Selenoproteins in Nervous System Development and Function

Selenoprotein P and apolipoprotein E receptor-2 interact at the blood-brain barrier and also within the brain to maintain an essential selenium pool that protects against neurodegeneration

(2014) Raymond F. Burk et al.   FASEB JOURNAL

Mice Lacking Selenoprotein P and Selenocysteine Lyase Exhibit Severe Neurological Dysfunction, Neurodegeneration, and Audiogenic Seizures

(2014) China N. Byrns et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Selenoprotein P is the essential selenium transporter for bones

(2014) Nicole Pietschmann et al.   Metallomics

Selenium and Topiramate Attenuates Blood Oxidative Toxicity in Patients with Epilepsy: A Clinical Pilot Study

(2013) Vedat Ali Yürekli et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Maternal-fetal transfer of selenium in the mouse

(2013) Raymond F. Burk et al.   FASEB JOURNAL

Deletion of Selenoprotein M Leads to Obesity without Cognitive Deficits

(2013) Matthew W. Pitts et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Perineuronal nets protect fast-spiking interneurons against oxidative stress

(2013) J.-H. Cabungcal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Selenoprotein W expression and regulation in mouse brain and neurons

(2013) Arjun V. Raman et al.   Brain and Behavior

Cerebellar Abnormalities in Mice Lacking Type 3 Deiodinase and Partial Reversal of Phenotype by Deletion of Thyroid Hormone Receptor α1

(2012) Robin P. Peeters et al.   ENDOCRINOLOGY

Deficiency of selenium and zinc as a causative factor for idiopathic intractable epilepsy

(2012) Mehmet Seven et al.   EPILEPSY RESEARCH

Absence of selenoprotein P but not selenocysteine lyase results in severe neurological dysfunction

(2012) A. V. Raman et al.   GENES BRAIN AND BEHAVIOR

Long Isoform Mouse Selenoprotein P (Sepp1) Supplies Rat Myoblast L8 Cells with Selenium via Endocytosis Mediated by Heparin Binding Properties and Apolipoprotein E Receptor-2 (ApoER2)

(2012) Suguru Kurokawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Disruption of the Selenocysteine Lyase-Mediated Selenium Recycling Pathway Leads to Metabolic Syndrome in Mice

(2012) L. A. Seale et al.   MOLECULAR AND CELLULAR BIOLOGY

Deletion of selenoprotein P results in impaired function of parvalbumin interneurons and alterations in fear learning and sensorimotor gating

(2012) M.W. Pitts et al.   NEUROSCIENCE

Glutathione Peroxidase-3 Deficiency Promotes Platelet-Dependent Thrombosis In Vivo

(2011) Richard C. Jin et al.   CIRCULATION

Disorders of selenium metabolism and selenoprotein function

(2011) Ulrich Schweizer et al.   CURRENT OPINION IN PEDIATRICS

Roles of the 15-kDa Selenoprotein (Sep15) in Redox Homeostasis and Cataract Development Revealed by the Analysis of Sep 15 Knockout Mice

(2011) Marina V. Kasaikina et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Selenoprotein K Is a Novel Target of m-Calpain, and Cleavage Is Regulated by Toll-like Receptor-induced Calpastatin in Macrophages

(2011) Zhi Huang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Selenoprotein K Knockout Mice Exhibit Deficient Calcium Flux in Immune Cells and Impaired Immune Responses

(2011) S. Verma et al.   JOURNAL OF IMMUNOLOGY

Glutathione Peroxidase 4 is associated with Neuromelanin in Substantia Nigra and Dystrophic Axons in Putamen of Parkinson's brain

(2011) Frederick P Bellinger et al.   Molecular Neurodegeneration

Targeting hyperphosphorylated tau with sodium selenate suppresses seizures in rodent models

(2011) Nigel C. Jones et al.   NEUROBIOLOGY OF DISEASE

Increased Muscle Stress-Sensitivity Induced by Selenoprotein N Inactivation in Mouse: A Mammalian Model for SEPN1-Related Myopathy

(2011) Mathieu Rederstorff et al.   PLoS One

Cortical parvalbumin interneurons and cognitive dysfunction in schizophrenia

(2011) David A. Lewis et al.   TRENDS IN NEUROSCIENCES

Mutations Disrupting Selenocysteine Formation Cause Progressive Cerebello-Cerebral Atrophy

(2010) Orly Agamy et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Mutation of megalin leads to urinary loss of selenoprotein P and selenium deficiency in serum, liver, kidneys and brain

(2010) Jazmin Chiu-Ugalde et al.   BIOCHEMICAL JOURNAL

Functional and physical interaction between the selenium-binding protein 1 (SBP1) and the glutathione peroxidase 1 selenoprotein

(2010) Wenfeng Fang et al.   CARCINOGENESIS

Selenoproteins—What unique properties can arise with selenocysteine in place of cysteine?

(2010) Elias S.J. Arnér   EXPERIMENTAL CELL RESEARCH

Methionine Sulfoxide Reductase B1 (MsrB1) Recovers TRPM6 Channel Activity during Oxidative Stress

(2010) Gang Cao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Selenoprotein-Related Disease in a Young Girl Caused by Nonsense Mutations in theSBP2Gene

(2010) Monalisa Ferreira Azevedo et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Mutations in the selenocysteine insertion sequence–binding protein 2 gene lead to a multisystem selenoprotein deficiency disorder in humans

(2010) Erik Schoenmakers et al.   JOURNAL OF CLINICAL INVESTIGATION

Sodium selenate specifically activates PP2A phosphatase, dephosphorylates tau and reverses memory deficits in an Alzheimer’s disease model

(2010) Niall M. Corcoran et al.   JOURNAL OF CLINICAL NEUROSCIENCE

Oxidative Stress in the Progression of Alzheimer Disease in the Frontal Cortex

(2010) Mubeen A. Ansari et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Type 3 Deiodinase, a Thyroid-Hormone-Inactivating Enzyme, Controls Survival and Maturation of Cone Photoreceptors

(2010) L. Ng et al.   JOURNAL OF NEUROSCIENCE

Selenium partially reverses the depletion of striatal dopamine and its metabolites in MPTP-treated C57BL mice

(2010) Haseeb Ahmad Khan   NEUROCHEMISTRY INTERNATIONAL

Sodium selenate mitigates tau pathology, neurodegeneration, and functional deficits in Alzheimer's disease models

(2010) J. van Eersel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure–Function Relations, Physiological Roles, and Evolution of Mammalian ER-Resident Selenoproteins

(2009) Valentina A. Shchedrina et al.   ANTIOXIDANTS & REDOX SIGNALING

Threading the Needle: Getting Selenocysteine Into Proteins

(2009) Jesse Donovan et al.   ANTIOXIDANTS & REDOX SIGNALING

The Neuroprotective Functions of Selenoprotein M and its Role in Cytosolic Calcium Regulation

(2009) Mariclair A. Reeves et al.   ANTIOXIDANTS & REDOX SIGNALING

The labour pains of biochemical selenology: The history of selenoprotein biosynthesis

(2009) Leopold Flohé   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Selenoprotein P—Expression, functions, and roles in mammals

(2009) Raymond F. Burk et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Serum Trace Element Levels in Febrile Convulsion

(2009) Mojtaba Amiri et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Life without Thyroxine to 3,5,3′-Triiodothyronine Conversion: Studies in Mice Devoid of the 5′-Deiodinases

(2009) Valerie Anne Galton et al.   ENDOCRINOLOGY

Neuronal selenoprotein expression is required for interneuron development and prevents seizures and neurodegeneration

(2009) Eva K. Wirth et al.   FASEB JOURNAL

Organoselenium (Sel-Plex diet) decreases amyloid burden and RNA and DNA oxidative damage in APP/PS1 mice

(2009) Mark A. Lovell et al.   FREE RADICAL BIOLOGY AND MEDICINE

The brain selenoproteome: priorities in the hierarchy and different levels of selenium homeostasis in the brain of selenium-deficient rats

(2009) Markus Kühbacher et al.   JOURNAL OF NEUROCHEMISTRY

Selenium attenuates Aβ production and Aβ-induced neuronal death

(2009) A-Ryeong Gwon et al.   NEUROSCIENCE LETTERS

Cellular glutathione peroxidase in human brain: cellular distribution, and its potential role in the degradation of Lewy bodies in Parkinson’s disease and dementia with Lewy bodies

(2008) John H. T. Power et al.   ACTA NEUROPATHOLOGICA

A Protective Role for Type 3 Deiodinase, a Thyroid Hormone-Inactivating Enzyme, in Cochlear Development and Auditory Function

(2008) Lily Ng et al.   ENDOCRINOLOGY

Selenoprotein T is a PACAP-regulated gene involved in intracellular Ca2+ mobilization and neuroendocrine secretion

(2008) Luca Grumolato et al.   FASEB JOURNAL

Eukaryotic selenoprotein synthesis: Mechanistic insight incorporating new factors and new functions for old factors

(2008) Jeffrey E. Squires et al.   IUBMB LIFE

MsrB1(Methionine-R-sulfoxide Reductase 1) Knock-out Mice

(2008) Dmitri E. Fomenko et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Megalin Mediates Selenoprotein P Uptake by Kidney Proximal Tubule Epithelial Cells

(2008) Gary E. Olson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neurodegeneration in Mice Resulting From Loss of Functional Selenoprotein P or Its Receptor Apolipoprotein E Receptor 2

(2008) William M. Valentine et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Sodium selenite inhibits γ-secretase activity through activation of ERK

(2008) Ying-Tsen Tung et al.   NEUROSCIENCE LETTERS

The Role of Thioredoxin Reductases in Brain Development

(2008) Jonna Soerensen et al.   PLoS One

Selenoprotein N is required for ryanodine receptor calcium release channel activity in human and zebrafish muscle

(2008) M. J. Jurynec et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA