Of Mice and Men: The Coronavirus MHV and Mouse Models as a Translational Approach to Understand SARS-CoV-2

Angiotensin-converting enzyme 2 (ACE2) as a SARS-CoV-2 receptor: molecular mechanisms and potential therapeutic target

(2020) Haibo Zhang et al.   INTENSIVE CARE MEDICINE

Clinical predictors of mortality due to COVID-19 based on an analysis of data of 150 patients from Wuhan, China

(2020) Qiurong Ruan et al.   INTENSIVE CARE MEDICINE

Presumed Asymptomatic Carrier Transmission of COVID-19

(2020) Yan Bai et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Updated understanding of the outbreak of 2019 novel coronavirus (2019‐nCoV) in Wuhan, China

(2020) Weier Wang et al.   JOURNAL OF MEDICAL VIROLOGY

Cross‐species transmission of the newly identified coronavirus 2019‐nCoV

(2020) Wei Ji et al.   JOURNAL OF MEDICAL VIROLOGY

Outbreak of pneumonia of unknown etiology in Wuhan, China: The mystery and the miracle

(2020) Hongzhou Lu et al.   JOURNAL OF MEDICAL VIROLOGY

Pulmonary pathology of early phase 2019 novel coronavirus (COVID-19) pneumonia in two patients with lung cancer

(2020) Sufang Tian et al.   Journal of Thoracic Oncology

Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study

(2020) Nanshan Chen et al.   LANCET

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

(2020) Chaolin Huang et al.   LANCET

A pneumonia outbreak associated with a new coronavirus of probable bat origin

(2020) Peng Zhou et al.   NATURE

Clinical Characteristics of Coronavirus Disease 2019 in China

(2020) Wei-jie Guan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Transmission of 2019-nCoV Infection from an Asymptomatic Contact in Germany

(2020) Camilla Rothe et al.   NEW ENGLAND JOURNAL OF MEDICINE

Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus–Infected Pneumonia

(2020) Qun Li et al.   NEW ENGLAND JOURNAL OF MEDICINE

High expression of ACE2 receptor of 2019-nCoV on the epithelial cells of oral mucosa

(2020) Hao Xu et al.   International Journal of Oral Science

Pathological findings of COVID-19 associated with acute respiratory distress syndrome

(2020) Zhe Xu et al.   Lancet Respiratory Medicine

On the origin and continuing evolution of SARS-CoV-2

(2020) Xiaolu Tang et al.   National Science Review

Understanding SARS-CoV-2-Mediated Inflammatory Responses: From Mechanisms to Potential Therapeutic Tools

(2020) Yajing Fu et al.   VIROLOGICA SINICA

Evaluation of ocular symptoms and tropism of SARS‐CoV‐2 in patients confirmed with COVID‐19

(2020) Nan Hong et al.   ACTA OPHTHALMOLOGICA

Clinical Characteristics of COVID-19 Patients With Digestive Symptoms in Hubei, China

(2020) Lei Pan et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Airborne transmission of severe acute respiratory syndrome coronavirus‐2 to healthcare workers: a narrative review

(2020) N. M. Wilson et al.   ANAESTHESIA

Single cell RNA sequencing of 13 human tissues identify cell types and receptors of human coronaviruses

(2020) Furong Qi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

COVID-19 and the cardiovascular system: implications for risk assessment, diagnosis, and treatment options

(2020) Tomasz J Guzik et al.   CARDIOVASCULAR RESEARCH

SARS-CoV-2 Reverse Genetics Reveals a Variable Infection Gradient in the Respiratory Tract

(2020) Yixuan J. Hou et al.   CELL

Targets of T Cell Responses to SARS-CoV-2 Coronavirus in Humans with COVID-19 Disease and Unexposed Individuals

(2020) Alba Grifoni et al.   CELL

Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein

(2020) Alexandra C. Walls et al.   CELL

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

(2020) Markus Hoffmann et al.   CELL

Infection and Rapid Transmission of SARS-CoV-2 in Ferrets

(2020) Young-Il Kim et al.   Cell Host & Microbe

A Mouse Model of SARS-CoV-2 Infection and Pathogenesis

(2020) Shi-Hui Sun et al.   Cell Host & Microbe

Characterization of the receptor-binding domain (RBD) of 2019 novel coronavirus: implication for development of RBD protein as a viral attachment inhibitor and vaccine

(2020) Wanbo Tai et al.   Cellular & Molecular Immunology

Diarrhea During COVID-19 Infection: Pathogenesis, Epidemiology, Prevention, and Management

(2020) Ferdinando D’Amico et al.   Clinical Gastroenterology and Hepatology

Simulation of the clinical and pathological manifestations of Coronavirus Disease 2019 (COVID-19) in golden Syrian hamster model: implications for disease pathogenesis and transmissibility

(2020) Jasper Fuk-Woo Chan et al.   CLINICAL INFECTIOUS DISEASES

Comparative replication and immune activation profiles of SARS-CoV-2 and SARS-CoV in human lungs: an ex vivo study with implications for the pathogenesis of COVID-19

(2020) Hin Chu et al.   CLINICAL INFECTIOUS DISEASES

Antibody responses to SARS-CoV-2 in patients of novel coronavirus disease 2019

(2020) Juanjuan Zhao et al.   CLINICAL INFECTIOUS DISEASES

Olfactory and gustatory dysfunctions as a clinical presentation of mild-to-moderate forms of the coronavirus disease (COVID-19): a multicenter European study

(2020) Jerome R. Lechien et al.   EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY

The pivotal link between ACE2 deficiency and SARS-CoV-2 infection

(2020) Paolo Verdecchia et al.   European Journal of Internal Medicine

Estimating the asymptomatic proportion of coronavirus disease 2019 (COVID-19) cases on board the Diamond Princess cruise ship, Yokohama, Japan, 2020

(2020) Kenji Mizumoto et al.   Eurosurveillance

Comparison of nasopharyngeal and oropharyngeal swabs for SARS-CoV-2 detection in 353 patients received tests with both specimens simultaneously

(2020) Xiong Wang et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

Digestive system involvement of novel coronavirus infection: Prevention and control infection from a gastroenterology perspective

(2020) Lian Yong Li et al.   Journal of Digestive Diseases

The presence of SARS‐CoV‐2 RNA in the feces of COVID‐19 patients

(2020) Yifei Chen et al.   JOURNAL OF MEDICAL VIROLOGY

COVID-19 in children

(2020) Mei-Jy Jeng   Journal of the Chinese Medical Association

A single mass gathering resulted in massive transmission of COVID-19 infections in Malaysia with further international spread

(2020) Nor Fazila Che Mat et al.   JOURNAL OF TRAVEL MEDICINE

Temporal profiles of viral load in posterior oropharyngeal saliva samples and serum antibody responses during infection by SARS-CoV-2: an observational cohort study

(2020) Kelvin Kai-Wang To et al.   LANCET INFECTIOUS DISEASES

Identifying SARS-CoV-2 related coronaviruses in Malayan pangolins

(2020) Tommy Tsan-Yuk Lam et al.   NATURE

Structural basis of receptor recognition by SARS-CoV-2

(2020) Jian Shang et al.   NATURE

Virological assessment of hospitalized patients with COVID-2019

(2020) Roman Wölfel et al.   NATURE

The pathogenicity of SARS-CoV-2 in hACE2 transgenic mice

(2020) Linlin Bao et al.   NATURE

The proximal origin of SARS-CoV-2

(2020) Kristian G. Andersen et al.   NATURE MEDICINE

SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes

(2020) Waradon Sungnak et al.   NATURE MEDICINE

Characteristics of pediatric SARS-CoV-2 infection and potential evidence for persistent fecal viral shedding

(2020) Yi Xu et al.   NATURE MEDICINE

Observational Study of Hydroxychloroquine in Hospitalized Patients with Covid-19

(2020) Joshua Geleris et al.   NEW ENGLAND JOURNAL OF MEDICINE

Aerosol and Surface Stability of SARS-CoV-2 as Compared with SARS-CoV-1

(2020) Neeltje van Doremalen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Coronavirus Infections in Children Including COVID-19

(2020) Petra Zimmermann et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

Effective treatment of severe COVID-19 patients with tocilizumab

(2020) Xiaoling Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Susceptibility of ferrets, cats, dogs, and other domesticated animals to SARS–coronavirus 2

(2020) Jianzhong Shi et al.   SCIENCE

Comparative pathogenesis of COVID-19, MERS, and SARS in a nonhuman primate model

(2020) Barry Rockx et al.   SCIENCE

Virology, Epidemiology, Pathogenesis, and Control of COVID-19

(2020) Yuefei Jin et al.   Viruses-Basel

Clinical, laboratory and imaging features of COVID-19: A systematic review and meta-analysis

(2020) Alfonso J. Rodriguez-Morales et al.   Travel Medicine and Infectious Disease

Network-based drug repurposing for novel coronavirus 2019-nCoV/SARS-CoV-2

(2020) Yadi Zhou et al.   Cell Discovery

ACE2 at the centre of COVID-19 from paucisymptomatic infections to severe pneumonia

(2020) Felice Rivellese et al.   AUTOIMMUNITY REVIEWS

Renin-angiotensin system at the heart of COVID-19 pandemic

(2020) Marco Alifano et al.   BIOCHIMIE

Generation of a Broadly Useful Model for COVID-19 Pathogenesis, Vaccination, and Treatment

(2020) Jing Sun et al.   CELL

A SARS-CoV-2 Infection Model in Mice Demonstrates Protection by Neutralizing Antibodies

(2020) Ahmed O. Hassan et al.   CELL

Gene expression and in situ protein profiling of candidate SARS-CoV-2 receptors in human airway epithelial cells and lung tissue

(2020) Jennifer A. Aguiar et al.   EUROPEAN RESPIRATORY JOURNAL

The pathogenesis and treatment of the `Cytokine Storm' in COVID-19

(2020) Qing Ye et al.   JOURNAL OF INFECTION

Transplacental transmission of SARS-CoV-2 infection

(2020) Alexandre J. Vivanti et al.   Nature Communications

Does the human placenta express the canonical cell entry mediators for SARS-CoV-2?

(2020) Roger Pique-Regi et al.   eLife

COVID-19, Renin-Angiotensin System and Endothelial Dysfunction

(2020) Razie Amraei et al.   Cells

Multiple sclerosis following SARS-CoV-2 infection

(2020) M. Palao et al.   Multiple Sclerosis and Related Disorders

An atlas of the aging lung mapped by single cell transcriptomics and deep tissue proteomics

(2019) Ilias Angelidis et al.   Nature Communications

Strain-dependent effects on lung structure, matrix remodeling and Stat3/Smad2 signaling in C57BL/6N and C57BL/6J mice after neonatal hyperoxia

(2019) Johannes P. Will et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Precision mouse models with expanded tropism for human pathogens

(2019) Angela Wahl et al.   NATURE BIOTECHNOLOGY

Elafin treatment rescues EGFR-Klf4 signaling and lung cell survival in ventilated newborn mice

(2018) Miguel A Alejandre Alcazar et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Angiotensin-converting enzyme in innate and adaptive immunity

(2018) Kenneth E. Bernstein et al.   Nature Reviews Nephrology

Intracranial Inoculation Is More Potent Than Intranasal Inoculation for Inducing Optic Neuritis in the Mouse Hepatitis Virus-Induced Model of Multiple Sclerosis

(2018) Manmeet Singh et al.   Frontiers in Cellular and Infection Microbiology

Fine Tuning the Cytokine Storm by IFN and IL-10 Following Neurotropic Coronavirus Encephalomyelitis

(2018) Carine Savarin et al.   Frontiers in Immunology

Neurovirulent Murine Coronavirus JHM.SD Uses Cellular Zinc Metalloproteases for Virus Entry and Cell-Cell Fusion

(2017) Judith M. Phillips et al.   JOURNAL OF VIROLOGY

Inflammaging and ‘Garb-aging’

(2017) Claudio Franceschi et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

The nsp1, nsp13, and M Proteins Contribute to the Hepatotropism of Murine Coronavirus JHM.WU

(2015) Rong Zhang et al.   JOURNAL OF VIROLOGY

Accessory proteins of SARS-CoV and other coronaviruses

(2014) Ding Xiang Liu et al.   ANTIVIRAL RESEARCH

Lung development: orchestrating the generation and regeneration of a complex organ

(2014) M. Herriges et al.   DEVELOPMENT

Depletion of Alveolar Macrophages Ameliorates Virus-Induced Disease following a Pulmonary Coronavirus Infection

(2014) Stacey M. Hartwig et al.   PLoS One

Coronavirus MHV-A59 infects the lung and causes severe pneumonia in C57BL/6 mice

(2014) Zhangsheng Yang et al.   VIROLOGICA SINICA

Type 2 alveolar cells are stem cells in adult lung

(2013) Christina E. Barkauskas et al.   JOURNAL OF CLINICAL INVESTIGATION

Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC

(2013) V. Stalin Raj et al.   NATURE

Genetic Heterogeneity and Risk of Acute Respiratory Distress Syndrome

(2013) Jason Christie et al.   SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE

Protective effects of long pentraxin PTX3 on lung injury in a severe acute respiratory syndrome model in mice

(2012) Bing Han et al.   LABORATORY INVESTIGATION

CD200 Receptor Controls Sex-Specific TLR7 Responses to Viral Infection

(2012) Guruswamy Karnam et al.   PLoS Pathogens

Molecular Determinants of Severe Acute Respiratory Syndrome Coronavirus Pathogenesis and Virulence in Young and Aged Mouse Models of Human Disease

(2011) M. Frieman et al.   JOURNAL OF VIROLOGY

T Cell Epitope Specificity and Pathogenesis of Mouse Hepatitis Virus-1-Induced Disease in Susceptible and Resistant Hosts

(2010) A. Khanolkar et al.   JOURNAL OF IMMUNOLOGY

Genetic Determinants of Mouse Hepatitis Virus Strain 1 Pneumovirulence

(2010) J. L. Leibowitz et al.   JOURNAL OF VIROLOGY

Proteasome Inhibition In Vivo Promotes Survival in a Lethal Murine Model of Severe Acute Respiratory Syndrome

(2010) X.-Z. Ma et al.   JOURNAL OF VIROLOGY

Exacerbated Innate Host Response to SARS-CoV in Aged Non-Human Primates

(2010) Saskia L. Smits et al.   PLoS Pathogens

Toll-Like Receptor 4 Deficiency Increases Disease and Mortality after Mouse Hepatitis Virus Type 1 Infection of Susceptible C3H Mice

(2009) A. Khanolkar et al.   JOURNAL OF VIROLOGY

Differential Virological and Immunological Outcome of Severe Acute Respiratory Syndrome Coronavirus Infection in Susceptible and Resistant Transgenic Mice Expressing Human Angiotensin-Converting Enzyme 2

(2009) N. Yoshikawa et al.   JOURNAL OF VIROLOGY

Protective and Pathologic Roles of the Immune Response to Mouse Hepatitis Virus Type 1: Implications for Severe Acute Respiratory Syndrome

(2009) A. Khanolkar et al.   JOURNAL OF VIROLOGY

Cellular Immune Responses to Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) Infection in Senescent BALB/c Mice: CD4+ T Cells Are Important in Control of SARS-CoV Infection

(2009) J. Chen et al.   JOURNAL OF VIROLOGY

The spike protein of SARS-CoV — a target for vaccine and therapeutic development

(2009) Lanying Du et al.   NATURE REVIEWS MICROBIOLOGY

A new mouse-adapted strain of SARS-CoV as a lethal model for evaluating antiviral agents in vitro and in vivo

(2009) Craig W. Day et al.   VIROLOGY

Mouse-Passaged Severe Acute Respiratory Syndrome-Associated Coronavirus Leads to Lethal Pulmonary Edema and Diffuse Alveolar Damage in Adult but Not Young Mice

(2008) Noriyo Nagata et al.   AMERICAN JOURNAL OF PATHOLOGY

Severe Acute Respiratory Syndrome Coronavirus Infection Causes Neuronal Death in the Absence of Encephalitis in Mice Transgenic for Human ACE2

(2008) J. Netland et al.   JOURNAL OF VIROLOGY

The inhibitory CD200R is differentially expressed on human and mouse T and B lymphocytes

(2007) Eva S.K. Rijkers et al.   MOLECULAR IMMUNOLOGY