The genetic basis of major depression

DeepWAS: Multivariate genotype-phenotype associations by directly integrating regulatory information using deep learning

(2020) Janine Arloth et al.   PLoS Computational Biology

A polygenic predictor of treatment-resistant depression using whole exome sequencing and genome-wide genotyping

(2020) Chiara Fabbri et al.   Translational Psychiatry

Genetic Liability for Depression, Social Factors and Their Interaction Effect in Depressive Symptoms and Depression Over Time in Older Adults

(2020) Najada Stringa et al.   AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY

Regulatory mechanisms of major depressive disorder risk variants

(2020) Shiwu Li et al.   MOLECULAR PSYCHIATRY

Minimal phenotyping yields genome-wide association signals of low specificity for major depression

(2020) Na Cai et al.   NATURE GENETICS

A phenome-wide association and Mendelian Randomisation study of polygenic risk for depression in UK Biobank

(2020) Xueyi Shen et al.   Nature Communications

Cohort profile: the Australian genetics of depression study

(2020) Enda M Byrne et al.   BMJ Open

Polygenic risk scores: from research tools to clinical instruments

(2020) Cathryn M. Lewis et al.   Genome Medicine

Risk in Relatives, Heritability, SNP-Based Heritability, and Genetic Correlations in Psychiatric Disorders: A Review

(2020) Bart M.L. Baselmans et al.   BIOLOGICAL PSYCHIATRY

Reviewing the genetics of heterogeneity in depression: operationalizations, manifestations and etiologies

(2020) Na Cai et al.   HUMAN MOLECULAR GENETICS

Epigenetic prediction of major depressive disorder

(2020) Miruna C. Barbu et al.   MOLECULAR PSYCHIATRY

High-definition likelihood inference of genetic correlations across human complex traits

(2020) Zheng Ning et al.   NATURE GENETICS

An Exposure-Wide and Mendelian Randomization Approach to Identifying Modifiable Factors for the Prevention of Depression

(2020) Karmel W. Choi et al.   AMERICAN JOURNAL OF PSYCHIATRY

Childhood trauma, suicide risk and inflammatory phenotypes of depression: insights from monocyte gene expression

(2020) Carmen Schiweck et al.   Translational Psychiatry

Bivariate genome-wide association analyses of the broad depression phenotype combined with major depressive disorder, bipolar disorder or schizophrenia reveal eight novel genetic loci for depression

(2019) Azmeraw T. Amare et al.   MOLECULAR PSYCHIATRY

Negr1 controls adult hippocampal neurogenesis and affective behaviors

(2019) Kyungchul Noh et al.   MOLECULAR PSYCHIATRY

Genome-wide by environment interaction studies of depressive symptoms and psychosocial stress in UK Biobank and Generation Scotland

(2019) Aleix Arnau-Soler et al.   Translational Psychiatry

The genetics of depression: successful genome-wide association studies introduce new challenges

(2019) Johan Ormel et al.   Translational Psychiatry

Association of Polygenic Liabilities for Major Depression, Bipolar Disorder, and Schizophrenia With Risk for Depression in the Danish Population

(2019) Katherine L. Musliner et al.   JAMA Psychiatry

A joint study of whole exome sequencing and structural MRI analysis in major depressive disorder

(2019) Yamin Zhang et al.   PSYCHOLOGICAL MEDICINE

Integration of GWAS and brain eQTL identifies FLOT1 as a risk gene for major depressive disorder

(2019) Jingmei Zhong et al.   NEUROPSYCHOPHARMACOLOGY

Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions

(2019) David M. Howard et al.   NATURE NEUROSCIENCE

Imputation of behavioral candidate gene repeat variants in 486,551 publicly-available UK Biobank individuals

(2019) Richard Border et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Genome-wide burden of rare short deletions is enriched in Major Depressive Disorder in four cohorts

(2019) Xianglong Zhang et al.   BIOLOGICAL PSYCHIATRY

No Support for Historical Candidate Gene or Candidate Gene-by-Interaction Hypotheses for Major Depression Across Multiple Large Samples

(2019) Richard Border et al.   AMERICAN JOURNAL OF PSYCHIATRY

Polygenic Risk: Predicting Depression Outcomes in Clinical and Epidemiological Cohorts of Youths

(2019) Thorhildur Halldorsdottir et al.   AMERICAN JOURNAL OF PSYCHIATRY

Genetic cross-disorder analysis in psychiatry: from methodology to clinical utility

(2019) Dick Schijven et al.   BRITISH JOURNAL OF PSYCHIATRY

Genome-wide association study identifies 30 loci associated with bipolar disorder

(2019) Eli A. Stahl et al.   NATURE GENETICS

Uncovering the Genetic Architecture of Major Depression

(2019) Andrew M. McIntosh et al.   NEURON

Prospective study of polygenic risk, protective factors, and incident depression following combat deployment in US Army soldiers

(2019) Karmel W. Choi et al.   PSYCHOLOGICAL MEDICINE

Association of Rare Copy Number Variants With Risk of Depression

(2019) Kimberley Marie Kendall et al.   JAMA Psychiatry

Genetic correlations of polygenic disease traits: from theory to practice

(2019) Wouter van Rheenen et al.   NATURE REVIEWS GENETICS

Genotype–covariate correlation and interaction disentangled by a whole-genome multivariate reaction norm model

(2019) Guiyan Ni et al.   Nature Communications

Genomic structural equation modelling provides insights into the multivariate genetic architecture of complex traits

(2019) Andrew D. Grotzinger et al.   Nature Human Behaviour

Unraveling the genetic architecture of major depressive disorder: merits and pitfalls of the approaches used in genome-wide association studies

(2019) I. Schwabe et al.   PSYCHOLOGICAL MEDICINE

Cell-Type-Specific Methylome-wide Association Studies Implicate Neurotrophin and Innate Immune Signaling in Major Depressive Disorder

(2019) Robin F. Chan et al.   BIOLOGICAL PSYCHIATRY

The genetics of the mood disorder spectrum: genome-wide association analyses of over 185,000 cases and 439,000 controls

(2019) Jonathan R.I. Coleman et al.   BIOLOGICAL PSYCHIATRY

Physical activity offsets genetic risk for incident depression assessed via electronic health records in a biobank cohort study

(2019) Karmel W. Choi et al.   DEPRESSION AND ANXIETY

Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders

(2019) Phil H. Lee et al.   CELL

Integrating genome-wide association study and expression quantitative trait loci data identifies NEGR1 as a causal risk gene of major depression disorder

(2019) Xin Wang et al.   JOURNAL OF AFFECTIVE DISORDERS

Molecular Genetic Analysis Subdivided by Adversity Exposure Suggests Etiologic Heterogeneity in Major Depression

(2018) Roseann E. Peterson et al.   AMERICAN JOURNAL OF PSYCHIATRY

The Genetic Epidemiology of Treated Major Depression in Sweden

(2018) Kenneth S. Kendler et al.   AMERICAN JOURNAL OF PSYCHIATRY

Does Childhood Trauma Moderate Polygenic Risk for Depression? A Meta-analysis of 5765 Subjects From the Psychiatric Genomics Consortium

(2018) Wouter J. Peyrot et al.   BIOLOGICAL PSYCHIATRY

Disease Heritability Inferred from Familial Relationships Reported in Medical Records

(2018) Fernanda C.G. Polubriaginof et al.   CELL

Genome-wide association study of depressive symptoms in the Hispanic Community Health Study/Study of Latinos

(2018) Erin C. Dunn et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

(2018) Naomi R. Wray et al.   NATURE GENETICS

Multi-trait analysis of genome-wide association summary statistics using MTAG

(2018) Patrick Turley et al.   NATURE GENETICS

Common variants on 6q16.2, 12q24.31 and 16p13.3 are associated with major depressive disorder

(2018) Xiaoyan Li et al.   NEUROPSYCHOPHARMACOLOGY

Analysis of shared heritability in common disorders of the brain

(2018) et al.   SCIENCE

Sources of Parent-Offspring Resemblance for Major Depression in a National Swedish Extended Adoption Study

(2018) Kenneth S. Kendler et al.   JAMA Psychiatry

Genome-wide meta-analyses of stratified depression in Generation Scotland and UK Biobank

(2018) Lynsey S. Hall et al.   Translational Psychiatry

Low-frequency and rare variants may contribute to elucidate the genetics of major depressive disorder

(2018) Chenglong Yu et al.   Translational Psychiatry

Sample Size for Successful Genome-Wide Association Study of Major Depressive Disorder

(2018) Jo Nishino et al.   Frontiers in Genetics

Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations

(2018) Amit V. Khera et al.   NATURE GENETICS

Genetics Factors in Major Depression Disease

(2018) Maria Shadrina et al.   Frontiers in Psychiatry

Evidence for increased genetic risk load for major depression in patients assigned to electroconvulsive therapy

(2018) Jerome C. Foo et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

Global, regional, and national disability-adjusted life-years (DALYs) for 359 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017

(2018) Hmwe Hmwe Kyu et al.   LANCET

Depression

(2018) Gin S Malhi et al.   LANCET

Investigation of copy number variation in subjects with major depression based on whole-genome sequencing data

(2017) Chenglong Yu et al.   JOURNAL OF AFFECTIVE DISORDERS

Gene-based interaction analysis shows GABAergic genes interacting with parenting in adolescent depressive symptoms

(2017) Evelien Van Assche et al.   JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY

Polygenic prediction of obsessive compulsive symptoms

(2017) N R Zilhão et al.   MOLECULAR PSYCHIATRY

A rare missense variant in RCL1 segregates with depression in extended families

(2017) N Amin et al.   MOLECULAR PSYCHIATRY

Genetic Association of Major Depression With Atypical Features and Obesity-Related Immunometabolic Dysregulations

(2017) Yuri Milaneschi et al.   JAMA Psychiatry

The Genetic Architecture of Major Depressive Disorder in Han Chinese Women

(2017) Roseann E. Peterson et al.   JAMA Psychiatry

Genetic effects influencing risk for major depressive disorder in China and Europe

(2017) T B Bigdeli et al.   Translational Psychiatry

High-Coverage Whole-Exome Sequencing Identifies Candidate Genes for Suicide in Victims with Major Depressive Disorder

(2017) Dóra Tombácz et al.   Scientific Reports

Novel variants inZNF34and other brain-expressed transcription factors are shared among early-onset MDD relatives

(2016) Ryan L. Subaran et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

Heritability of Perinatal Depression and Genetic Overlap With Nonperinatal Depression

(2016) Alexander Viktorin et al.   AMERICAN JOURNAL OF PSYCHIATRY

Phenotypic Association Analyses With Copy Number Variation in Recurrent Depressive Disorder

(2016) James J.H. Rucker et al.   BIOLOGICAL PSYCHIATRY

Olfactomedin 4 expression and functions in innate immunity, inflammation, and cancer

(2016) Wenli Liu et al.   CANCER AND METASTASIS REVIEWS

GENOME-WIDE ASSOCIATION STUDY (GWAS) AND GENOME-WIDE BY ENVIRONMENT INTERACTION STUDY (GWEIS) OF DEPRESSIVE SYMPTOMS IN AFRICAN AMERICAN AND HISPANIC/LATINA WOMEN

(2016) Erin C. Dunn et al.   DEPRESSION AND ANXIETY

Shortened telomere length in patients with depression: A meta-analytic study

(2016) Pao-Yen Lin et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Exome-sequencing in a large population-based study reveals a rare Asn396Ser variant in the LIPG gene associated with depressive symptoms

(2016) N Amin et al.   MOLECULAR PSYCHIATRY

The PHF21B gene is associated with major depression and modulates the stress response

(2016) M-L Wong et al.   MOLECULAR PSYCHIATRY

Genetic variants associated with subjective well-being, depressive symptoms and neuroticism identified through genome-wide analyses

(2016) Aysu Okbay et al.   NATURE GENETICS

Identification of 15 genetic loci associated with risk of major depression in individuals of European descent

(2016) Craig L Hyde et al.   NATURE GENETICS

Somatic, positive and negative domains of the Center for Epidemiological Studies Depression (CES-D) scale: a meta-analysis of genome-wide association studies

(2016) A. Demirkan et al.   PSYCHOLOGICAL MEDICINE

Comparative genome-wide association studies of a depressive symptom phenotype in a repeated measures setting by race/ethnicity in the multi-ethnic study of atherosclerosis

(2015) Erin B. Ware et al.   BMC GENETICS

The neurobiological effects of stress as contributors to psychiatric disorders: focus on epigenetics

(2015) Nadine Provencal et al.   CURRENT OPINION IN NEUROBIOLOGY

High-throughput sequencing of the synaptome in major depressive disorder

(2015) M Pirooznia et al.   MOLECULAR PSYCHIATRY

Evaluating historical candidate genes for schizophrenia

(2015) M S Farrell et al.   MOLECULAR PSYCHIATRY

Sparse whole-genome sequencing identifies two loci for major depressive disorder

(2015) Na Cai et al.   NATURE

Meta-analysis of the heritability of human traits based on fifty years of twin studies

(2015) Tinca J C Polderman et al.   NATURE GENETICS

An atlas of genetic correlations across human diseases and traits

(2015) Brendan Bulik-Sullivan et al.   NATURE GENETICS

Genetic Differences in the Immediate Transcriptome Response to Stress Predict Risk-Related Brain Function and Psychiatric Disorders

(2015) Janine Arloth et al.   NEURON

Polygenic interactions with environmental adversity in the aetiology of major depressive disorder

(2015) N. Mullins et al.   PSYCHOLOGICAL MEDICINE

Epidemiology and Heritability of Major Depressive Disorder, Stratified by Age of Onset, Sex, and Illness Course in Generation Scotland: Scottish Family Health Study (GS:SFHS)

(2015) Ana Maria Fernandez-Pujals et al.   PLoS One

Rare-Variant Association Analysis: Study Designs and Statistical Tests

(2014) Seunggeung Lee et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Genetic Studies of Major Depressive Disorder: Why Are There No Genome-wide Association Study Findings and What Can We Do About It?

(2014) Douglas F. Levinson et al.   BIOLOGICAL PSYCHIATRY

Rare Copy Number Variation in Treatment-Resistant Major Depressive Disorder

(2014) Colm O’Dushlaine et al.   BIOLOGICAL PSYCHIATRY

Effect of polygenic risk scores on depression in childhood trauma

(2014) Wouter J. Peyrot et al.   BRITISH JOURNAL OF PSYCHIATRY

Research Review: Polygenic methods and their application to psychiatric traits

(2014) Naomi R. Wray et al.   JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY

Refining analyses of copy number variation identifies specific genes associated with developmental delay

(2014) Bradley P Coe et al.   NATURE GENETICS

The Genetics of Major Depression

(2014) Jonathan Flint et al.   NEURON

Copy number variants and therapeutic response to antidepressant medication in major depressive disorder

(2014) K E Tansey et al.   PHARMACOGENOMICS JOURNAL

Inference of the Genetic Architecture Underlying BMI and Height with the Use of 20,240 Sibling Pairs

(2013) Gibran Hemani et al.   AMERICAN JOURNAL OF HUMAN GENETICS

The Epidemiology of Depression Across Cultures

(2013) Ronald C. Kessler et al.   Annual Review of Public Health

A Genome-Wide Association Study of Depressive Symptoms

(2013) Karin Hek et al.   BIOLOGICAL PSYCHIATRY

Prevalence and Characteristics of Probable Major Depression and Bipolar Disorder within UK Biobank: Cross-Sectional Study of 172,751 Participants

(2013) Daniel J. Smith et al.   PLoS One

Using summary data from the Danish National Registers to estimate heritabilities for schizophrenia, bipolar disorder, and major depressive disorder

(2013) Naomi Wray   Frontiers in Genetics

Association between copy number variants in 16p11.2 and major depressive disorder in a German case-control sample

(2012) Franziska Degenhardt et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

Estimation of pleiotropy between complex diseases using single-nucleotide polymorphism-derived genomic relationships and restricted maximum likelihood

(2012) S.H. Lee et al.   BIOINFORMATICS

A mega-analysis of genome-wide association studies for major depressive disorder

(2012)   MOLECULAR PSYCHIATRY

Copy Number Variation in Subjects with Major Depressive Disorder Who Attempted Suicide

(2012) Roy H. Perlis et al.   PLoS One

A Genome-Wide Significant Linkage for Severe Depression on Chromosome 3: The Depression Network Study

(2011) Gerome Breen et al.   AMERICAN JOURNAL OF PSYCHIATRY

A Critical Review of the First 10 Years of Candidate Gene-by-Environment Interaction Research in Psychiatry

(2011) Laramie E. Duncan et al.   AMERICAN JOURNAL OF PSYCHIATRY

Cross-national epidemiology of DSM-IV major depressive episode

(2011) Evelyn Bromet et al.   BMC Medicine

Genome-wide association analysis of copy number variation in recurrent depressive disorder

(2011) J J H Rucker et al.   MOLECULAR PSYCHIATRY

A copy number variation morbidity map of developmental delay

(2011) Gregory M Cooper et al.   NATURE GENETICS

The Neuronal Transporter Gene SLC6A15 Confers Risk to Major Depression

(2011) Martin A. Kohli et al.   NEURON

Genome-Wide Association Study of Major Recurrent Depression in the U.K. Population

(2010) Cathryn M. Lewis et al.   AMERICAN JOURNAL OF PSYCHIATRY

A Genome-Wide Screen for Depression in Two Independent Dutch Populations

(2010) Suzanne Schol-Gelok et al.   BIOLOGICAL PSYCHIATRY

Genome-Wide Association-, Replication-, and Neuroimaging Study Implicates HOMER1 in the Etiology of Major Depression

(2010) Marcella Rietschel et al.   BIOLOGICAL PSYCHIATRY

Genome-wide association study of recurrent early-onset major depressive disorder

(2010) J Shi et al.   MOLECULAR PSYCHIATRY

Poor replication of candidate genes for major depressive disorder using genome-wide association data

(2010) F J Bosker et al.   MOLECULAR PSYCHIATRY

Genome-wide association study of major depressive disorder: new results, meta-analysis and lessons learned

(2010) N R Wray et al.   MOLECULAR PSYCHIATRY

Duplication of the SLIT3 Locus on 5q35.1 Predisposes to Major Depressive Disorder

(2010) Joseph T. Glessner et al.   PLoS One

The PCLO gene and depressive disorders: replication in a population-based study

(2009) Karin Hek et al.   HUMAN MOLECULAR GENETICS

Novel loci for major depression identified by genome-wide association study of Sequenced Treatment Alternatives to Relieve Depression and meta-analysis of three studies

(2009) S I Shyn et al.   MOLECULAR PSYCHIATRY

Finding the missing heritability of complex diseases

(2009) Teri A. Manolio et al.   NATURE

Genome-wide association study of recurrent major depressive disorder in two European case–control cohorts

(2008) P Muglia et al.   MOLECULAR PSYCHIATRY

Genome-wide association for major depressive disorder: a possible role for the presynaptic protein piccolo

(2008) P F Sullivan et al.   MOLECULAR PSYCHIATRY

Rare chromosomal deletions and duplications increase risk of schizophrenia

(2008) Jennifer L. Stone et al.   NATURE

Large recurrent microdeletions associated with schizophrenia

(2008) Hreinn Stefansson et al.   NATURE

Heritability in the genomics era — concepts and misconceptions

(2008) Peter M. Visscher et al.   NATURE REVIEWS GENETICS