Review
Clinical Neurology
Dario Moreno-Agostino, Yu-Tzu Wu, Christina Daskalopoulou, M. Tasdik Hasan, Martijn Huisman, Matthew Prina
Summary: Evidence suggests that there is an increasing trend in the likelihood of experiencing depression over time in the general population, with no significant impact from factors such as gender, age, and type of prevalence. Moreover, the high heterogeneity across studies was not explained by any of the design variables considered, and no evidence for publication bias was found.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Review
Clinical Neurology
Katrina N. Kidd, Divya Prasad, Jasmyn E. A. Cunningham, Taiane de Azevedo Cardoso, Benicio N. Frey
Summary: This study found that poor-quality parent-child relationships may increase the risk of mood and anxiety disorders in adulthood. Individuals with major depression, panic disorder, or persistent depressive disorder reported lower parental care and higher overprotection. Those with mood or anxiety disorders tended to report higher parental abuse.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Review
Environmental Sciences
Dongying Li, Yue Zhang, Xiaoyu Li, Kai Zhang, Yi Lu, Robert D. Brown
Summary: This study conducted a systematic review and meta-analysis of the associations between climatic exposure and mental and behavioral health conditions, finding that high temperatures and heatwaves were associated with increased risk of mental and behavioral disorders, while cold temperatures were not.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Review
Medicine, General & Internal
Blake Noyes, Aleks Biorac, Gustavo Vazquez, Sarosh Khalid-Khan, Douglas Munoz, Linda Booij
Summary: This study will conduct a systematic review and meta-analysis on eye-tracking research in adults with major depressive disorder or other clinically diagnosed depressive disorders. The study will include non-randomized studies using eye movement tasks and assess the risk of bias and confidence in cumulative evidence.
Review
Behavioral Sciences
Susana Gomes-da-Costa, Wolfgang Marx, Filippo Corponi, Gerard Anmella, Andrea Murru, Maria Teresa Pons-Cabrera, Anna Gimenez-Palomo, Felipe Gutierrez-Arango, Cristian Daniel Llach, Giovanna Fico, Georgios D. Kotzalidis, Norma Verdolini, Marc Valenti, Michael Berk, Eduard Vieta, Isabella Pacchiarotti
Summary: This study found through a systematic review and meta-analysis that the use of lithium in patients with Bipolar Disorder does not significantly lead to weight gain. Shorter treatment duration is associated with more pronounced weight gain. There were no significant differences in weight gain between lithium and placebo, but weight gain with lithium was lower compared to other active comparators.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Article
Medicine, General & Internal
Constantin Yves Plessen, Eirini Karyotaki, Pim Cuijpers
Summary: This article introduces a method of evaluating the entire literature on psychological treatments for depression through a multiverse meta-analysis. Researchers will conduct systematic literature searches, including all randomized controlled trials comparing psychological treatments with control conditions, and extract various relevant information. The results will be published in a peer-reviewed journal and follow open science practices.
Article
Medicine, General & Internal
Anne M. de Graaff, Pim Cuijpers, Ceren Acarturk, Aemal Akhtar, Mhd Salem Alkneme, May Aoun, Manar Awwad, Ahmad Y. Bawaneh, Felicity L. Brown, Richard Bryant, Sebastian Burchert, Kenneth Carswell, Annelieke Drogendijk, Michelle Engels, Daniela C. Fuhr, Pernille Hansen, Edith van't Hof, Luana Giardinelli, Mahmoud Hemmo, Jonas M. Hessling, Zeynep Ilkkursun, Mark J. D. Jordans, Nikolai Kiselev, Christine Knaevelsrud, Gulsah Kurt, Saara Martinmaki, David McDaid, Naser Morina, Hadeel Naser, A-La Park, Monique C. Pfaltz, Bayard Roberts, Matthis Schick, Ulrich Schnyder, Julia Spaaij, Frederik Steen, Karine Taha, Ersin Uygun, Peter Ventevogel, Claire Whitney, Anke B. Witteveen, Marit Sijbrandij
Summary: This study protocol aims to evaluate the effectiveness, cost-effectiveness, and implementation of scalable psychological interventions for Syrian refugees. The study will conduct a meta-analysis and economic evaluation using data from multiple randomized controlled trials. The results will contribute to improving the mental health of Syrian refugees.
Review
Clinical Neurology
Jimmy Li, Lawrence Ledoux-Hutchinson, Denahin Hinnoutondji Toffa
Summary: This systematic review with meta-analysis aimed to estimate the prevalence of bipolar symptoms and bipolar disorder in people with epilepsy. The analysis of 17 studies found a prevalence of 12.3% for bipolar symptoms and 4.5% for bipolar disorder in people with epilepsy. There was considerable heterogeneity in the studies, warranting further research.
Review
Substance Abuse
Jo-Anne Puddephatt, Patricia Irizar, Andrew Jones, Suzanne H. Gage, Laura Goodwin
Summary: Individuals with common mental disorders (depression, anxiety, phobia) are twice as likely to report an alcohol use disorder compared to those without common mental disorders. There were no clear differences in the odds of having an AUD among different types of CMDs, and study characteristics did not provide clear explanations for heterogeneity in results. No distinct patterns were found in the associations between having a CMD and binge drinking or alcohol consumption, respectively.
Review
Medicine, General & Internal
Meghna Ranganathan, Joyce Wamoyi, Isabelle Pearson, Heidi Stockl
Summary: This systematic review synthesized evidence on sexual harassment prevalence and its association with depressive symptoms in LMICs. The findings suggest a higher prevalence of sexual harassment in educational institutions and workplaces, with some evidence of an association between sexual harassment and depressive symptoms. However, there is a need for improved measurement and rigorously designed prevalence studies using validated measures in LMICs.
Review
Clinical Neurology
Debora de A. Simoes Moreira, Luis Eduardo Gauer, Guilherme Teixeira, Amanda Carolina Fonseca da Silva, Stefanie Cavalcanti, Joao Quevedo
Summary: This study compared the efficacy and tolerability of electroconvulsive therapy (ECT) and ketamine for different depression outcomes. The results showed no significant difference between ketamine and ECT in reducing the severity of depressive symptoms and response to therapy. However, there was a significant decrease in the risk of muscle pain with ketamine compared to ECT during treatment.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Review
Behavioral Sciences
Danilo Arnone, Omar Omar, Teresa Arora, Linda Ostlundh, Reshma Ramaraj, Syed Javaid, Romona Devi Govender, Bassam R. Ali, George P. Patrinos, Allan H. Young, Emmanuel Stip
Summary: Pharmacogenomic tests based on CYP2D6 and CYP2C19 genomic variants can guide the choice and dosing of antidepressants, improving treatment outcomes for major depressive disorders. A meta-analysis study demonstrated the effectiveness of these tests in improving, responding to, and achieving remission in patients with major depression.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Article
Neurosciences
Paulo M. G. Sales, Ezra Schrage, Richard Coico, Michele Pato
Summary: This study analyzed the alterations in tryptophan catabolic pathways in mental disorders such as major depressive disorder, schizophrenia, and bipolar disorder. The results showed that patients with major depressive disorder had lower levels of tryptophan and higher activity of the catabolic pathway. Significant differences were found in schizophrenia for any of the tryptophan catabolites. Unique changes in levels of tryptophan catabolites were also observed in bipolar disorder. Furthermore, dynamic changes in cytokines and other immune/inflammatory elements played an important role in regulating the kynurenine catabolic pathway.
Review
Clinical Neurology
Nicolas A. Nunez, Boney Joseph, Mehak Pahwa, Rakesh Kumar, Manuel Gardea Resendez, Larry J. Prokop, Marin Veldic, Ashok Seshadri, Joanna M. Biernacka, Mark A. Frye, Zhen Wang, Balwinder Singh
Summary: This study compared the efficacy and discontinuation of augmentation agents in adult patients with treatment-resistant depression through a systematic review and network meta-analyses. The findings suggest that certain adjunctive atypical antipsychotics, thyroid hormones, dopamine compounds, and lithium are superior in terms of efficacy. However, ziprasidone, mirtazapine, and cariprazine had higher discontinuation rates. Further research and head-to-head studies are needed to strengthen treatment options for treatment-resistant depression.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Medicine, General & Internal
Zhongfang Fu, Marlies Brouwer, Mitzy Kennis, Alishia Williams, Pim Cuijpers, Claudi Bockting
Summary: This study provides a comprehensive overview of the evidence for psychological interventions for major depressive disorder (MDD), finding that factors derived from cognitive and personality-based theories predict the onset of MDD. However, there is limited evidence for psychodynamic and behavioral theories, highlighting the need for further research in this area.
