Evaluation of a human neurite growth assay as specific screen for developmental neurotoxicants

Food for thought ... considerations and guidelines for basic test method descriptions in toxicology

(2016) Marcel Leist   ALTEX-Alternatives to Animal Experimentation

Evidence-based toxicology – the toolbox of validation for the 21st century?

(2016) Thomas Hartung   ALTEX-Alternatives to Animal Experimentation

The therapeutic effects of Rho-ROCK inhibitors on CNS disorders

(2016) Takekazu Kubo   Therapeutics and Clinical Risk Management

Advancing the science of developmental neurotoxicity (DNT): testing for better safety evaluation

(2014) Anna Bal-Price   ALTEX-Alternatives to Animal Experimentation

Evidence-based toxicology for the 21st century: Opportunities and challenges

(2014) Martin Stephens   ALTEX-Alternatives to Animal Experimentation

Perspectives on validation of high-throughput assays supporting 21st century toxicity testing

(2014) Richard Judson   ALTEX-Alternatives to Animal Experimentation

Evaluation of Developmental Toxicants and Signaling Pathways in a Functional Test Based on the Migration of Human Neural Crest Cells

(2012) Bastian Zimmer et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Compound selection for in vitro modeling of developmental neurotoxicity

(2012) Suzanne Kadereit   Frontiers in Bioscience-Landmark

Epigenetic changes and disturbed neural development in a human embryonic stem cell-based model relating to the fetal valproate syndrome

(2012) Nina V. Balmer et al.   HUMAN MOLECULAR GENETICS

NODDI: Practical in vivo neurite orientation dispersion and density imaging of the human brain

(2012) Hui Zhang et al.   NEUROIMAGE

Validation and quality control of replacement alternatives – current status and future challenges

(2012) Marcel Leist et al.   Toxicology Research

Rapid, complete and large-scale generation of post-mitotic neurons from the human LUHMES cell line

(2011) Diana Scholz et al.   JOURNAL OF NEUROCHEMISTRY

ECVAM prevalidation study on in vitro cell transformation assays: General outline and conclusions of the study

(2011) Raffaella Corvi et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Translating neurobehavioural endpoints of developmental neurotoxicity tests into in vitro assays and readouts

(2011) Christoph van Thriel et al.   NEUROTOXICOLOGY

Uncoupling of ATP-depletion and cell death in human dopaminergic neurons

(2011) Dominik Pöltl et al.   NEUROTOXICOLOGY

Diffusion-Weighted MRI and Quantitative Biophysical Modeling of Hippocampal Neurite Loss in Chronic Stress

(2011) Peter Vestergaard-Poulsen et al.   PLoS One

Assessment of Chemical-Induced Impairment of Human Neurite Outgrowth by Multiparametric Live Cell Imaging in High-Density Cultures

(2011) Nina V. Stiegler et al.   TOXICOLOGICAL SCIENCES

Comparative sensitivity of human and rat neural cultures to chemical-induced inhibition of neurite outgrowth

(2011) Joshua A. Harrill et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

A noise-reduction GWAS analysis implicates altered regulation of neurite outgrowth and guidance in autism

(2011) John P Hussman et al.   Molecular Autism

Coordinated waves of gene expression during neuronal differentiation of embryonic stem cells as basis for novel approaches to developmental neurotoxicity testing

(2010) B Zimmer et al.   CELL DEATH AND DIFFERENTIATION

Changes in Prefrontal Axons May Disrupt the Network in Autism

(2010) B. Zikopoulos et al.   JOURNAL OF NEUROSCIENCE

The network formation assay: a spatially standardized neurite outgrowth analytical display for neurotoxicity screening

(2010) Jean-Philippe Frimat et al.   LAB ON A CHIP

Quantitative assessment of neurite outgrowth in human embryonic stem cell-derived hN2™ cells using automated high-content image analysis

(2010) Joshua A. Harrill et al.   NEUROTOXICOLOGY

Microtubules Regulate Migratory Polarity through Rho/ROCK Signaling in T Cells

(2010) Aya Takesono et al.   PLoS One

Use of high content image analysis to detect chemical-induced changes in synaptogenesis in vitro

(2010) Joshua A. Harrill et al.   TOXICOLOGY IN VITRO

Endogenous Nmnat2 Is an Essential Survival Factor for Maintenance of Healthy Axons

(2010) Jonathan Gilley et al.   PLOS BIOLOGY

Preface

(2009) C Griesinger et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

Narciclasine, a plant growth modulator, activates Rho and stress fibers in glioblastoma cells

(2009) F. Lefranc et al.   MOLECULAR CANCER THERAPEUTICS

Requirement of a dopaminergic neuronal phenotype for toxicity of low concentrations of 1-methyl-4-phenylpyridinium to human cells

(2009) Stefan Schildknecht et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Inhibition by rotenone of mesencephalic neural stem-cell migration in a neurosphere assay in vitro

(2009) Masami Ishido et al.   TOXICOLOGY IN VITRO

“ToxRTool”, a new tool to assess the reliability of toxicological data

(2009) Klaus Schneider et al.   TOXICOLOGY LETTERS

Developmental Exposure to Polychlorinated Biphenyls Interferes with Experience-Dependent Dendritic Plasticity and Ryanodine Receptor Expression in Weanling Rats

(2008) Dongren Yang et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Developmental neurotoxicity testing in vitro: Models for assessing chemical effects on neurite outgrowth

(2008) Nicholas M. Radio et al.   NEUROTOXICOLOGY

Rotenone-Induced Toxicity is Mediated by Rho-GTPases in Hippocampal Neurons

(2008) Monica Sanchez et al.   TOXICOLOGICAL SCIENCES

Assessment of Chemical Effects on Neurite Outgrowth in PC12 cells Using High Content Screening

(2008) Nicholas M. Radio et al.   TOXICOLOGICAL SCIENCES

Gene expression as a sensitive endpoint to evaluate cell differentiation and maturation of the developing central nervous system in primary cultures of rat cerebellar granule cells (CGCs) exposed to pesticides

(2008) Helena T. Hogberg et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Rotenone-induced PC12 cell toxicity is caused by oxidative stress resulting from altered dopamine metabolism

(2008) Yan Sai et al.   TOXICOLOGY IN VITRO