The FXR agonist obeticholic acid inhibits the cancerogenic potential of human cholangiocarcinoma
Published 2019 View Full Article
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Title
The FXR agonist obeticholic acid inhibits the cancerogenic potential of human cholangiocarcinoma
Authors
Keywords
Apoptosis, Cell proliferation, Cancer treatment, Cell cultures, Cell migration, Primary cell culture, Bile, Gene expression
Journal
PLoS One
Volume 14, Issue 1, Pages e0210077
Publisher
Public Library of Science (PLoS)
Online
2019-01-25
DOI
10.1371/journal.pone.0210077
References
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Related references
Note: Only part of the references are listed.- Differential effects of FXR or TGR5 activation in cholangiocarcinoma progression
- (2018) O. Erice et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- FXR Acts as a Metastasis Suppressor in Intrahepatic Cholangiocarcinoma by Inhibiting IL-6-Induced Epithelial-Mesenchymal Transition
- (2018) Bei Lv et al. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
- β-Catenin regulation of farnesoid X receptor signaling and bile acid metabolism during murine cholestasis
- (2018) Michael D. Thompson et al. HEPATOLOGY
- Bile acids and colon cancer: Is FXR the solution of the conundrum?
- (2017) Raffaella Maria Gadaleta et al. MOLECULAR ASPECTS OF MEDICINE
- Cryopreservation protocol for human biliary tree stem/progenitors, hepatic and pancreatic precursors
- (2017) Lorenzo Nevi et al. Scientific Reports
- Hyaluronan coating improves liver engraftment of transplanted human biliary tree stem/progenitor cells
- (2017) Lorenzo Nevi et al. Stem Cell Research & Therapy
- TGF-β signaling is an effective target to impair survival and induce apoptosis of human cholangiocarcinoma cells: A study on human primary cell cultures
- (2017) Anna Maria Lustri et al. PLoS One
- Modeling and Experimental Studies of Obeticholic Acid Exposure and the Impact of Cirrhosis Stage
- (2016) JE Edwards et al. CTS-Clinical and Translational Science
- Farnesoid X receptor activation increases reverse cholesterol transport by modulating bile acid composition and cholesterol absorption in mice
- (2016) Yang Xu et al. HEPATOLOGY
- Cholangiocarcinoma: current knowledge and future perspectives consensus statement from the European Network for the Study of Cholangiocarcinoma (ENS-CCA)
- (2016) Jesus M. Banales et al. Nature Reviews Gastroenterology & Hepatology
- FXR agonists enhance the sensitivity of biliary tract cancer cells to cisplatin via SHP dependent inhibition of Bcl-xL expression
- (2016) Wei Wang et al. Oncotarget
- Profiles of Cancer Stem Cell Subpopulations in Cholangiocarcinomas
- (2015) Vincenzo Cardinale et al. AMERICAN JOURNAL OF PATHOLOGY
- Sensitivity of Human Intrahepatic Cholangiocarcinoma Subtypes to Chemotherapeutics and Molecular Targeted Agents: A Study on Primary Cell Cultures
- (2015) Alice Fraveto et al. PLoS One
- Prevention of spontaneous hepatocarcinogenesis in farnesoid X receptor-null mice by intestinal-specific farnesoid X receptor reactivation
- (2014) Chiara Degirolamo et al. HEPATOLOGY
- Pathogenesis and classification of intrahepatic cholangiocarcinoma: different characters of perihilar large duct type versus peripheral small duct type
- (2014) Shinichi Aishima et al. Journal of Hepato-Biliary-Pancreatic Sciences
- Evidence for multipotent endodermal stem/progenitor cell populations in human gallbladder
- (2014) Guido Carpino et al. JOURNAL OF HEPATOLOGY
- Morphological subclassification of intrahepatic cholangiocarcinoma: etiological, clinicopathological and molecular features
- (2014) Jau-Yu Liau et al. MODERN PATHOLOGY
- Pathogenesis, Diagnosis, and Management of Cholangiocarcinoma
- (2013) Sumera Rizvi et al. GASTROENTEROLOGY
- Bile acid receptors as targets for drug development
- (2013) Frank G. Schaap et al. Nature Reviews Gastroenterology & Hepatology
- Downregulation of nuclear receptor FXR is associated with multiple malignant clinicopathological characteristics in human hepatocellular carcinoma
- (2012) Hongying Su et al. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
- Guidelines for the diagnosis and treatment of cholangiocarcinoma: an update
- (2012) Shahid A Khan et al. GUT
- Histological diversity in cholangiocellular carcinoma reflects the different cholangiocyte phenotypes
- (2012) Mina Komuta et al. HEPATOLOGY
- No Correlation between the Expression of FXR and Genes Involved in Multidrug Resistance Phenotype of Primary Liver Tumors
- (2012) P. Martinez-Becerra et al. MOLECULAR PHARMACEUTICS
- FXR Controls the Tumor Suppressor NDRG2 and FXR Agonists Reduce Liver Tumor Growth and Metastasis in an Orthotopic Mouse Xenograft Model
- (2012) Ulrich Deuschle et al. PLoS One
- Multiple cells of origin in cholangiocarcinoma underlie biological, epidemiological and clinical heterogeneity
- (2012) Vincenzo Cardinale World Journal of Gastrointestinal Oncology
- Carcinogenicity of deoxycholate, a secondary bile acid
- (2011) Carol Bernstein et al. ARCHIVES OF TOXICOLOGY
- Proteomics for the discovery of nuclear bile acid receptor FXR targets
- (2011) Cissi Gardmo et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- MicroRNA-421 functions as an oncogenic miRNA in biliary tract cancer through down-regulating farnesoid X receptor expression
- (2011) Xiang-yu Zhong et al. GENE
- Expression of the nuclear bile acid receptor/farnesoid X receptor is reduced in human colon carcinoma compared to nonneoplastic mucosa independent from site and may be associated with adverse prognosis
- (2011) Sigurd Lax et al. INTERNATIONAL JOURNAL OF CANCER
- Impact of bile acids on the growth of human cholangiocarcinoma via FXR
- (2011) Jiaqi Dai et al. Journal of Hematology & Oncology
- Clinical diagnosis and staging of cholangiocarcinoma
- (2011) Boris Blechacz et al. Nature Reviews Gastroenterology & Hepatology
- Farnesoid X receptor inhibits tamoxifen-resistant MCF-7 breast cancer cell growth through downregulation of HER2 expression
- (2011) C Giordano et al. ONCOGENE
- Cisplatin plus Gemcitabine versus Gemcitabine for Biliary Tract Cancer
- (2010) Juan Valle et al. NEW ENGLAND JOURNAL OF MEDICINE
- Role of Bile Acids and Bile Acid Receptors in Metabolic Regulation
- (2009) Philippe Lefebvre et al. PHYSIOLOGICAL REVIEWS
- Farnesoid X receptor antagonizes nuclear factor κB in hepatic inflammatory response
- (2008) Yan-Dong Wang et al. HEPATOLOGY
- Farnesoid X Receptor Deficiency in Mice Leads to Increased Intestinal Epithelial Cell Proliferation and Tumor Development
- (2008) R. R.M. Maran et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
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