Potential intestinal infection and faecal–oral transmission of SARS-CoV-2

A Case Series of children with 2019 novel coronavirus infection: clinical and epidemiological features

(2020) Jiehao Cai et al.   CLINICAL INFECTIOUS DISEASES

Evidence for gastrointestinal infection of SARS-CoV-2

(2020) Fei Xiao et al.   GASTROENTEROLOGY

Diarrhoea may be underestimated: a missing link in 2019 novel coronavirus

(2020) Weicheng Liang et al.   GUT

SARS-CoV-2 induced diarrhoea as onset symptom in patient with COVID-19

(2020) Y Song et al.   GUT

Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China

(2020) Zunyou Wu et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Epidemiologic Features and Clinical Course of Patients Infected With SARS-CoV-2 in Singapore

(2020) Barnaby Edward Young et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus–Infected Pneumonia in Wuhan, China

(2020) Dawei Wang et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study

(2020) Nanshan Chen et al.   LANCET

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

(2020) Chaolin Huang et al.   LANCET

A pneumonia outbreak associated with a new coronavirus of probable bat origin

(2020) Peng Zhou et al.   NATURE

Clinical Characteristics of Coronavirus Disease 2019 in China

(2020) Wei-jie Guan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Pathological findings of COVID-19 associated with acute respiratory distress syndrome

(2020) Zhe Xu et al.   Lancet Respiratory Medicine

SARS-CoV-2 infection in ambulatory and hospitalised Spanish children

(2020) María de Ceano-Vivas et al.   ARCHIVES OF DISEASE IN CHILDHOOD

Single cell RNA sequencing of 13 human tissues identify cell types and receptors of human coronaviruses

(2020) Furong Qi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19

(2020) Daniel Blanco-Melo et al.   CELL

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

(2020) Markus Hoffmann et al.   CELL

Infection and Rapid Transmission of SARS-CoV-2 in Ferrets

(2020) Young-Il Kim et al.   Cell Host & Microbe

A Mouse Model of SARS-CoV-2 Infection and Pathogenesis

(2020) Shi-Hui Sun et al.   Cell Host & Microbe

Serum IgA, IgM, and IgG responses in COVID-19

(2020) Huan Ma et al.   Cellular & Molecular Immunology

Persistence and clearance of viral RNA in 2019 novel coronavirus disease rehabilitation patients

(2020) Yun Ling et al.   CHINESE MEDICAL JOURNAL

Covid-19 digestive system involvement and clinical outcomes in a large academic hospital in Milan, Italy.

(2020) Alessio Aghemo et al.   Clinical Gastroenterology and Hepatology

Epidemiological and Clinical Predictors of COVID-19

(2020) Yinxiaohe Sun et al.   CLINICAL INFECTIOUS DISEASES

Development of SARS-CoV-2 vaccines: should we focus on mucosal immunity?

(2020) Leticia Moreno-Fierros et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Gastrointestinal and Hepatic Manifestations of 2019 Novel Coronavirus Disease in a Large Cohort of Infected Patients From New York: Clinical Implications.

(2020) Kaveh Hajifathalian et al.   GASTROENTEROLOGY

Are Gastrointestinal Symptoms Specific for COVID-19 Infection? A Prospective Case-Control Study from the United States

(2020) Alan Chen et al.   GASTROENTEROLOGY

AGA Institute Rapid Review of the GI and Liver Manifestations of COVID-19, Meta-Analysis of International Data, and Recommendations for the Consultative Management of Patients with COVID-19

(2020) Shahnaz Sultan et al.   GASTROENTEROLOGY

High Prevalence of Concurrent Gastrointestinal Manifestations in Patients with SARS-CoV-2: Early Experience from California

(2020) George Cholankeril et al.   GASTROENTEROLOGY

Alterations in Gut Microbiota of Patients With COVID-19 During Time of Hospitalization

(2020) Tao Zuo et al.   GASTROENTEROLOGY

Initial Gastrointestinal Manifestations in Patients with SARS-CoV-2 in 112 patients from Veracruz (Southeastern Mexico).

(2020) Jose María Remes-Troche; et al.   GASTROENTEROLOGY

Gastrointestinal Manifestations of SARS-CoV-2 Infection and Virus Load in Fecal Samples from the Hong Kong Cohort and Systematic Review and Meta-analysis

(2020) Ka Shing Cheung et al.   GASTROENTEROLOGY

Symptom profiles and risk factors for hospitalization in patients with SARS-CoV-2 and COVID-19: A Large Cohort from South America

(2020) Luis Antonio Díaz et al.   GASTROENTEROLOGY

Gastrointestinal Symptoms and COVID-19: Case-Control Study from the United States

(2020) Yael R. Nobel et al.   GASTROENTEROLOGY

Prevalence and Characteristics of Gastrointestinal Symptoms in Patients with SARS-CoV-2 Infection in the United States: A Multicenter Cohort Study

(2020) Walker D. Redd et al.   GASTROENTEROLOGY

Faecal calprotectin indicates intestinal inflammation in COVID-19

(2020) Maria Effenberger et al.   GUT

Digestive system is a potential route of COVID-19: an analysis of single-cell coexpression pattern of key proteins in viral entry process

(2020) Hao Zhang et al.   GUT

Gastrointestinal symptoms of 95 cases with SARS-CoV-2 infection

(2020) Lu Lin et al.   GUT

Epidemiological, clinical and virological characteristics of 74 cases of coronavirus-infected disease 2019 (COVID-19) with gastrointestinal symptoms

(2020) Xi Jin et al.   GUT

Tocilizumab treatment in COVID-19: A single center experience

(2020) Pan Luo et al.   JOURNAL OF MEDICAL VIROLOGY

The presence of SARS‐CoV‐2 RNA in the feces of COVID‐19 patients

(2020) Yifei Chen et al.   JOURNAL OF MEDICAL VIROLOGY

Prolonged viral shedding in feces of pediatric patients with coronavirus disease 2019

(2020) Yu-Han Xing et al.   JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION

Triple combination of interferon beta-1b, lopinavir–ritonavir, and ribavirin in the treatment of patients admitted to hospital with COVID-19: an open-label, randomised, phase 2 trial

(2020) Ivan Fan-Ngai Hung et al.   LANCET

Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study

(2020) Fei Zhou et al.   LANCET

COVID-19: consider cytokine storm syndromes and immunosuppression

(2020) Puja Mehta et al.   LANCET

Pathogenesis and transmission of SARS-CoV-2 in golden hamsters

(2020) Sin Fun Sia et al.   NATURE

Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor

(2020) Jun Lan et al.   NATURE

Virological assessment of hospitalized patients with COVID-2019

(2020) Roman Wölfel et al.   NATURE

Respiratory disease in rhesus macaques inoculated with SARS-CoV-2

(2020) Vincent J. Munster et al.   NATURE

The pathogenicity of SARS-CoV-2 in hACE2 transgenic mice

(2020) Linlin Bao et al.   NATURE

Clinical and virologic characteristics of the first 12 patients with coronavirus disease 2019 (COVID-19) in the United States

(2020)   NATURE MEDICINE

Infection of bat and human intestinal organoids by SARS-CoV-2

(2020) Jie Zhou et al.   NATURE MEDICINE

Characteristics of pediatric SARS-CoV-2 infection and potential evidence for persistent fecal viral shedding

(2020) Yi Xu et al.   NATURE MEDICINE

Children with Covid-19 in Pediatric Emergency Departments in Italy

(2020) Niccolò Parri et al.   NEW ENGLAND JOURNAL OF MEDICINE

SARS-CoV-2 Infection in Children

(2020) Xiaoxia Lu et al.   NEW ENGLAND JOURNAL OF MEDICINE

Effective treatment of severe COVID-19 patients with tocilizumab

(2020) Xiaoling Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SARS-CoV-2 productively infects human gut enterocytes

(2020) Mart M. Lamers et al.   SCIENCE

Susceptibility of ferrets, cats, dogs, and other domesticated animals to SARS–coronavirus 2

(2020) Jianzhong Shi et al.   SCIENCE

Comparative pathogenesis of COVID-19, MERS, and SARS in a nonhuman primate model

(2020) Barry Rockx et al.   SCIENCE

Viral load dynamics and disease severity in patients infected with SARS-CoV-2 in Zhejiang province, China, January-March 2020: retrospective cohort study

(2020) Shufa Zheng et al.   BMJ-British Medical Journal

Coronavirus Disease 2019 in Children — United States, February 12–April 2, 2020

(2020) et al.   MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT

Prolonged presence of SARS-CoV-2 viral RNA in faecal samples

(2020) Yongjian Wu et al.   Lancet Gastroenterology & Hepatology

TMPRSS2 and TMPRSS4 promote SARS-CoV-2 infection of human small intestinal enterocytes

(2020) Ruochen Zang et al.   Science Immunology

A SARS-CoV-2 Infection Model in Mice Demonstrates Protection by Neutralizing Antibodies

(2020) Ahmed O. Hassan et al.   CELL

Analysis of Gastrointestinal and Hepatic Manifestations of SARS-CoV-2 Infection in 892 Patients in Queens, NY

(2020) Samson Ferm et al.   Clinical Gastroenterology and Hepatology

Detection of SARS-CoV-2 in Fecal Samples From Patients With Asymptomatic and Mild COVID-19 in Korea

(2020) Soo-kyung Park et al.   Clinical Gastroenterology and Hepatology

Alterations of the Gut Microbiota in Patients With Coronavirus Disease 2019 or H1N1 Influenza

(2020) Silan Gu et al.   CLINICAL INFECTIOUS DISEASES

Direct evidence of active SARS-CoV-2 replication in the intestine

(2020) Qun Qian et al.   CLINICAL INFECTIOUS DISEASES

Comparative Pathogenesis of Bovine and Porcine Respiratory Coronaviruses in the Animal Host Species and SARS-CoV-2 in Humans

(2020) Linda J. Saif et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Factors affecting stability and infectivity of SARS-CoV-2

(2020) Kwok-Hung Chan et al.   JOURNAL OF HOSPITAL INFECTION

Epidemiological features and viral shedding in children with SARS‐CoV‐2 infection

(2020) Chun‐Zhen Hua et al.   JOURNAL OF MEDICAL VIROLOGY

Association between detectable SARS‐COV‐2 RNA in anal swabs and disease severity in patients with coronavirus disease 2019

(2020) Weiyin Lin et al.   JOURNAL OF MEDICAL VIROLOGY

Longitudinal analyses reveal immunological misfiring in severe COVID-19

(2020) Carolina Lucas et al.   NATURE

Primary exposure to SARS-CoV-2 protects against reinfection in rhesus macaques

(2020) Wei Deng et al.   SCIENCE

First confirmed detection of SARS-CoV-2 in untreated wastewater in Australia: A proof of concept for the wastewater surveillance of COVID-19 in the community

(2020) Warish Ahmed et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Of Mice and Men: The Coronavirus MHV and Mouse Models as a Translational Approach to Understand SARS-CoV-2

(2020) Robert W. Körner et al.   Viruses-Basel

SARS-CoV-2 is transmitted via contact and via the air between ferrets

(2020) Mathilde Richard et al.   Nature Communications

Critical Role of Type III Interferon in Controlling SARS-CoV-2 Infection in Human Intestinal Epithelial Cells

(2020) Megan L. Stanifer et al.   Cell Reports

The Coronavirus Disease 2019 (COVID-19) in Children: A Study in an Iranian Children’s Referral Hospital

(2020) Shima Mahmoudi et al.   Infection and Drug Resistance

SARS-CoV-2 Titers in Wastewater Are Higher than Expected from Clinically Confirmed Cases

(2020) Fuqing Wu et al.   mSystems

Enteric involvement in hospitalised patients with COVID-19 outside Wuhan

(2020) Yunle Wan et al.   Lancet Gastroenterology & Hepatology

Probable Evidence of Fecal Aerosol Transmission of SARS-CoV-2 in a High-Rise Building

(2020) Min Kang et al.   ANNALS OF INTERNAL MEDICINE

Epidemiology and Clinical Features of Coronavirus Disease 2019 in Moroccan Children

(2020) K. El Fakiri et al.   INDIAN PEDIATRICS

SARS-CoV-2 detection, viral load and infectivity over the course of an infection

(2020) Kieran A. Walsh et al.   JOURNAL OF INFECTION

Efficacy of Tocilizumab in Patients Hospitalized with Covid-19

(2020) John H. Stone et al.   NEW ENGLAND JOURNAL OF MEDICINE

Re-detectable positive SARS-CoV-2 RNA tests in patients who recovered from COVID-19 with intestinal infection

(2020) Wanyin Tao et al.   Protein & Cell

Effect of Tocilizumab vs Usual Care in Adults Hospitalized With COVID-19 and Moderate or Severe Pneumonia

(2020) Olivier Hermine et al.   JAMA Internal Medicine

The gastrointestinal tract is an alternative route for SARS-CoV-2 infection in a nonhuman primate model

(2020) Li Jiao et al.   GASTROENTEROLOGY

Tocilizumab in Patients Hospitalized with Covid-19 Pneumonia

(2020) Carlos Salama et al.   NEW ENGLAND JOURNAL OF MEDICINE

IgA dominates the early neutralizing antibody response to SARS-CoV-2

(2020) Delphine Sterlin et al.   Science Translational Medicine

Microbiota-derived acetate protects against respiratory syncytial virus infection through a GPR43-type 1 interferon response

(2019) Krist Helen Antunes et al.   Nature Communications

Virus structures constrain transmission modes

(2019) Frederic D. Bushman et al.   Nature Microbiology

Norovirus encounters in the gut: multifaceted interactions and disease outcomes

(2019) Ebrahim Hassan et al.   Mucosal Immunology

Comparison of different histological indexes in the assessment of UC activity and their accuracy regarding endoscopic outcomes and faecal calprotectin levels

(2018) Fernando Magro et al.   GUT

Dietary Fiber Confers Protection against Flu by Shaping Ly6c − Patrolling Monocyte Hematopoiesis and CD8 + T Cell Metabolism

(2018) Aurélien Trompette et al.   IMMUNITY

Impacts of microbiome metabolites on immune regulation and autoimmunity

(2018) Stefanie Haase et al.   IMMUNOLOGY

STAG2 deficiency induces interferon responses via cGAS-STING pathway and restricts virus infection

(2018) Siyuan Ding et al.   Nature Communications

Influenza A virus infection impacts systemic microbiota dynamics and causes quantitative enteric dysbiosis

(2018) Soner Yildiz et al.   Microbiome

Origin and evolution of pathogenic coronaviruses

(2018) Jie Cui et al.   NATURE REVIEWS MICROBIOLOGY

Respiratory Viral Infection-Induced Microbiome Alterations and Secondary Bacterial Pneumonia

(2018) Shigeo Hanada et al.   Frontiers in Immunology

IL-6 Signaling Regulates Small Intestinal Crypt Homeostasis

(2017) Victoria Jeffery et al.   JOURNAL OF IMMUNOLOGY

Mechanism of Human Influenza Virus RNA Persistence and Virion Survival in Feces: Mucus Protects Virions From Acid and Digestive Juices

(2017) Ryohei Hirose et al.   JOURNAL OF INFECTIOUS DISEASES

Nlrp9b inflammasome restricts rotavirus infection in intestinal epithelial cells

(2017) Shu Zhu et al.   NATURE

Middle East Respiratory Syndrome

(2017) Yaseen M. Arabi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Rotavirus infection

(2017) Sue E. Crawford et al.   Nature Reviews Disease Primers

Human intestinal tract serves as an alternative infection route for Middle East respiratory syndrome coronavirus

(2017) Jie Zhou et al.   Science Advances

Dysregulated Type I Interferon and Inflammatory Monocyte-Macrophage Responses Cause Lethal Pneumonia in SARS-CoV-Infected Mice

(2016) Rudragouda Channappanavar et al.   Cell Host & Microbe

Middle East respiratory syndrome

(2015) Alimuddin Zumla et al.   LANCET

Nlrp6 regulates intestinal antiviral innate immunity

(2015) Penghua Wang et al.   SCIENCE

Diagnosis and classification of ulcerative colitis

(2014) Karsten Conrad et al.   AUTOIMMUNITY REVIEWS

Intestinal IgA production and its role in host-microbe interaction

(2014) Cindy Gutzeit et al.   IMMUNOLOGICAL REVIEWS

Respiratory influenza virus infection induces intestinal immune injury via microbiota-mediated Th17 cell–dependent inflammation

(2014) Jian Wang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IL-6-Dependent Mucosal Protection Prevents Establishment of a Microbial Niche for Attaching/Effacing Lesion-Forming Enteric Bacterial Pathogens

(2014) S. M. Dann et al.   JOURNAL OF IMMUNOLOGY

Acute Infectious Diarrhea in Immunocompetent Adults

(2014) Herbert L. DuPont   NEW ENGLAND JOURNAL OF MEDICINE

Isolation and characterization of a bat SARS-like coronavirus that uses the ACE2 receptor

(2013) Xing-Yi Ge et al.   NATURE

Detection of NH1N1 Influenza Virus in Nonrespiratory Sites Among Children

(2013) Susan. H. Wootton et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

Efficient Replication of the Novel Human Betacoronavirus EMC on Primary Human Epithelium Highlights Its Zoonotic Potential

(2013) E. Kindler et al.   mBio

ACE2 links amino acid malnutrition to microbial ecology and intestinal inflammation

(2012) Tatsuo Hashimoto et al.   NATURE

NLRP6 Inflammasome Regulates Colonic Microbial Ecology and Risk for Colitis

(2011) Eran Elinav et al.   CELL

IL-37 is a fundamental inhibitor of innate immunity

(2010) Marcel F Nold et al.   NATURE IMMUNOLOGY

IL-6 and Stat3 Are Required for Survival of Intestinal Epithelial Cells and Development of Colitis-Associated Cancer

(2009) Sergei Grivennikov et al.   CANCER CELL

Norovirus Gastroenteritis

(2009) Roger I. Glass et al.   NEW ENGLAND JOURNAL OF MEDICINE

Dissolution Media Simulating Conditions in the Proximal Human Gastrointestinal Tract: An Update

(2008) Ekarat Jantratid et al.   PHARMACEUTICAL RESEARCH