Host-targeted niclosamide inhibits C. difficile virulence and prevents disease in mice without disrupting the gut microbiota
Published 2018 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Host-targeted niclosamide inhibits C. difficile virulence and prevents disease in mice without disrupting the gut microbiota
Authors
Keywords
-
Journal
Nature Communications
Volume 9, Issue 1, Pages -
Publisher
Springer Nature
Online
2018-12-03
DOI
10.1038/s41467-018-07705-w
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Niclosamide Exhibits Potent Anticancer Activity and Synergizes with Sorafenib in Human Renal Cell Cancer Cells
- (2018) Xinyi Yu et al. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
- The impact of a helminth-modified microbiome on host immunity
- (2018) Tara P. Brosschot et al. Mucosal Immunology
- Dietary trehalose enhances virulence of epidemic Clostridium difficile
- (2018) J. Collins et al. NATURE
- Enteric Helminths Promote Salmonella Coinfection by Altering the Intestinal Metabolome
- (2017) Lisa A. Reynolds et al. JOURNAL OF INFECTIOUS DISEASES
- Niclosamide-conjugated polypeptide nanoparticles inhibit Wnt signaling and colon cancer growth
- (2017) Jayanta Bhattacharyya et al. Nanoscale
- Bezlotoxumab for Prevention of Recurrent Clostridium difficile Infection
- (2017) Mark H. Wilcox et al. NEW ENGLAND JOURNAL OF MEDICINE
- Bezlotoxumab: A Novel Agent for the Prevention of Recurrent Clostridium difficile Infection
- (2017) Wesley D. Kufel et al. PHARMACOTHERAPY
- Niclosamide enhances the antitumor effects of radiation by inhibiting the hypoxia-inducible factor-1α/vascular endothelial growth factor signaling pathway in human lung cancer cells
- (2017) Mei Xiang et al. Oncology Letters
- Niclosamide loaded biodegradable chitosan nanocargoes: an in vitro study for potential application in cancer therapy
- (2017) Saba Naqvi et al. Royal Society Open Science
- Diagnostic testing for Clostridium difficile in Italian microbiological laboratories
- (2016) Patrizia Spigaglia et al. ANAEROBE
- Niclosamide inhibits colon cancer progression through downregulation of the Notch pathway and upregulation of the tumor suppressor miR-200 family
- (2016) Mohammed A. Suliman et al. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
- Identification of small-molecule inhibitors of Zika virus infection and induced neural cell death via a drug repurposing screen
- (2016) Miao Xu et al. NATURE MEDICINE
- DADA2: High-resolution sample inference from Illumina amplicon data
- (2016) Benjamin J Callahan et al. NATURE METHODS
- Comment on "A small-molecule antivirulence agent for treating Clostridium difficile infection"
- (2016) G. L. Beilhartz et al. Science Translational Medicine
- Reprofiled anthelmintics abate hypervirulent stationary-phase Clostridium difficile
- (2016) Major Gooyit et al. Scientific Reports
- Error filtering, pair assembly and error correction for next-generation sequencing reads
- (2015) Robert C. Edgar et al. BIOINFORMATICS
- Small Molecule Inhibitors of Clostridium difficile Toxin B-Induced Cellular Damage
- (2015) John Tam et al. CHEMISTRY & BIOLOGY
- Infection with Toxin A-Negative, Toxin B-Negative, Binary Toxin-Positive Clostridium difficile in a Young Patient with Ulcerative Colitis
- (2015) Grace O. Androga et al. JOURNAL OF CLINICAL MICROBIOLOGY
- A screen of approved drugs and molecular probes identifies therapeutics with anti–Ebola virus activity
- (2015) Lisa M. Johansen et al. Science Translational Medicine
- A small-molecule antivirulence agent for treating Clostridium difficile infection
- (2015) Kristina Oresic Bender et al. Science Translational Medicine
- Small Molecules Take A Big Step Against Clostridium difficile
- (2015) Greg L. Beilhartz et al. TRENDS IN MICROBIOLOGY
- Defining the Roles of TcdA and TcdB in Localized Gastrointestinal Disease, Systemic Organ Damage, and the Host Response during Clostridium difficile Infections
- (2015) Glen P. Carter et al. mBio
- Mechanisms of Protection against Clostridium difficile Infection by the Monoclonal Antitoxin Antibodies Actoxumab and Bezlotoxumab
- (2014) Zhiyong Yang et al. INFECTION AND IMMUNITY
- Toxin-Mediated Paracellular Transport of Antitoxin Antibodies Facilitates Protection against Clostridium difficile Infection
- (2014) Z. Zhang et al. INFECTION AND IMMUNITY
- The serine protease inhibitor Ecotin is required for full virulence of Burkholderia pseudomallei
- (2014) Philip M. Ireland et al. MICROBIAL PATHOGENESIS
- Niclosamide ethanolamine–induced mild mitochondrial uncoupling improves diabetic symptoms in mice
- (2014) Hanlin Tao et al. NATURE MEDICINE
- Translocation domain mutations affecting cellular toxicity identify the Clostridium difficile toxin B pore
- (2014) Z. Zhang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- An improved dual-indexing approach for multiplexed 16S rRNA gene sequencing on the Illumina MiSeq platform
- (2014) Douglas W Fadrosh et al. Microbiome
- Identification of Novel Host-Targeted Compounds That Protect from Anthrax Lethal Toxin-Induced Cell Death
- (2013) Louise H. Slater et al. ACS Chemical Biology
- New derivatives of salicylamides: Preparation and antimicrobial activity against various bacterial species
- (2013) Karel Pauk et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Antibiotics and hospital-acquired Clostridium difficile infection: update of systematic review and meta-analysis
- (2013) Claudia Slimings et al. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
- Importance of Toxin A, Toxin B, and CDT in Virulence of an Epidemic Clostridium difficile Strain
- (2013) Sarah A. Kuehne et al. JOURNAL OF INFECTIOUS DISEASES
- phyloseq: An R Package for Reproducible Interactive Analysis and Graphics of Microbiome Census Data
- (2013) Paul J. McMurdie et al. PLoS One
- Clostridium difficile toxin B-induced necrosis is mediated by the host epithelial cell NADPH oxidase complex
- (2013) M. A. Farrow et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A Chimeric Toxin Vaccine Protects against Primary and Recurrent Clostridium difficile Infection
- (2012) Haiying Wang et al. INFECTION AND IMMUNITY
- Emergence and global spread of epidemic healthcare-associated Clostridium difficile
- (2012) Miao He et al. NATURE GENETICS
- Niclosamide Is a Proton Carrier and Targets Acidic Endosomes with Broad Antiviral Effects
- (2012) Andreas Jurgeit et al. PLoS Pathogens
- An improved Greengenes taxonomy with explicit ranks for ecological and evolutionary analyses of bacteria and archaea
- (2011) Daniel McDonald et al. ISME Journal
- High-ThroughputGiardia lambliaViability Assay Using Bioluminescent ATP Content Measurements
- (2010) Catherine Z. Chen et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- TagCleaner: Identification and removal of tag sequences from genomic and metagenomic datasets
- (2010) Robert Schmieder et al. BMC BIOINFORMATICS
- A new macrocyclic antibiotic, fidaxomicin (OPT-80), causes less alteration to the bowel microbiota of Clostridium difficile-infected patients than does vancomycin
- (2010) G. W. Tannock et al. MICROBIOLOGY-SGM
- The role of toxin A and toxin B in Clostridium difficile infection
- (2010) Sarah A. Kuehne et al. NATURE
- Variations in TcdB Activity and the Hypervirulence of Emerging Strains of Clostridium difficile
- (2010) Jordi M. Lanis et al. PLoS Pathogens
- Toxin B is essential for virulence of Clostridium difficile
- (2009) Dena Lyras et al. NATURE
- Expression of recombinant Clostridium difficile toxin A and B in Bacillus megaterium
- (2008) Guilin Yang et al. BMC MICROBIOLOGY
- Emergence ofClostridium difficileInfection Due to a New Hypervirulent Strain, Polymerase Chain Reaction Ribotype 078
- (2008) Abraham Goorhuis et al. CLINICAL INFECTIOUS DISEASES
- A Mouse Model of Clostridium difficile–Associated Disease
- (2008) Xinhua Chen et al. GASTROENTEROLOGY
- The tragedy of the uncommon: understanding limitations in the analysis of microbial diversity
- (2008) Stephen J Bent et al. ISME Journal
Find the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
SearchAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started