Article
Biochemistry & Molecular Biology
Lichao Zhong, Zhizhang Yang, Hao Tang, Yifan Xu, Xingyou Liu, Jie Shen
Summary: The decline of climbing behavior in aging fruit flies is a common phenomenon. By analyzing the climbing trajectories of individual fruit flies, it was found that climbing ability decreases with age and is stronger in female fruit flies compared to males.
ARCHIVES OF INSECT BIOCHEMISTRY AND PHYSIOLOGY
(2022)
Article
Neurosciences
Thiago C. Moulin, Federico Ferro, Angela Hoyer, Pierre Cheung, Michael J. Williams, Helgi B. Schioth
Summary: Over 320 million people worldwide suffer from depression, with major depression being almost twice as common in women than in men. Fruit fly models can help identify the molecular mechanisms underlying sex-specific differences in depressive disorder prevalence.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Environmental Sciences
Fanghuan Zhu, Jun Wang, Jingjing Jiao, Yu Zhang
Summary: Exposure to acrylamide has adverse effects on skeletal development, including decreased survival and hatching rates, shortened body length, cartilage malformation, and disturbed bone mineral density. It disrupts the differentiation and maturation of osteoblasts and cartilage matrix, and promotes the formation of osteoclasts, ultimately leading to skeletal abnormalities.
ENVIRONMENTAL POLLUTION
(2021)
Article
Biotechnology & Applied Microbiology
Safy Hadiya, Reham A. Ibrahem, Rehab M. Abd El-Baky, Mahmoud Elsabahy, Abeer M. R. Hussein, Mohammed E. M. Tolba, Sherine A. Aly
Summary: This study demonstrates that loading ciprofloxacin and meropenem into nanocarriers can enhance their synergistic effect, providing a promising approach to rejuvenate antibiotics ineffective against resistant pathogens. Nanocarrier-loaded antibiotics exhibited a bactericidal effect and significantly reduced bacterial load, indicating their potential in treating bacterial infections.
Article
Biochemistry & Molecular Biology
Jelena Markovic Filipovic, Marko Miler, Danijela Kojic, Jelena Karan, Ivana Ivelja, Jovana Cukuranovic Kokoris, Milica Matavulj
Summary: The treatment of Acrylamide can affect protein expression and cellular redox status in the liver, leading to changes in cellular metabolic potential.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Anna Verbe, Dominique Martinez, Stephane Viollet
Summary: We investigated how hoverflies use sensory cues to correct their orientation while falling. Leg proprioceptive information was sufficient for the flies to right themselves properly. However, visual and antennal cues were also used to recover faster and resolve sensory conflicts. Surprisingly, in one experimental condition, hoverflies flew upside-down while still flapping their wings. In all other conditions, flies were able to right themselves using fast or slow roll dynamics depending on the cues present.
SCIENTIFIC REPORTS
(2023)
Article
Agriculture, Multidisciplinary
Lu Li, Ziyue Wang, Yucai Li, Fuying Ma, Xinwei Wang, Haiyang Yan, Wenliang Li, Yong Pang, Yuan Yuan
Summary: The study found that allicin can protect the kidney from the harmful effects of acrylamide. Allicin restores mitochondrial function, inhibits p53 acetylation, prevents the translocation of cytochrome c, and reduces caspase expression, thereby relieving mitochondrial apoptosis caused by acrylamide.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Biology
Joyce Rigal, Ane Martin Anduaga, Elena Bitman, Emma Rivellese, Sebastian Kadener, Michael T. Marr
Summary: This study demonstrates that active transposable elements can act as effectors in the aging process by accelerating aging phenotypes and shortening lifespan in fruit flies. Increased transposable element activity leads to increased sensitivity to oxidative stress and a decline in circadian rhythmicity. Overexpression of the FOXO stress response transcription factor can partially rescue the detrimental effects of increased transposable element activity on lifespan.
Article
Chemistry, Applied
Maria Alessia Schouten, Silvia Tappi, Simone Angeloni, Manuela Cortese, Giovanni Caprioli, Sauro Vittori, Santina Romani
Summary: The study found that during the coffee roasting process, acrylamide levels and antioxidant activity reached a peak at lower roasting degrees, then decreased as heating time increased. The thermal reduction had a greater impact on acrylamide compared to antioxidant activity, as there was a balance between the degradation and formation of antioxidant compounds.
Article
Biochemistry & Molecular Biology
Eliana Jardim Fernandes, Marcia Rosula Poetini, Magna Sotelo Barrientos, Vandreza Cardoso Bortolotto, Stifani Machado Araujo, Elize Aparecida Santos Musachio, Amarilis Santos De Carvalho, Fernanda Vitoria Leimann, Odinei Hess Goncalves, Bruna Piaia Ramborger, Rafael Roehrs, Marina Prigol, Gustavo Petri Guerra
Summary: The study showed that lutein-loaded nanoparticles protected against locomotor damage and neurotoxicity induced by Parkinson's disease model in fruit flies, restored dopamine levels and oxidative stress markers.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Biology
Ratan Othayoth, Chen Li
Summary: Terrestrial animals such as the discoid cockroach self-right by using wing opening and leg flailing to increase the probability of successfully correcting themselves when overturned on the ground. A potential energy landscape model was used to study the physical interactions and energy barriers involved in the self-righting process, demonstrating the usefulness of this model for understanding self-righting transitions.
Article
Biochemistry & Molecular Biology
Xiaohan Hu, Sheng Tang, Feiyi Yang, Pengwu Zheng, Shan Xu, Qingshan Pan, Wufu Zhu
Summary: Two series of olmutinib derivatives containing an acrylamide moiety were synthesized and evaluated for their IC50 values against five cancer cell lines, showing moderate cytotoxic activity. The most promising compound, H10, exhibited excellent activity against EGFR kinase and positive biological activity against PI3K kinase. The SAR indicated that the introduction of dimethylamine scaffolds with smaller spatial structures was more favorable for antitumor activity. Overall, compounds H7 and H10 were confirmed as promising antitumor agents.
Article
Environmental Sciences
Yiqi Wang, Lian Duan, Xing Zhang, Yang Jiao, Ying Liu, Lingling Dai, Hong Yan
Summary: The study demonstrated that chronic exposure to ACR can impair motor skills, muscle strength, and coordination in rats, as well as damage the morphology of the cerebellum, leading to increased apoptosis and initiation of autophagy.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Marine & Freshwater Biology
Eli S. J. Thore, Luc Brendonck, Tom Pinceel
Summary: The ongoing pollution of aquatic ecosystems with neurochemical compounds necessitates a better understanding of how this affects key organisms. Research on freshwater crustaceans with non-generic life-history strategies is currently lacking, hindering meaningful predictions. In this study, exposure to the anxiolytic pharmaceutical fluoxetine was found to affect the behavioral trade-offs between conspicuous morphology and antipredator behavior in the freshwater fairy shrimp.
