Crosstalk Between ATP-P2X7 and Adenosine A2A Receptors Controlling Neuroinflammation in Rats Subject to Repeated Restraint Stress

Pathological ATPergic Signaling in Major Depression and Bipolar Disorder

(2020) Peter Illes et al.   Frontiers in Molecular Neuroscience

Regulation of microglia by glutamate and its signal pathway in neurodegenerative diseases

(2020) Xinyue Zhang et al.   DRUG DISCOVERY TODAY

Neuroinflammation and depression: A review

(2020) Romain Troubat et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

New insights into the effects of caffeine on adult hippocampal neurogenesis in stressed mice: Inhibition of CORT‐induced microglia activation

(2020) Zhong‐Fu Mao et al.   FASEB JOURNAL

Microglia: A Central Player in Depression

(2020) Si-long Deng et al.   Current Medical Science

Purinergic signaling orchestrating neuron-glia communication

(2020) Paula Agostinho et al.   PHARMACOLOGICAL RESEARCH

Increased expression of the P2X7 receptor in temporal lobe epilepsy: Animal models and clinical evidence

(2019) Penghui Song et al.   Molecular Medicine Reports

Amyloid Peptide Induced Neuroinflammation Increases the P2X7 Receptor Expression in Microglial Cells, Impacting on Its Functionality

(2019) Carlos Martínez-Frailes et al.   Frontiers in Cellular Neuroscience

Antidepressant-like Effects Induced by Chronic Blockade of the Purinergic 2X7 Receptor through Inhibition of Non-like Receptor Protein 1 Inflammasome in Chronic Unpredictable Mild Stress Model of Depression in Rats

(2019) Feyza Aricioglu et al.   Clinical Psychopharmacology and Neuroscience

P2X7 Receptor Signaling in Stress and Depression

(2019) Deidiane Elisa Ribeiro et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The physiological effects of caffeine on synaptic transmission and plasticity in the mouse hippocampus selectively depend on adenosine A1 and A2A receptors

(2019) João P. Lopes et al.   BIOCHEMICAL PHARMACOLOGY

Enhanced ATP release and CD73‐mediated adenosine formation sustain adenosine A 2A receptor over‐activation in a rat model of Parkinson's disease

(2019) Marta Carmo et al.   BRITISH JOURNAL OF PHARMACOLOGY

Microglia cytoarchitecture in the brain of adenosine A 2A receptor knockout mice: brain region and sex specificities

(2019) Carla Filipa Simões Henriques et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Relationship between daily coffee intake and suicidal ideation

(2019) Hwanjin Park et al.   JOURNAL OF AFFECTIVE DISORDERS

Synaptic and memory dysfunction in a β-amyloid model of early Alzheimer's disease depends on increased formation of ATP-derived extracellular adenosine

(2019) Francisco Q. Gonçalves et al.   NEUROBIOLOGY OF DISEASE

Age-related shift in LTD is dependent on neuronal adenosine A2A receptors interplay with mGluR5 and NMDA receptors

(2018) Mariana Temido-Ferreira et al.   MOLECULAR PSYCHIATRY

The P2RX7 polymorphism rs2230912 is associated with depression: A meta-analysis

(2018) D. Czamara et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

A P2X7 receptor antagonist reverses behavioural alterations, microglial activation and neuroendocrine dysregulation in an unpredictable chronic mild stress (UCMS) model of depression in mice

(2018) Rai Khalid Farooq et al.   PSYCHONEUROENDOCRINOLOGY

Astrocytic rather than neuronal P2X7 receptors modulate the function of the tri-synaptic network in the rodent hippocampus

(2018) Muhammad Tahir Khan et al.   BRAIN RESEARCH BULLETIN

Emerging role of the P2X7-NLRP3-IL1β pathway in mood disorders

(2018) Anindya Bhattacharya et al.   PSYCHONEUROENDOCRINOLOGY

P2 receptor interaction and signalling cascades in neuroprotection

(2018) Mª Teresa Miras-Portugal et al.   BRAIN RESEARCH BULLETIN

Region-specific control of microglia by adenosine A2A receptors: uncoupling anxiety and associated cognitive deficits in female rats

