The “irisin system”: From biological roles to pharmacological and nutraceutical perspectives

Vitamin D supplementation improves SIRT1, Irisin, and glucose indices in overweight or obese type 2 diabetic patients: a double-blind randomized placebo-controlled clinical trial

(2020) Peivasteh Safarpour et al.   BMC Family Practice

The effect of fenugreek seed supplementation on serum irisin levels, blood pressure, and liver and kidney function in patients with type 2 diabetes mellitus: A parallel randomized clinical trial

(2020) Amir Hadi et al.   COMPLEMENTARY THERAPIES IN MEDICINE

Recombinant Irisin Prevents the Reduction of Osteoblast Differentiation Induced by Stimulated Microgravity through Increasing β-Catenin Expression

(2020) Zhihao Chen et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Irisin activates Opa1-induced mitophagy to protect cardiomyocytes against apoptosis following myocardial infarction

(2020) Ting Xin et al.   Aging-US

Effects of Short Term Metformin Treatment on Brown Adipose Tissue Activity and Plasma Irisin Levels in Women with Polycystic Ovary Syndrome: A Randomized Controlled Trial

(2020) Flávia R. Oliveira et al.   HORMONE AND METABOLIC RESEARCH

Impact of Vigorous-Intensity Physical Activity on Body Composition Parameters, Lipid Profile Markers, and Irisin Levels in Adolescents: A Cross-Sectional Study

(2020) Catia Morelli et al.   Nutrients

Irisin: Still chasing shadows

(2020) Elke Albrecht et al.   Molecular Metabolism

Serum irisin levels are decreased in patients with sepsis, and exogenous irisin suppresses ferroptosis in the liver of septic mice

(2020) Shasha Wei et al.   Clinical and Translational Medicine

Irisin interaction with adipose tissue secretions by exercise training and flaxseed oil supplement

(2019) Hossein Shirvani et al.   Lipids in Health and Disease

3,5 Diiodo-l-Thyronine (T2) Promotes the Browning of White Adipose Tissue in High-Fat Diet-Induced Overweight Male Rats Housed at Thermoneutrality

(2019) Rosalba Senese et al.   Cells

Genistein increases the thermogenic program of subcutaneous WAT and increases energy expenditure in mice

(2019) Berenice Palacios-González et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

A novel interplay between irisin and PTH: from basic studies to clinical evidence in hyperparathyroidism

(2019) Andrea Palermo et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Green cardamom supplementation improves serum irisin, glucose indices, and lipid profiles in overweight or obese non-alcoholic fatty liver disease patients: a double-blind randomized placebo-controlled clinical trial

(2019) Milad Daneshi-Maskooni et al.   BMC Complementary and Alternative Medicine

Effect of resveratrol on expression of genes involved thermogenesis in mice and humans

(2019) João Marcus Oliveira Andrade et al.   BIOMEDICINE & PHARMACOTHERAPY

Effect of Metformin Treatment on Insulin Resistance Markers, and Circulating Irisin in Women with Polycystic Ovarian Syndrome (PCOS)

(2019) Asiyeh Masaeli et al.   HORMONE AND METABOLIC RESEARCH

Genistein ameliorated obesity accompanied with adipose tissue browning and attenuation of hepatic lipogenesis in ovariectomized rats with high-fat diet

(2019) Hsin-Hsueh Shen et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Icariin induces irisin/FNDC5 expression in C2C12 cells via the AMPK pathway

(2019) Sui-Qing Chen et al.   BIOMEDICINE & PHARMACOTHERAPY

Irisin as a Multifunctional Protein: Implications for Health and Certain Diseases

(2019) Paulina Korta et al.   Medicina-Lithuania

Irisin Enhances Doxorubicin-Induced Cell Apoptosis in Pancreatic Cancer by Inhibiting the PI3K/AKT/NF-κB Pathway

(2019) Jiayu Liu et al.   MEDICAL SCIENCE MONITOR

Superiority of the Non-Glycosylated Form Over the Glycosylated Form of Irisin in the Attenuation of Adipocytic Meta-Inflammation: A Potential Factor in the Fight Against Insulin Resistance

(2019) Mazur-Bialy   Biomolecules

Upregulation of FNDC5 gene expression in C2C12 cells after single and combined treatments of resveratrol and ATRA

(2019) Elahe Abedi-Taleb et al.   Lipids in Health and Disease

Hesperidin: A Therapeutic Agent For Obesity

(2019) Haijun Xiong et al.   Drug Design Development and Therapy

Effect of a Very-Low-Calorie Ketogenic Diet on Circulating Myokine Levels Compared with the Effect of Bariatric Surgery or a Low-Calorie Diet in Patients with Obesity

(2019) Sajoux et al.   Nutrients

The effects of resistance exercise training followed by de-training on irisin and some metabolic parameters in type 2 diabetic rat model

(2019) Hassan Tavassoli et al.   ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY

Correction: Intraperitoneal administration of follistatin promotes adipocyte browning in high-fat diet-induced obese mice

(2019) Haoyu Li et al.   PLoS One

Irisin attenuates intestinal injury, oxidative and endoplasmic reticulum stress in mice with L-arginine-induced acute pancreatitis

(2019) Yi-Fan Ren et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Trans-anethole ameliorates obesity via induction of browning in white adipocytes and activation of brown adipocytes

(2018) Nam Hyeon Kang et al.   BIOCHIMIE

Retinoic Acid Increases Fatty Acid Oxidation and Irisin Expression in Skeletal Muscle Cells and Impacts Irisin In Vivo

(2018) Jaume Amengual et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Essential oils of culinary herbs and spices display agonist and antagonist activities at human aryl hydrocarbon receptor AhR

(2018) Iveta Bartoňková et al.   FOOD AND CHEMICAL TOXICOLOGY

Irisin and leptin concentrations in relation to obesity, and developing type 2 diabetes: A cross sectional and a prospective case-control study nested in the Normative Aging Study

(2018) Ayse Sahin-Efe et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Raspberry Supplementation Improves Insulin Signaling and Promotes Brown-Like Adipocyte Development in White Adipose Tissue of Obese Mice

(2018) Tong Xing et al.   MOLECULAR NUTRITION & FOOD RESEARCH

High irisin levels in overweight/obese children and its positive correlation with metabolic profile, blood pressure, and endothelial progenitor cells

(2018) F. De Meneck et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

Drugs Involved in Dyslipidemia and Obesity Treatment: Focus on Adipose Tissue

(2018) Sofia Dias et al.   International Journal of Endocrinology

Irisin Serum Levels in Metabolic Syndrome Patients Treated with Three Different Diets: A Post-Hoc Analysis from a Randomized Controlled Clinical Trial

(2018) Alberto Osella et al.   Nutrients

Immature Citrus reticulata Extract Promotes Browning of Beige Adipocytes in High-Fat Diet-Induced C57BL/6 Mice

(2018) Ya-Chun Chou et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors

(2018) Hyeonwoo Kim et al.   CELL

Myricanol mitigates lipid accumulation in 3T3-L1 adipocytes and high fat diet-fed zebrafish via activating AMP-activated protein kinase

(2018) Shengnan Shen et al.   FOOD CHEMISTRY

The Effect and Mechanism of TLR9/KLF4 in FFA-Induced Adipocyte Inflammation

(2018) Cuizhe Wang et al.   MEDIATORS OF INFLAMMATION

Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer’s models

(2018) Mychael V. Lourenco et al.   NATURE MEDICINE

Dietary polyphenols and their roles in fat browning

(2018) Allwin Jennifa Silvester et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

5 years later: irisin detection still an issue

(2017) Alexandra B Cooke et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Novel Blood-Based Biomarkers of Cognition, Stress, and Physical or Cognitive Training in Older Adults at Risk of Dementia: Preliminary Evidence for a Role of BDNF, Irisin, and the Kynurenine Pathway

(2017) Olivia C. Küster et al.   JOURNAL OF ALZHEIMERS DISEASE

Metabolic Responses to the Yukon Arctic Ultra

(2017) ROBERT H. COKER et al.   MEDICINE AND SCIENCE IN SPORTS AND EXERCISE

Effects of Dietary Macronutrient Composition on FNDC5 and Irisin in Mice Skeletal Muscle

(2017) Simone Moreira de Macêdo et al.   Metabolic Syndrome and Related Disorders

Physiology and role of irisin in glucose homeostasis

(2017) Nikolaos Perakakis et al.   Nature Reviews Endocrinology

Effects of Irisin and Exercise on Metabolic Parameters and Reproductive Hormone Levels in High-Fat Diet-Induced Obese Female Mice

(2017) Ercan Bastu et al.   Reproductive Sciences

Apigenin enhances skeletal muscle hypertrophy and myoblast differentiation by regulating Prmt7

(2017) Young Jin Jang et al.   Oncotarget

Glucocorticoid receptor positively regulates transcription of FNDC5 in the liver

(2017) Hyoung Kyu Kim et al.   Scientific Reports

Differences in analytical and biological results between older and newer lots of a widely used irisin immunoassay question the validity of previous studies

(2016) Rafael Montes-Nieto et al.   CLINICAL CHEMISTRY AND LABORATORY MEDICINE

Diet quality and diet patterns in relation to circulating cardiometabolic biomarkers

(2016) Byung-Joon Ko et al.   CLINICAL NUTRITION

Biological roles of glycans

(2016) Ajit Varki   GLYCOBIOLOGY

FNDC5 is produced in the stomach and associated to body composition

(2016) S. Barja-Fernández et al.   Scientific Reports

FNDC5 expression and circulating irisin levels are modified by diet and hormonal conditions in hypothalamus, adipose tissue and muscle

(2016) B. M. Varela-Rodríguez et al.   Scientific Reports

PPAR-α agonist elicits metabolically active brown adipocytes and weight loss in diet-induced obese mice

(2015) Tamiris Lima Rachid et al.   CELL BIOCHEMISTRY AND FUNCTION

Detection and Quantitation of Circulating Human Irisin by Tandem Mass Spectrometry

(2015) Mark P. Jedrychowski et al.   Cell Metabolism

Study on the Distribution and Elimination of the New Hormone Irisin In Vivo: New Discoveries Regarding Irisin

(2015) J. Lv et al.   HORMONE AND METABOLIC RESEARCH

Serum Irisin Levels Are Regulated by Acute Strenuous Exercise

(2015) Dennis Löffler et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Fenofibrate (PPARalpha agonist) induces beige cell formation in subcutaneous white adipose tissue from diet-induced male obese mice

(2015) Tamiris Lima Rachid et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Irisin levels before and after physical activity among school-age children with different BMI: A direct relation with leptin

(2015) Berenice Palacios-González et al.   Obesity

Circulating irisin detection: Does it really work?

(2015) Fabian Sanchis-Gomar et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

PPAR-αAgonist Fenofibrate Decreased Serum Irisin Levels in Type 2 Diabetes Patients with Hypertriglyceridemia

(2015) Xiaomeng Feng et al.   PPAR Research

Irisin – a myth rather than an exercise-inducible myokine

(2015) Elke Albrecht et al.   Scientific Reports

Irisin in Blood Increases Transiently after Single Sessions of Intense Endurance Exercise and Heavy Strength Training

(2015) Håvard Nygaard et al.   PLoS One

Circulating Irisin Levels Are Positively Associated with Metabolic Risk Factors in Sedentary Subjects

(2015) María Moreno et al.   PLoS One

Metformin promotes irisin release from murine skeletal muscle independently of AMP-activated protein kinase activation

(2014) D.-J. Li et al.   Acta Physiologica

Irisin and FGF21 Are Cold-Induced Endocrine Activators of Brown Fat Function in Humans

(2014) Paul Lee et al.   Cell Metabolism

Plasma irisin levels progressively increase in response to increasing exercise workloads in young, healthy, active subjects

(2014) Stella S Daskalopoulou et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Resveratrol increases brown adipose tissue thermogenesis markers by increasing SIRT1 and energy expenditure and decreasing fat accumulation in adipose tissue of mice fed a standard diet

(2014) João Marcus Oliveira Andrade et al.   EUROPEAN JOURNAL OF NUTRITION

Irisin Is Elevated in Skeletal Muscle and Serum of Mice Immediately after Acute Exercise

(2014) Julia Brenmoehl et al.   International Journal of Biological Sciences

Effects of the exercise-inducible myokine irisin on malignant and non-malignant breast epithelial cell behaviorin vitro

(2014) Nicholas P. Gannon et al.   INTERNATIONAL JOURNAL OF CANCER

Ursolic Acid-Induced Elevation of Serum Irisin Augments Muscle Strength During Resistance Training in Men

(2014) Hyun Seok Bang et al.   KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY

Effect of Citrus Flavonoids, Naringin and Naringenin, on Metabolic Syndrome and Their Mechanisms of Action

(2014) M. Ashraful Alam et al.   Advances in Nutrition

Exercise Induces Hippocampal BDNF through a PGC-1α/FNDC5 Pathway

(2013) Christiane D. Wrann et al.   Cell Metabolism

Pharmacokinetics and Pharmacokinetic–Pharmacodynamic Correlations of Therapeutic Peptides

(2013) Lei Diao et al.   CLINICAL PHARMACOKINETICS

Irisin Stimulates Browning of White Adipocytes Through Mitogen-Activated Protein Kinase p38 MAP Kinase and ERK MAP Kinase Signaling

(2013) Y. Zhang et al.   DIABETES

The Structure of Irisin Reveals a Novel Intersubunit β-Sheet Fibronectin Type III (FNIII) Dimer

(2013) Maria A. Schumacher et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Irisin Is Expressed and Produced by Human Muscle and Adipose Tissue in Association With Obesity and Insulin Resistance

(2013) José María Moreno-Navarrete et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Irisin is inversely associated with intrahepatic triglyceride contents in obese adults

(2013) Hui-Jie Zhang et al.   JOURNAL OF HEPATOLOGY

Effects of obesity, diabetes and exercise onFndc5gene expression and irisin release in human skeletal muscle and adipose tissue:in vivoandin vitrostudies

(2013) Timea Kurdiova et al.   JOURNAL OF PHYSIOLOGY-LONDON

Effects of Lipid-Lowering Drugs on Irisin in Human Subjects In Vivo and in Human Skeletal Muscle Cells Ex Vivo

(2013) Ioanna Gouni-Berthold et al.   PLoS One

FNDC5 and irisin in humans: I. Predictors of circulating concentrations in serum and plasma and II. mRNA expression and circulating concentrations in response to weight loss and exercise

(2012) Joo Young Huh et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis

(2012) Pontus Boström et al.   NATURE

Dietary phytochemicals and their potential effects on obesity: A review

(2011) Marta González-Castejón et al.   PHARMACOLOGICAL RESEARCH

Centralized Modularity of N-Linked Glycosylation Pathways in Mammalian Cells

(2009) Pan-Jun Kim et al.   PLoS One

The role of exercise and PGC1α in inflammation and chronic disease

(2008) Christoph Handschin et al.   NATURE