AQUATIC TOXICOLOGY
(2021)
Article
Behavioral Sciences
Daniel Alberto Burbano Lombana, Simone Macri, Maurizio Porfiri
Summary: Research shows that in zebrafish, individual anxiety-related behaviors can be transmitted to untreated conspecifics through pharmacological modulation, and the emotional contagion is directional, with the treated individual influencing untreated subjects rather than vice versa.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2021)
Article
Behavioral Sciences
Sherry A. Ferguson, C. Delbert Law, Sumit Sarkar
BEHAVIOURAL BRAIN RESEARCH
(2015)
Article
Neurosciences
Sherry A. Ferguson, Merle G. Paule, Zhen He
Article
Neurosciences
Zhen He, Li Cui, Merle G. Paule, Sherry A. Ferguson
MOLECULAR NEUROBIOLOGY
(2015)
Article
Neurosciences
Sherry A. Ferguson, C. Delbert Law, Leyla Sahin, Susan V. Montenegro
NEUROTOXICOLOGY AND TERATOLOGY
(2015)
Article
Neurosciences
Amy K. Goodwin, Susan M. Lantz-McPeak, Bonnie L. Robinson, C. Delbert Law, Syed F. Ali, Sherry A. Ferguson
NEUROTOXICOLOGY AND TERATOLOGY
(2015)
Review
Reproductive Biology
Jerrold J. Heindel, Retha R. Newbold, John R. Bucher, Luisa Camacho, K. Barry Delclos, Sherry M. Lewis, Michelle Vanlandingham, Mona I. Churchwell, Nathan C. Twaddle, Michelle McLellen, Mani Chidambaram, Matthew Bryant, Kellie Woodling, Goncalo Gamboa da Costa, Sherry A. Ferguson, Jodi Flaws, Paul C. Howard, Nigel J. Walker, R. Thomas Zoeller, Jennifer Fostel, Carolyn Favaro, Thaddeus T. Schug
REPRODUCTIVE TOXICOLOGY
(2015)
Article
Behavioral Sciences
Sarah A. Johnson, Angela B. Javurek, Michele S. Painter, Mark R. Ellersieck, Thomas H. Welsh, Luisa Camacho, Sherry M. Lewis, Michelle M. Vanlandingham, Sherry A. Ferguson, Cheryl S. Rosenfeld
HORMONES AND BEHAVIOR
(2016)
Article
Medicine, Research & Experimental
Syed Z. Imam, Zhen He, Elvis Cuevas, Hector Rosas-Hernandez, Susan M. Lantz, Sumit Sarkar, James Raymick, Bonnie Robinson, Joseph P. Hanig, David Herr, Denise MacMillan, Aaron Smith, Serguei Liachenko, Sherry Ferguson, James O'Callaghan, Diane Miller, Christopher Somps, Ingrid D. Pardo, William Slikker, Jennifer B. Pierson, Ruth Roberts, Binsheng Gong, Weida Tong, Michael Aschner, Mary J. Kallman, David Calligaro, Merle G. Paule
EXPERIMENTAL BIOLOGY AND MEDICINE
(2018)
Article
Neurosciences
Sherry A. Ferguson, John J. Panos, Daniel Sloper, Vijayalakshmi Varma
JOURNAL OF ALZHEIMERS DISEASE
(2017)
Article
Neurosciences
Zhen He, Li Cui, Sherry A. Ferguson, Merle G. Paule
MOLECULAR NEUROBIOLOGY
(2018)
Article
Toxicology
Timothy J. Flanigan, Julie E. Anderson, Ikram Elayan, Antino R. Allen, Sherry A. Ferguson
TOXICOLOGICAL SCIENCES
(2018)
Article
Neurosciences
John J. Panos, James P. O'Callaghan, Diane B. Miller, Sherry A. Ferguson
NEUROTOXICOLOGY AND TERATOLOGY
(2014)
Article
Neurosciences
Christopher L. Moore, Timothy J. Flanigan, Charles D. Law, Lucie Loukotkova, Kellie A. Woodling, Goncalo Gamboa da Costa, Suzanne C. Fitzpatrick, Sherry A. Ferguson
NEUROTOXICOLOGY AND TERATOLOGY
(2019)
Article
Endocrinology & Metabolism
Sherry A. Ferguson, Vijayalakshmi Varma, Daniel Sloper, John J. Panos, Sumit Sarkar
METABOLIC BRAIN DISEASE
(2020)
Article
Neurosciences
Jennifer L. Walters, John J. Chelonis, Charles M. Fogle, Sherry A. Ferguson, Sumit Sarkar, Merle G. Paule, John C. Talpos
NEUROTOXICOLOGY AND TERATOLOGY
(2020)