Article
Clinical Neurology
Nadia Deflorin, Ulrike Ehlert, Rita T. Amiel Castro
Summary: Changes in the gut microbiome of infants have been associated with maternal psychological symptoms during pregnancy. This study found that maternal prenatal depressive symptoms are associated with lower diversity of the infant's microbiome, while maternal saliva cortisol levels are linked to increased diversity and changes in specific bacterial groups. Further research is needed to understand the implications of these microbiota alterations for child health.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Zheng Ma, Hui-Xia Zhou, Da-Chun Chen, Dong-Mei Wang, Xiang-Yang Zhang
Summary: The impaired glucose metabolism in drug-na & iuml;ve schizophrenia patients is strongly associated with suicidal behavior, suggesting that glucose metabolism abnormalities may be potential biomarkers of suicide in schizophrenia patients. Regular monitoring of glucose metabolism variables is essential for suicide prevention.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Katie M. Lavigne, Jiaxuan Deng, Delphine Raucher-Chene, Adele Hotte-Meunier, Chloe Voyer, Lisa Sarraf, Martin Lepage, Genevieve Sauve
Summary: Psychiatric disorders are characterized by cognitive deficits and cognitive biases, which are associated with specific symptoms. While cognitive biases are present across diagnoses, their severity varies.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Yong-Yu Yin, Jiao-Zhao Yan, Shi-Xin Lai, Qian-Qian Wei, Si-Rui Sun, Li-Ming Zhang, Yun-Feng Li
Summary: This study found that gamma oscillations are closely associated with depression and may serve as predictive biomarkers of depression. Chronic restraint stress and lipopolysaccharide induced significant depression-like behaviors in mice and reduced gamma oscillations in the medial prefrontal cortex. Administration of ketamine, scopolamine, or fluoxetine increased gamma oscillations and exhibited rapid-acting antidepressant effects.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Veronica Begni, Moira Marizzoni, Kerstin Camile Creutzberg, Diana Morena Silipo, Mariusz Papp, Annamaria Cattaneo, Marco Andrea Riva
Summary: Exposure to stressful experiences is a significant risk factor for mental disorders, and pharmacological interventions targeting stress-induced alterations can help restore brain function. Lurasidone, an antipsychotic drug, has been shown to normalize the impairments caused by stress exposure and could be a valuable treatment for stress-induced mental illnesses. However, the mechanisms underlying the therapeutic effects of lurasidone are not well understood. This study found that chronic lurasidone treatment counteracted some of the transcriptional changes induced by chronic mild stress exposure, providing new insights into the potential therapeutic effects of lurasidone.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Esther E. Palacios-Barrios, Kunal Patel, Jamie L. Hanson
Summary: This review examines the association between early life interpersonal stress (ELIS) and depression, as well as the underlying mechanisms. The research shows that ELIS affects how youth respond to social rewards, and similar impairments in social reward processing are observed in youth with depression. The authors propose a preliminary model that suggests neurobehavioral disruptions in social reward processing as a mediating factor in the connection between ELIS and depression.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Rui Li, Jiaming Tang, Yizhuo Wang, Ying Wang, Hua Yang, Hongen Wei
Summary: Restricted and repetitive behaviors (RRBs) are characteristic features of neuropsychiatric disorders. This study focused on repetitive self-grooming behavior and investigated the involvement of the Pax2 gene in its control. Through the use of Pax2 neuron-specific deletion mice, the study found that the deletion of Pax2 gene affects the expression of the Arc gene in the prefrontal cortex, leading to impaired synaptic plasticity and excitatory/inhibitory imbalance, thereby contributing to the occurrence of repetitive self-grooming behavior.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Sara Derosa, Paulina Misztak, Jessica Mingardi, Giulia Mazzini, Heidi Kaastrup Muller, Laura Musazzi
Summary: This study investigated the involvement of neurotrophic signaling pathways in stress vulnerability/resilience and fast antidepressant response/non-response to ketamine in a rat model of depression. The findings showed that stress and ketamine induced specific changes in these pathways in different brain areas and subcellular fractions.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Review
Clinical Neurology
Georgia F. Caruana, Sean P. Carruthers, Michael Berk, Susan L. Rossell, Tamsyn E. Van Rheenen
Summary: Cognitive impairment is related to both white matter macrostructure and microstructure in bipolar disorder patients. However, there is inconsistency in the results of the studies examining this relationship. Some studies have found an association between higher fractional anisotropy in white matter and better complex attention skills and executive functioning in bipolar disorder patients, while others have found no associations. Further research with increased statistical power and standardized methods is needed.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Review
Clinical Neurology
Alberto Galimberti, Martin Tik, Giovanni Pellegrino, Anna-Lisa Schuler
Summary: This study provides a systematic review and meta-analysis on the effectiveness of repetitive transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS) for post-traumatic brain injury (TBI) symptoms. The results show that non-invasive brain stimulation techniques have a small overall effect on TBI sequelae, with significant effects observed for anxiety and headache. However, larger randomized controlled trials with longer follow-ups, optimized stimulation parameters, and standardized methodology are needed to establish the efficacy of these techniques in addressing TBI sequelae.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Amanda J. Sales, Pedro H. Gobira, Joa F. C. Pedrazzi, Joao R. Silveia, Elaine Del Bel, Felipe V. Gomes, Francisco S. Guimaraes
Summary: The study found that doxycycline can inhibit metalloproteinase in the brain and attenuate the rewarding effects and locomotor sensitization of drug abuse. This suggests that doxycycline could be repurposed for the treatment of substance use disorders.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Alejandro Borrego-Ruiz, Juan J. Borrego
Summary: There is substantial evidence that the development of the nervous system is related to the composition and functions of the gut microbiome. The communication between the central nervous system (CNS) and the gut microbiota is bidirectional, with various routes such as immune, endocrine, and neural circuits. Dysbiosis of the gut microbiota has been associated with neuropsychiatric diseases and psychological disorders. Fecal microbiota transplantation (FMT) therapy has shown a causal-effect relationship between the gut microbiota and behavioral features. Interventions based on prebiotics, probiotics, or synbiotics have demonstrated their influence on neurological disorders through the synthesis of neuroactive compounds and regulation of inflammatory and endocrine processes. Further research is needed to explore the impact of gut microbiota dysbiosis on psychiatric and psychological disorders and the potential therapeutic role of microbiota-based interventions.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Zhinan Li, Zhuang Kang, Xiaowei Xia, Leijun Li, Junyan Wu, Jiamin Dai, Tong Liu, Cai Chen, Yong Qiu, Ming Chen, Yanxi Liu, Ziyi Zhang, Zili Han, Zhengjia Dai, Qinling Wei
Summary: This study found that patients with schizophrenia showed lower levels of resilience and cognitive functions compared to healthy controls, as well as abnormal global properties and nodal metrics in brain networks. Furthermore, characteristic path length might moderate the relationship between resilience and working memory in these patients.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
David H. Adamowicz, Tsung-Chin Wu, Rebecca Daly, Michael R. Irwin, Dilip Jeste, Xin M. Tu, Lisa T. Eyler, Ellen E. Lee
Summary: This study aimed to explore the relationship between executive functioning and inflammatory biomarkers in people with schizophrenia. The results showed that systemic inflammation did not predict long-term declines in executive functioning. This suggests the need for further research to better understand the relationship and mechanisms between inflammation and cognition in schizophrenia.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Nina Walter, Julian Wenzel, Shalaila S. Haas, Letizia Squarcina, Carolina Bonivento, Anne Ruef, Dominic Dwyer, Theresa Lichtenstein, Oeznur Bastruek, Alexandra Stainton, Linda A. Antonucci, Paolo Brambilla, Stephen J. Wood, Rachel Upthegrove, Stefan Borgwardt, Rebekka Lencer, Eva Meisenzahl, Raimo K. R. Salokangas, Christos Pantelis, Alessandro Bertolino, Nikolaos Koutsouleris, Joseph Kambeitz, Lana Kambeitz-Ilankovic
Summary: Clinical and neuroimaging data can be used to predict the potential of cognitive training to improve social functioning in recent onset psychosis patients. The use of multivariate pattern analysis and support vector machine classifier allows for the prediction of social functioning improvement based on baseline cognitive data. The findings suggest that cognitive data can provide a robust individual estimate of future social functioning for patients with recent onset psychosis.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)