Direct construction of vicinal all-carbon quaternary stereocenters in natural product synthesis

Biogenetically-Inspired Total Synthesis of Epidithiodiketopiperazines and Related Alkaloids

(2015) Justin Kim et al.   ACCOUNTS OF CHEMICAL RESEARCH

Large-Scale Green Chemical Synthesis of Adjacent Quaternary Chiral Centers by Continuous Flow Photodecarbonylation of Aqueous Suspensions of Nanocrystalline Ketones

(2015) María Guadalupe Hernández-Linares et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Palladium-Catalyzed Asymmetric Decarboxylative Cycloaddition of Vinylethylene Carbonates with Michael Acceptors: Construction of Vicinal Quaternary Stereocenters

(2014) Ajmal Khan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Catalytic Enantioselective Nazarov Cyclization: Construction of Vicinal All-Carbon-Atom Quaternary Stereocenters

(2014) Anais Jolit et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Chiral Thioxanthone as an Organocatalyst for Enantioselective [2+2] Photocycloaddition Reactions Induced by Visible Light

(2014) Rafael Alonso et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

All-Carbon Quaternary Stereogenic Centers in Acyclic Systems through the Creation of Several C–C Bonds per Chemical Step

(2014) Ilan Marek et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Total Synthesis of Taiwaniadducts B, C, and D

(2014) Jun Deng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Total Synthesis of (−)-Crinipellin A

(2014) Taek Kang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Construction of Enantioenriched [3.1.0] Bicycles via a Ruthenium-Catalyzed Asymmetric Redox Bicycloisomerization Reaction

(2014) Barry M. Trost et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Catalytic enantioselective synthesis of quaternary carbon stereocentres

(2014) Kyle W. Quasdorf et al.   NATURE

Rapid Access to the Heterocyclic Core of the Calyciphylline A and Daphnicyclidin A-Type Daphniphyllum Alkaloids via Tandem Cyclization of a Neutral Aminyl Radical

(2014) Ahmad A. Ibrahim et al.   ORGANIC LETTERS

Asymmetric total synthesis of (−)-lingzhiol via a Rh-catalysed [3+2] cycloaddition

(2014) Rong Long et al.   Nature Communications

Palladium-Catalyzed Asymmetric Construction of Vicinal All-Carbon Quaternary Stereocenters and its Application to the Synthesis of Cyclotryptamine Alkaloids

(2013) Barry M. Trost et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Divergent Total Synthesis of Indoxamycins A, C, and F

(2013) Chi He et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Total Syntheses of (−)-Acutumine and (−)-Dechloroacutumine

(2013) Sandra M. King et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Total Synthesis of (+)-Asperolide C by Iridium-Catalyzed Enantioselective Polyene Cyclization

(2013) Oliver F. Jeker et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Dearomatizing Conjugate Addition to Quinolinyl Amidines for the Synthesis of Dehaloperophoramidine through Tandem Arylation and Allylation

(2013) Takayuki Ishida et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Highly Enantioselective Bromocyclization of Tryptamines and Its Application in the Synthesis of (−)-Chimonanthine

(2013) Weiqing Xie et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Bio-Inspired Dimerization Reaction of Tryptophan Derivatives in Aqueous Acidic Media: Three-Step Syntheses of (+)-WIN 64821, (−)-Ditryptophenaline, and (+)-Naseseazine B

(2013) Shinji Tadano et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Diastereospecific Nazarov Cyclization of Fully Substituted Dienones: Generation of Vicinal All-Carbon-Atom Quaternary Stereocenters

(2013) Anais Jolit et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Asymmetric Substitution at the Tetrasubstituted Chiral Carbon: Catalytic Ring-Opening Alkylation of Racemic 2,2-Disubstituted Aziridines with 3-Substituted Oxindoles

(2013) Kohsuke Ohmatsu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Highly Stereoselective Olefin Cyclopropanation of Diazooxindoles Catalyzed by a C2-Symmetric Spiroketal Bisphosphine/Au(I) Complex

(2013) Zhong-Yan Cao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Construction of Vicinal All-Carbon Quaternary Stereocenters by Catalytic Asymmetric Alkylation Reaction of 3-Bromooxindoles with 3-Substituted Indoles: Total Synthesis of (+)-Perophoramidine

(2013) Hailong Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Ligand-enabled multiple absolute stereocontrol in metal-catalysed cycloaddition for construction of contiguous all-carbon quaternary stereocentres

(2013) Kohsuke Ohmatsu et al.   Nature Chemistry

Lingzhiols, Unprecedented Rotary Door-Shaped Meroterpenoids as Potent and Selective Inhibitors of p-Smad3 from Ganoderma lucidum

(2013) Yong-Ming Yan et al.   ORGANIC LETTERS

Extensive Rigid Analogue Design Maps the Binding Conformation of Potent N-Benzylphenethylamine 5-HT2A Serotonin Receptor Agonist Ligands

(2012) Jose I. Juncosa et al.   ACS Chemical Neuroscience

A Synthesis of Echinopine B

(2012) Theo D. Michels et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Total Synthesis of (±)-Merrilactone A

(2012) Jianwei Chen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Catalytic Asymmetric Claisen Rearrangement of Enolphosphonates: Construction of Vicinal Tertiary and All-Carbon Quaternary Centers

(2012) Jiajing Tan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Recent advances in the total synthesis of cyclopropane-containing natural products

(2012) David Y.-K. Chen et al.   CHEMICAL SOCIETY REVIEWS

Highly Enantio- and Diastereoselective Generation of Two Quaternary Centers in Spirocyclopropanation of Oxindole Derivatives.

(2012) Artur Noole et al.   CHEMISTRY-A EUROPEAN JOURNAL

Experimental and Theoretical Studies on the Nazarov Cyclization/Wagner–Meerwein Rearrangement Sequence

(2012) David Lebœuf et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Iridium-Catalyzed Enantioselective Polyene Cyclization

(2012) Michael A. Schafroth et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Formal Synthesis of Merrilactone A Using a Domino Cyanide 1,4-Addition–Aldol Cyclization

(2012) Naim Nazef et al.   ORGANIC LETTERS

Manganese(III) Acetate Mediated Oxidative Radical Cyclizations. Toward Vicinal All-Carbon Quaternary Stereocenters

(2012) Angus W.J. Logan et al.   ORGANIC LETTERS

Construction of Asymmetric Quaternary Carbon Centers with High Enantioselectivity

(2011) Masaki Shimizu   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Using Nazarov Electrocyclization to Stage Chemoselective [1,2]-Migrations: Stereoselective Synthesis of Functionalized Cyclopentenones

(2011) David Lebœuf et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Formal Asymmetric Synthesis of Echinopine A and B

(2011) Philippe A. Peixoto et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Photochemical Reactions as Key Steps in Natural Product Synthesis

(2011) Thorsten Bach et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enantioselective synthesis of all-carbon quaternary stereogenic centers in acyclic systems

(2011) Jaya Prakash Das et al.   CHEMICAL COMMUNICATIONS

Synthetic Studies toward Communesins

(2011) Zhiwei Zuo et al.   ISRAEL JOURNAL OF CHEMISTRY

Oxazaborolidinium Ion-Catalyzed Cyclopropanation of α-Substituted Acroleins: Enantioselective Synthesis of Cyclopropanes Bearing Two Chiral Quaternary Centers

(2011) Lizhu Gao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Propargyl Alcohols as β-Oxocarbenoid Precursors for the Ruthenium-Catalyzed Cyclopropanation of Unactivated Olefins by Redox Isomerization

(2011) Barry M. Trost et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Transition-State Charge Stabilization through Multiple Non-covalent Interactions in the Guanidinium-Catalyzed Enantioselective Claisen Rearrangement

(2011) Christopher Uyeda et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Exercising Regiocontrol in Palladium-Catalyzed Asymmetric Prenylations and Geranylation: Unifying Strategy toward Flustramines A and B

(2011) Barry M. Trost et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Expedient Route to the Functionalized Calyciphylline A-Type Skeleton via a Michael Addition–RCM Strategy

(2011) Filippo Sladojevich et al.   ORGANIC LETTERS

Total Synthesis of Echinopines A and B: Exploiting a Bioinspired Late-Stage Intramolecular Cyclopropanation

(2011) Philippe A. Peixoto et al.   ORGANIC LETTERS

Buchner and Beyond: Arene Cyclopropanation as Applied to Natural Product Total Synthesis

(2011) Sarah Reisman et al.   SYNLETT

Highly diastereoselective Claisen rearrangement leading to vicinal quaternary carbons construction of oxindoles

(2011) Yumiko Matsuta et al.   TETRAHEDRON LETTERS

Catalytic Enantioselective Claisen Rearrangements of O-Allyl β-Ketoesters

(2010) Christopher Uyeda et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis of (±)-Merrilactone A and (±)-Anislactone A

(2010) Lei Shi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Catalytic Asymmetric Total Synthesis ofent-Hyperforin

(2010) Yohei Shimizu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Metal-catalyzed asymmetric conjugate addition reaction: formation of quaternary stereocenters

(2010) Christine Hawner et al.   CHEMICAL COMMUNICATIONS

General Approach to Epipolythiodiketopiperazine Alkaloids: Total Synthesis of (+)-Chaetocins A and C and (+)-12,12′-Dideoxychetracin A

(2010) Justin Kim et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Total Synthesis of Echinopines A and B

(2010) K. C. Nicolaou et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Copper(I)-Catalyzed Addition of Grignard Reagents to in Situ-DerivedN-Sulfonyl Azoalkenes: An Umpolung Alkylation Procedure Applicable to the Formation of Up to Three Contiguous Quaternary Centers

(2010) John M. Hatcher et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Total Synthesis of (+)-Chaetocin and its Analogues: Their Histone Methyltransferase G9a Inhibitory Activity

(2010) Eriko Iwasa et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Total Synthesis of (+)-Perophoramidine and Determination of the Absolute Configuration

(2010) Haoxing Wu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enantioselective Total Synthesis of (+)-Salvileucalin B

(2010) Sergiy Levin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Defying Ring Strain: New Approaches to Cyclopropanes

(2009) Sébastien R. Goudreau et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Biogenetically inspired syntheses of alkaloid natural products

(2009) Justin Kim et al.   CHEMICAL SOCIETY REVIEWS

[3,3]-Sigmatropic rearrangements: recent applications in the total synthesis of natural products

(2009) Elizabeth A. Ilardi et al.   CHEMICAL SOCIETY REVIEWS

Stereocontrolled and Versatile Total Synthesis of Bispyrrolidinoindoline Diketopiperazine Alkaloids: Structural Revision of the Fungal Isolate (+)-Asperdimin

(2009) Carlos Pérez-Balado et al.   CHEMISTRY-A EUROPEAN JOURNAL

The Daphniphyllum Alkaloids

(2009) Mei Dong et al.   CURRENT ORGANIC CHEMISTRY

PtCl2-Catalyzed Cycloisomerization of 1,6-Enynes for the Synthesis of Substituted Bicyclo[3.1.0]hexanes

(2009) Liu Ye et al.   JOURNAL OF ORGANIC CHEMISTRY

Indoxamycins A−F. Cytotoxic Tricycklic Polypropionates from a Marine-Derived Actinomycete

(2009) Seizo Sato et al.   JOURNAL OF ORGANIC CHEMISTRY

Chiral Crown Conformation of Rh2(S-PTTL)4: Enantioselective Cyclopropanation with α-Alkyl-α-diazoesters

(2009) Andrew DeAngelis et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Total Synthesis of (−)-Penifulvin A, an Insecticide with a Dioxafenestrane Skeleton

(2009) Tanja Gaich et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The Daphniphyllum alkaloids

(2009) Jun'ichi Kobayashi et al.   NATURAL PRODUCT REPORTS

Total Syntheses of (+)-Echinopine A and B: Determination of Absolute Stereochemistry

(2009) Thomas Magauer et al.   ORGANIC LETTERS

From Silphinenes to Penifulvins: A Biomimetic Approach to Penifulvins B and C

(2009) Tanja Gaich et al.   ORGANIC LETTERS

Total Synthesis of (+)-11,11'-Dideoxyverticillin A

(2009) J. Kim et al.   SCIENCE

Extending Pummerer reaction chemistry. Examination of the prospects for forming vicinal quaternary carbon centers

(2009) Ken S. Feldman et al.   TETRAHEDRON LETTERS

Concise Total Synthesis of (+)-WIN 64821 and (−)-Ditryptophenaline

(2008) Mohammad Movassaghi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cycloisomerization of 1,n-Enynes: Challenging Metal-Catalyzed Rearrangements and Mechanistic Insights

(2008) Véronique Michelet et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Atom transfer radical addition and polymerization reactions catalyzed by ppm amounts of copper complexes

(2008) Tomislav Pintauer et al.   CHEMICAL SOCIETY REVIEWS

Enantioselective Claisen Rearrangements with a Hydrogen-Bond Donor Catalyst

(2008) Christopher Uyeda et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Echinopines A and B:  Sesquiterpenoids Possessing an Unprecedented Skeleton fromEchinops spinosus

(2008) Mei Dong et al.   ORGANIC LETTERS

Expedient Total Syntheses of WIN 64745 and WIN 64821

(2008) Carlos Pérez-Balado et al.   ORGANIC LETTERS

Salvileucalin B, A Novel Diterpenoid with an Unprecedented Rearranged Neoclerodane Skeleton from Salvia leucantha Cav.

(2008) Yutaka Aoyagi et al.   ORGANIC LETTERS

Recent developments in asymmetric cyclopropanation

(2008) Hélène Pellissier   TETRAHEDRON

Recent studies on the reactions of α-diazocarbonyl compounds

(2008) Zhenhua Zhang et al.   TETRAHEDRON

Total Synthesis of (±)-Merrilactone A

(2007) Wei He et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY