The genetics of depression: successful genome-wide association studies introduce new challenges

Bivariate genome-wide association analyses of the broad depression phenotype combined with major depressive disorder, bipolar disorder or schizophrenia reveal eight novel genetic loci for depression

(2019) Azmeraw T. Amare et al.   MOLECULAR PSYCHIATRY

Psychiatric Genomics: An Update and an Agenda

(2018) Patrick F. Sullivan et al.   AMERICAN JOURNAL OF PSYCHIATRY

Common Disease Is More Complex Than Implied by the Core Gene Omnigenic Model

(2018) Naomi R. Wray et al.   CELL

Evaluating the potential role of pleiotropy in Mendelian randomization studies

(2018) Gibran Hemani et al.   HUMAN MOLECULAR GENETICS

Comparative efficacy and acceptability of 21 antidepressant drugs for the acute treatment of adults with major depressive disorder: a systematic review and network meta-analysis

(2018) Andrea Cipriani et al.   LANCET

Psychiatric genetics and the structure of psychopathology

(2018) Jordan W. Smoller et al.   MOLECULAR PSYCHIATRY

Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

(2018) Naomi R. Wray et al.   NATURE GENETICS

Item-level analyses reveal genetic heterogeneity in neuroticism

(2018) Mats Nagel et al.   Nature Communications

Improving genetic prediction by leveraging genetic correlations among human diseases and traits

(2018) Robert M. Maier et al.   Nature Communications

Genome-wide association study of depression phenotypes in UK Biobank identifies variants in excitatory synaptic pathways

(2018) David M. Howard et al.   Nature Communications

Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

(2018) Evangelos Evangelou et al.   NATURE GENETICS

Missing heritability: is the gap closing? An analysis of 32 complex traits in the Lifelines Cohort Study

(2017) Ilja M Nolte et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Collaborative meta-analysis finds no evidence of a strong interaction between stress and 5-HTTLPR genotype contributing to the development of depression

(2017) R C Culverhouse et al.   MOLECULAR PSYCHIATRY

Rare and low-frequency coding variants alter human adult height

(2017) Eirini Marouli et al.   NATURE

Association analysis in over 329,000 individuals identifies 116 independent variants influencing neuroticism

(2017) Michelle Luciano et al.   NATURE GENETICS

HPA Axis Genes, and Their Interaction with Childhood Maltreatment, are Related to Cortisol Levels and Stress-Related Phenotypes

(2017) Lotte Gerritsen et al.   NEUROPSYCHOPHARMACOLOGY

Etiology in psychiatry: embracing the reality of poly-gene-environmental causation of mental illness

(2017) Rudolf Uher et al.   World Psychiatry

Genetic Association of Major Depression With Atypical Features and Obesity-Related Immunometabolic Dysregulations

(2017) Yuri Milaneschi et al.   JAMA Psychiatry

The Genetic Architecture of Major Depressive Disorder in Han Chinese Women

(2017) Roseann E. Peterson et al.   JAMA Psychiatry

The genetic overlap between mood disorders and cardiometabolic diseases: a systematic review of genome wide and candidate gene studies

(2017) A T Amare et al.   Translational Psychiatry

Schizophrenia risk from complex variation of complement component 4

(2016) Aswin Sekar et al.   NATURE

Genetic variants associated with subjective well-being, depressive symptoms and neuroticism identified through genome-wide analyses

(2016) Aysu Okbay et al.   NATURE GENETICS

Identification of 15 genetic loci associated with risk of major depression in individuals of European descent

(2016) Craig L Hyde et al.   NATURE GENETICS

Integration of summary data from GWAS and eQTL studies predicts complex trait gene targets

(2016) Zhihong Zhu et al.   NATURE GENETICS

Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof of concept

(2016) Barbara Franke et al.   NATURE NEUROSCIENCE

Genetic pleiotropy in complex traits and diseases: implications for genomic medicine

(2016) Jacob Gratten et al.   Genome Medicine

Investigating the Causal Relationship of C-Reactive Protein with 32 Complex Somatic and Psychiatric Outcomes: A Large-Scale Cross-Consortium Mendelian Randomization Study

(2016) Bram. P. Prins et al.   PLOS MEDICINE

Cleaving depressive diseases from depressive disorders and non-clinical states

(2015) G. Parker et al.   ACTA PSYCHIATRICA SCANDINAVICA

In Silico Post Genome-Wide Association Studies Analysis of C-Reactive Protein Loci Suggests an Important Role for InterferonsCLINICAL PERSPECTIVE

(2015) Ahmad Vaez et al.   Circulation-Cardiovascular Genetics

Developing Medicines That Mimic the Natural Successes of the Human Genome

(2015) Sekar Kathiresan   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Sparse whole-genome sequencing identifies two loci for major depressive disorder

(2015) Na Cai et al.   NATURE

Meta-analysis of the heritability of human traits based on fifty years of twin studies

(2015) Tinca J C Polderman et al.   NATURE GENETICS

Genetic variance estimation with imputed variants finds negligible missing heritability for human height and body mass index

(2015) Jian Yang et al.   NATURE GENETICS

Cell Specific eQTL Analysis without Sorting Cells

(2015) Harm-Jan Westra et al.   PLoS Genetics

In Silico Post Genome-Wide Association Studies Analysis of C-Reactive Protein Loci Suggests an Important Role for InterferonsCLINICAL PERSPECTIVE

(2015) Ahmad Vaez et al.   Circulation-Cardiovascular Genetics

The Global Burden of Mental, Neurological and Substance Use Disorders: An Analysis from the Global Burden of Disease Study 2010

(2015) Harvey A. Whiteford et al.   PLoS One

Effect of polygenic risk scores on depression in childhood trauma

(2014) Wouter J. Peyrot et al.   BRITISH JOURNAL OF PSYCHIATRY

CRISPR/Cas9 for genome editing: progress, implications and challenges

(2014) F. Zhang et al.   HUMAN MOLECULAR GENETICS

The global prevalence of common mental disorders: a systematic review and meta-analysis 1980–2013

(2014) Zachary Steel et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Defining the role of common variation in the genomic and biological architecture of adult human height

(2014) Andrew R Wood et al.   NATURE GENETICS

Large-scale genomics unveils the genetic architecture of psychiatric disorders

(2014) Jacob Gratten et al.   NATURE NEUROSCIENCE

A heavy burden on young minds: the global burden of mental and substance use disorders in children and youth

(2014) H. E. Erskine et al.   PSYCHOLOGICAL MEDICINE

The new frontier of genome engineering with CRISPR-Cas9

(2014) J. A. Doudna et al.   SCIENCE

Predictive validation of single-episode uncomplicated depression as a benign subtype of unipolar major depression

(2013) J. C. Wakefield et al.   ACTA PSYCHIATRICA SCANDINAVICA

Burden of Depressive Disorders by Country, Sex, Age, and Year: Findings from the Global Burden of Disease Study 2010

(2013) Alize J. Ferrari et al.   PLOS MEDICINE

Discovery and Fine Mapping of Serum Protein Loci through Transethnic Meta-analysis

(2012) Nora Franceschini et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Evidence for a differential role of HPA-axis function, inflammation and metabolic syndrome in melancholic versus atypical depression

(2012) F Lamers et al.   MOLECULAR PSYCHIATRY

Rare and common variants: twenty arguments

(2012) Greg Gibson   NATURE REVIEWS GENETICS

The heterogeneity of the depressive syndrome: when numbers get serious

(2011) S. D. Østergaard et al.   ACTA PSYCHIATRICA SCANDINAVICA

Cross-national epidemiology of DSM-IV major depressive episode

(2011) Evelyn Bromet et al.   BMC Medicine

Genetic Sensitivity to the Environment: The Case of the Serotonin Transporter Gene and Its Implications for Studying Complex Diseases and Traits

(2010) Avshalom Caspi et al.   AMERICAN JOURNAL OF PSYCHIATRY

Poor replication of candidate genes for major depressive disorder using genome-wide association data

(2010) F J Bosker et al.   MOLECULAR PSYCHIATRY

Common SNPs explain a large proportion of the heritability for human height

(2010) Jian Yang et al.   NATURE GENETICS

Mendelian randomization: use of genetics to enable causal inference in observational studies

(2010) M. Verduijn et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

The role of genetic variation in the causation of mental illness: an evolution-informed framework

(2009) R Uher   MOLECULAR PSYCHIATRY

Mendelian randomization: Using genes as instruments for making causal inferences in epidemiology

(2007) Debbie A. Lawlor et al.   STATISTICS IN MEDICINE