Article
Medicine, Research & Experimental
Ires van der Zwaan, Frans Franek, Rebecca Fransson, Ulrika Tehler, Goran Frenning
Summary: This study describes an extended mathematical model that allows for the dissolution of polydisperse powders and subsequent diffusion of dissolved drugs. The model was used to analyze the in vitro dissolution profiles of three drugs. The developed mechanistic model provides a more accurate dissolution rate, while the Weibull model provides a slower and effective rate.
MOLECULAR PHARMACEUTICS
(2022)
Review
Pharmacology & Pharmacy
Basanth Babu Eedara, Rakesh Bastola, Shyamal C. Das
Summary: Dry powder inhalation therapy has been effective in treating localized lung diseases, but there is currently no standard method for evaluating the dissolution behavior of inhalable dry powder particles in the lungs.
Article
Pharmacology & Pharmacy
Snezana Radivojev, Gerfried Luschin-Ebengreuth, Joana T. Pinto, Peter Laggner, Alessandro Cavecchi, Nicola Cesari, Massimo Cella, Fabrizio Melli, Amrit Paudel, Eleonore Froehlich
Summary: Orally inhaled products are receiving increasing attention for the treatment of various diseases via pulmonary delivery. This study used an in vitro-in silico approach to investigate the biopharmaceutics behavior of inhaled Salbutamol Sulphate and Budesonide. The results showed that media containing lipids and albumin had the most significant impact on Budesonide solubility, while no notable impact was seen for Salbutamol Sulphate. The use of simple media like phosphate buffer saline may be sufficient for soluble and permeable drugs, but may be limited for poorly soluble drugs due to potential interactions in vivo.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Pharmacology & Pharmacy
Elham Amini, Abhinav Kurumaddali, Sharvari Bhagwat, Simon M. Berger, Gunther Hochhaus
Summary: This study aimed to optimize the Transwell(R) system for assessing the dissolution behavior of orally inhaled drug products (OIDPs) using fluticasone propionate as a model drug. The results indicated that using a 0.4 mu m polycarbonate membrane, stirring the receptor compartment, and placing the drug-containing side of the filter paper face downwards towards the PC membrane can improve the uniform presentation of drug particles during dissolution testing. Additionally, the study highlighted the importance of experimental conditions on the interplay of dissolution and diffusion within a volume-limited system under non-sink conditions.
Article
Chemistry, Analytical
Eshani Hettiarachchi, Milton Das, Daniel Cadol, Bonnie A. Frey, Gayan Rubasinghege
Summary: This study investigated the solubility of uranium from dust and sediment samples near two uranium mines in New Mexico in simulated gastrointestinal fluids. The results showed that the mineralogy, fluid pH, and composition of the samples affected the dissolution of uranium from dust.
ENVIRONMENTAL SCIENCE-PROCESSES & IMPACTS
(2022)
Review
Pharmacology & Pharmacy
Li Ding, Jieliang Wang, Shihao Cai, Hugh Smyth, Zhengrong Cui
Summary: Certain pulmonary diseases are often accompanied by respiratory tract infections, which may lead to chronic biofilm-based infections that are challenging to treat with antimicrobial agents. Therefore, effective agents and delivery carriers must be developed to target biofilms in the lung. This review focuses on inhalable agents to treat biofilms, discussing existing options as well as promising novel agents and delivery devices.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Review
Respiratory System
Hetal Dhruve, David J. Jackson
Summary: Infrequent use of inhaled corticosteroids and over-reliance of short-acting beta-agonists are recognized as key contributors to increased morbidity and mortality in asthma. Electronic monitoring devices have the potential to improve asthma care by accurately tracking medication use and providing feedback to patients. This is a significant step forward in asthma management.
EUROPEAN RESPIRATORY REVIEW
(2022)
Review
Biochemistry & Molecular Biology
Holly R. Keir, Marco Contoli, James D. Chalmers
Summary: The overprescription of inhaled corticosteroids (ICS) in COPD patients may increase the risk of respiratory infections, and changes in the lung microbiome have been associated with disease progression and exacerbation frequency, with the immunosuppressive effects of ICS potentially contributing to detrimental airway microbiota changes.
Review
Pharmacology & Pharmacy
Kazuhiro Ito
Summary: This review discusses the limitations of current antifungal therapy, the benefits of inhaled antifungal agents, the clinical development of inhaled antifungal triazoles, and the challenges of developing inhaled antifungal agents. Inhaled antifungal treatment provides an attractive option by changing the risk benefit ratio of treatment. Clinical studies have shown that new inhaled antifungal triazoles are well tolerated. However, there are still challenges and unresolved issues that need to be addressed.
