Palladium-Catalyzed Asymmetric Direct Intermolecular Allylation of α-Aryl Cyclic Vinylogous Esters: Divergent Synthesis of (+)-Oxomaritidine and (−)-Mesembrine

Pd-Catalyzed Decarboxylative Asymmetric Allylic Alkylation: Development, Mechanistic Understanding and Recent Advances

(2019) Jinju James et al.   ADVANCED SYNTHESIS & CATALYSIS

Catalytic Enantioselective Pinacol and Meinwald Rearrangements for the Construction of Quaternary Stereocenters

(2019) Hua Wu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Nickel-Catalyzed Desymmetric Hydrogenation of Cyclohexadienones: An Efficient Approach to All-Carbon Quaternary Stereocenters

(2019) Cai You et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Palladium-Catalyzed Cascade Arylation of Vinylogous Esters Enabled by Tris(1-adamantyl)phosphine

(2019) Yi-Chi Yang et al.   ORGANIC LETTERS

Palladium-Catalyzed Enantioselective Desymmetrizing Aza-Wacker Reaction: Development and Application to the Total Synthesis of (−)-Mesembrane and (+)-Crinane

(2018) Xu Bao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Divergent Strategy in Natural Product Total Synthesis

(2018) Lei Li et al.   CHEMICAL REVIEWS

Total Synthesis of Mesembrine - The Construction of Quaternary Stereocenters by Gold-Catalyzed Diyne Desymmetrization

(2018) Constantin Czekelius   ISRAEL JOURNAL OF CHEMISTRY

Diversity-oriented approach towards the syntheses of amaryllidaceae alkaloids via a common chiral synthon

(2018) Prachi Verma et al.   JOURNAL OF ORGANIC CHEMISTRY

Enantioselective palladium-catalyzed allylic alkylation reactions in the synthesis of Aspidosperma and structurally related monoterpene indole alkaloids

(2018) Beau P. Pritchett et al.   NATURAL PRODUCT REPORTS

Catalytic Asymmetric Total Syntheses of Naturally Occurring Amarylidaceae Alkaloids, (−)-Crinine, (−)-epi-Crinine, (−)-Oxocrinine, (+)-epi-Elwesine, (+)-Vittatine, and (+)-epi-Vittatine*

(2018) Mrinal K. Das et al.   ORGANIC LETTERS

Asymmetric Synthesis of Remote Quaternary Centers by Copper-Catalyzed Desymmetrization: An Enantioselective Total Synthesis of (+)-Mesembrine

(2018) Apparao Bokka et al.   ORGANIC LETTERS

Palladium-Catalyzed Asymmetric Allylic Alkylation Strategies for the Synthesis of Acyclic Tetrasubstituted Stereocenters

(2018) Barry Trost et al.   SYNTHESIS-STUTTGART

Mesembrine alkaloids: Review of their occurrence, chemistry, and pharmacology

(2017) John L. Krstenansky   JOURNAL OF ETHNOPHARMACOLOGY

Palladium-Catalyzed α-Arylation of Cyclic Vinylogous Esters for the Synthesis of γ-Arylcyclohexenones and Total Synthesis of Aromatic Podocarpane Diterpenoids

(2017) Wen-Yi Hou et al.   ORGANIC LETTERS

Asymmetric Syntheses of Amaryllidaceae Alkaloids (−)-Crinane and (+)-4a-Dehydroxycrinamabine

(2017) Ya-Ru Gao et al.   ORGANIC LETTERS

Efficient syntheses of (−)-crinine and (−)-aspidospermidine, and the formal synthesis of (−)-minfiensine by enantioselective intramolecular dearomative cyclization

(2017) Kang Du et al.   Chemical Science

Bioinspired enantioselective synthesis of crinine-type alkaloids via iridium-catalyzed asymmetric hydrogenation of enones

(2017) Xiao-Dong Zuo et al.   Chemical Science

Asymmetric Induction at Remote Quaternary Centers of Cyclohexadienones by Rhodium-Catalyzed Conjugate Hydrosilylation

(2016) Yuki Naganawa et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Pyrone Diels-Alder Routes to Indolines and Hydroindolines: Syntheses of Gracilamine, Mesembrine, and Δ7 -Mesembrenone

(2016) Pei Gan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Catalytic Enantioselective Desymmetrization Reactions to All-Carbon Quaternary Stereocenters

(2016) Xing-Ping Zeng et al.   CHEMICAL REVIEWS

A Concise Total Synthesis of (−)-Mesembrine

(2016) Lu-Ning Wang et al.   JOURNAL OF ORGANIC CHEMISTRY

Total Synthesis of (+)-Mesembrine Applying Asymmetric Gold Catalysis

(2016) Michael Spittler et al.   JOURNAL OF ORGANIC CHEMISTRY

Diastereodivergent Construction of Bicyclic γ-Lactones via Enantioselective Ketone Hydroacylation

(2016) Xuesong Wu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Amaryllidaceae and Sceletium alkaloids

(2016) Zhong Jin   NATURAL PRODUCT REPORTS

Palladium-Catalyzed α-Arylation of Vinylogous Esters for the Synthesis of γ,γ-Disubstituted Cyclohexenones

(2016) Thomas Johnson et al.   ORGANIC LETTERS

Asymmetric construction of all-carbon quaternary stereocenters in the total synthesis of natural products

(2016) Wen Chen et al.   Science China-Chemistry

All-carbon quaternary centers in natural products and medicinal chemistry: recent advances

(2016) Taotao Ling et al.   TETRAHEDRON

Catalytic Enantioselective Construction of Quaternary Stereocenters: Assembly of Key Building Blocks for the Synthesis of Biologically Active Molecules

(2015) Yiyang Liu et al.   ACCOUNTS OF CHEMICAL RESEARCH

Direct construction of vicinal all-carbon quaternary stereocenters in natural product synthesis

(2015) Rong Long et al.   NATURAL PRODUCT REPORTS

Synthesis of (−)-mesembrine using the quaternary carbon-constructing allylic substitution

(2015) Takuri Ozaki et al.   Organic Chemistry Frontiers

Catalytic enantioselective synthesis of quaternary carbon stereocentres

(2014) Kyle W. Quasdorf et al.   NATURE

Development of (Trimethylsilyl)ethyl Ester Protected Enolates and Applications in Palladium-Catalyzed Enantioselective Allylic Alkylation: Intermolecular Cross-Coupling of Functionalized Electrophiles

(2014) Corey M. Reeves et al.   ORGANIC LETTERS

Enantioselective Palladium-Catalyzed Decarboxylative Allylation of Carbazolones: Total Synthesis of (−)-Aspidospermidine and (+)-Kopsihainanine A

(2013) Zeqian Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enantioselective Synthesis ofAmaryllidaceaeAlkaloids (+)-Vittatine, (+)-epi-Vittatine, and (+)-Buphanisine

(2013) Meng-Xue Wei et al.   Chemistry-An Asian Journal

The Construction of All-Carbon Quaternary Stereocenters by Use of Pd-Catalyzed Asymmetric Allylic Alkylation Reactions in Total Synthesis

(2013) Allen Y. Hong et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Double Reduction of Cyclic Aromatic Sulfonamides: Synthesis of (+)-Mesembrine and (+)-Mesembranol

(2013) Kimberly Geoghegan et al.   JOURNAL OF ORGANIC CHEMISTRY

Construction of a Chiral Quaternary Carbon Center by Catalytic Asymmetric Alkylation of 2-Arylcyclohexanones under Phase-Transfer Conditions

(2013) Taichi Kano et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Iridium-Catalyzed Asymmetric Hydrogenation of α-Substituted α,β-Unsaturated Acyclic Ketones: Enantioselective Total Synthesis of (−)-Mesembrine

(2012) Qian-Qian Zhang et al.   ORGANIC LETTERS

Enantioselective synthesis of all-carbon quaternary stereogenic centers in acyclic systems

(2011) Jaya Prakash Das et al.   CHEMICAL COMMUNICATIONS

Synthesis of enantioenriched γ-quaternary cycloheptenones using a combined allylic alkylation/Stork–Danheiser approach: preparation of mono-, bi-, and tricyclic systems

(2011) Nathan B. Bennett et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Desymmetrization of cyclohexadienones via cinchonine derived thiourea-catalyzed enantioselective aza-Michael reaction and total synthesis of (-)-Mesembrine

(2011) Qing Gu et al.   Chemical Science

A New Powerful Strategy for the Organocatalytic Asymmetric Construction of a Quaternary Carbon Stereogenic Center

(2010) Yogo Inokoishi et al.   ORGANIC LETTERS

Highly Enantioselective Palladium-Catalyzed Alkylation of Acyclic Amides

(2008) Kai Zhang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Palladium-Catalyzed Sequential Arylation and Allylic Alkylation of Highly Functionalized Ketones: A Concise Synthesis of Mesembrine

(2008) Yuanhong Zhao et al.   ORGANIC LETTERS

The Catalytic Asymmetric Total Synthesis of Elatol

(2007) David E. White et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY