Roflumilast ameliorates cognitive impairment in APP/PS1 mice via cAMP/CREB/BDNF signaling and anti-neuroinflammatory effects

Acute administration of roflumilast enhances immediate recall of verbal word memory in healthy young adults

(2018) M.A. Van Duinen et al.   NEUROPHARMACOLOGY

Cyclic AMP Pathway Suppress Autoimmune Neuroinflammation by Inhibiting Functions of Encephalitogenic CD4 T Cells and Enhancing M2 Macrophage Polarization at the Site of Inflammation

(2018) Tatyana Veremeyko et al.   Frontiers in Immunology

Neuroinflammatory responses in Alzheimer’s disease

(2017) Cira Dansokho et al.   JOURNAL OF NEURAL TRANSMISSION

FFPM, a PDE4 inhibitor, reverses learning and memory deficits in APP/PS1 transgenic mice via cAMP/PKA/CREB signaling and anti-inflammatory effects

(2017) Haibiao Guo et al.   NEUROPHARMACOLOGY

The PDE4 inhibitor roflumilast improves memory in rodents at non-emetic doses

(2016) Tim Vanmierlo et al.   BEHAVIOURAL BRAIN RESEARCH

Effects of rolipram and roflumilast, phosphodiesterase-4 inhibitors, on hypertension-induced defects in memory function in rats

(2015) Sobhana George Sugin Lal Jabaris et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Neuroinflammatory Signals in Alzheimer Disease and APP/PS1 Transgenic Mice

(2015) Irene López-González et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Amyloid cascade hypothesis: Pathogenesis and therapeutic strategies in Alzheimer's disease

(2015) Sagar H. Barage et al.   NEUROPEPTIDES

Donepezil improves learning and memory deficits in APP/PS1 mice by inhibition of microglial activation

(2015) H.B. Guo et al.   NEUROSCIENCE

Apremilast: First Global Approval

(2014) Raewyn M. Poole et al.   DRUGS

A Positive Autoregulatory BDNF Feedback Loop via C/EBP  Mediates Hippocampal Memory Consolidation

(2014) D. Bambah-Mukku et al.   JOURNAL OF NEUROSCIENCE

Improvement of spatial memory function in APPswe/PS1dE9 mice after chronic inhibition of phosphodiesterase type 4D

(2013) A.S.R. Sierksma et al.   NEUROPHARMACOLOGY

Comprehensive behavioral characterization of an APP/PS-1 double knock-in mouse model of Alzheimer's disease

(2013) Scott J Webster et al.   Alzheimers Research & Therapy

Phosphodiesterases as Therapeutic Targets for Alzheimer's Disease

(2012) Ana García-Osta et al.   ACS Chemical Neuroscience

Roflumilast: A Phosphodiesterase-4 Inhibitor for the Treatment of Severe Chronic Obstructive Pulmonary Disease

(2012) Nathan A. Pinner et al.   CLINICAL THERAPEUTICS

Characterization of cognitive deficits in a transgenic mouse model of Alzheimer's disease and effects of donepezil and memantine

(2012) Akira Nagakura et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Zymosan activates protein kinase A via adenylyl cyclase VII to modulate innate immune responses during inflammation

(2012) Lily I. Jiang et al.   MOLECULAR IMMUNOLOGY

Neoechinulin A suppresses amyloid-β oligomer-induced microglia activation and thereby protects PC-12 cells from inflammation-mediated toxicity

(2012) Pradeep Dewapriya et al.   NEUROTOXICOLOGY

‘PUFA–GPR40–CREB signaling’ hypothesis for the adult primate neurogenesis

(2012) Tetsumori Yamashima   PROGRESS IN LIPID RESEARCH

The molecular biology of memory: cAMP, PKA, CRE, CREB-1, CREB-2, and CPEB

(2012) Eric R Kandel   Molecular Brain

Epigenetic Mechanisms in Alzheimer's Disease

(2011) M. Daniilidou et al.   CURRENT MEDICINAL CHEMISTRY

The phosphodiesterase-4 inhibitor rolipram reverses Aβ-induced cognitive impairment and neuroinflammatory and apoptotic responses in rats

(2011) Chuang Wang et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics

(2011) Eric Karran et al.   NATURE REVIEWS DRUG DISCOVERY

Cognitive impairment in humanized APP×PS1 mice is linked to Aβ1–42 and NOX activation

(2011) Annadora J. Bruce-Keller et al.   NEUROBIOLOGY OF DISEASE

Aβ plaque-associated glial reaction as a determinant of apoptotic neuronal death and cortical gliogenesis: A study in APP mutant mice

(2011) Ilaria Luccarini et al.   NEUROSCIENCE LETTERS

Alzheimer’s Disease Pathologic Cascades: Who Comes First, What Drives What

(2011) Russell H. Swerdlow   NEUROTOXICITY RESEARCH

The role of CREB signaling in Alzheimer’s disease and other cognitive disorders

(2011) Carlos A. Saura et al.   REVIEWS IN THE NEUROSCIENCES

Targeting CREB signalling in neurogenesis

(2010) Sebastian Dworkin et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Quantitative comparison of phosphodiesterase mRNA distribution in human brain and peripheral tissues

(2010) Viktor Lakics et al.   NEUROPHARMACOLOGY

Tripchlorolide protects neuronal cells from microglia-mediated β-amyloid neurotoxicity through inhibiting NF-κB and JNK signaling

(2009) Xiao-Dong Pan et al.   GLIA

Reversal of long-term dendritic spine alterations in Alzheimer disease models

(2009) D. L. Smith et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA