Asymmetric construction of all-carbon quaternary stereocenters in the total synthesis of natural products

Synthetic Strategies toward Natural Products Containing Contiguous Stereogenic Quaternary Carbon Atoms

(2016) Martin Büschleb et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Catalytic Enantioselective Construction of Quaternary Stereocenters: Assembly of Key Building Blocks for the Synthesis of Biologically Active Molecules

(2015) Yiyang Liu et al.   ACCOUNTS OF CHEMICAL RESEARCH

Total Synthesis of Schilancitrilactones B and C

(2015) Liang Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Asymmetric Total Synthesis of Mycoleptodiscin A

(2015) Shupeng Zhou et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Catalytic Asymmetric Total Synthesis of (−)-Galanthamine and (−)-Lycoramine

(2015) Lei Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Total synthesis of (−)-depyranoversicolamide B

(2015) Wen-Fang Qin et al.   CHEMICAL COMMUNICATIONS

Copper catalyzed sequential arylation−oxidative dimerization of o-haloanilides: synthesis of dimeric HPI alkaloids

(2015) Xianfu Shen et al.   CHEMICAL COMMUNICATIONS

Organocatalytic Highly Enantioselective Substitution of 3-(1-Tosylalkyl)indoles with Oxindoles Enables the First Total Synthesis of (+)-Trigolutes B

(2015) Jian-Zhou Huang et al.   CHEMISTRY-A EUROPEAN JOURNAL

Total Synthesis of Codeine

(2015) Qilin Li et al.   CHEMISTRY-A EUROPEAN JOURNAL

Studies of a Diazo Cyclopropanation Strategy for the Total Synthesis of (−)-Lundurine A

(2015) Hong-Xiu Huang et al.   CHEMISTRY-A EUROPEAN JOURNAL

Total Syntheses of (−)-Isoschizogamine and (−)-2-Hydroxyisoschizogamine

(2015) Xiaobei Wang et al.   CHEMISTRY-A EUROPEAN JOURNAL

Formal Total Synthesis of (+)-Cortistatins A and J

(2015) Liping Kuang et al.   CHEMISTRY-A EUROPEAN JOURNAL

Total Synthesis of (+)-Iresin

(2015) Bian-Lin Wang et al.   JOURNAL OF ORGANIC CHEMISTRY

Enantioselective Total Synthesis of (−)-Incarviatone A

(2015) Benke Hong et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Asymmetric Total Synthesis of Propindilactone G

(2015) Lin You et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Asymmetric Total Synthesis of Apocynaceae Hydrocarbazole Alkaloids (+)-Deethylibophyllidine and (+)-Limaspermidine

(2015) Ji-Yuan Du et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Direct construction of vicinal all-carbon quaternary stereocenters in natural product synthesis

(2015) Rong Long et al.   NATURAL PRODUCT REPORTS

Protecting-Group-Free Total Synthesis of (−)-Jiadifenolide: Development of a [4 + 1] Annulation toward Multisubstituted Tetrahydrofurans

(2015) Yang Shen et al.   ORGANIC LETTERS

Total synthesis of illicidione A and illihendione A

(2015) Xiao-Dong Ren et al.   TETRAHEDRON

Total synthesis of (+)-fusarisetin A

(2015) Jun Huang et al.   TETRAHEDRON

Total synthesis of (+)-gelsemine via an organocatalytic Diels–Alder approach

(2015) Xiaoming Chen et al.   Nature Communications

Total synthesis and antiviral activity of indolosesquiterpenoids from the xiamycin and oridamycin families

(2015) Zhanchao Meng et al.   Nature Communications

Enantioselective Michael/aza-Michael/Cyclization Organocascade to Tetracyclic Spiroindolines: Concise Total Synthesis of Kopsinine and Aspidofractine

(2014) Xiaoyu Wu et al.   ADVANCED SYNTHESIS & CATALYSIS

Total Synthesis of (−)-Lundurine A and Determination of its Absolute Configuration

(2014) Shuaijiang Jin et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Total Syntheses of (−)-Huperzine Q and (+)-Lycopladines B and C

(2014) Benke Hong et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Bioinspired Total Synthesis of Sespenine

(2014) Yu Sun et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Iodine mediated deprotection of N-tert-butanesulfinyl amines: a functional group compatible method

(2014) Wen Chen et al.   CHEMICAL COMMUNICATIONS

Stereoselective Total Synthesis and Structural Elucidation of (−)-Indoxamycins A-F

(2014) Chi He et al.   CHEMISTRY-A EUROPEAN JOURNAL

Asymmetric Total Synthesis of Onoseriolide, Bolivianine, and Isobolivianine

(2014) Biao Du et al.   CHEMISTRY-A EUROPEAN JOURNAL

Total Synthesis of Aphadilactones A–D

(2014) Jian-Peng Yin et al.   JOURNAL OF ORGANIC CHEMISTRY

Divergent Total Synthesis of Triptolide, Triptonide, Tripdiolide, 16-Hydroxytriptolide, and Their Analogues

(2014) Hongtao Xu et al.   JOURNAL OF ORGANIC CHEMISTRY

Protecting-Group-Free Total Synthesis of Aplykurodinone-1

(2014) Yu Tang et al.   JOURNAL OF ORGANIC CHEMISTRY

Catalytic Enantioselective and Divergent Total Synthesis of (+)-10-Oxocylindrocarpidine, (+)-Cylindrocarpidine, (−)-N-Acetylcylindrocarpinol, and (+)-Aspidospermine

(2014) Xiao-Lei Shen et al.   JOURNAL OF ORGANIC CHEMISTRY

Total Synthesis of Taiwaniadducts B, C, and D

(2014) Jun Deng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Catalytic enantioselective synthesis of quaternary carbon stereocentres

(2014) Kyle W. Quasdorf et al.   NATURE

Collective Total Synthesis of Tetracyclic Diquinane Lycopodium Alkaloids (+)-Paniculatine, (−)-Magellanine, (+)-Magellaninone and Analogues Thereof

(2014) Shi-Zhi Jiang et al.   ORGANIC LETTERS

Enantioselective Total Synthesis of (−)-Walsucochin B

(2014) Shiyan Xu et al.   ORGANIC LETTERS

Scalable Asymmetric Total Syntheses of (+)-Psoracorylifol B and (+)-ent-Psoracorylifol C

(2014) Jingyun Ren et al.   ORGANIC LETTERS

Total Synthesis of (−)-Goniomitine

(2014) Shiqiang Zhou et al.   ORGANIC LETTERS

Synthetic applications of homoiodo allylsilane II. Total syntheses of (−)-andrographolide and (+)-rostratone

(2014) Hai-Tao Gao et al.   TETRAHEDRON

Total synthesis of ent-(−)-azonazine using a biomimetic direct oxidative cyclization and structural reassignment of natural product

(2014) Ji-Chen Zhao et al.   TETRAHEDRON

Catalytic asymmetric formal total synthesis of (+)-dichroanone and (+)-taiwaniaquinone H

(2014) Liang-Qun Li et al.   TETRAHEDRON LETTERS

Chiasmatic and achiasmatic inverted meiosis of plants with holocentric chromosomes

(2014) Gabriela Cabral et al.   Nature Communications

Enantioselective Organocatalytic Addition of Nitroalkanes to Oxindolylideneindolenines for the Construction of Chiral 3,3-Disubstituted Oxindoles

(2013) Jian-Zhou Huang et al.   ADVANCED SYNTHESIS & CATALYSIS

Enantioselective Palladium-Catalyzed Decarboxylative Allylation of Carbazolones: Total Synthesis of (−)-Aspidospermidine and (+)-Kopsihainanine A

(2013) Zeqian Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enantioselective Palladium-Catalyzed Decarboxylative Allylation of Carbazolones and Indolones: Formal Synthesis of (+)-Kopsihainanine A

(2013) Christopher J. Gartshore et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Recent Developments in the Catalytic, Asymmetric Construction of Pyrroloindolines Bearing All-Carbon Quaternary Stereocenters

(2013) Lindsay M. Repka et al.   JOURNAL OF ORGANIC CHEMISTRY

Biomimetic Total Synthesis of (+)-Gelsemine

(2012) Xuan Zhou et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Iridium-Catalyzed Enantioselective Polyene Cyclization

(2012) Michael A. Schafroth et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Copper-Catalyzed Arylation of o-Bromoanilides: Highly Flexible Synthesis of Hexahydropyrroloindole Alkaloids

(2012) Yongyun Zhou et al.   ORGANIC LETTERS

ChiralN,N′-Dioxides: New Ligands and Organocatalysts for Catalytic Asymmetric Reactions

(2011) XiaoHua Liu et al.   ACCOUNTS OF CHEMICAL RESEARCH

Synthesis of spirocyclic β-keto-lactams: copper catalyzed process

(2011) Zhongxuan Xu et al.   CHEMICAL COMMUNICATIONS

Enantioselective synthesis of all-carbon quaternary stereogenic centers in acyclic systems

(2011) Jaya Prakash Das et al.   CHEMICAL COMMUNICATIONS

Oxo-Tethered Ruthenium(II) Complex as a Bifunctional Catalyst for Asymmetric Transfer Hydrogenation and H2Hydrogenation

(2011) Taichiro Touge et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Palladium-Catalyzed Asymmetric Conjugate Addition of Arylboronic Acids to Five-, Six-, and Seven-Membered β-Substituted Cyclic Enones: Enantioselective Construction of All-Carbon Quaternary Stereocenters

(2011) Kotaro Kikushima et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Hypervalent iodine reagents in the total synthesis of natural products

(2011) Luiz F. Silva et al.   NATURAL PRODUCT REPORTS

Collective synthesis of natural products by means of organocascade catalysis

(2011) Spencer B. Jones et al.   NATURE

Oxidative dearomatization in the synthesis of erythrina, oxindole and hexahydropyrrolo[2,3-b]indole skeletons

(2010) Jixuan Liang et al.   CHEMICAL COMMUNICATIONS

Synthesis and Applications oftert-Butanesulfinamide

(2010) MaryAnn T. Robak et al.   CHEMICAL REVIEWS

Cationic Pd(II)/Bipyridine-Catalyzed Conjugate Addition of Arylboronic Acids to β,β-Disubstituted Enones: Construction of Quaternary Carbon Centers

(2010) Shaohui Lin et al.   ORGANIC LETTERS

Efficient Asymmetric Synthesis ofabeo-Abietane-Type Diterpenoids by Using the Intramolecular Heck Reaction

(2009) Manabu Node et al.   JOURNAL OF ORGANIC CHEMISTRY

Total Synthesis and Biological Evaluation of Cortistatins A and J and Analogues Thereof

(2009) K. C. Nicolaou et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Total Synthesis of Vinblastine, Vincristine, Related Natural Products, and Key Structural Analogues

(2009) Hayato Ishikawa et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Oxidative Carbon−Carbon Bond Formation in the Synthesis of Bioactive Spiro β-Lactams

(2009) Jixuan Liang et al.   ORGANIC LETTERS

Total Synthesis of (+)-Cortistatin A

(2008) K. C. Nicolaou et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Application of a Domino Friedel−Crafts Acylation/Alkylation Reaction to the Formal Syntheses of (±)-Taiwaniaquinol B and (±)-Dichroanone

(2008) Shouchu Tang et al.   ORGANIC LETTERS

Picolinoxy Group, a New Leaving Group for anti SN2′ Selective Allylic Substitution with Aryl Anions Based on Grignard Reagents

(2008) Yohei Kiyotsuka et al.   ORGANIC LETTERS