The phosphodiesterase type 2 inhibitor BAY 60-7550 reverses functional impairments induced by brain ischemia by decreasing hippocampal neurodegeneration and enhancing hippocampal neuronal plasticity

The PDE4 inhibitor roflumilast improves memory in rodents at non-emetic doses

(2016) Tim Vanmierlo et al.   BEHAVIOURAL BRAIN RESEARCH

Targeting New Pharmacological Approaches for Alzheimer's Disease: Potential for Statins and Phosphodiesterase Inhibitors

(2016) Fabrizio Sallustio et al.   CNS & Neurological Disorders-Drug Targets

Towards selective phosphodiesterase 2A (PDE2A) inhibitors: a patent review (2010 - present)

(2016) Andrés A. Trabanco et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Phosphodiesterase Inhibition and Regulation of Dopaminergic Frontal and Striatal Functioning: Clinical Implications

(2016) Pim R. A. Heckman et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Sildenafil, a cyclic GMP phosphodiesterase inhibitor, induces microglial modulation after focal ischemia in the neonatal mouse brain

(2016) Raffaella Moretti et al.   Journal of Neuroinflammation

Protective effects of cilostazol against hemorrhagic stroke: Current and future perspectives

(2016) Toshinori Takagi et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Inhibition of phosphodiesterase-4 reverses the cognitive dysfunction and oxidative stress induced by Aβ25–35 in rats

(2016) Yeye Zhuo et al.   METABOLIC BRAIN DISEASE

Rolipram improves cognition, reduces anxiety- and despair-like behaviors and impacts hippocampal neuroplasticity after transient global cerebral ischemia

(2016) Lígia Mendes Soares et al.   NEUROSCIENCE

An emerging role of cGMP in the treatment of schizophrenia: A review

(2016) Seong Shim et al.   SCHIZOPHRENIA RESEARCH

Discovery of novel PDE9 inhibitors capable of inhibiting Aβ aggregation as potential candidates for the treatment of Alzheimer’s disease

(2016) Tao Su et al.   Scientific Reports

Phosphodiesterase Inhibition as a Therapeutic Target for Brain Ischemia

(2015) Ligia Soares et al.   CNS & Neurological Disorders-Drug Targets

Combined Ampakine and BDNF Treatments Enhance Poststroke Functional Recovery in Aged Mice via AKT-CREB Signaling

(2015) Andrew N Clarkson et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Inhibition of phosphodiesterase 2 reverses impaired cognition and neuronal remodeling caused by chronic stress

(2015) Ying Xu et al.   NEUROBIOLOGY OF AGING

Anti-depressant effects of phosphodiesterase 3 inhibitor cilostazol in chronic mild stress-treated mice after ischemic stroke

(2015) Yu Ri Kim et al.   PSYCHOPHARMACOLOGY

Protective effects of phosphodiesterase 2 inhibitor on depression- and anxiety-like behaviors: Involvement of antioxidant and anti-apoptotic mechanisms

(2014) Lianshu Ding et al.   BEHAVIOURAL BRAIN RESEARCH

Phosphodiesterase: An Interface Connecting Cognitive Deficits to Neuropsychiatric and Neurodegenerative Diseases

(2014) Zhen-Zhen Wang et al.   CURRENT PHARMACEUTICAL DESIGN

The Roles of Phosphodiesterase 2 in the Central Nervous and Peripheral Systems

(2014) Chong Zhang et al.   CURRENT PHARMACEUTICAL DESIGN

Advances in targeting cyclic nucleotide phosphodiesterases

(2014) Donald H. Maurice et al.   NATURE REVIEWS DRUG DISCOVERY

Neurological consequences of cardiac arrest: Where do we stand?

(2013) G. Geri et al.   ANNALES FRANCAISES D ANESTHESIE ET DE REANIMATION

PDE2 inhibition: Potential for the treatment of cognitive disorders

(2013) Laurent Gomez et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Object recognition testing: Methodological considerations on exploration and discrimination measures

(2012) Sven Akkerman et al.   BEHAVIOURAL BRAIN RESEARCH

Inhibition of phoshodiesterase type 2 or type 10 reverses object memory deficits induced by scopolamine or MK-801

(2012) Olga A.H. Reneerkens et al.   BEHAVIOURAL BRAIN RESEARCH

Chronic treatment with the phosphodiesterase type 5 inhibitors sildenafil and tadalafil display anxiolytic effects in Flinders Sensitive Line rats

(2012) Nico Liebenberg et al.   METABOLIC BRAIN DISEASE

Chronic phosphodiesterase type 2 inhibition improves memory in the APPswe/PS1dE9 mouse model of Alzheimer's disease

(2012) Annerieke S.R. Sierksma et al.   NEUROPHARMACOLOGY

Consistent Injury to Medium Spiny Neurons and White Matter in the Mouse Striatum after Prolonged Transient Global Cerebral Ischemia

(2011) Hideyuki Yoshioka et al.   JOURNAL OF NEUROTRAUMA

Selective phosphodiesterase inhibitors improve performance on the ED/ID cognitive task in rats

(2011) Joshua S. Rodefer et al.   NEUROPHARMACOLOGY

Cilostazol enhances neovascularization in the mouse hippocampus after transient forebrain ischemia

(2010) Hwa Kyoung Shin et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Determinants of quality of life in survivors of cardiac arrest

(2010) VRMP Moulaert et al.   JOURNAL OF REHABILITATION MEDICINE

Cilostazol attenuates ischemic brain injury and enhances neurogenesis in the subventricular zone of adult mice after transient focal cerebral ischemia

(2010) Y. Tanaka et al.   NEUROSCIENCE

Anxiolytic Effects of Phosphodiesterase-2 Inhibitors Associated with Increased cGMP Signaling

(2009) A. Masood et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Antidepressant- and Anxiolytic-like Effects of the Phosphodiesterase-4 Inhibitor Rolipram on Behavior Depend on Cyclic AMP Response Element Binding Protein-Mediated Neurogenesis in the Hippocampus

(2009) Yun-Feng Li et al.   NEUROPSYCHOPHARMACOLOGY

Phosphodiesterase Inhibitors Enhance Object Memory Independent of Cerebral Blood Flow and Glucose Utilization in Rats

(2009) Kris Rutten et al.   NEUROPSYCHOPHARMACOLOGY

Brain-Derived Neurotrophic Factor Contributes to Recovery of Skilled Reaching After Focal Ischemia in Rats

(2009) Michelle Ploughman et al.   STROKE

The effect of selective inhibition of cyclic GMP hydrolyzing phosphodiesterases 2 and 5 on learning and memory processes and nitric oxide synthase activity in brain during aging

(2008) K. Domek-Łopacińska et al.   BRAIN RESEARCH

Reversal of Oxidative Stress-Induced Anxiety by Inhibition of Phosphodiesterase-2 in Mice

(2008) A. Masood et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Selective phosphodiesterase inhibitors: a promising target for cognition enhancement

(2008) Olga A. H. Reneerkens et al.   PSYCHOPHARMACOLOGY

Nitric oxide-mediated anxiolytic-like and antidepressant-like effects in animal models of anxiety and depression

(2007) A SPIACCIJR et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR