Article
Genetics & Heredity
Rui Chen, Zhihui Yang, Jiewei Liu, Xin Cai, Yongxia Huo, Zhijun Zhang, Ming Li, Hong Chang, Xiong-Jian Luo
Summary: The study identified 16 functional SNPs in 9 risk loci that disrupted the binding of 7 transcription factors, such as CTCF and REST. Potential target genes regulated by these functional SNPs in the human brain were identified through eQTL analysis. Dysregulation of target genes of the identified TF binding-disrupting SNPs was shown in BD patients compared with controls, and overexpression of PACS1 reduced dendritic spine density, revealing possible biological mechanisms of these functional SNPs in BD.
Article
Neurosciences
Suraj Upadhya, Hongliang Liu, Sheng Luo, Michael W. Lutz, Ornit Chiba-Falek
Summary: This study provided insights into the genetic factors contributing to depression onset in late-onset Alzheimer's Disease (LOAD) patients and advanced our knowledge of the genetics underlying the heterogeneity of depression in LOAD. The developed polygenic risk scores accurately predicted LOAD patients with depressive symptoms, with potential clinical implications for early diagnosis and treatment.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Psychiatry
Qinglai Bian, Jianbei Chen, Jiajia Wu, Fengmin Ding, Xiaojuan Li, Qingyu Ma, Liqing Zhang, Xiaojuan Zou, Jiaxu Chen
Summary: This study utilized WGCNA, PPI network, and TF-miRNA-lncRNA regulatory network to explore the co-expression modules and hub genes in MDD, offering new insights for investigating key pathways, diagnostic biomarkers, and therapeutic targets of MDD.
PSYCHIATRY RESEARCH
(2021)
Article
Psychology, Clinical
David T. Liebers, Mehdi Pirooznia, Andrea Ganna, Fernando S. Goes
Summary: The study demonstrates that psychiatric polygenic risk scores can modestly improve the distinction between BD and MDD cases based on clinical grounds, potentially providing utility for subjects at the extremes of the distribution or those with poorly measured clinical symptoms.
PSYCHOLOGICAL MEDICINE
(2021)
Article
Clinical Neurology
Yi-Hsien Chen, Wei-Ming Wang, I-Hsun Li, Hui-Han Kao, Chin-Bin Yeh, Li-Ting Kao
Summary: The study provides evidence that MDD is an independent risk factor for developing psoriasis, with a higher risk in males. Further investigation is needed to explore the underlying pathological mechanisms in the psychiatric field.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Review
Genetics & Heredity
Muhammad Kamran, Farhana Bibi, Asim Ur Rehman, Derek W. Morris
Summary: Major depressive disorder (MDD) is a common mental disorder characterized by symptoms associated with mood, pleasure and daily life activities. The pathogenesis of MDD is complex and not fully understood. Utilizing genetic data to understand the molecular mechanism of MDD, large genome-wide association studies have identified hundreds of loci, providing important information on the risk genes for MDD.
Article
Multidisciplinary Sciences
Chia-Min Chen, Chia-Yu Kuo, Meng-Ni Wu, Jen-Yu Hung, Chung-Yao Hsu, Ming-Ju Tsai
Summary: The study found that patients with sleep apnea have an increased risk of developing major depressive disorder. Physicians should pay attention to the psychosocial health status of sleep apnea patients.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Gregory C. Wilson, Simone Keitsch, Matthias Soddemann, Barbara Wilker, Michael J. Edwards, Erich Gulbins
Summary: This study investigates the role of tyrosine nitrosylation in the pathogenesis of Major Depressive Disorder (MDD). The results show that tyrosine nitrosylation is induced by stress and can be prevented by antidepressant treatment. Inhibition of tyrosine nitrosylation can partly restore normal behavior in stressed mice. These findings suggest that targeting tyrosine nitrosylation may contribute to the treatment of MDD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Behavioral Sciences
Gislaine Z. Reus, Luana. M. Manosso, Joao Quevedo, Andre F. Carvalho
Summary: Inflammation may play a role in the pathophysiology of major depressive disorder, as shown by increased peripheral inflammatory markers. Factors such as alterations in the gut microbiota may promote chronic systemic inflammation. Antidepressant drugs and nutritional strategies that reduce inflammation could improve depressive symptoms.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Article
Biochemistry & Molecular Biology
Laura K. M. Han, Richard Dinga, Tim Hahn, Christopher R. K. Ching, Lisa T. Eyler, Lyubomir Aftanas, Moji Aghajani, Andre Aleman, Bernhard T. Baune, Klaus Berger, Ivan Brak, Geraldo Busatto Filho, Angela Carballedo, Colm G. Connolly, Baptiste Couvy-Duchesne, Kathryn R. Cullen, Udo Dannlowski, Christopher G. Davey, Danai Dima, Fabio L. S. Duran, Verena Enneking, Elena Filimonova, Stefan Frenzel, Thomas Frodl, Cynthia H. Y. Fu, Beata R. Godlewska, Ian H. Gotlib, Hans J. Grabe, Nynke A. Groenewold, Dominik Grotegerd, Oliver Gruber, Geoffrey B. Hall, Ben J. Harrison, Sean N. Hatton, Marco Hermesdorf, Ian B. Hickie, Tiffany C. Ho, Norbert Hosten, Andreas Jansen, Claas Kaehler, Tilo Kircher, Bonnie Klimes-Dougan, Bernd Kraemer, Axel Krug, Jim Lagopoulos, Ramona Leenings, Frank P. MacMaster, Glenda MacQueen, Andrew McIntosh, Quinn McLellan, Katie L. McMahon, Sarah E. Medland, Bryon A. Mueller, Benson Mwangi, Evgeny Osipov, Maria J. Portella, Elena Pozzi, Liesbeth Reneman, Jonathan Repple, Pedro G. P. Rosa, Matthew D. Sacchet, Philipp G. Saemann, Knut Schnell, Anouk Schrantee, Egle Simulionyte, Jair C. Soares, Jens Sommer, Dan J. Stein, Olaf Steinstraeter, Lachlan T. Strike, Sophia I. Thomopoulos, Marie-Jose van Tol, Ilya M. Veer, Robert R. J. M. Vermeiren, Henrik Walter, Nic J. A. van der Wee, Steven J. A. van der Werff, Heather Whalley, Nils R. Winter, Katharina Wittfeld, Margaret J. Wright, Mon-Ju Wu, Henry Voelzke, Tony T. Yang, Vasileios Zannias, Greig I. de Zubicaray, Giovana B. Zunta-Soares, Christoph Abe, Martin Alda, Ole A. Andreassen, Erlend Boen, Caterina M. Bonnin, Erick J. Canales-Rodriguez, Dara Cannon, Xavier Caseras, Tiffany M. Chaim-Avancini, Torbjorn Elvsashagen, Pauline Favre, Sonya F. Foley, Janice M. Fullerton, Jose M. Goikolea, Bartholomeus C. M. Haarman, Tomas Hajek, Chantal Henry, Josselin Houenou, Fleur M. Howells, Martin Ingvar, Rayus Kuplicki, Beny Lafer, Mikael Landen, Rodrigo Machado-Vieira, Ulrik F. Malt, Colm McDonald, Philip B. Mitchell, Leila Nabulsi, Maria Concepcion Garcia Otaduy, Bronwyn J. Overs, Mircea Polosan, Edith Pomarol-Clotet, Joaquim Radua, Maria M. Rive, Gloria Roberts, Henricus G. Ruhe, Raymond Salvador, Salvador Sarro, Theodore D. Satterthwaite, Jonathan Savitz, Aart H. Schene, Peter R. Schofield, Mauricio H. Serpa, Kang Sim, Marcio Gerhardt Soeiro-de-Souza, Ashley N. Sutherland, Henk S. Temmingh, Garrett M. Timmons, Anne Uhlmann, Eduard Vieta, Daniel H. Wolf, Marcus V. Zanetti, Neda Jahanshad, Paul M. Thompson, Dick J. Veltman, Brenda W. J. H. Penninx, Andre F. Marquand, James H. Cole, Lianne Schmaal
Summary: Major depressive disorder is associated with increased risk of brain atrophy, aging-related diseases, and mortality. This study found that MDD patients showed a higher brain-predicted age difference compared to controls, but this difference did not seem to be driven by specific clinical characteristics. Subtle patterns of age-related structural brain abnormalities in MDD were observed, highlighting the need for further longitudinal studies to assess the clinical value of these findings.
