Inhibition of PDE2 and PDE4 synergistically improves memory consolidation processes
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Title
Inhibition of PDE2 and PDE4 synergistically improves memory consolidation processes
Authors
Keywords
Phosphodiesterases, Synergy, Neuronal plasticity, Memory consolidation
Journal
NEUROPHARMACOLOGY
Volume 184, Issue -, Pages 108414
Publisher
Elsevier BV
Online
2020-11-27
DOI
10.1016/j.neuropharm.2020.108414
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Note: Only part of the references are listed.- Roflumilast ameliorates cognitive impairment in APP/PS1 mice via cAMP/CREB/BDNF signaling and anti-neuroinflammatory effects
- (2019) Huancun Feng et al. METABOLIC BRAIN DISEASE
- Regulation of Neuronal Survival and Axon Growth by a Perinuclear cAMP Compartment
- (2019) Tomasz Boczek et al. JOURNAL OF NEUROSCIENCE
- Target Engagement of a Phosphodiesterase 2 (PDE2) Inhibitor Affecting Long-Term Memory in the Rat
- (2019) Guibao Gu et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- Pro-cognitive effect of upregulating cyclic guanosine monophosphate signalling during memory acquisition or early consolidation is mediated by increased AMPA receptor trafficking
- (2019) Elentina K Argyrousi et al. JOURNAL OF PSYCHOPHARMACOLOGY
- Design and Synthesis of Novel and Selective Glycine Transporter-1 (GlyT1) Inhibitors with Memory Enhancing Properties
- (2018) Vincent J. Santora et al. JOURNAL OF MEDICINAL CHEMISTRY
- Phosphodiesterase 2A Inhibitor TAK-915 Ameliorates Cognitive Impairments and Social Withdrawal inN-Methyl-d-Aspartate Receptor Antagonist–Induced Rat Models of Schizophrenia
- (2018) Masato Nakashima et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- A Nonhuman Primate PET Study: Measurement of Brain PDE4 Occupancy by Roflumilast Using (R)-[11C]Rolipram
- (2018) Akihiro Takano et al. MOLECULAR IMAGING AND BIOLOGY
- Acute administration of roflumilast enhances immediate recall of verbal word memory in healthy young adults
- (2018) M.A. Van Duinen et al. NEUROPHARMACOLOGY
- Sub-efficacious doses of phosphodiesterase 4 and 5 inhibitors improve memory in a mouse model of Alzheimer's disease
- (2018) Walter Gulisano et al. NEUROPHARMACOLOGY
- Memory enhancing effects of BPN14770, an allosteric inhibitor of phosphodiesterase-4D, in wild-type and humanized mice
- (2018) Chong Zhang et al. NEUROPSYCHOPHARMACOLOGY
- Application of Structure-Based Design and Parallel Chemistry to Identify a Potent, Selective, and Brain Penetrant Phosphodiesterase 2A Inhibitor
- (2017) Christopher J. Helal et al. JOURNAL OF MEDICINAL CHEMISTRY
- Design and Synthesis of Novel and Selective Phosphodiesterase 2 (PDE2a) Inhibitors for the Treatment of Memory Disorders
- (2017) Laurent Gomez et al. JOURNAL OF MEDICINAL CHEMISTRY
- Discovery of Clinical Candidate N-((1S)-1-(3-Fluoro-4-(trifluoromethoxy)phenyl)-2-methoxyethyl)-7-methoxy-2-oxo-2,3-dihydropyrido[2,3-b]pyrazine-4(1H)-carboxamide (TAK-915): A Highly Potent, Selective, and Brain-Penetrating Phosphodiesterase 2A Inhibitor for the Treatment of Cognitive Disorders
- (2017) Satoshi Mikami et al. JOURNAL OF MEDICINAL CHEMISTRY
- FFPM, a PDE4 inhibitor, reverses learning and memory deficits in APP/PS1 transgenic mice via cAMP/PKA/CREB signaling and anti-inflammatory effects
- (2017) Haibiao Guo et al. NEUROPHARMACOLOGY
- PDE4 Inhibition Restores the Balance Between Excitation and Inhibition in VTA Dopamine Neurons Disrupted by Repeated In Vivo Cocaine Exposure
- (2017) Xiaojie Liu et al. NEUROPSYCHOPHARMACOLOGY
- Comparison of the Pharmacological Profiles of Selective PDE4B and PDE4D Inhibitors in the Central Nervous System
- (2017) Chong Zhang et al. Scientific Reports
- The PDE4 inhibitor roflumilast improves memory in rodents at non-emetic doses
- (2016) Tim Vanmierlo et al. BEHAVIOURAL BRAIN RESEARCH
- The phosphodiesterase type 2 inhibitor BAY 60-7550 reverses functional impairments induced by brain ischemia by decreasing hippocampal neurodegeneration and enhancing hippocampal neuronal plasticity
- (2016) Ligia Mendes Soares et al. EUROPEAN JOURNAL OF NEUROSCIENCE
- Cross-regulation of Phosphodiesterase 1 and Phosphodiesterase 2 Activities Controls Dopamine-mediated Striatal α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor Trafficking
- (2016) Roy S. Song et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Calcium-Permeable AMPA Receptors Mediate the Induction of the Protein Kinase A-Dependent Component of Long-Term Potentiation in the Hippocampus
- (2016) P. Park et al. JOURNAL OF NEUROSCIENCE
- Rolipram-induced improvement of cognitive function correlates with changes in hippocampal CREB phosphorylation, BDNF and Arc protein levels
- (2016) Yuan Zhong et al. NEUROSCIENCE LETTERS
- Object memory enhancement by combining sub-efficacious doses of specific phosphodiesterase inhibitors
- (2015) E. Bollen et al. NEUROPHARMACOLOGY
- Cyclic GMP–mediated memory enhancement in the object recognition test by inhibitors of phosphodiesterase-2 in mice
- (2015) Lindsay M. Lueptow et al. PSYCHOPHARMACOLOGY
- Inhibition of PDE2A, but not PDE9A, modulates presynaptic short-term plasticity measured by paired-pulse facilitation in the CA1 region of the hippocampus
- (2015) Diego Fernández-Fernández et al. SYNAPSE
- A Multicenter, Double-Blind, Placebo-Controlled Trial of the PDE9A Inhibitor, PF-04447943, in Alzheimer’s Disease
- (2014) Elias Schwam et al. Current Alzheimer Research
- Phosphodiesterase Inhibitors as a Target for Cognition Enhancement in Aging and Alzheimer’s Disease: A Translational Overview
- (2014) P.R.A. Heckman et al. CURRENT PHARMACEUTICAL DESIGN
- Icariin, a phoshphodiesterase-5 inhibitor, improves learning and memory in APP/PS1 transgenic mice by stimulation of NO/cGMP signalling
- (2014) Feng Jin et al. INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
- Phosphodiesterase-5 inhibitor sildenafil prevents neuroinflammation, lowers beta-amyloid levels and improves cognitive performance in APP/PS1 transgenic mice
- (2013) Junfang Zhang et al. BEHAVIOURAL BRAIN RESEARCH
- PDE2 inhibition: Potential for the treatment of cognitive disorders
- (2013) Laurent Gomez et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- PDE10 inhibition increases GluA1 and CREB phosphorylation and improves spatial and recognition memories in a Huntington's disease mouse model
- (2013) Albert Giralt et al. HIPPOCAMPUS
- Improvement of spatial memory function in APPswe/PS1dE9 mice after chronic inhibition of phosphodiesterase type 4D
- (2013) A.S.R. Sierksma et al. NEUROPHARMACOLOGY
- The NO/cGMP pathway inhibits transient cAMP signals through the activation of PDE2 in striatal neurons
- (2013) Marina Polito et al. Frontiers in Cellular Neuroscience
- A Functional Role for CREB as a Positive Regulator of Memory Formation and LTP
- (2013) Satoshi Kida Experimental Neurobiology
- Object recognition testing: Methodological considerations on exploration and discrimination measures
- (2012) Sven Akkerman et al. BEHAVIOURAL BRAIN RESEARCH
- Object recognition testing: Statistical considerations
- (2012) Sven Akkerman et al. BEHAVIOURAL BRAIN RESEARCH
- Inhibition of phoshodiesterase type 2 or type 10 reverses object memory deficits induced by scopolamine or MK-801
- (2012) Olga A.H. Reneerkens et al. BEHAVIOURAL BRAIN RESEARCH
- Phosphodiesterase-2 inhibitor reverses corticosterone-induced neurotoxicity and related behavioural changes via cGMP/PKG dependent pathway
- (2012) Ying Xu et al. INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
- Design and Discovery of 6-[(3S,4S)-4-Methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one (PF-04447943), a Selective Brain Penetrant PDE9A Inhibitor for the Treatment of Cognitive Disorders
- (2012) Patrick R. Verhoest et al. JOURNAL OF MEDICINAL CHEMISTRY
- Phosphodiesterase type 5 (PDE5) inhibition improves object recognition memory: Indications for central and peripheral mechanisms
- (2012) Olga A.H. Reneerkens et al. NEUROBIOLOGY OF LEARNING AND MEMORY
- Chronic phosphodiesterase type 2 inhibition improves memory in the APPswe/PS1dE9 mouse model of Alzheimer's disease
- (2012) Annerieke S.R. Sierksma et al. NEUROPHARMACOLOGY
- The distribution of phosphodiesterase 2A in the rat brain
- (2012) D.T. Stephenson et al. NEUROSCIENCE
- The molecular biology of memory: cAMP, PKA, CRE, CREB-1, CREB-2, and CPEB
- (2012) Eric R Kandel Molecular Brain
- Phosphodiesterase-4D Knock-Out and RNA Interference-Mediated Knock-Down Enhance Memory and Increase Hippocampal Neurogenesis via Increased cAMP Signaling
- (2011) Y.-F. Li et al. JOURNAL OF NEUROSCIENCE
- Upregulation of CREB-Mediated Transcription Enhances Both Short- and Long-Term Memory
- (2011) A. Suzuki et al. JOURNAL OF NEUROSCIENCE
- The selective phosphodiesterase 9 (PDE9) inhibitor PF-04447943 (6-[(3S,4S)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one) enhances synaptic plasticity and cognitive function in rodents
- (2011) P.H. Hutson et al. NEUROPHARMACOLOGY
- Role of phosphodiesterase 5 in synaptic plasticity and memory
- (2011) Daniela Puzzo Neuropsychiatric Disease and Treatment
- The human area postrema and other nuclei related to the emetic reflex express cAMP phosphodiesterases 4B and 4D
- (2010) F. Mori et al. JOURNAL OF CHEMICAL NEUROANATOMY
- Sildenafil protects against 3-nitropropionic acid neurotoxicity through the modulation of calpain, CREB, and BDNF
- (2010) Elena Puerta et al. NEUROBIOLOGY OF DISEASE
- Quantitative comparison of phosphodiesterase mRNA distribution in human brain and peripheral tissues
- (2010) Viktor Lakics et al. NEUROPHARMACOLOGY
- The preclinical pharmacology of roflumilast – A selective, oral phosphodiesterase 4 inhibitor in development for chronic obstructive pulmonary disease
- (2010) Armin Hatzelmann et al. PULMONARY PHARMACOLOGY & THERAPEUTICS
- Compartmentalized signalling: spatial regulation of cAMP by the action of compartmentalized phosphodiesterases
- (2009) George S. Baillie FEBS Journal
- Dual Acylation of PDE2A Splice Variant 3
- (2009) Corina Russwurm et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Immunohistochemical Localization of Phosphodiesterase 2A in Multiple Mammalian Species
- (2009) Diane T. Stephenson et al. JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY
- Phosphodiesterase 5 Inhibition Improves Synaptic Function, Memory, and Amyloid- Load in an Alzheimer's Disease Mouse Model
- (2009) D. Puzzo et al. JOURNAL OF NEUROSCIENCE
- The effect of selective inhibition of cyclic GMP hydrolyzing phosphodiesterases 2 and 5 on learning and memory processes and nitric oxide synthase activity in brain during aging
- (2008) K. Domek-Łopacińska et al. BRAIN RESEARCH
- The novel selective PDE9 inhibitor BAY 73-6691 improves learning and memory in rodents
- (2008) F. Josef van der Staay et al. NEUROPHARMACOLOGY
- Spine-Type-Specific Recruitment of Newly Synthesized AMPA Receptors with Learning
- (2008) N. Matsuo et al. SCIENCE
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