Does the food processing contaminant acrylamide cause developmental neurotoxicity? A review and identification of knowledge gaps

Assessment of developmental neurotoxicity induced by chemical mixtures using an adverse outcome pathway concept

(2020) Francesca Pistollato et al.   Environmental Health

Chronic acrylamide exposure induced glia cell activation, NLRP3 infl-ammasome upregulation and cognitive impairment

(2020) Ying Liu et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Targeting redox metabolism: the perfect storm induced by acrylamide poisoning in the brain

(2020) Demetrio Raldúa et al.   Scientific Reports

Acrylamide alters CREB and retinoic acid signalling pathways during differentiation of the human neuroblastoma SH-SY5Y cell line

(2020) Kristina Attoff et al.   Scientific Reports

Sensorineural hearing loss and volatile organic compound metabolites in urine

(2019) Charles Pudrith et al.   AMERICAN JOURNAL OF OTOLARYNGOLOGY

Role of microglial activation and neuroinflammation in neurotoxicity of acrylamide in vivo and in vitro

(2019) Cai Zong et al.   ARCHIVES OF TOXICOLOGY

Beyond detoxification: Pleiotropic functions of multiple glutathione S-transferase isoforms protect mice against a toxic electrophile

(2019) Kelsey A. Behrens et al.   PLoS One

Brain Organoids: Human Neurodevelopment in a Dish

(2019) Silvia Benito-Kwiecinski et al.   Cold Spring Harbor Perspectives in Biology

Tau hyperphosphorylation and P-CREB reduction are involved in acrylamide-induced spatial memory impairment: Suppression by curcumin

(2018) Dandan Yan et al.   BRAIN BEHAVIOR AND IMMUNITY

Dietary acrylamide intake during pregnancy and postnatal growth and obesity: Results from the Norwegian Mother and Child Cohort Study (MoBa)

(2018) Manik Kadawathagedara et al.   ENVIRONMENT INTERNATIONAL

Mitochondrial network responses in oxidative physiology and disease

(2018) Young-Mi Go et al.   FREE RADICAL BIOLOGY AND MEDICINE

Learning, memory deficits, and impaired neuronal maturation attributed to acrylamide

(2018) Seulah Lee et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES

Modulation of thiol-dependent redox system by metal ions via thioredoxin and glutaredoxin systems

(2018) Yanfang Ouyang et al.   Metallomics

Acrylamide applied during pregnancy causes the neurotoxic effect by lowering BDNF levels in the fetal brain

(2018) Mehmet Erman Erdemli et al.   NEUROTOXICOLOGY AND TERATOLOGY

OUP accepted manuscript

(2018)   TOXICOLOGICAL SCIENCES

Design and validation of an ontology-driven animal-free testing strategy for developmental neurotoxicity testing

(2018) Ellen V.S. Hessel et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Recommendation on test readiness criteria for new approach methods in toxicology: Exemplified for developmental neurotoxicity

(2018) Anna Bal-Price   ALTEX-Alternatives to Animal Experimentation

Maternal Acrylamide Intake during Pregnancy and Sex Hormone Levels in Maternal and Umbilical Cord Blood and Birth Size of Offspring

(2018) Chisato Nagata et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Microglia Increase Inflammatory Responses in iPSC-Derived Human BrainSpheres

(2018) Celina Monteiro Abreu et al.   Frontiers in Microbiology

Organoselenium compounds as mimics of selenoproteins and thiol modifier agents

(2017) Nilda V. Barbosa et al.   Metallomics

Biochemical characterization of the selenoproteome in Gallus gallus via bioinformatics analysis: structure–function relationships and interactions of binding molecules

(2017) Shi-Yong Zhu et al.   Metallomics

Toxic effect of acrylamide on the development of hippocampal neurons of weaning rats

(2017) Jing Liu et al.   Neural Regeneration Research

The Role of CYP2E1 in the Drug Metabolism or Bioactivation in the Brain

(2017) W. A. García-Suástegui et al.   Oxidative Medicine and Cellular Longevity

Whole genome microarray analysis of neural progenitor C17.2 cells during differentiation and validation of 30 neural mRNA biomarkers for estimation of developmental neurotoxicity

(2017) Kristina Attoff et al.   PLoS One

Comparison of neurons derived from mouse P19, rat PC12 and human SH-SY5Y cells in the assessment of chemical- and toxin-induced neurotoxicity

(2017) Dina Popova et al.   BMC Pharmacology & Toxicology

Impaired cross-talk between the thioredoxin and glutathione systems is related to ASK-1 mediated apoptosis in neuronal cells exposed to mercury

(2017) Vasco Branco et al.   Redox Biology

Omnisphero: a high-content image analysis (HCA) approach for phenotypic developmental neurotoxicity (DNT) screenings of organoid neurosphere cultures in vitro

(2016) Martin R. Schmuck et al.   ARCHIVES OF TOXICOLOGY

Dietary acrylamide intake during pregnancy and anthropometry at birth in the French EDEN mother-child cohort study

(2016) M. Kadawathagedara et al.   ENVIRONMENTAL RESEARCH

Measurement and meaning of cellular thiol:disufhide redox status

(2016) Marcelo A. Comini   FREE RADICAL RESEARCH

Investigation of the effects of acrylamide applied during pregnancy on fetal brain development in rats and protective role of the vitamin E

(2016) ME Erdemli et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

The consequences of fetal growth restriction on brain structure and neurodevelopmental outcome

(2016) Suzanne L. Miller et al.   JOURNAL OF PHYSIOLOGY-LONDON

The Cellular and Molecular Landscapes of the Developing Human Central Nervous System

(2016) John C. Silbereis et al.   NEURON

Acrylamide affects proliferation and differentiation of the neural progenitor cell line C17.2 and the neuroblastoma cell line SH-SY5Y

(2016) K. Attoff et al.   TOXICOLOGY IN VITRO

Inhibition of Neurosphere Formation in Neural Stem/Progenitor Cells by Acrylamide

(2015) Jong-Hang Chen et al.   CELL TRANSPLANTATION

Two-year carcinogenicity study of acrylamide in Wistar Han rats with in utero exposure

(2015) R.R. Maronpot et al.   EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY

Acrylamide inhibits cellular differentiation of human neuroblastoma and glioblastoma cells

(2015) Jong-Hang Chen et al.   FOOD AND CHEMICAL TOXICOLOGY

A Combination Supplement of Fructo- and Xylo-Oligosaccharides Significantly Abrogates Oxidative Impairments and Neurotoxicity in Maternal/Fetal Milieu Following Gestational Exposure to Acrylamide in Rat

(2015) Gokul Krishna et al.   NEUROCHEMICAL RESEARCH

Determination of acrylamide and glycidamide in various biological matrices by liquid chromatography–tandem mass spectrometry and its application to a pharmacokinetic study

(2015) Tae Hwan Kim et al.   TALANTA

Investigation of the reactions of acrylamide during in vitro multistep enzymatic digestion of thermally processed foods

(2015) Aytül Hamzalıoğlu et al.   Food & Function

Fetal exposure to dietary carcinogens and risk of childhood cancer: what the NewGeneris project tells us: Table 1 

(2015) Jos Kleinjans et al.   BMJ-British Medical Journal

Fetal exposure to dietary carcinogens and risk of childhood cancer: what the NewGeneris project tells us: Table 1 

(2015) Jos Kleinjans et al.   BMJ-British Medical Journal

Hyperlipidemia exacerbates cerebral injury through oxidative stress, inflammation and neuronal apoptosis in MCAO/reperfusion rats

(2015) Xiao-Lu Cao et al.   EXPERIMENTAL BRAIN RESEARCH

Alkylation of Adenosine Deaminase and Thioredoxin by Acrylamide in Human Cell Cultures

(2015) Thomas Schwend et al.   ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES

Effect of acrylamide on the development of medulla oblongata in albino rat: Biochemical and morphological studies

(2014) A. A.   African Journal of Pharmacy and Pharmacology

Selenoproteins in Nervous System Development and Function

(2014) Matthew W. Pitts et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Selenium and selenoprotein function in brain disorders

(2014) Roshan Pillai et al.   IUBMB LIFE

Thioredoxin System Regulation in the Central Nervous System: Experimental Models and Clinical Evidence

(2014) Daniela Silva-Adaya et al.   Oxidative Medicine and Cellular Longevity

Mouse Spermatocytes Express CYP2E1 and Respond to Acrylamide Exposure

(2014) Belinda J. Nixon et al.   PLoS One

Evaluation of a human neurite growth assay as specific screen for developmental neurotoxicants

(2013) Anne K. Krug et al.   ARCHIVES OF TOXICOLOGY

Dynamics of Hippocampal Neurogenesis in Adult Humans

(2013) Kirsty L. Spalding et al.   CELL

Comparison of PBTK model and biomarker based estimates of the internal dosimetry of acrylamide

(2013) R.S. DeWoskin et al.   FOOD AND CHEMICAL TOXICOLOGY

Mechanistic insights into the cytotoxicity and genotoxicity induced by glycidamide in human mammary cells

(2013) S. Bandarra et al.   MUTAGENESIS

Assessment of the developmental neurotoxicity of compounds by measuring locomotor activity in zebrafish embryos and larvae

(2013) Ingrid W.T. Selderslaghs et al.   NEUROTOXICOLOGY AND TERATOLOGY

Acrylamide neurotoxicity

(2013) Pinar Erkekoglu et al.   NUTRITIONAL NEUROSCIENCE

Protein targets of acrylamide adduct formation in cultured rat dopaminergic cells

(2013) Christopher J. Martyniuk et al.   TOXICOLOGY LETTERS

Neurotoxicity of Acrylamide in Exposed Workers

(2013) Manuela Pennisi et al.   International Journal of Environmental Research and Public Health

Reversible aberration of neurogenesis targeting late-stage progenitor cells in the hippocampal dentate gyrus of rat offspring after maternal exposure to acrylamide

(2012) Bunichiro Ogawa et al.   ARCHIVES OF TOXICOLOGY

Diverse action of acrylamide on cytochrome P450 and glutathione S-transferase isozyme activities, mRNA levels and protein levels in human hepatocarcinoma cells

(2012) Alaattin Sen et al.   CELL BIOLOGY AND TOXICOLOGY

Molecular Mechanism of Acrylamide Neurotoxicity: Lessons Learned from Organic Chemistry

(2012) Richard M. LoPachin et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Birth Weight, Head Circumference, and Prenatal Exposure to Acrylamide from Maternal Diet: The European Prospective Mother–Child Study (NewGeneris)

(2012) Marie Pedersen et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Dietary Acrylamide Intake during Pregnancy and Fetal Growth—Results from the Norwegian Mother and Child Cohort Study (MoBa)

(2012) Talita Duarte-Salles et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Meta-analysis of data from human ex vivo placental perfusion studies on genotoxic and immunotoxic agents within the integrated European project NewGeneris

(2012) T. Mose et al.   PLACENTA

Application of the Hard and Soft, Acids and Bases (HSAB) Theory to Toxicant–Target Interactions

(2011) Richard M. LoPachin et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Analysis of Hemoglobin Adducts from Acrylamide, Glycidamide, and Ethylene Oxide in Paired Mother/Cord Blood Samples from Denmark

(2011) Hans von Stedingk et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Acrylamide Analysis in Tobacco, Alternative Tobacco Products, and Cigarette Smoke

(2011) S. C. Moldoveanu et al.   JOURNAL OF CHROMATOGRAPHIC SCIENCE

Spatio-temporal transcriptome of the human brain

(2011) Hyo Jung Kang et al.   NATURE

Structural and ultrastructural evidence of neurotoxic effects of fried potato chips on rat postnatal development

(2011) Hassan I. El-Sayyad et al.   NUTRITION

Self-reported symptoms and neuropsychological function among tunnel workers previously exposed to acrylamide and N-methylolacryl­amide

(2011) Lars Ole Goffeng et al.   SCANDINAVIAN JOURNAL OF WORK ENVIRONMENT & HEALTH

Effect of sub-acute exposure to acrylamide on GABAergic neurons and astrocytes in weaning rat cerebellum

(2011) Jing Shi et al.   TOXICOLOGY AND INDUSTRIAL HEALTH

Prenatal and perinatal acrylamide disrupts the development of cerebellum in rat: Biochemical and morphological studies

(2011) A. Allam et al.   TOXICOLOGY AND INDUSTRIAL HEALTH

Modification of major plasma proteins by acrylamide and glycidamide: Preliminary screening by nano liquid chromatography with tandem mass spectrometry

(2010) Chia-Hsien Feng et al.   ANALYTICA CHIMICA ACTA

Disruptive neuronal development by acrylamide in the hippocampal dentate hilus after developmental exposure in rats

(2010) Bunichiro Ogawa et al.   ARCHIVES OF TOXICOLOGY

Long-lasting inhibition of presynaptic metabolism and neurotransmitter release by protein S-nitrosylation

