microbial diversity and dominant bacteria in the four stomach compartments compared to wild-type cattle, but with significant differences in microbiota composition. Metabolomics analysis revealed differences in certain metabolites between the two types of cattle in the rumen, reticulum, and abomasum, with differences in metabolic pathways. Spearman correlation network analysis demonstrated a significant correlation between microflora composition and metabolic pathways.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
Lin Zhu, Chunling Bai, Xueqiao Wang, Zhuying Wei, Mingjuan Gu, Xinyu Zhou, Guanghua Su, Xuefei Liu, Lei Yang, Guangpeng Li
Summary: The knockdown of MSTN accelerates the pentose phosphate pathway, thereby enhancing the antioxidant capacity of erythrocytes. These findings provide important insights into the role of MSTN in erythrocyte antioxidant regulation after exhaustive exercise.
Article
Materials Science, Multidisciplinary
Kevin Hofhuis, Xueqiao Wang, Ales Hrabec, Zhaochu Luo, Zhentao Liu, Pietro Gambardella, Peter M. Derlet, Laura J. Heyderman
Summary: In this paper, the formation of antiferromagnetic (AFM) domains and the role of magnetic disorder are investigated using a synthetic AFM with tunable coupling. The experiments show that AFM domains spontaneously nucleate and pin at locally disordered sites, defining their size and shape. The manipulation of AFM domain morphology is achieved by varying the interaction strength.
PHYSICAL REVIEW MATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Xueqiao Wang, Lin Zhu, Zhuying Wei, Mingjuan Gu, Miaomiao Yang, Xinyu Zhou, Chunling Bai, Guanghua Su, Xuefei Liu, Lei Yang, Guangpeng Li
Summary: This study investigated the effects of exogenous fat-1 transgene on energy metabolism and its relationship with DNA methylation. The results showed that exogenous fat-1 transgene significantly increased n-3 PUFA content, while decreasing n-6 PUFA content and the n-6: n-3 PUFA ratio. Furthermore, the increase in exogenous fat-1 transgene reduced ATP synthesis and the activity and expression of key rate-limiting enzymes in glycolysis, the tricarboxylic acid cycle, and oxidative phosphorylation. DNA methylation sequencing indicated that the inhibition of gene expression may be due to altered DNA methylation. Thus, altering the balance of n-6/n-3 PUFA could regulate DNA methylation, which in turn affects mitochondrial energy metabolism.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Pharmacology & Pharmacy
Xueqiao Wang, Xinhua Dai, Shiqi Wan, Yu Fan, Lijuan Wu, Huan Xu, Lin Yan, Xingxin Gong, Yamei Li, Yao Luo, Yangjuan Bai, Yi Li
Summary: In this study, a new method combining VAMS and UPLC-MS/MS was developed to simultaneously quantify TAC, MPA, and Cre concentrations in renal transplant recipients. The method was successfully validated and showed higher patient satisfaction compared to dried blood spots.
Article
Materials Science, Multidisciplinary
Jeanne Colbois, Kevin Hofhuis, Zhaochu Luo, Xueqiao Wang, Ales Hrabec, Laura J. Heyderman, Frederic Mila
Summary: The article compares the simulation results of the nearest-neighbor and farther-neighbor kagome Ising antiferromagnet models with the experimental spin-spin correlations of a kagome lattice of chirally coupled nanomagnets. Despite the smaller ratios between the farther-neighbor couplings and the nearest-neighbor couplings, they still play an essential role in selecting the correlations.
Article
Materials Science, Multidisciplinary
Xueqiao Wang, Jonathan M. Yaeger, Carolyn E. Stanek, Samuel M. Pennell, Samuel D. Stewart, Juan Alejandro Munoz, Shawn A. Gregory, Blair K. Brettmann
ACS APPLIED POLYMER MATERIALS
(2020)
Article
Materials Science, Composites
Bo Song, Wanchen He, Xueqiao Wang, Xiaoliang Zeng, Mengting Cheng, Fan Wu, Kyoung-sik Moon, Ching-Ping Wong
COMPOSITES SCIENCE AND TECHNOLOGY
(2020)