Development and evaluation of inhalable composite niclosamide-lysozyme particles: A broad-spectrum, patient-adaptable treatment for coronavirus infections and sequalae

Asymptomatic carrier state, acute respiratory disease, and pneumonia due to severe acute respiratory syndrome coronavirus 2 (SARSCoV-2): Facts and myths

(2020) Chih-Cheng Lai et al.   JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION

Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV

(2020) Timothy P. Sheahan et al.   Nature Communications

Identification of antiviral drug candidates against SARS-CoV-2 from FDA-approved drugs

(2020) Sangeun Jeon et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Nervous system involvement after infection with COVID-19 and other coronaviruses

(2020) Yeshun Wu et al.   BRAIN BEHAVIOR AND IMMUNITY

SARS-CoV-2 Reverse Genetics Reveals a Variable Infection Gradient in the Respiratory Tract

(2020) Yixuan J. Hou et al.   CELL

Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study

(2020) Fei Zhou et al.   LANCET

Projecting the transmission dynamics of SARS-CoV-2 through the postpandemic period

(2020) Stephen M. Kissler et al.   SCIENCE

Disease and healthcare burden of COVID-19 in the United States

(2020) Ian F. Miller et al.   NATURE MEDICINE

Estimated Demand for US Hospital Inpatient and Intensive Care Unit Beds for Patients With COVID-19 Based on Comparisons With Wuhan and Guangzhou, China

(2020) Ruoran Li et al.   JAMA Network Open

Development of Remdesivir as a Dry Powder for Inhalation by Thin Film Freezing

(2020) Sawittree Sahakijpijarn et al.   Pharmaceutics

The Anthelmintic Drug Niclosamide Synergizes with Colistin and Reverses Colistin Resistance in Gram-Negative Bacilli

(2019) Ronald Domalaon et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

An In Vitro Study of Aromatic Stacking of Drug Molecules

(2019) Shelley N. Jackson et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Antiviral effects of nisin, lysozyme, lactoferrin and their mixtures against bovine viral diarrhoea virus

(2019) Joanna Małaczewska et al.   BMC Veterinary Research

Investigation of complexation of amlodipine with lysozyme and its effect on lysozyme crystal growth

(2019) Satish Pawar et al.   SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY

SKP2 attenuates autophagy through Beclin1-ubiquitination and its inhibition reduces MERS-Coronavirus infection

(2019) Nils C. Gassen et al.   Nature Communications

Influence of Formulation Factors on the Aerosol Performance and Stability of Lysozyme Powders: a Systematic Approach

(2018) Silvia Ferrati et al.   AAPS PHARMSCITECH

Niclosamide: Beyond an antihelminthic drug

(2018) Wei Chen et al.   CELLULAR SIGNALLING

A phase I study of niclosamide in combination with enzalutamide in men with castration-resistant prostate cancer

(2018) Michael T. Schweizer et al.   PLoS One

Repurposing the anthelmintic drug niclosamide to combat Helicobacter pylori

(2018) Nagendran Tharmalingam et al.   Scientific Reports

Design and development of a biorelevant simulated human lung fluid

(2018) Mireille Hassoun et al.   JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY

An Antiviral Branch of the IL-1 Signaling Pathway Restricts Immune-Evasive Virus Replication

(2018) Megan H. Orzalli et al.   MOLECULAR CELL

Nebulized Mannitol, Particle Distribution, and Cough in Idiopathic Pulmonary Fibrosis

(2018) Pooja M Kanth et al.   Respiratory Care

Host-targeted niclosamide inhibits C. difficile virulence and prevents disease in mice without disrupting the gut microbiota

(2018) John Tam et al.   Nature Communications

Niclosamide as a promising antibiofilm agent

(2017) M. V. Zhurina et al.   MICROBIOLOGY

From bacterial killing to immune modulation: Recent insights into the functions of lysozyme

(2017) Stephanie A. Ragland et al.   PLoS Pathogens

Screening a Commercial Library of Pharmacologically Active Small Molecules against Staphylococcus aureus Biofilms

(2016) Nelson S. Torres et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Resazurin-based 96-well plate microdilution method for the determination of minimum inhibitory concentration of biosurfactants

(2016) Mohamed Elshikh et al.   BIOTECHNOLOGY LETTERS

Immunogenicity of Therapeutic Protein Aggregates

(2016) Ehab M. Moussa et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

The Impact of Inspiratory Flow Rate on Drug Delivery to the Lungs with Dry Powder Inhalers

(2016) Jeffry Weers et al.   PHARMACEUTICAL RESEARCH

Measurements of Deposition, Lung Surface Area and Lung Fluid for Simulation of Inhaled Compounds

(2016) Eleonore Fröhlich et al.   Frontiers in Pharmacology

A Novel High Content Imaging-Based Screen Identifies the Anti-Helminthic Niclosamide as an Inhibitor of Lysosome Anterograde Trafficking and Prostate Cancer Cell Invasion

(2016) Magdalena L. Circu et al.   PLoS One

Extracellular pH Modulates Neuroendocrine Prostate Cancer Cell Metabolism and Susceptibility to the Mitochondrial Inhibitor Niclosamide

(2016) Joseph E. Ippolito et al.   PLoS One

Structure–activity studies of Wnt/β-catenin inhibition in the Niclosamide chemotype: Identification of derivatives with improved drug exposure

(2015) Robert A. Mook et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Anti-Inflammatory Effects of Lysozyme Against HMGB1 in Human Endothelial Cells and in Mice

(2015) Wonhwa Lee et al.   INFLAMMATION

Complexation of Lysozyme with Sodium Poly(styrenesulfonate) via the Two-State and Non-Two-State Unfoldings of Lysozyme

(2015) Fu-Gen Wu et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Toward Repositioning Niclosamide for Antivirulence Therapy of Pseudomonas aeruginosa Lung Infections: Development of Inhalable Formulations through Nanosuspension Technology

(2015) Gabriella Costabile et al.   MOLECULAR PHARMACEUTICS

Evaluation of the Transwell System for Characterization of Dissolution Behavior of Inhalation Drugs: Effects of Membrane and Surfactant

(2015) Marc Rohrschneider et al.   MOLECULAR PHARMACEUTICS

Repurposing Salicylanilide Anthelmintic Drugs to Combat Drug Resistant Staphylococcus aureus

(2015) Rajmohan Rajamuthiah et al.   PLoS One

Multi-targeted therapy of cancer by niclosamide: A new application for an old drug

(2014) Yonghe Li et al.   CANCER LETTERS

Severe acute respiratory syndrome-coronavirus infection in aged nonhuman primates is associated with modulated pulmonary and systemic immune responses

(2014) Candice C Clay et al.   Immunity & Ageing

Activities of Drug Combinations against Mycobacterium tuberculosis Grown in Aerobic and Hypoxic Acidic Conditions

(2013) Giovanni Piccaro et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Immunogenicity of therapeutic proteins: Influence of aggregation

(2013) Kirsty D. Ratanji et al.   Journal of Immunotoxicology

Study on Antimicrobial and Antiviral Activities of Lysozyme From Marine Strain S-12-86 In Vitro

(2012) Xiu ZHANG et al.   Agricultural Sciences in China

New Life for an Old Drug: the Anthelmintic Drug Niclosamide Inhibits Pseudomonas aeruginosa Quorum Sensing

(2012) F. Imperi et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Pharmaceutical Cocrystals of Niclosamide

(2012) Palash Sanphui et al.   CRYSTAL GROWTH & DESIGN

Immunogenicity of protein aggregates—Concerns and realities

(2012) Wei Wang et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Structure-Activity Analysis of Niclosamide Reveals Potential Role for Cytoplasmic pH in Control of Mammalian Target of Rapamycin Complex 1 (mTORC1) Signaling

(2012) Bruno D. Fonseca et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Impaired NLRP3 Inflammasome Function in Elderly Mice during Influenza Infection Is Rescued by Treatment with Nigericin

(2012) H. W. Stout-Delgado et al.   JOURNAL OF IMMUNOLOGY

Overcoming sink limitations in dissolution testing: a review of traditional methods and the potential utility of biphasic systems

(2012) Daniel J. Phillips et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

Rethinking the term “pi-stacking”

(2012) Chelsea R. Martinez et al.   Chemical Science

Niclosamide Is a Proton Carrier and Targets Acidic Endosomes with Broad Antiviral Effects

(2012) Andreas Jurgeit et al.   PLoS Pathogens

Human Lysozyme Possesses Novel Antimicrobial Peptides within Its N-terminal Domain that Target Bacterial Respiration

(2011) Hisham R. Ibrahim et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Automated actuation of nasal spray products: determination and comparison of adult and pediatric settings

(2010) Diane V. Doughty et al.   DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY

Lysozymes in the animal kingdom

(2010) Lien Callewaert et al.   JOURNAL OF BIOSCIENCES

In Vitro Aqueous Fluid-Capacity-Limited Dissolution Testing of Respirable Aerosol Drug Particles Generated from Inhaler Products

(2010) Deepika Arora et al.   PHARMACEUTICAL RESEARCH

Transcription profiles of LPS-stimulated THP-1 monocytes and macrophages: a tool to study inflammation modulating effects of food-derived compounds

(2010) Wasaporn Chanput et al.   Food & Function