EXPERT OPINION ON DRUG DELIVERY
(2022)
Article
Medicine, General & Internal
Ly-Mee Yu, Mona Bafadhel, Jienchi Dorward, Gail Hayward, Benjamin R. Saville, Oghenekome Gbinigie, Oliver Van Hecke, Emma Ogburn, Philip H. Evans, Nicholas P. B. Thomas, Mahendra G. Patel, Duncan Richards, Nicholas Berry, Michelle A. Detry, Christina Saunders, Mark Fitzgerald, Victoria Harris, Milensu Shanyinde, Simon De Lusignan, Monique I. Andersson, Peter J. Barnes, Richard E. K. Russell, Dan V. Nicolau, Sanjay Ramakrishnan, F. D. Richard Hobbs, Christopher C. Butler
Summary: The study found that inhaled budesonide can reduce recovery time and potentially decrease the risk of hospital admissions or deaths among high-risk COVID-19 patients in the community.
Article
Engineering, Environmental
Soyeon Jeon, Wang Sik Lee, Kyung Seuk Song, Jiyoung Jeong, Sinuk Lee, Songyeon Kim, Gyuri Kim, Ji-Su Kim, Jinyoung Jeong, Wan-Seob Cho
Summary: The biotransformation and differential lung clearance kinetics of PEGylated silver nanoparticles (AgNP-PEGs) and PEGylated gold nanoparticles (AuNP-PEGs) were evaluated. The results showed that AgNP-PEGs were quickly dissolved and transformed into insoluble silver sulfide, while AuNP-PEGs were scarcely cleared or biotransformed in the lungs. The study highlights the importance of using the proteinase K digestion method for quantitative and qualitative evaluation of nanoparticle biotransformation and lung clearance kinetics.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Medicine, Research & Experimental
Nisha Gulati, Dinesh Kumar Chellappan, Ronan MacLoughlin, Kamal Dua, Harish Dureja
Summary: Inflammatory lung diseases result in significant economic burden, with the lungs being an ideal target for treatment. Inhaled nanomedicines offer targeted treatment and improved patient compliance, potentially enhancing treatment efficiency.
Review
Biochemistry & Molecular Biology
Ellenmae W. X. Leong, Ruowen Ge
Summary: Lipid nanoparticles (LNPs) have emerged as a powerful non-viral carrier for drug delivery. Current investigations are focusing on applying LNPs to deliver inhaled therapeutics directly to the lungs, particularly in respiratory diseases. This review evaluates the advantages and challenges of pulmonary drug delivery system and provides a perspective on the future prospects of LNP-mediated delivery of inhaled therapeutics for respiratory diseases.
Review
Pharmacology & Pharmacy
Thomas Secher, Nathalie Heuze-Vourc'h
Summary: This review discusses the barriers that can affect the fate of inhaled therapeutic antibodies (Abs) in the lungs, including both physical and biological barriers. It emphasizes the importance of considering the pathological changes during respiratory diseases which can intensify these barriers.
EXPERT OPINION ON DRUG DELIVERY
(2023)
Article
Pharmacology & Pharmacy
Adriana Martinez Ledo, Thomas Dimke, William R. Tschantz, David Rowlands, Ellena Growcott
Summary: In this study, the absorption and clearance mechanisms of antibodies in healthy and diseased pulmonary epithelium were investigated using human bronchial epithelial cell models. The study identified the potential role of intercellular paracellular transport and target-mediated transcytosis in the transport of antibodies, as well as impaired antibody diffusion in mucus gels.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Pharmacology & Pharmacy
Julia F. Alopaeus, Anja Goebel, Joerg Breitkreutz, Sverre Arne Sande, Ingunn Tho
Summary: The study aimed to enhance the solubility of two lipophilic model drugs by forming inclusion complexes with hydroxypropyl-beta-cyclodextrin while hindering taste sensation. The inclusion complexes showed improved taste perception compared to plain drugs, indicating successful tastemasking.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Olga Kiefer, Bjoern Fischer, Joerg Breitkreutz
Summary: Individualized medicine is gaining attention in pharmaceutical research, requiring new concepts and manufacturing technologies. The combination of orodispersible films and inkjet printing technology provides precise and acceptable doses of MPT for pediatric use. Uniform dosages can be achieved, but considerations are needed for implementation of inkjet printing in pharmaceutical production due to nozzle aging affecting printed quantity.
Article
Pharmacology & Pharmacy
Anja Goebel, Joerg Breitkreutz
Summary: This paper presents a modification of the solvent casting technique to divide oral films into multiple compartments, aiming to improve handling properties, safety of application, drug release kinetics, and long-term stability. Feasibility studies showed that combination of different film-forming polymers can achieve these objectives.
Article
Pharmacology & Pharmacy
Rebecca Chamberlain, Hellen Windolf, Simon Geissler, Julian Quodbach, Joerg Breitkreutz
Summary: The aim of this research was to produce low-dosed filaments via hot-melt extrusion (HME) with a model drug for Parkinson's disease treatment. It was found that deviation from target drug concentration occurred due to degradation products in certain formulations. Material temperature and the formation of anhydrous drug in the extruded filaments should be considered for the calculation of recovered API. The study showed that equilibrium condition for drug content was reached relatively late in the process, and the calculated RSD by Stange-Poole equation can be used to evaluate the deviations of drug content in equilibrium conditions.
Article
Pharmacology & Pharmacy
Rebecca Chamberlain, Hellen Windolf, Bjoern B. Burckhardt, Joerg Breitkreutz, Bjoern Fischer
Summary: Individual dosing of pharmaceutics and personalized medicine have become important for therapeutic safety, including dose adjustments, biorelevant drug release, and combination of multiple active substances. This requires both innovative drug products and new analytical methods for drug development and quality control. The liquid-core waveguide UV absorbance flow cell detector coupled to an existing HPLC-UV system allows for simultaneous determination of different active ingredients and wide concentration ranges, increasing sensitivity and reducing analysis time.
Article
Pharmacology & Pharmacy
Valentinee Elezaj, Ard Lura, Luis Canha, Joerg Breitkreutz
Summary: Epidermolysis bullosa is a skin fragility disorder that can be treated with mini-tablets containing losartan potassium. The development process faced several challenges, but successful formulation of the mini-tablets was achieved through dry granulation and appropriate coating, meeting pharmacopoeial requirements and demonstrating promising stability.
Article
Pharmacology & Pharmacy
Hellen Windolf, Rebecca Chamberlain, Joerg Breitkreutz, Julian Quodbach
Summary: Treating Parkinson's disease is challenging, and personalized therapy is crucial due to specific requirements of drug therapy. This study utilized 3D printing to create personalized medication, including both rapid and prolonged drug release formulations, to meet the varying drug release needs. This provides a more personalized and effective treatment option for patients with Parkinson's disease.
Article
Pharmacology & Pharmacy
Stephanie Laeer, Willi Cawello, Bjoern B. Burckhardt, Laszlo Ablonczy, Milica Bajcetic, Johannes M. P. J. Breur, Michiel Dalinghaus, Christoph Male, Saskia N. de Wildt, Joerg Breitkreutz, Muhammed Faisal, Anne Keatley-Clarke, Ingrid Klingmann, Florian B. Lagler
Summary: This study investigated the pharmacokinetics of enalapril in pediatric heart failure patients using a novel oral disintegrating tablet formulation, finding the rate and extent of enalapril and its active metabolite, and supporting the tolerability and safety of the appropriate dosing schedule.
Article
Pharmacology & Pharmacy
Bakul Sarker, Mariele Fligge, Tanja Knaab, Joerg Breitkreutz
Summary: A novel electronic liquid dispensing system (ELDS) was investigated for producing individualized dose strengths of hard capsules. The ELDS showed good dosing accuracy and content uniformity compared to manual preparation, with almost no drug loss.
Article
Pharmacology & Pharmacy
Lena Hoffmann, Joerg Breitkreutz, Julian Quodbach
Summary: The aim of this research was to produce extrudates for the treatment of hypertension and heart failure and investigate the degradation of the drug enalapril maleate during hot-melt extrusion (HME). The study found that the use of specific polymer formulations prevented thermal degradation and maintained high dissolution. These findings have important implications for developing similar drug formulations.
Article
Pharmacology & Pharmacy
Malin Hermeling, Christoph Nueboldt, Roman Heumann, Werner Hoheisel, Joerg Breitkreutz
Summary: Amorphous solid dispersions (ASD) are a prominent formulation approach for poorly soluble drugs. This study introduces a novel process technology called Nano-Dry-Melting (NDM) as an alternative option for ASD manufacturing. Feasibility studies and proof-of-concept experiments demonstrate the successful production of amorphous samples with NDM, even for drug candidates that cannot be processed by conventional methods.
Article
Pharmacology & Pharmacy
Mariele Fligge, Ilse Letofsky-Papst, Miriam Baeumers, Andreas Zimmer, Joerg Breitkreutz
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Pharmacology & Pharmacy
Lena Hoffmann, Joerg Breitkreutz, Julian Quodbach
Summary: In this study, 3D printed tablets containing enalapril maleate were produced using Fused deposition modeling (FDM) technology, and two different formulations were prepared to investigate drug degradation during the printing process. Despite attempts to prevent degradation using various methods, it was not completely successful, but significant differences in degradation levels were observed between formulations with different polymers.
Review
Pharmacology & Pharmacy
Ross L. Walenga, Clare Butler, Brent A. Craven, P. Worth Longest, Raja Mohamed, Bryan Newman, Bo Olsson, Guenther Hochhaus, Bing Li, Markham C. Luke, Liang Zhao, Andrzej Przekwas, Robert Lionberger
Summary: This article summarizes a workshop session that focuses on the use of in silico models in predicting outcomes of orally inhaled drug products. It discusses the status of such models and how to establish their credibility.
CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Lukas C. Lammerding, Joerg Breitkreutz
Summary: The study investigated the use of inkjet printing as a manufacturing technology for dissolvable microneedle array patches. It was found that using printing method could precisely control the dosage and reduce drug waste. This study demonstrated the potential of inkjet printing technology in the manufacturing of personalized microneedle array patches.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)