(2018) Joana Mendes Duarte et al.   GLIA

A central role for P2X7 receptors in human microglia

(2018) Laura Janks et al.   Journal of Neuroinflammation

Impact of genetic variations in ADORA2A gene on depression and symptoms: a cross-sectional population-based study

(2018) Sílvia Oliveira et al.   Purinergic Signalling

CD73-derived adenosine controls inflammation and neurodegeneration by modulating dopamine signalling

(2018) Fan Meng et al.   BRAIN

Fish oil supplementation attenuates neuroinflammation and alleviates depressive-like behavior in rats submitted to repeated lipopolysaccharide

(2017) Ruili Dang et al.   EUROPEAN JOURNAL OF NUTRITION

CD39 limits P2X7 receptor inflammatory signaling and attenuates sepsis-induced liver injury

(2017) Luiz Eduardo Baggio Savio et al.   JOURNAL OF HEPATOLOGY

Activation of P2X7 receptor and NLRP3 inflammasome assembly in hippocampal glial cells mediates chronic stress-induced depressive-like behaviors

(2017) Na Yue et al.   Journal of Neuroinflammation

Protective effect of low dose caffeine on psychological stress and cognitive function

(2017) Ozgur Kasimay Cakir et al.   PHYSIOLOGY & BEHAVIOR

Astrocytic Lrp4 (Low-Density Lipoprotein Receptor–Related Protein 4) Contributes to Ischemia-Induced Brain Injury by Regulating ATP Release and Adenosine-A2AR (Adenosine A2A Receptor) Signaling

(2017) Xin-Chun Ye et al.   STROKE

Caffeine, Adenosine Receptors, and Synaptic Plasticity

(2017) Ana Rita Costenla et al.   JOURNAL OF ALZHEIMERS DISEASE

Psychological Stress Activates the Inflammasome via Release of Adenosine Triphosphate and Stimulation of the Purinergic Type 2X7 Receptor

(2016) Masaaki Iwata et al.   BIOLOGICAL PSYCHIATRY

Synaptic Plasticity, Metaplasticity and Depression

(2016) Linnea Vose et al.   Current Neuropharmacology

Microglia-derived purines modulate mossy fibre synaptic transmission and plasticity through P2X4and A1receptors

(2016) Jimmy George et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

How does adenosine control neuronal dysfunction and neurodegeneration?

(2016) Rodrigo A. Cunha   JOURNAL OF NEUROCHEMISTRY

Inhibiting purinergic P2X7 receptors with the antagonist brilliant blue G is neuroprotective in an intranigral lipopolysaccharide animal model of Parkinson's disease

(2016) Xin-Hong Wang et al.   Molecular Medicine Reports

Caffeine Reverts Memory But Not Mood Impairment in a Depression-Prone Mouse Strain with Up-Regulated Adenosine A2A Receptor in Hippocampal Glutamate Synapses

(2016) Nuno J. Machado et al.   MOLECULAR NEUROBIOLOGY

Adenosine A2A receptor regulation of microglia morphological remodeling-gender bias in physiology and in a model of chronic anxiety

(2016) L Caetano et al.   MOLECULAR PSYCHIATRY

Pathogenesis of depression: Insights from human and rodent studies

(2016) C. Ménard et al.   NEUROSCIENCE

Selective A2A receptor antagonist prevents microglia-mediated neuroinflammation and protects retinal ganglion cells from high intraocular pressure–induced transient ischemic injury

(2016) Maria H. Madeira et al.   Translational Research

Depression as a Glial-Based Synaptic Dysfunction

(2016) Daniel Rial et al.   Frontiers in Cellular Neuroscience

Coffee and caffeine consumption and depression: A meta-analysis of observational studies

(2015) Longfei Wang et al.   AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY

Adenosine derived from ecto-nucleotidases in calcific aortic valve disease promotes mineralization through A2a adenosine receptor

(2015) Ablajan Mahmut et al.   CARDIOVASCULAR RESEARCH

CD73-mediated adenosine production promotes stem cell-like properties in mouse Tc17 cells

(2015) Felipe Flores-Santibáñez et al.   IMMUNOLOGY

Neuroprotective effects of brilliant blue G on the brain following traumatic brain injury in rats

(2015) YONG-CHAO WANG et al.   Molecular Medicine Reports

Temporal Dissociation of Striatum and Prefrontal Cortex Uncouples Anhedonia and Defense Behaviors Relevant to Depression in 6-OHDA-Lesioned Rats

(2015) Filipe C. Matheus et al.   MOLECULAR NEUROBIOLOGY

Coffee, tea, caffeine and risk of depression: A systematic review and dose-response meta-analysis of observational studies

(2015) Giuseppe Grosso et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Caffeine acts through neuronal adenosine A2Areceptors to prevent mood and memory dysfunction triggered by chronic stress

(2015) Manuella P. Kaster et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chronic caffeine treatment enhances the resilience to social defeat stress in mice

(2015) Yong-Qin Yin et al.   Food & Function

ATP as a multi-target danger signal in the brain

(2015) Ricardo J. Rodrigues et al.   Frontiers in Neuroscience

Chronic stress induces prolonged suppression of the P2X7 receptor within multiple regions of the hippocampus: A cumulative threshold spectra analysis

(2014) Ratchaniporn Kongsui et al.   BRAIN BEHAVIOR AND IMMUNITY

The P2X7 receptor antagonist Brilliant Blue G attenuates contralateral rotations in a rat model of Parkinsonism through a combined control of synaptotoxicity, neurotoxicity and gliosis

(2014) Marta R.S. Carmo et al.   NEUROPHARMACOLOGY

Overexpression of Adenosine A2A Receptors in Rats: Effects on Depression, Locomotion, and Anxiety

(2014) Joana E. Coelho et al.   Frontiers in Psychiatry

Functional interaction between pre-synaptic α6β2-containing nicotinic and adenosine A2Areceptors in the control of dopamine release in the rat striatum

(2013) P Garção et al.   BRITISH JOURNAL OF PHARMACOLOGY

Increased neocortical expression of the P2X7 receptor after status epilepticus and anticonvulsant effect of P2X7 receptor antagonist A-438079

(2013) Alba Jimenez-Pacheco et al.   EPILEPSIA

Activation of microglial cells triggers a release of brain-derived neurotrophic factor (BDNF) inducing their proliferation in an adenosine A2A receptor-dependent manner: A2A receptor blockade prevents BDNF release and proliferation of microglia

(2013) Catarina Gomes et al.   Journal of Neuroinflammation

Ecto-5'-Nucleotidase (CD73)-Mediated Formation of Adenosine Is Critical for the Striatal Adenosine A2A Receptor Functions

(2013) E. Augusto et al.   JOURNAL OF NEUROSCIENCE

Antidepressant-like activity of the adenosine A2A receptor antagonist, istradefylline (KW-6002), in the forced swim test and the tail suspension test in rodents

(2013) Koji Yamada et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Adenosine Receptor Antagonists Including Caffeine Alter Fetal Brain Development in Mice

(2013) C. G. Silva et al.   Science Translational Medicine

Coffee, caffeine, and risk of completed suicide: Results from three prospective cohorts of American adults

(2013) Michel Lucas et al.   WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY

Effect of long-term caffeine administration on depressive-like behavior in rats exposed to chronic unpredictable stress

(2012) Daniela M. Pechlivanova et al.   BEHAVIOURAL PHARMACOLOGY

Extracellular ATP differentially affects epileptiform activity via purinergic P2X7 and adenosine A1receptors in naive and chronic epileptic rats