MOLECULAR PSYCHIATRY
(2021)
Review
Pharmacology & Pharmacy
V. Vadim Tarasov, N. Nikolay Ivanets, A. Andrey Svistunov, N. Vladimir Chubarev, A. Marina Kinkulkina, G. Yuliya Tikhonova, S. Nikita Syzrantsev, V. Ivan Chubarev, Cristian Muresanu, G. Siva Somasundaram, E. Cecil Kirkland, Gjumrakch Aliev
Summary: This review summarizes recent findings in molecular biology and neuroimaging for the classification and identification of depression. While there are currently no reliable biomarkers for the diagnosis of depression types, further research into the molecular mechanisms of different types of depression is promising.
CURRENT PHARMACEUTICAL DESIGN
(2021)
Review
Biochemistry & Molecular Biology
Seok-Won Jeoung, Hyun-Sun Park, Zae Young Ryoo, Dong-Hyung Cho, Hyun-Shik Lee, Hong-Yeoul Ryu
Summary: SUMOylation plays a significant role in maintaining neuronal function in the development of major depressive disorder (MDD).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Sarah Rizwan Qazi, Muhammad Irfan, Zoobia Ramzan, Muhammad Jahanzaib, Maleeha Zaman Khan, Mahrukh Nasir, Muhammad Shakeel, Ishtiaq Ahmad Khan
Summary: This study identified both common and rare variants associated with the pathogenesis of MDD in Pakistani patients through whole exome sequencing. The genetic variations in BCR, RELN, and stress-associated PABPC1 suggest potential roles in the development of MDD.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Clinical Neurology
Eduardo Duarte-Silva, Michel Gomes de Melo, Michael Maes, Adriano Jose Maia Chaves Filho, Danielle Macedo, Christina Alves Peixoto
Summary: Type 2 Diabetes Mellitus and Major Depressive Disorder share common neuroimmune mechanisms, such as neurodegeneration and neuroinflammation. Understanding and addressing depressive symptoms in diabetic patients is crucial for fully addressing the pathophysiology and treatment of T2DM.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2021)
Article
Clinical Neurology
Alessandro Miola, Leonardo Tondo, Marco Pinna, Martina Contu, Ross J. Baldessarini
Summary: The study compared patients diagnosed with DSM-5 type II bipolar disorder (BD2) and major depressive disorder (MDD). The results showed significant differences between BD2 and MDD patients in terms of symptoms, morbidity, and treatment, which can contribute to better differentiation and treatment planning for the two disorders.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Psychiatry
Xin Cai, Zhi-Hui Yang, Hui-Juan Li, Xiao Xiao, Ming Li, Hong Chang
Summary: Recent advances in functional genomics have led to the identification of multiple genes and isoforms associated with the genetic risk of schizophrenia, with a specific focus on the SNP rs7085104 and VNTR at 10q24.32. This study demonstrates the direct regulation of AS3MT(d2d3) mRNA expression by the VNTR, along with its association with schizophrenia risk in East Asians. Overexpression of AS3MT(d2d3) in cultured hippocampal neurons results in reduced densities of dendritic spines, highlighting its potential functional impact on neuroplasticity.
SCHIZOPHRENIA BULLETIN
(2021)
Article
Biochemistry & Molecular Biology
Chu-Yi Zhang, Xiao Xiao, Zhuohua Zhang, Zhonghua Hu, Ming Li
Summary: Transcriptomic and long-read sequencing analyses have revealed alternative splicing characteristics of schizophrenia risk genes, identifying new spliced isoforms and providing examples for investigating these isoforms in vitro and in vivo.
MOLECULAR PSYCHIATRY
(2022)
Review
Biochemistry & Molecular Biology
Fanglin Guan, Tong Ni, Weili Zhu, L. Keoki Williams, Long-Biao Cui, Ming Li, Justin Tubbs, Pak-Chung Sham, Hongsheng Gui
Summary: Schizophrenia is a debilitating neuropsychiatric disorder with high heritability and complex inheritance. Various Omics technologies have been applied to study the pathogenesis of schizophrenia. Integration of multi-Omics data has emerged as a crucial approach to provide a more comprehensive view of biological complexity and improve clinical assessments and interventions.
MOLECULAR PSYCHIATRY
(2022)
Article
Biochemistry & Molecular Biology
Wenqiang Li, Luxian Lv, Xiong-Jian Luo
MOLECULAR PSYCHIATRY
(2022)
Review
Biochemistry & Molecular Biology
Xiao Xiao, Chu-Yi Zhang, Zhuohua Zhang, Zhonghua Hu, Ming Li, Tao Li
Summary: GWAS have identified genetic components in psychiatric disorders, but tandem repeats, often overlooked by GWAS, may hold missing pieces of heritability. These repeats may regulate gene expression and human phenotypes, modulating biological traits related to psychiatric disorders.
MOLECULAR PSYCHIATRY
(2022)
Review
Biochemistry & Molecular Biology
Ming Li, Tao Li, Xiao Xiao, Jun Chen, Zhonghua Hu, Yiru Fang
Summary: GWAS studies have identified BD risk genes that have been shown to affect clinical manifestations of BD and provide insights into the neurobiology of the disorder.
MOLECULAR PSYCHIATRY
(2022)
Article
Clinical Neurology
Junyang Wang, Jiewei Liu, Shiwu Li, Xiaoyan Li, Jinfeng Yang, Xinglun Dang, Changgai Mu, Yifan Li, Kaiqin Li, Jiao Li, Rui Chen, Yixing Liu, Di Huang, Zhijun Zhang, Xiong-Jian Luo
Summary: Genome-wide association studies have identified 10q24.32 as a robust schizophrenia risk locus. Researchers have discovered a regulatory variant, rs10786700, that disrupts binding of transcription factors at 10q24.32 and have uncovered the biological mechanism underlying the association between rs10786700 and schizophrenia.
Letter
Biochemistry & Molecular Biology
Chu-Yi Zhang, Xin Cai, Lei Guo, Lu Wang, Zhongchun Liu, Xiong-Jian Luo, Ming Li, Chuang Wang, Tao Li, Xiao Xiao
MOLECULAR PSYCHIATRY
(2023)
Article
Neurosciences
Jiewei Liu, Yuqi Cheng, Ming Li, Zhijun Zhang, Tao Li, Xiong-Jian Luo
Summary: Psychiatric disorders have a significant economic burden and limited effective drugs available. By integrating molecular and genetic data, we identified potential drug targets for psychiatric disorders and provided opportunities for new therapeutics development.
NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Clinical Neurology
Hao-Xiang Qi, Xiao Xiao, Tao Li, Ming Li
Summary: Through the analysis of BD GWAS risk genes and druggable targets, several drugs that are either clinically approved for BD or can be repurposed for BD treatment in the future have been identified. These genes are also relevant to the pathophysiology of BD.
Article
Neurosciences
Meng-Yuan Shang, Chu-Yi Zhang, Yong Wu, Lu Wang, Chuang Wang, Ming Li
Summary: This study utilized genome-wide association studies to investigate the polygenic overlap between bipolar disorder (BD) and brain structural phenotypes. It discovered shared genomic loci and identified novel risk genes. These findings provide insights into the genetic basis of BD and its developmental origins.
Article
Neurosciences
Xinglun Dang, Jiewei Liu, Zhijun Zhang, Xiong-Jian Luo
Summary: Multiple risk genes whose genetically regulated expression in dopaminergic neurons may have a causal role in schizophrenia (SCZ) were identified in this study. The time point-specific genetic regulatory effects were observed in young post-mitotic dopaminergic neurons and more mature dopaminergic neurons. Two high-confidence risk genes were prioritized when comparing the results from dopaminergic neurons with bulk brain tissues.
MOLECULAR NEUROBIOLOGY
(2023)
Editorial Material
Neurosciences
Deng-Feng Zhang, Ming Li
BIOLOGICAL PSYCHIATRY
(2023)