- Home
- Publications
- Publication Search
- Publication Details
Title
Therapeutic targets of cancer drugs: Modulation by melatonin
Authors
Keywords
Tumor, Metastasis, MAPK, Cyclins, C-Myc
Journal
LIFE SCIENCES
Volume 267, Issue -, Pages 118934
Publisher
Elsevier BV
Online
2020-12-30
DOI
10.1016/j.lfs.2020.118934
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Melatonin inhibits Warburg-dependent cancer by redirecting glucose oxidation to the mitochondria: a mechanistic hypothesis
- (2020) Russel J. Reiter et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Melatonin in Mitochondria: Mitigating Clear and Present Dangers
- (2020) Russel J. Reiter et al. PHYSIOLOGY
- Clinical impact of melatonin on breast cancer patients undergoing chemotherapy; effects on cognition, sleep and depressive symptoms: A randomized, double-blind, placebo-controlled trial
- (2020) Ana Claudia Souza Palmer et al. PLoS One
- Safety and efficacy profile of cyclin‐dependent kinases 4/6 inhibitor palbociclib in cancer therapy: A meta‐analysis of clinical trials
- (2019) Linghong Guo et al. Cancer Medicine
- Immunoregulatory role of melatonin in cancer
- (2019) Fatemeh Moradkhani et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Modulation of apoptosis by melatonin for improving cancer treatment efficiency: An updated review
- (2019) Keywan Mortezaee et al. LIFE SCIENCES
- Efficacy of Melatonin in prevention of radiation‐induced oral mucositis: A randomized clinical trial
- (2019) Hossam H. Elsabagh et al. ORAL DISEASES
- Melatonin inhibits epithelial‑to‑mesenchymal transition in gastric cancer cells via attenuation of IL‑1β/NF‑κB/MMP2/MMP9 signaling
- (2018) Xiaoting Wang et al. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
- Melatonin disturbs SUMOylation-mediated crosstalk between c-Myc and nestin via MT1 activation and promotes the sensitivity of paclitaxel in brain cancer stem cells
- (2018) Hyemin Lee et al. JOURNAL OF PINEAL RESEARCH
- Melatonin restrains angiogenic factors in triple-negative breast cancer by targeting miR-152-3p: In vivo and in vitro studies
- (2018) Jéssica H.M. Marques et al. LIFE SCIENCES
- Does the use of melatonin overcome drug resistance in cancer chemotherapy?
- (2018) Mohammad Hossein Asghari et al. LIFE SCIENCES
- Dose-dependent proliferative and cytotoxic effects of melatonin on human epidermoid carcinoma and normal skin fibroblast cells
- (2018) Abdurrahim Kocyigit et al. MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS
- Melatonin suppresses thyroid cancer growth and overcomes radioresistance via inhibition of p65 phosphorylation and induction of ROS
- (2018) Zhen-Wei Zou et al. Redox Biology
- Recent advances in searching c-Myc transcriptional cofactors during tumorigenesis
- (2018) Matteo Caforio et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Melatonin and 5-fluorouracil co-suppress colon cancer stem cells by regulating cellular prion protein-Oct4 axis
- (2018) Jun Hee Lee et al. JOURNAL OF PINEAL RESEARCH
- Melatonin Sensitizes Hepatocellular Carcinoma Cells to Chemotherapy Through Long Non-Coding RNA RAD51-AS1-Mediated Suppression of DNA Repair
- (2018) Chin-Chuan Chen et al. Cancers
- The protective effects of melatonin on blood cell counts of rectal cancer patients following radio-chemotherapy: a randomized controlled trial
- (2018) N. Kouhi Habibi et al. Clinical & Translational Oncology
- Melatonin restricts the viability and angiogenesis of vascular endothelial cells by suppressing HIF-1α/ROS/VEGF
- (2018) Jiao Cheng et al. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
- Melatonin Reduces Angiogenesis in Serous Papillary Ovarian Carcinoma of Ethanol-Preferring Rats
- (2017) Yohan Zonta et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Melatonin potentiates the antitumor effect of curcumin by inhibiting IKKβ/NF-κB/COX-2 signaling pathway
- (2017) Sandeep Shrestha et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- Melatonin as a multifunctional anti-cancer molecule: Implications in gastric cancer
- (2017) Mohammad Hossein Asghari et al. LIFE SCIENCES
- Complementary actions of melatonin on angiogenic factors, the angiopoietin/Tie2 axis and VEGF, in co‑cultures of human endothelial and breast cancer cells
- (2017) Alicia Gonz�lez-Gonz�lez et al. ONCOLOGY REPORTS
- Inhibition of VEGF-Induced VEGFR-2 Activation and HUVEC Migration by Melatonin and Other Bioactive Indolic Compounds
- (2017) Ana Cerezo et al. Nutrients
- Melatonin enhances the anti-tumor effect of sorafenib via AKT/p27-mediated cell cycle arrest in hepatocarcinoma cell lines
- (2017) Fei Long et al. RSC Advances
- Targeting NF-κB RelA/p65 phosphorylation overcomes RITA resistance
- (2016) Yiwen Bu et al. CANCER LETTERS
- Inhibition of the NF-κB pathway by nafamostat mesilate suppresses colorectal cancer growth and metastasis
- (2016) Yun-Xin Lu et al. CANCER LETTERS
- DNA Methylation in Cancer and Aging
- (2016) M. Klutstein et al. CANCER RESEARCH
- Inhibition of ERK1/2 Signaling Pathway is Involved in Melatonin's Antiproliferative Effect on Human MG-63 Osteosarcoma Cells
- (2016) Lifeng Liu et al. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
- A review of the protective effect of melatonin in pesticide-induced toxicity
- (2016) Mohammad Hossein Asghari et al. Expert Opinion on Drug Metabolism & Toxicology
- From junk to master regulators of invasion: lncRNA functions in migration, EMT and metastasis
- (2016) Sonam Dhamija et al. INTERNATIONAL JOURNAL OF CANCER
- Melatonin inhibits MMP-9 transactivation and renal cell carcinoma metastasis by suppressing Akt-MAPKs pathway and NF-κB DNA-binding activity
- (2016) Yung-Wei Lin et al. JOURNAL OF PINEAL RESEARCH
- Cancer metastasis: Mechanisms of inhibition by melatonin
- (2016) Shih-Chi Su et al. JOURNAL OF PINEAL RESEARCH
- Melatonin synergizes the chemotherapeutic effect of 5-fluorouracil in colon cancer by suppressing PI3K/AKT and NF-κB/iNOS signaling pathways
- (2016) Yue Gao et al. JOURNAL OF PINEAL RESEARCH
- Treating cancer with selective CDK4/6 inhibitors
- (2016) Ben O'Leary et al. Nature Reviews Clinical Oncology
- Melatonin induces cell apoptosis in Mia PaCa-2 cells via the suppression of nuclear factor-κB and activation of ERK and JNK: A novel therapeutic implication for pancreatic cancer
- (2016) Weimin Li et al. ONCOLOGY REPORTS
- miR-150 exerts antileukemia activity in vitro and in vivo through regulating genes in multiple pathways
- (2016) Zhi Hong Fang et al. Cell Death & Disease
- Effects of melatonin on HIF-1α and VEGF expression and on the invasive properties of hepatocarcinoma cells
- (2016) JUCIMARA COLOMBO et al. Oncology Letters
- Melatonin downregulates nuclear receptor RZR/RORγ expression causing growth-inhibitory and anti-angiogenesis activity in human gastric cancer cells in vitro and in vivo
- (2016) Ri-Xiong Wang et al. Oncology Letters
- miR-150 Suppresses the Proliferation and Tumorigenicity of Leukemia Stem Cells by Targeting the Nanog Signaling Pathway
- (2016) Dan-dan Xu et al. Frontiers in Pharmacology
- Inhibition of nestin suppresses stem cell phenotype of glioblastomas through the alteration of post-translational modification of heat shock protein HSPA8/HSC71
- (2015) Yoko Matsuda et al. CANCER LETTERS
- Melatonin Induces Cell Apoptosis in AGS Cells Through the Activation of JNK and P38 MAPK and the Suppression of Nuclear Factor-Kappa B: a Novel Therapeutic Implication for Gastric Cancer
- (2015) Weimin Li et al. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
- Molecular Pathways: Targeting the Cyclin D-CDK4/6 Axis for Cancer Treatment
- (2015) T. VanArsdale et al. CLINICAL CANCER RESEARCH
- A Phase II, Single-Arm, Open-Label, Multicenter Study to Evaluate the Efficacy and Safety of P276-00, a Cyclin-Dependent Kinase Inhibitor, in Patients With Relapsed or Refractory Mantle Cell Lymphoma
- (2015) Ryan D. Cassaday et al. Clinical Lymphoma Myeloma & Leukemia
- Melatonin overcomes gemcitabine resistance in pancreatic ductal adenocarcinoma by abrogating nuclear factor-κB activation
- (2015) Huai-Qiang Ju et al. JOURNAL OF PINEAL RESEARCH
- Melatonergic system-based two-gene index is prognostic in human gliomas
- (2015) Gabriela S. Kinker et al. JOURNAL OF PINEAL RESEARCH
- Involvement of ROS-alpha v beta 3 integrin-FAK/Pyk2 in the inhibitory effect of melatonin on U251 glioma cell migration and invasion under hypoxia
- (2015) Cheng-Shi Xu et al. Journal of Translational Medicine
- Whole-genome fingerprint of the DNA methylome during human B cell differentiation
- (2015) Marta Kulis et al. NATURE GENETICS
- Long Noncoding RNA in Digestive Tract Cancers: Function, Mechanism, and Potential Biomarker
- (2015) S. Zeng et al. ONCOLOGIST
- Melatonin inhibits AP-2β/hTERT, NF-κB/COX-2 and Akt/ERK and activates caspase/Cyto C signaling to enhance the antitumor activity of berberine in lung cancer cells
- (2015) Jian-Jun Lu et al. Oncotarget
- The circadian timing system in clinical oncology
- (2014) Pasquale F. Innominato et al. ANNALS OF MEDICINE
- Circadian and Melatonin Disruption by Exposure to Light at Night Drives Intrinsic Resistance to Tamoxifen Therapy in Breast Cancer
- (2014) R. T. Dauchy et al. CANCER RESEARCH
- Targeting DNA damage response in cancer therapy
- (2014) Noriko Hosoya et al. CANCER SCIENCE
- Extrapineal melatonin: sources, regulation, and potential functions
- (2014) Darío Acuña-Castroviejo et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Local Melatonin Regulates Inflammation Resolution: A Common Factor in Neurodegenerative, Psychiatric and Systemic Inflammatory Disorders
- (2014) George Anderson et al. CNS & Neurological Disorders-Drug Targets
- Platelet-activating factor enhances tumour metastasis via the reactive oxygen species-dependent protein kinase casein kinase 2-mediated nuclear factor-κB activation
- (2014) Kyoung-Jin Kim et al. IMMUNOLOGY
- Melatonin treatment induces interplay of apoptosis, autophagy, and senescence in human colorectal cancer cells
- (2014) Yunkyung Hong et al. JOURNAL OF PINEAL RESEARCH
- Antitumour activity of melatonin in a mouse model of human prostate cancer: relationship with hypoxia signalling
- (2014) Rita Paroni et al. JOURNAL OF PINEAL RESEARCH
- Effect of Melatonin on Tumor Growth and Angiogenesis in Xenograft Model of Breast Cancer
- (2014) Bruna Victorasso Jardim-Perassi et al. PLoS One
- Melatonin Enhances the Anti-Tumor Effect of Fisetin by Inhibiting COX-2/iNOS and NF-κB/p300 Signaling Pathways
- (2014) Canhui Yi et al. PLoS One
- Effect of Cnidii Rhizoma on nitric oxide production and invasion of human colorectal adenocarcinoma HT-29 cells
- (2014) KYUNG-SOO NAM et al. Oncology Letters
- MYC Degradation
- (2014) A. S. Farrell et al. Cold Spring Harbor Perspectives in Medicine
- MYC and the Control of DNA Replication
- (2014) D. Dominguez-Sola et al. Cold Spring Harbor Perspectives in Medicine
- Melatonin-induced methylation of the ABCG2/BCRP promoter as a novel mechanism to overcome multidrug resistance in brain tumour stem cells
- (2013) V Martín et al. BRITISH JOURNAL OF CANCER
- Inhibition of VEGF expression through blockade of Hif1α and STAT3 signalling mediates the anti-angiogenic effect of melatonin in HepG2 liver cancer cells
- (2013) S Carbajo-Pescador et al. BRITISH JOURNAL OF CANCER
- X-Inactivation, Imprinting, and Long Noncoding RNAs in Health and Disease
- (2013) Jeannie T. Lee et al. CELL
- Long Noncoding RNAs: Cellular Address Codes in Development and Disease
- (2013) Pedro J. Batista et al. CELL
- Light at night and melatonin have opposite effects on breast cancer tumors in mice assessed by growth rates and global DNA methylation
- (2013) Hagit Schwimmer et al. CHRONOBIOLOGY INTERNATIONAL
- Melatonin Suppresses the Expression of 45S Preribosomal RNA and Upstream Binding Factor and Enhances the Antitumor Activity of Puromycin in MDA-MB-231 Breast Cancer Cells
- (2013) Ji Hoon Jung et al. Evidence-based Complementary and Alternative Medicine
- Melatonin antagonizes hypoxia-mediated glioblastoma cell migration and invasion via inhibition of HIF-1α
- (2013) Yanmin Zhang et al. JOURNAL OF PINEAL RESEARCH
- The complexity of NF-κB signaling in inflammation and cancer
- (2013) Bastian Hoesel et al. Molecular Cancer
- Differential effects of arsenic trioxide on chemosensitization in human hepatic tumor and stellate cell lines
- (2012) Fatima Rangwala et al. BMC CANCER
- KrasG12D-Induced IKK2/β/NF-κB Activation by IL-1α and p62 Feedforward Loops Is Required for Development of Pancreatic Ductal Adenocarcinoma
- (2012) Jianhua Ling et al. CANCER CELL
- Direct Short-Term Cytotoxic Effects of BIBR 1532 on Acute Promyelocytic Leukemia Cells Through Induction of p21 Coupled with Downregulation of c-Myc and hTERT Transcription
- (2012) D. Bashash et al. CANCER INVESTIGATION
- Small heat shock proteins HSP27 (HspB1), αB-crystallin (HspB5) and HSP22 (HspB8) as regulators of cell death
- (2012) Julie Acunzo et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- Simultaneous modulation of COX-2, p300, Akt, and Apaf-1 signaling by melatonin to inhibit proliferation and induce apoptosis in breast cancer cells
- (2012) Jingshu Wang et al. JOURNAL OF PINEAL RESEARCH
- Mitochondria and chloroplasts as the original sites of melatonin synthesis: a hypothesis related to melatonin's primary function and evolution in eukaryotes
- (2012) Dun-Xian Tan et al. JOURNAL OF PINEAL RESEARCH
- Genome-wide profiling in melatonin-exposed human breast cancer cell lines identifies differentially methylated genes involved in the anticancer effect of melatonin
- (2012) Seung Eun Lee et al. JOURNAL OF PINEAL RESEARCH
- Homologous recombination and its regulation
- (2012) L. Krejci et al. NUCLEIC ACIDS RESEARCH
- Suppression of heat shock protein 27 induces long-term dormancy in human breast cancer
- (2012) O. Straume et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- An Alternate Perspective on the Roles of TIMPs and MMPs in Pathology
- (2011) Craig S. Moore et al. AMERICAN JOURNAL OF PATHOLOGY
- Hallmarks of Cancer: The Next Generation
- (2011) Douglas Hanahan et al. CELL
- Overexpression of osteopontin and integrin αv in laryngeal and hypopharyngeal carcinomas associated with differentiation and metastasis
- (2011) Jian Guang Lu et al. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
- Melatonin synergistically enhances cisplatin-induced apoptosis via the dephosphorylation of ERK/p90 ribosomal S6 kinase/heat shock protein 27 in SK-OV-3 cells
- (2011) Ji-Hyun Kim et al. JOURNAL OF PINEAL RESEARCH
- Sphingosine kinase 1 pathway is involved in melatonin-induced HIF-1α inactivation in hypoxic PC-3 prostate cancer cells
- (2011) Sung-Yun Cho et al. JOURNAL OF PINEAL RESEARCH
- A survey of molecular details in the human pineal gland in the light of phylogeny, structure, function and chronobiological diseases
- (2011) Jörg H. Stehle et al. JOURNAL OF PINEAL RESEARCH
- Melatonin as a natural ally against oxidative stress: a physicochemical examination
- (2011) Annia Galano et al. JOURNAL OF PINEAL RESEARCH
- Extrapineal melatonin: analysis of its subcellular distribution and daily fluctuations
- (2011) Carmen Venegas et al. JOURNAL OF PINEAL RESEARCH
- Proteasome inhibitors in cancer therapy
- (2011) Lisa J. Crawford et al. Journal of Cell Communication and Signaling
- Targeting heat shock proteins in cancer
- (2010) Gaëtan Jego et al. CANCER LETTERS
- Myc-Nick: A Cytoplasmic Cleavage Product of Myc that Promotes α-Tubulin Acetylation and Cell Differentiation
- (2010) Maralice Conacci-Sorrell et al. CELL
- The Tight Junction Protein, Occludin, Regulates the Directional Migration of Epithelial Cells
- (2010) Dan Du et al. DEVELOPMENTAL CELL
- Signal transduction of receptor-mediated antiproliferative action of melatonin on human prostate epithelial cells involves dual activation of Gαs and Gαq proteins
- (2010) Stephen Y. W. Shiu et al. JOURNAL OF PINEAL RESEARCH
- Melatonin, cardiolipin and mitochondrial bioenergetics in health and disease
- (2010) Giuseppe Paradies et al. JOURNAL OF PINEAL RESEARCH
- Matrix metalloproteinases in health and disease: regulation by melatonin
- (2010) Snehasikta Swarnakar et al. JOURNAL OF PINEAL RESEARCH
- Melatonin suppresses tumor angiogenesis by inhibiting HIF-1α stabilization under hypoxia
- (2010) Shi-Young Park et al. JOURNAL OF PINEAL RESEARCH
- The landscape of somatic copy-number alteration across human cancers
- (2010) Rameen Beroukhim et al. NATURE
- Significance and application of melatonin in the regulation of brown adipose tissue metabolism: relation to human obesity
- (2010) D.-X. Tan et al. Obesity Reviews
- Melatonin inhibits mitogenic cross-talk between retinoic acid-related orphan receptor alpha (RORα) and ERα in MCF-7 human breast cancer cells
- (2010) Chunmin Dong et al. STEROIDS
- Ablation of Key Oncogenic Pathways by RITA-Reactivated p53 Is Required for Efficient Apoptosis
- (2009) Vera V. Grinkevich et al. CANCER CELL
- Melatonin sensitizes human malignant glioma cells against TRAIL-induced cell death
- (2009) Vanesa Martín et al. CANCER LETTERS
- Reducing oxidative/nitrosative stress: a newly-discovered genre for melatonin
- (2009) Russel J. Reiter et al. CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY
- Molecular Mechanisms of Melatonin Anticancer Effects
- (2009) Steven M. Hill et al. INTEGRATIVE CANCER THERAPIES
- Nuclear cyclin D1: An oncogenic driver in human cancer
- (2009) Jong Kyong Kim et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Membrane-bound melatonin receptor MT1 down-regulates estrogen responsive genes in breast cancer cells
- (2009) Rainer Girgert et al. JOURNAL OF PINEAL RESEARCH
- Melatonin induces apoptotic death in LNCaP cells via p38 and JNK pathways: therapeutic implications for prostate cancer
- (2009) Seong Soo Joo et al. JOURNAL OF PINEAL RESEARCH
- Role of NF-κB in thyroid cancer
- (2009) Francesco Pacifico et al. MOLECULAR AND CELLULAR ENDOCRINOLOGY
- Role of melatonin in the epigenetic regulation of breast cancer
- (2008) Ahmet Korkmaz et al. BREAST CANCER RESEARCH AND TREATMENT
- Epigenetic repression of the estrogen-regulated Homeobox B13 gene in breast cancer
- (2008) Benjamin A.T. Rodriguez et al. CARCINOGENESIS
- NF-κB and epithelial to mesenchymal transition of cancer
- (2008) Chengyin Min et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- Refractory Thyroid Cancer: A Paradigm Shift in Treatment Is Not Far Off
- (2008) David G. Pfister et al. JOURNAL OF CLINICAL ONCOLOGY
- The antiproliferative activity of melatonin in B65 rat dopaminergic neuroblastoma cells is related to the downregulation of cell cycle-related genes
- (2008) Javier G. Pizarro et al. JOURNAL OF PINEAL RESEARCH
- ROCK-regulated cytoskeletal dynamics participate in the inhibitory effect of melatonin on cancer cell migration
- (2008) Leonardo Ortíz-López et al. JOURNAL OF PINEAL RESEARCH
- Inhibition of benzopyrene-diol-epoxide (BPDE)-induced bax and caspase-9 by cadmium: Role of mitogen activated protein kinase
- (2008) Jagat J. Mukherjee et al. MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
- c-Myc Is Required for Maintenance of Glioma Cancer Stem Cells
- (2008) Jialiang Wang et al. PLoS One
- Physiological effects of melatonin: Role of melatonin receptors and signal transduction pathways
- (2008) S PANDIPERUMAL et al. PROGRESS IN NEUROBIOLOGY
- An epigenetic disorder may cause aberrant expression of aromatase gene in endometriotic stromal cells
- (2007) Masao Izawa et al. FERTILITY AND STERILITY
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started