Melatonin and 5-fluorouracil co-suppress colon cancer stem cells by regulating cellular prion protein-Oct4 axis

Cellular Prion Protein Enhances Drug Resistance of Colorectal Cancer Cells via Regulation of a Survival Signal Pathway

(2018) Jun Hee Lee et al.   Biomolecules & Therapeutics

Role of HSPA1L as a cellular prion protein stabilizer in tumor progression via HIF-1α/GP78 axis

(2017) J H Lee et al.   ONCOGENE

Engagement of cellular prion protein with the co-chaperone Hsp70/90 organizing protein regulates the proliferation of glioblastoma stem-like cells

(2017) Rebeca Piatniczka Iglesia et al.   Stem Cell Research & Therapy

Cancer metastasis: Mechanisms of inhibition by melatonin

(2016) Shih-Chi Su et al.   JOURNAL OF PINEAL RESEARCH

The emerging roles of Oct4 in tumor-initiating cells

(2015) Ying-Jie Wang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

The role of heat shock proteins in cancer

(2015) Georgios D. Lianos et al.   CANCER LETTERS

Melatonin potentiates cisplatin-induced apoptosis and cell cycle arrest in human lung adenocarcinoma cells

(2015) P. Plaimee et al.   CELL PROLIFERATION

Coexpression of gene Oct4 and Nanog initiates stem cell characteristics in hepatocellular carcinoma and promotes epithelial-mesenchymal transition through activation of Stat3/Snail signaling

(2015) Xin Yin et al.   Journal of Hematology & Oncology

Apoptosis, autophagy, necroptosis, and cancer metastasis

(2015) Zhenyi Su et al.   Molecular Cancer

Effects of ghrelin, leptin and melatonin on the levels of reactive oxygen species, antioxidant enzyme activity and viability of the HCT 116 human colorectal carcinoma cell line

(2015) RAFAŁ JAKUB BUŁDAK et al.   Molecular Medicine Reports

Targeting prion protein interactions in cancer

(2015) Tiago G Santos et al.   Prion

Evolution of the Cancer Stem Cell Model

(2014) Antonija Kreso et al.   Cell Stem Cell

Melatonin treatment induces interplay of apoptosis, autophagy, and senescence in human colorectal cancer cells

(2014) Yunkyung Hong et al.   JOURNAL OF PINEAL RESEARCH

Melatonin reduces endothelin-1 expression and secretion in colon cancer cells through the inactivation of FoxO-1 and NF-κβ

(2014) Josefa León et al.   JOURNAL OF PINEAL RESEARCH

Protective effects of melatonin in reducing oxidative stress and in preserving the fluidity of biological membranes: a review

(2014) Joaquín J. García et al.   JOURNAL OF PINEAL RESEARCH

Self-consumption: the interplay of autophagy and apoptosis

(2014) Guillermo Mariño et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Disruption of prion protein–HOP engagement impairs glioblastoma growth and cognitive decline and improves overall survival

(2014) M H Lopes et al.   ONCOGENE

Oct-4 is required for an antiapoptotic behavior of chemoresistant colorectal cancer cells enriched for cancer stem cells: Effects associated with STAT3/Survivin

(2013) Kunming Wen et al.   CANCER LETTERS

CD44-Positive Cancer Stem Cells Expressing Cellular Prion Protein Contribute to Metastatic Capacity in Colorectal Cancer

(2013) L. Du et al.   CANCER RESEARCH

A microRNA miR-34a-Regulated Bimodal Switch Targets Notch in Colon Cancer Stem Cells

(2013) Pengcheng Bu et al.   Cell Stem Cell

Cancer incidence and mortality patterns in Europe: Estimates for 40 countries in 2012

(2013) J. Ferlay et al.   EUROPEAN JOURNAL OF CANCER

CD44/Cellular prion protein interact in multidrug resistant breast cancer cells and correlate with responses to neoadjuvant chemotherapy in breast cancer patients

(2013) Yuanyuan Cheng et al.   MOLECULAR CARCINOGENESIS

A unique Oct4 interface is crucial for reprogramming to pluripotency

(2013) Daniel Esch et al.   NATURE CELL BIOLOGY

Rottlerin induces autophagy which leads to apoptotic cell death through inhibition of PI3K/Akt/mTOR pathway in human pancreatic cancer stem cells

(2012) Brahma N. Singh et al.   BIOCHEMICAL PHARMACOLOGY

Autophagosomal Membrane Serves as Platform for Intracellular Death-inducing Signaling Complex (iDISC)-mediated Caspase-8 Activation and Apoptosis

(2012) Megan M. Young et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Melatonin suppresses tumor progression by reducing angiogenesis stimulated by HIF-1 in a mouse tumor model

(2012) Kil-Jung Kim et al.   JOURNAL OF PINEAL RESEARCH

Reciprocal Regulation of Akt and Oct4 Promotes the Self-Renewal and Survival of Embryonal Carcinoma Cells

(2012) Yuanji Lin et al.   MOLECULAR CELL

Cellular prion protein accelerates colorectal cancer metastasis via the Fyn-SP1-SATB1 axis

(2012) QIANWEI WANG et al.   ONCOLOGY REPORTS

OCT4 regulates epithelial-mesenchymal transition and its knockdown inhibits colorectal cancer cell migration and invasion

(2012) XINZHENG DAI et al.   ONCOLOGY REPORTS

Allosteric function and dysfunction of the prion protein

(2011) Rafael Linden et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Cell surface proteomics identifies glucose transporter type 1 and prion protein as candidate biomarkers for colorectal adenoma-to-carcinoma progression

(2011) Meike de Wit et al.   GUT

Cellular prion protein promotes glucose uptake through the Fyn-HIF-2α-Glut1 pathway to support colorectal cancer cell survival

(2010) Qing-Quan Li et al.   CANCER SCIENCE

Expression and knockdown of cellular prion protein (PrPC) in differentiating mouse embryonic stem cells

(2010) Oscar A. Peralta et al.   DIFFERENTIATION

Octamer 4 (Oct4) mediates chemotherapeutic drug resistance in liver cancer cells through a potential Oct4-AKT-ATP-binding cassette G2 pathway

(2010) Xiao Qi Wang et al.   HEPATOLOGY

Synergistic antitumor effect of melatonin with several chemotherapeutic drugs on human Ewing sarcoma cancer cells: potentiation of the extrinsic apoptotic pathway

(2009) Sara Casado-Zapico et al.   JOURNAL OF PINEAL RESEARCH

Octamer 4 Small Interfering RNA Results in Cancer Stem Cell-Like Cell Apoptosis

(2008) T. Hu et al.   CANCER RESEARCH

The role of P-glycoprotein/cellular prion protein interaction in multidrug-resistant breast cancer cells treated with paclitaxel

(2008) Q.-Q. Li et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The role of the thalamus in sleep, pineal melatonin production, and circadian rhythm sleep disorders

(2008) James E. Jan et al.   JOURNAL OF PINEAL RESEARCH