Research Review: Polygenic methods and their application to psychiatric traits

Genetic Risk for Attention-Deficit/Hyperactivity Disorder Contributes to Neurodevelopmental Traits in the General Population

(2014) Joanna Martin et al.   BIOLOGICAL PSYCHIATRY

Editorial Perspective: Why is there such a mismatch between traditional heritability estimates and molecular genetic findings for behavioural traits?

(2014) Anita Thapar et al.   JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY

A Genome-wide Association Meta-analysis of Preschool Internalizing Problems

(2014) Kelly S. Benke et al.   JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY

De novo mutations in schizophrenia implicate synaptic networks

(2014) Menachem Fromer et al.   NATURE

The emerging molecular architecture of schizophrenia, polygenic risk scores and the clinical implications for GxE research

(2014) Conrad Iyegbe et al.   SOCIAL PSYCHIATRY AND PSYCHIATRIC EPIDEMIOLOGY

Statistical Power to Detect Genetic (Co)Variance of Complex Traits Using SNP Data in Unrelated Samples

(2014) Peter M. Visscher et al.   PLoS Genetics

Additive Genetic Variation in Schizophrenia Risk Is Shared by Populations of African and European Descent

(2013) Teresa R. de Candia et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Detection of Clinically Relevant Genetic Variants in Autism Spectrum Disorder by Whole-Genome Sequencing

(2013) Yong-hui Jiang et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Selected rapporteur summaries from the XX world congress of psychiatric genetics, Hamburg, Germany, october 14-18, 2012

(2013) Heike Anderson-Schmidt et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

Polygenic transmission and complex neuro developmental network for attention deficit hyperactivity disorder: Genome-wide association study of both common and rare variants

(2013) Li Yang et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

High Loading of Polygenic Risk for ADHD in Children With Comorbid Aggression

(2013) Marian L. Hamshere et al.   AMERICAN JOURNAL OF PSYCHIATRY

Polygenic Risk and White Matter Integrity in Individuals at High Risk of Mood Disorder

(2013) Heather C. Whalley et al.   BIOLOGICAL PSYCHIATRY

Shared polygenic contribution between childhood attention-deficit hyperactivity disorder and adult schizophrenia

(2013) Marian L. Hamshere et al.   BRITISH JOURNAL OF PSYCHIATRY

Risk of bipolar disorder and schizophrenia in relatives of people with attention-deficit hyperactivity disorder

(2013) Henrik Larsson et al.   BRITISH JOURNAL OF PSYCHIATRY

Commentary: Missing heritability, polygenic scores, and gene-environment correlation

(2013) Robert Plomin   JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY

No Genetic Influence for Childhood Behavior Problems From DNA Analysis

(2013) Maciej Trzaskowski et al.   JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY

Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis

(2013)   LANCET

Genetics of rheumatoid arthritis contributes to biology and drug discovery

(2013) Yukinori Okada et al.   NATURE

Interpreting the role of de novo protein-coding mutations in neuropsychiatric disease

(2013) Jacob Gratten et al.   NATURE GENETICS

Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs

(2013) S Hong Lee et al.   NATURE GENETICS

Projecting the performance of risk prediction based on polygenic analyses of genome-wide association studies

(2013) Nilanjan Chatterjee et al.   NATURE GENETICS

Genome-wide association analysis identifies 13 new risk loci for schizophrenia

(2013) Stephan Ripke et al.   NATURE GENETICS

Validating therapeutic targets through human genetics

(2013) Robert M. Plenge et al.   NATURE REVIEWS DRUG DISCOVERY

Epistasis and quantitative traits: using model organisms to study gene–gene interactions

(2013) Trudy F. C. Mackay   NATURE REVIEWS GENETICS

The heritability of human disease: estimation, uses and abuses

(2013) Albert Tenesa et al.   NATURE REVIEWS GENETICS

Bringing genome-wide association findings into clinical use

(2013) Teri A. Manolio   NATURE REVIEWS GENETICS

Pitfalls of predicting complex traits from SNPs

(2013) Naomi R. Wray et al.   NATURE REVIEWS GENETICS

First Genome-Wide Association Study on Anxiety-Related Behaviours in Childhood

(2013) Maciej Trzaskowski et al.   PLoS One

Assumptions and Properties of Limiting Pathway Models for Analysis of Epistasis in Complex Traits

(2013) Sven Stringer et al.   PLoS One

Genetics of Callous-Unemotional Behavior in Children

(2013) Essi Viding et al.   PLoS One

Molecular Validation of the Schizophrenia Spectrum

(2013) T. B. Bigdeli et al.   SCHIZOPHRENIA BULLETIN

Where GWAS and Epidemiology Meet: Opportunities for the Simultaneous Study of Genetic and Environmental Risk Factors in Schizophrenia

(2013) J. J. McGrath et al.   SCHIZOPHRENIA BULLETIN

Partitioning the Heritability of Tourette Syndrome and Obsessive Compulsive Disorder Reveals Differences in Genetic Architecture