(2010) Alena Rudkouskaya et al.   FREE RADICAL BIOLOGY AND MEDICINE

Toxicity Testing in the 21st Century: A Vision and a Strategy

(2010) Daniel Krewski et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS

The Basics of Brain Development

(2010) Joan Stiles et al.   NEUROPSYCHOLOGY REVIEW

Preweaning behaviors, developmental landmarks, and acrylamide and glycidamide levels after pre- and postnatal acrylamide treatment in rats

(2010) Sherry A. Ferguson et al.   NEUROTOXICOLOGY AND TERATOLOGY

The inhibitory effect of acrylamide on NCAM expression in human neuroblastoma cells: Involvement of CK2/Ikaros signaling pathway

(2010) Hye-Rim Lee et al.   TOXICOLOGY IN VITRO

Limited lactational transfer of acrylamide to rat offspring on maternal oral administration during the gestation and lactation periods

(2009) Miwa Takahashi et al.   ARCHIVES OF TOXICOLOGY

Protein Modification by Acrolein: Formation and Stability of Cysteine Adducts

(2009) Jian Cai et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Development of a physiologically-based toxicokinetic model of acrylamide and glycidamide in rats and humans

(2009) Lisa M. Sweeney et al.   FOOD AND CHEMICAL TOXICOLOGY

Acrylamide as environmental noxious agent

(2009) Birgitta Kütting et al.   INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH

Effects of chronic oral acrylamide exposure on incremental repeated acquisition (learning) task performance in Fischer 344 rats

(2009) Joan Garey et al.   NEUROTOXICOLOGY AND TERATOLOGY

mRNA Expression is a Relevant Tool to Identify Developmental Neurotoxicants Using an In Vitro Approach

(2009) Helena T. Hogberg et al.   TOXICOLOGICAL SCIENCES

Biomarkers of Human Exposure to Acrylamide and Relation to Polymorphisms in Metabolizing Genes

(2009) Nur Duale et al.   TOXICOLOGICAL SCIENCES

Acrylamide induces cell death in neural progenitor cells and impairs hippocampal neurogenesis

(2009) Hee Ra Park et al.   TOXICOLOGY LETTERS

Biochemical analysis of selenoprotein expression in brain cell lines and in distinct brain regions

(2008) Barbara Hoppe et al.   CELL AND TISSUE RESEARCH

Development of a Stable Isotope Dilution Assay for the Quantitation of Glycidamide and Its Application to Foods and Model Systems

(2008) Michael Granvogl et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Using Dietary Exposure and Physiologically Based Pharmacokinetic/Pharmacodynamic Modeling in Human Risk Extrapolations for Acrylamide Toxicity

(2008) Daniel R. Doerge et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Inhibition of the Human Thioredoxin System

(2008) Cristina M. L. Carvalho et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pathological assessment of the nervous and male reproductive systems of rat offspring exposed maternally to acrylamide during the gestation and lactation periods − a preliminary study

(2008) Miwa Takahashi et al.   JOURNAL OF TOXICOLOGICAL SCIENCES

Regulation of glutathione synthesis

(2008) Shelly C. Lu   MOLECULAR ASPECTS OF MEDICINE

Neurons born in the adult dentate gyrus form functional synapses with target cells

(2008) Nicolas Toni et al.   NATURE NEUROSCIENCE

Nerve conduction, visual evoked responses and electroretinography in tunnel workers previously exposed to acrylamide and N-methylolacrylamide containing grouting agents

(2008) Lars Ole Goffeng et al.   NEUROTOXICOLOGY AND TERATOLOGY

Differentiating human NT2/D1 neurospheres as a versatile in vitro 3D model system for developmental neurotoxicity testing

(2008) E.J. Hill et al.   TOXICOLOGY

Gene expression as a sensitive endpoint to evaluate cell differentiation and maturation of the developing central nervous system in primary cultures of rat cerebellar granule cells (CGCs) exposed to pesticides

(2008) Helena T. Hogberg et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Transplacental transfer of acrylamide and glycidamide are comparable to that of antipyrine in perfused human placenta

(2008) K ANNOLA et al.   TOXICOLOGY LETTERS

Colour vision and light sensitivity in tunnel workers previously exposed to acrylamide and N-methylolacrylamide containing grouting agents

(2007) Lars Ole Goffeng et al.   NEUROTOXICOLOGY