Melatonin inhibits Warburg-dependent cancer by redirecting glucose oxidation to the mitochondria: a mechanistic hypothesis
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Title
Melatonin inhibits Warburg-dependent cancer by redirecting glucose oxidation to the mitochondria: a mechanistic hypothesis
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Journal
CELLULAR AND MOLECULAR LIFE SCIENCES
Volume -, Issue -, Pages -
Publisher
Springer Science and Business Media LLC
Online
2020-01-23
DOI
10.1007/s00018-019-03438-1
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Note: Only part of the references are listed.- Inhibition of TFEB oligomerization by co-treatment of melatonin with vorinostat promotes the therapeutic sensitivity in glioblastoma and glioma stem cells
- (2019) Gi-Jun Sung et al. JOURNAL OF PINEAL RESEARCH
- The role of melatonin in targeting cell signaling pathways in neurodegeneration
- (2019) Mayuri Shukla et al. Annals of the New York Academy of Sciences
- Parkin recruitment to impaired mitochondria for nonselective ubiquitylation is facilitated by MITOL
- (2019) Fumika Koyano et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The potential utility of melatonin in the treatment of childhood cancer
- (2019) Yu‐Hua Chao et al. JOURNAL OF CELLULAR PHYSIOLOGY
- The emergence of melatonin in oncology: Focus on colorectal cancer
- (2019) Emilio Gil‐Martín et al. MEDICINAL RESEARCH REVIEWS
- Melatonin Synthesis and Function: Evolutionary History in Animals and Plants
- (2019) Dake Zhao et al. Frontiers in Endocrinology
- Repercussions of melatonin on the risk of breast cancer: a systematic review and meta-analysis
- (2019) Eduardo Carvalho de Arruda Veiga et al. Revista da Associacao Medica Brasileira
- The Warburg Effect, Lactate, and Nearly a Century of Trying to Cure Cancer
- (2019) Netanya Y. Spencer et al. SEMINARS IN NEPHROLOGY
- Inhibition of SGK1 confers vulnerability to redox dysregulation in cervical cancer
- (2019) Min Wang et al. Redox Biology
- Metabolic Plasticity and Epithelial-Mesenchymal Transition
- (2019) Timothy M. Thomson et al. Journal of Clinical Medicine
- Metabolic Regulation of Redox Balance in Cancer
- (2019) Vinee Purohit et al. Cancers
- Melatonin Promotes Apoptosis of Oxaliplatin-resistant Colorectal Cancer Cells Through Inhibition of Cellular Prion Protein
- (2018) ANTICANCER RESEARCH
- Biological effects of melatonin on osteoblast/osteoclast cocultures, bone, and quality of life: Implications of a role for MT2 melatonin receptors, MEK1/2, and MEK5 in melatonin-mediated osteoblastogenesis
- (2018) Sifat Maria et al. JOURNAL OF PINEAL RESEARCH
- Melatonin and its metabolites vs oxidative stress: From individual actions to collective protection
- (2018) Annia Galano et al. JOURNAL OF PINEAL RESEARCH
- Does the use of melatonin overcome drug resistance in cancer chemotherapy?
- (2018) Mohammad Hossein Asghari et al. LIFE SCIENCES
- Suppression of Melatonin Secretion in Totally Visually Blind People by Ocular Exposure to White Light
- (2018) Joseph T. Hull et al. OPHTHALMOLOGY
- Shift Work and Cancer
- (2018) Thomas C. Erren et al. Deutsches Arzteblatt International
- MELATONIN AS A HORMONE: NEW PHYSIOLOGICAL AND CLINICAL INSIGHTS
- (2018) José Cipolla-Neto et al. ENDOCRINE REVIEWS
- The protective role of melatonin in chemotherapy‐induced nephrotoxicity: a systematic review of non-clinical studies
- (2018) Hamed Haghi-Aminjan et al. Expert Opinion on Drug Metabolism & Toxicology
- Melatonin Mitigates Mitochondrial Meltdown: Interactions with SIRT3
- (2018) Russel Reiter et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Mitochondrial functions and melatonin: a tour of the reproductive cancers
- (2018) Luiz Gustavo de Almeida Chuffa et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Hypothesis: ubiquitous circadian disruption can cause cancer
- (2018) Thomas C. Erren et al. EUROPEAN JOURNAL OF EPIDEMIOLOGY
- Melatonin Sensitizes Human Colorectal Cancer Cells to γ-ray Ionizing Radiation In Vitro and In Vivo
- (2018) Qin Wang et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Disruption of sleep, sleep-wake activity rhythm, and nocturnal melatonin production in breast cancer patients undergoing adjuvant chemotherapy: prospective cohort study
- (2018) Wentao Li et al. SLEEP MEDICINE
- Relationships of salivary cortisol and melatonin rhythms to sleep quality, emotion, and fatigue levels in patients with newly diagnosed lung cancer
- (2017) Wen-Pei Chang et al. European Journal of Oncology Nursing
- Melatonin, a Full Service Anti-Cancer Agent: Inhibition of Initiation, Progression and Metastasis
- (2017) Russel Reiter et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Melatonin Decreases Glucose Metabolism in Prostate Cancer Cells: A 13C Stable Isotope-Resolved Metabolomic Study
- (2017) David Hevia et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Effect of Melatonin Supplementation on Antioxidant Status and DNA Damage in High Intensity Trained Athletes
- (2017) Manuel Ortiz-Franco et al. INTERNATIONAL JOURNAL OF SPORTS MEDICINE
- Involvement of the Warburg effect in non-tumor diseases processes
- (2017) Zhe Chen et al. JOURNAL OF CELLULAR PHYSIOLOGY
- The role of melatonin on chemotherapy-induced reproductive toxicity
- (2017) Hamed Haghi-Aminjan et al. JOURNAL OF PHARMACY AND PHARMACOLOGY
- Human transporters, PEPT1/2, facilitate melatonin transportation into mitochondria of cancer cells: An implication of the therapeutic potential
- (2017) Xiaokui Huo et al. JOURNAL OF PINEAL RESEARCH
- Melatonin protects against maternal obesity-associated oxidative stress and meiotic defects in oocytes via the SIRT3-SOD2-dependent pathway
- (2017) Longsen Han et al. JOURNAL OF PINEAL RESEARCH
- Melatonin regulates lipid metabolism in porcine oocytes
- (2017) Jun-Xue Jin et al. JOURNAL OF PINEAL RESEARCH
- Efficacy and Safety of Pediatric Prolonged-Release Melatonin for Insomnia in Children With Autism Spectrum Disorder
- (2017) Paul Gringras et al. JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
- Therapeutic Targeting of the Pyruvate Dehydrogenase Complex/Pyruvate Dehydrogenase Kinase (PDC/PDK) Axis in Cancer
- (2017) Peter W Stacpoole JNCI-Journal of the National Cancer Institute
- A review of sleep disorders and melatonin
- (2017) Zizhen Xie et al. NEUROLOGICAL RESEARCH
- Therapeutic applications of dichloroacetate and the role of glutathione transferase zeta-1
- (2017) Margaret O. James et al. PHARMACOLOGY & THERAPEUTICS
- Dual role of mitochondria in producing melatonin and driving GPCR signaling to block cytochrome c release
- (2017) Yalikun Suofu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Dichloroacetate induces protective autophagy in esophageal squamous carcinoma cells
- (2017) Hong-Yu Jia et al. Oncology Letters
- Fatty acid metabolism in breast cancer subtypes
- (2017) Marie E. Monaco Oncotarget
- Melatonin enhances sorafenib actions in human hepatocarcinoma cells by inhibiting mTORC1/p70S6K/HIF-1α and hypoxia-mediated mitophagy
- (2017) Néstor Prieto-Domínguez et al. Oncotarget
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- Therapeutic Targeting of the Pyruvate Dehydrogenase Complex/Pyruvate Dehydrogenase Kinase (PDC/PDK) Axis in Cancer
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- (2016) Jiabei Liu et al. Annual Review of Pharmacology and Toxicology
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- (2016) Ralf Jockers et al. BRITISH JOURNAL OF PHARMACOLOGY
- Melatonin as an antioxidant: under promises but over delivers
- (2016) Russel J. Reiter et al. JOURNAL OF PINEAL RESEARCH
- Physiological melatonin levels in healthy older people: A systematic review
- (2016) Rikie M. Scholtens et al. JOURNAL OF PSYCHOSOMATIC RESEARCH
- Cancer heterogeneity is not compatible with one unique cancer cell metabolic map
- (2016) A Strickaert et al. ONCOGENE
- The key role of the sequential proton loss electron transfer mechanism on the free radical scavenging activity of some melatonin-related compounds
- (2016) Ruslán Álvarez-Diduk et al. THEORETICAL CHEMISTRY ACCOUNTS
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- (2016) Zhiqiang Ma et al. Oncotarget
- Melatonin Prevents Mitochondrial Damage Induced by Doxorubicin in Mouse Fibroblasts Through Ampk-Ppar Gamma-Dependent Mechanisms
- (2016) Celal Guven et al. MEDICAL SCIENCE MONITOR
- Mitochondrial diseases
- (2016) Gráinne S. Gorman et al. Nature Reviews Disease Primers
- Reprogramming of glucose, fatty acid and amino acid metabolism for cancer progression
- (2015) Zhaoyong Li et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- The Safety of Melatonin in Humans
- (2015) Lars Peter Holst Andersen et al. CLINICAL DRUG INVESTIGATION
- Restoration of mitochondria function as a target for cancer therapy
- (2015) Tariq A. Bhat et al. DRUG DISCOVERY TODAY
- Melatonin: an inhibitor of breast cancer
- (2015) S. M. Hill et al. ENDOCRINE-RELATED CANCER
- Quinone reductase 2 as a promising target of melatonin therapeutic actions
- (2015) Jean A Boutin EXPERT OPINION ON THERAPEUTIC TARGETS
- The pyruvate dehydrogenase complex in cancer: An old metabolic gatekeeper regulated by new pathways and pharmacological agents
- (2015) Elise Saunier et al. INTERNATIONAL JOURNAL OF CANCER
- A phase I open-labeled, single-arm, dose-escalation, study of dichloroacetate (DCA) in patients with advanced solid tumors
- (2015) Quincy Siu-Chung Chu et al. INVESTIGATIONAL NEW DRUGS
- Melatonin suppression of aerobic glycolysis (Warburg effect), survival signalling and metastasis in human leiomyosarcoma
- (2015) Lulu Mao et al. JOURNAL OF PINEAL RESEARCH
- Doxorubicin resistance in breast cancer is driven by light at night-induced disruption of the circadian melatonin signal
- (2015) Shulin Xiang et al. JOURNAL OF PINEAL RESEARCH
- Short-wavelength enrichment of polychromatic light enhances human melatonin suppression potency
- (2015) George C. Brainard et al. JOURNAL OF PINEAL RESEARCH
- Melatonin: an ancient molecule that makes oxygen metabolically tolerable
- (2015) Lucien C. Manchester et al. JOURNAL OF PINEAL RESEARCH
- Electric light, particularly at night, disrupts human circadian rhythmicity: is that a problem?
- (2015) R. G. Stevens et al. PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
- The Role of Reactive Oxygen Species in Mesenchymal Stem Cell Adipogenic and Osteogenic Differentiation: A Review
- (2015) Fatemeh Atashi et al. STEM CELLS AND DEVELOPMENT
- The effect of melatonin on sleep and quality of life in patients with advanced breast cancer
- (2015) Pasquale F. Innominato et al. SUPPORTIVE CARE IN CANCER
- Inhibition of the pentose phosphate pathway by dichloroacetate unravels a missing link between aerobic glycolysis and cancer cell proliferation
- (2015) Géraldine De Preter et al. Oncotarget
- Warburg Effect or Reverse Warburg Effect? A Review of Cancer Metabolism
- (2015) Xiao Dong Xu et al. Oncology Research and Treatment
- Reactive oxygen species and mitochondria: A nexus of cellular homeostasis
- (2015) Joe Dan Dunn et al. Redox Biology
- HIF-1α pathway: role, regulation and intervention for cancer therapy
- (2015) Georgina N. Masoud et al. Acta Pharmaceutica Sinica B
- Melatonin Cytotoxicity Is Associated to Warburg Effect Inhibition in Ewing Sarcoma Cells
- (2015) Ana M. Sanchez-Sanchez et al. PLoS One
- Mitochondrial dysfunction in cancer chemoresistance
- (2014) Nicoletta Guaragnella et al. BIOCHEMICAL PHARMACOLOGY
- Dichloroacetate and cancer: New home for an orphan drug?
- (2014) Shyam Kankotia et al. BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
- Circadian and Melatonin Disruption by Exposure to Light at Night Drives Intrinsic Resistance to Tamoxifen Therapy in Breast Cancer
- (2014) R. T. Dauchy et al. CANCER RESEARCH
- Mitochondrial catastrophe during doxorubicin-induced cardiotoxicity: a review of the protective role of melatonin
- (2014) Jenelle Govender et al. JOURNAL OF PINEAL RESEARCH
- Melatonin: a well-documented antioxidant with conditional pro-oxidant actions
- (2014) Hong-Mei Zhang et al. JOURNAL OF PINEAL RESEARCH
- Combination of Taxol® and dichloroacetate results in synergistically inhibitory effects on Taxol-resistant oral cancer cells under hypoxia
- (2014) QI XIE et al. Molecular Medicine Reports
- Dichloroacetate Enhances Adriamycin-Induced Hepatoma Cell Toxicity In Vitro and In Vivo by Increasing Reactive Oxygen Species Levels
- (2014) Yunhai Dai et al. PLoS One
- Light Exposure at Night Disrupts Host/Cancer Circadian Regulatory Dynamics: Impact on the Warburg Effect, Lipid Signaling and Tumor Growth Prevention
- (2014) David E. Blask et al. PLoS One
- Antioxidants that protect mitochondria reduce interleukin-6 and oxidative stress, improve mitochondrial function, and reduce biochemical markers of organ dysfunction in a rat model of acute sepsis
- (2013) D.A. Lowes et al. BRITISH JOURNAL OF ANAESTHESIA
- Proliferation-Independent Control of Tumor Glycolysis by PDGFR-Mediated AKT Activation
- (2013) C. Ran et al. CANCER RESEARCH
- Cellular Fatty Acid Metabolism and Cancer
- (2013) Erin Currie et al. Cell Metabolism
- Melatonin antagonizes hypoxia-mediated glioblastoma cell migration and invasion via inhibition of HIF-1α
- (2013) Yanmin Zhang et al. JOURNAL OF PINEAL RESEARCH
- Melatonin and the theories of aging: a critical appraisal of melatonin's role in antiaging mechanisms
- (2013) Rüdiger Hardeland JOURNAL OF PINEAL RESEARCH
- Targeting cellular metabolism to improve cancer therapeutics
- (2013) Y Zhao et al. Cell Death & Disease
- Activating oxidative phosphorylation by a pyruvate dehydrogenase kinase inhibitor overcomes sorafenib resistance of hepatocellular carcinoma
- (2012) Y-C Shen et al. BRITISH JOURNAL OF CANCER
- Melatonin-mitochondria Interplay in Health and Disease
- (2012) Dario Acuna Castroviejo et al. CURRENT TOPICS IN MEDICINAL CHEMISTRY
- Melatonin uses in oncology: breast cancer prevention and reduction of the side effects of chemotherapy and radiation
- (2012) Emilio J Sanchez-Barcelo et al. EXPERT OPINION ON INVESTIGATIONAL DRUGS
- Mitochondria and chloroplasts as the original sites of melatonin synthesis: a hypothesis related to melatonin's primary function and evolution in eukaryotes
- (2012) Dun-Xian Tan et al. JOURNAL OF PINEAL RESEARCH
- Melatonin suppresses tumor progression by reducing angiogenesis stimulated by HIF-1 in a mouse tumor model
- (2012) Kil-Jung Kim et al. JOURNAL OF PINEAL RESEARCH
- Work at night and breast cancer – report on evidence-based options for preventive actions
- (2012) Jens Peter Bonde et al. SCANDINAVIAN JOURNAL OF WORK ENVIRONMENT & HEALTH
- The Melatonin MT1 Receptor Axis Modulates Mutant Huntingtin-Mediated Toxicity
- (2011) X. Wang et al. JOURNAL OF NEUROSCIENCE
- Extrapineal melatonin: analysis of its subcellular distribution and daily fluctuations
- (2011) Carmen Venegas et al. JOURNAL OF PINEAL RESEARCH
- SirT3 suppresses hypoxia inducible factor 1α and tumor growth by inhibiting mitochondrial ROS production
- (2011) E L Bell et al. ONCOGENE
- Dichloroacetate induces apoptosis and cell-cycle arrest in colorectal cancer cells
- (2010) B M Madhok et al. BRITISH JOURNAL OF CANCER
- SIRT3 Is a Mitochondria-Localized Tumor Suppressor Required for Maintenance of Mitochondrial Integrity and Metabolism during Stress
- (2010) Hyun-Seok Kim et al. CANCER CELL
- Neurotoxins: Free Radical Mechanisms and Melatonin Protection
- (2010) Russel J. Reiter et al. Current Neuropharmacology
- The Dichloroacetate Dilemma: Environmental Hazard versus Therapeutic Goldmine—Both or Neither?
- (2010) Peter W. Stacpoole ENVIRONMENTAL HEALTH PERSPECTIVES
- Dichloroacetate shifts the metabolism from glycolysis to glucose oxidation and exhibits synergistic growth inhibition with cisplatin in HeLa cells
- (2010) Fang INTERNATIONAL JOURNAL OF ONCOLOGY
- Melatonin induces pro-apoptotic signaling pathway in human pancreatic carcinoma cells (PANC-1)
- (2010) Anna Leja-Szpak et al. JOURNAL OF PINEAL RESEARCH
- Sirtuin regulation of mitochondria: energy production, apoptosis, and signaling
- (2010) Eric Verdin et al. TRENDS IN BIOCHEMICAL SCIENCES
- Reversal of the glycolytic phenotype by dichloroacetate inhibits metastatic breast cancer cell growth in vitro and in vivo
- (2009) Ramon C. Sun et al. BREAST CANCER RESEARCH AND TREATMENT
- Kynuramines, metabolites of melatonin and other indoles: the resurrection of an almost forgotten class of biogenic amines
- (2009) Rüdiger Hardeland et al. JOURNAL OF PINEAL RESEARCH
- Role of melatonin in the epigenetic regulation of breast cancer
- (2008) Ahmet Korkmaz et al. BREAST CANCER RESEARCH AND TREATMENT
- Dichloroacetate (DCA) as a potential metabolic-targeting therapy for cancer
- (2008) E D Michelakis et al. BRITISH JOURNAL OF CANCER
- Tumor Cell Metabolism: Cancer's Achilles' Heel
- (2008) Guido Kroemer et al. CANCER CELL
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