(2013) Lea K. Davis et al.   PLoS Genetics

Power and Predictive Accuracy of Polygenic Risk Scores

(2013) Frank Dudbridge   PLoS Genetics

All SNPs Are Not Created Equal: Genome-Wide Association Studies Reveal a Consistent Pattern of Enrichment among Functionally Annotated SNPs

(2013) Andrew J. Schork et al.   PLoS Genetics

Common variation contributes to the genetic architecture of social communication traits

(2013) Beate St Pourcain et al.   Molecular Autism

Using summary data from the Danish National Registers to estimate heritabilities for schizophrenia, bipolar disorder, and major depressive disorder

(2013) Naomi Wray   Frontiers in Genetics

Improved Heritability Estimation from Genome-wide SNPs

(2012) Doug Speed et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Five Years of GWAS Discovery

(2012) Peter M. Visscher et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Genome-wide association uncovers shared genetic effects among personality traits and mood states

(2012) Michelle Luciano et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

No evidence that common genetic risk variation is shared between schizophrenia and autism

(2012) Jacob A.S. Vorstman et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

Genome-Wide Association Study of Clinical Dimensions of Schizophrenia: Polygenic Effect on Disorganized Symptoms

(2012) Ayman H. Fanous et al.   AMERICAN JOURNAL OF PSYCHIATRY

Genome-Wide Association Study of Multiplex Schizophrenia Pedigrees

(2012) Douglas F. Levinson et al.   AMERICAN JOURNAL OF PSYCHIATRY

Family History of Schizophrenia and Bipolar Disorder as Risk Factors for Autism

(2012) Patrick F. Sullivan et al.   ARCHIVES OF GENERAL PSYCHIATRY

Estimation of pleiotropy between complex diseases using single-nucleotide polymorphism-derived genomic relationships and restricted maximum likelihood

(2012) S.H. Lee et al.   BIOINFORMATICS

A Better Coefficient of Determination for Genetic Profile Analysis

(2012) Sang Hong Lee et al.   GENETIC EPIDEMIOLOGY

Performance and Robustness of Penalized and Unpenalized Methods for Genetic Prediction of Complex Human Disease

(2012) Gad Abraham et al.   GENETIC EPIDEMIOLOGY

The interplay of genes and adolescent development in substance use disorders: leveraging findings from GWAS meta-analyses to test developmental hypotheses about nicotine consumption

(2012) Scott I. Vrieze et al.   HUMAN GENETICS

Heritability in the genome-wide association era

(2012) Noah Zaitlen et al.   HUMAN GENETICS

Individual common variants exert weak effects on the risk for autism spectrum disorders

(2012) Richard Anney et al.   HUMAN MOLECULAR GENETICS

Estimation and partitioning of polygenic variation captured by common SNPs for Alzheimer's disease, multiple sclerosis and endometriosis

(2012) S. H. Lee et al.   HUMAN MOLECULAR GENETICS

Individual Differences in Amygdala-Medial Prefrontal Anatomy Link Negative Affect, Impaired Social Functioning, and Polygenic Depression Risk

(2012) A. J. Holmes et al.   JOURNAL OF NEUROSCIENCE

Identifying bipolar disorder susceptibility loci in a densely affected pedigree

(2012) A L Collins et al.   MOLECULAR PSYCHIATRY

Why has it taken so long for biological psychiatry to develop clinical tests and what to do about it?

(2012) S Kapur et al.   MOLECULAR PSYCHIATRY

Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease

(2012) Luke Jostins et al.   NATURE

Use of genome-wide association studies for drug repositioning

(2012) Philippe Sanseau et al.   NATURE BIOTECHNOLOGY

Estimating the proportion of variation in susceptibility to schizophrenia captured by common SNPs

(2012) S Hong Lee et al.   NATURE GENETICS

Investigation of the Genetic Association between Quantitative Measures of Psychosis and Schizophrenia: A Polygenic Risk Score Analysis

(2012) Eske M. Derks et al.   PLoS One

The genetic architecture of economic and political preferences

(2012) D. J. Benjamin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The mystery of missing heritability: Genetic interactions create phantom heritability

(2012) O. Zuk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Common genetic variants, acting additively, are a major source of risk for autism

(2012) Lambertus Klei et al.   Molecular Autism

Meta-analysis of genome-wide association studies for panic disorder in the Japanese population

(2012) T Otowa et al.   Translational Psychiatry

The influence of polygenic risk for bipolar disorder on neural activation assessed using fMRI

(2012) H C Whalley et al.   Translational Psychiatry

Common SNPs explain some of the variation in the personality dimensions of neuroticism and extraversion

(2012) A A E Vinkhuyzen et al.   Translational Psychiatry

A genome-wide meta-analysis of association studies of Cloninger's Temperament Scales

(2012) S K Service et al.   Translational Psychiatry

Genome-wide significant association between alcohol dependence and a variant in the ADH gene cluster

(2011) Josef Frank et al.   ADDICTION BIOLOGY

Risk Prediction of Complex Diseases from Family History and Known Susceptibility Loci, with Applications for Cancer Screening