(2012) Zin-Juan Klaft et al.   EPILEPSIA

Purinergic receptors in microglia: Functional modal shifts of microglia mediated by P2 and P1 receptors

(2012) Schuichi Koizumi et al.   GLIA

Blockade of adenosine A2A receptors prevents interleukin-1β-induced exacerbation of neuronal toxicity through a p38 mitogen-activated protein kinase pathway

(2012) Ana Patrícia Simões et al.   Journal of Neuroinflammation

Caffeine Consumption Prevents Diabetes-Induced Memory Impairment and Synaptotoxicity in the Hippocampus of NONcZNO10/LTJ Mice

(2012) João M. N. Duarte et al.   PLoS One

Pathophysiology of astroglial purinergic signalling

(2012) Heike Franke et al.   Purinergic Signalling

Cellular function and molecular structure of ecto-nucleotidases

(2012) Herbert Zimmermann et al.   Purinergic Signalling

Are We Getting Closer to Valid Translational Models for Major Depression?

(2012) O. Berton et al.   SCIENCE

Synaptic Dysfunction in Depression: Potential Therapeutic Targets

(2012) R. S. Duman et al.   SCIENCE

Selective Activation of Adenosine A2A Receptors on Immune Cells by a CD73-Dependent Prodrug Suppresses Joint Inflammation in Experimental Rheumatoid Arthritis

(2012) U. Flogel et al.   Science Translational Medicine

P2X4 receptors interact with both P2X2 and P2X7 receptors in the form of homotrimers

(2011) LS Antonio et al.   BRITISH JOURNAL OF PHARMACOLOGY

Enhanced role of adenosine A2A receptors in the modulation of LTP in the rat hippocampus upon ageing

(2011) Ana R. Costenla et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Adenosine A2A receptors control neuroinflammation and consequent hippocampal neuronal dysfunction

(2011) Nelson Rebola et al.   JOURNAL OF NEUROCHEMISTRY

In vivo P2X7 inhibition reduces amyloid plaques in Alzheimer's disease through GSK3β and secretases

(2011) Juan Ignacio Diaz-Hernandez et al.   NEUROBIOLOGY OF AGING

P2X7 receptor blockade prevents ATP excitotoxicity in neurons and reduces brain damage after ischemia

(2011) Joana Arbeloa et al.   NEUROBIOLOGY OF DISEASE

Adenosine A2A receptor gene: Evidence for association of risk variants with panic disorder and anxious personality

(2010) Christa Hohoff et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Caffeine attenuates lipopolysaccharide-induced neuroinflammation

(2010) Holly M. Brothers et al.   NEUROSCIENCE LETTERS

Physiological roles of A1 and A2A adenosine receptors in regulating heart rate, body temperature, and locomotion as revealed using knockout mice and caffeine

(2009) Jiang-Ning Yang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Altered P2X7-receptor level and function in mouse models of Huntington’s disease and therapeutic efficacy of antagonist administration

(2009) Miguel Díaz-Hernández et al.   FASEB JOURNAL

Caffeine consumption attenuates neurochemical modifications in the hippocampus of streptozotocin-induced diabetic rats

(2009) João M. N. Duarte et al.   JOURNAL OF NEUROCHEMISTRY

Caffeine and an adenosine A2Areceptor antagonist prevent memory impairment and synaptotoxicity in adult rats triggered by a convulsive episode in early life

(2009) Giana P. Cognato et al.   JOURNAL OF NEUROCHEMISTRY

Adenosine A2A receptor mediates microglial process retraction

(2009) Anna G Orr et al.   NATURE NEUROSCIENCE

Adenosine A2A Receptors Are Essential for Long-Term Potentiation of NMDA-EPSCs at Hippocampal Mossy Fiber Synapses

(2008) Nelson Rebola et al.   NEURON

The ectonucleotidasecd39/ENTPDase1 modulates purinergic-mediated microglial migration

(2007) Katrin Färber et al.   GLIA