(2011) Hon-Cheong So et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Estimating Missing Heritability for Disease from Genome-wide Association Studies

(2011) Sang Hong Lee et al.   AMERICAN JOURNAL OF HUMAN GENETICS

A Critical Review of the First 10 Years of Candidate Gene-by-Environment Interaction Research in Psychiatry

(2011) Laramie E. Duncan et al.   AMERICAN JOURNAL OF PSYCHIATRY

Polygenic dissection of the bipolar phenotype

(2011) M. L. Hamshere et al.   BRITISH JOURNAL OF PSYCHIATRY

Genomic inflation factors under polygenic inheritance

(2011) Jian Yang et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Evaluating the heritability explained by known susceptibility variants: a survey of ten complex diseases

(2011) Hon-Cheong So et al.   GENETIC EPIDEMIOLOGY

Research Review: Gene-environment interaction research in youth depression - a systematic review with recommendations for future research

(2011) Erin C. Dunn et al.   JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY

Meta-Analysis of Genome-Wide Association Studies of Attention-Deficit/Hyperactivity Disorder

(2011) Benjamin M. Neale et al.   JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY

Don't give up on GWAS

(2011) P Sullivan et al.   MOLECULAR PSYCHIATRY

Genome-wide association study identifies five new schizophrenia loci

(2011)   NATURE GENETICS

Schizophrenia Genetics: Where Next?

(2011) Y. Kim et al.   SCHIZOPHRENIA BULLETIN

The genetic association between personality and major depression or bipolar disorder. A polygenic score analysis using genome-wide association data

(2011) C M Middeldorp et al.   Translational Psychiatry

Pharmacogenetics and pharmacogenomics: a clinical reality

(2011) R. Ferraldeschi et al.   ANNALS OF CLINICAL BIOCHEMISTRY

GCTA: A Tool for Genome-wide Complex Trait Analysis

(2010) Jian Yang et al.   AMERICAN JOURNAL OF HUMAN GENETICS

The Genetics of Autism Spectrum Disorders and Related Neuropsychiatric Disorders in Childhood

(2010) Paul Lichtenstein et al.   AMERICAN JOURNAL OF PSYCHIATRY

Genome-Wide Association Study of Schizophrenia in a Japanese Population

(2010) Masashi Ikeda et al.   BIOLOGICAL PSYCHIATRY

Shared heritability of attention-deficit/hyperactivity disorder and autism spectrum disorder

(2010) Nanda N. J. Rommelse et al.   EUROPEAN CHILD & ADOLESCENT PSYCHIATRY

Risk prediction using genome-wide association studies

(2010) Charles Kooperberg et al.   GENETIC EPIDEMIOLOGY

A genome-wide scan for common alleles affecting risk for autism

(2010) R. Anney et al.   HUMAN MOLECULAR GENETICS

Genetic risk profiles for depression and anxiety in adult and elderly cohorts

(2010) A Demirkan et al.   MOLECULAR PSYCHIATRY

Biological, clinical and population relevance of 95 loci for blood lipids

(2010) Tanya M. Teslovich et al.   NATURE

Common SNPs explain a large proportion of the heritability for human height

(2010) Jian Yang et al.   NATURE GENETICS

Genomewide Association Studies and Assessment of the Risk of Disease

(2010) Teri A. Manolio   NEW ENGLAND JOURNAL OF MEDICINE

Personality and bipolar disorder: dissecting state and trait associations between mood and personality

(2010) J. H. Barnett et al.   PSYCHOLOGICAL MEDICINE

The Genetic Interpretation of Area under the ROC Curve in Genomic Profiling

(2010) Naomi R. Wray et al.   PLoS Genetics

Common genetic determinants of schizophrenia and bipolar disorder in Swedish families: a population-based study

(2009) Paul Lichtenstein et al.   LANCET

Finding the missing heritability of complex diseases

(2009) Teri A. Manolio et al.   NATURE

Tandem repeat polymorphisms: modulators of disease susceptibility and candidates for ‘missing heritability’

(2009) Anthony J. Hannan   TRENDS IN GENETICS

Genomic selection: prediction of accuracy and maximisation of long term response

(2008) Mike Goddard   GENETICA

Efficient Methods to Compute Genomic Predictions

(2008) P.M. VanRaden   JOURNAL OF DAIRY SCIENCE

Whole-genome association study of bipolar disorder

(2008) P Sklar et al.   MOLECULAR PSYCHIATRY

Genome-wide association for major depressive disorder: a possible role for the presynaptic protein piccolo

(2008) P F Sullivan et al.   MOLECULAR PSYCHIATRY

Rare chromosomal deletions and duplications increase risk of schizophrenia

(2008) Jennifer L. Stone et al.   NATURE

Large recurrent microdeletions associated with schizophrenia

(2008) Hreinn Stefansson et al.   NATURE

Heritability in the genomics era — concepts and misconceptions

(2008) Peter M. Visscher et al.   NATURE REVIEWS GENETICS

Data and Theory Point to Mainly Additive Genetic Variance for Complex Traits

(2008) William G. Hill et al.   PLoS Genetics