Article
Plant Sciences
Hongbo Li, Juan Wei, Yanglan Liao, Xiaoling Cheng, Shuhong Yang, Xiaohong Zhuang, Zhonghui Zhang, Wenjin Shen, Caiji Gao
Summary: This study reveals a previously unidentified function of plant-specific casein kinase I members in attenuating ABA signaling by regulating the phosphorylation and nuclear accumulation of FREE1.
PLANT CELL AND ENVIRONMENT
(2022)
Article
Chemistry, Applied
Jinyang Cai, Xin Li, Xing Wang, Chengfei Jiang, Dan Shen, Xianwei Cui, Kaipeng Xie, Chenbo Ji, Yan Cao
Summary: In this study, a novel peptide named BCCY-1 corresponding to human beta-casein sequence was identified in human milk, showing immunomodulatory activity by enhancing monocyte migration. BCCY-1 exerts its effects by activating NF-κB and MAPK signaling pathways.
Article
Oncology
Jiecheng Ye, Wanying Deng, Ying Zhong, Hui Liu, Baoyin Guo, Zixi Qin, Peiwen Li, Xueyun Zhong, Lihui Wang
Summary: This study revealed that MELK is highly expressed in ESCC tissues and associated with poor prognosis. Knockdown of MELK inhibits growth and invasive ability of ESCC cells. MELK interacts with IKK to activate the NF-kappa B pathway and induce changes in epithelial-mesenchymal transition-related proteins.
INTERNATIONAL JOURNAL OF ONCOLOGY
(2022)
Article
Oncology
YingYing He, Zhicheng He, Xiaoyu Zhang, Shubai Liu
Summary: The study revealed abnormal overexpression of PAF-AH IB2 in ovarian cancer, and knocking down PAF-AH IB2 significantly inhibited cancer cell proliferation, migration, and tumorigenicity, and increased cell sensitivity to PAF.
CANCER CELL INTERNATIONAL
(2021)
Article
Cell Biology
Helene Hoenigsperger, Lennart Koepke, Dhiraj Acharya, Victoria Hunszinger, Dennis Freisem, Alexander Grenzner, Sebastian Wiese, Frank Kirchhoff, Michaela U. Gack, Konstantin M. J. Sparrer
Summary: This study identifies CSNK2/CK2 as a negative regulator of autophagy, which can limit autophagy by interacting with TRIM family members. CSNK2 inhibits autophagy by phosphorylating TRIM3. This finding is significant for the treatment of diseases and viral infections associated with dysregulated autophagy.
Article
Plant Sciences
Ying Li, Shu-Min Wang, Xing Li, Chang-Jun Lv, Ling-Yun Peng, Xiao-Feng Yu, Ying-Jian Song, Cong-Jie Wang
Summary: This study found that PTE pre-treatment can suppress the inflammatory response of acute lung injury (ALI) induced by LPS and improve the survival rate. Moreover, PTE pre-treatment can exert its effects by regulating the expression of NR4A1.
PHARMACEUTICAL BIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Linna Cao, Yiwei Zhang, Jinxia Mi, Zhanhao Shi, Zhaoqin Fang, Dongwei Jia, Zhiqiang Pan, Peike Peng
Summary: The study found that alpha-Hederin can serve as a potential anti-HCC metastasis drug by inhibiting the PAF/PTAFR pathway and reducing cell migration, invasion, and lung metastasis. Additionally, alpha-Hederin also reduces PAF-induced matrix metalloproteinase-2 expression by inhibiting the activation of STAT3.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Integrative & Complementary Medicine
Abdullah S. Shatoor, Ali Shati, S. Al Humayed, Sultan AL-Qahtani, Mahmoud Alkhateeb
Summary: At a concentration of 200 mg/kg, C. aronia inhibits platelet aggregation by downregulating P2Y12 synthesis and expression, stimulating cAMP levels and p-VASP protein levels, inhibiting THXB2 release and P-selectin protein levels in platelets. It also reduces ROS levels and NF-kappa B activation, which are important signaling pathways for P2Y12 expression. On the other hand, at a concentration of 2,000 mg/kg, C. aronia has opposite effects on platelet aggregation and molecular markers. Co-administration of N-acetylcysteine prevents these alterations and inhibits platelet aggregation.
CHINESE JOURNAL OF INTEGRATIVE MEDICINE
(2021)
Article
Medicine, General & Internal
Jordi Roca-Ferrer, Maria Perez-Gonzalez, Isam Alobid, Valeria Tubita, Mireya Fuentes, Marina Bantula, Rosa Munoz-Cano, Antonio Valero, Inaki Izquierdo, Joaquim Mullol, Jacopo Galli
Summary: This study aimed to assess the role of the Platelet-Activating Factor (PAF)/receptor (PAFR) system in chronic rhinosinusitis with nasal polyps (CRSwNP). The study found that PAFR protein was expressed in nasal mucosa and nasal polyps, and Lyso-PAF concentrations were higher in nasal polyps of asthmatic patients. These findings suggest that the PAF/PAFR system may play a role in CRSwNP pathogenesis.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Fisheries
Tong Zhang, Jiejie Sun, Liyan Wang, Hongsheng Yao, Zhicheng Guo, Wei Wu, Yinan Li, Lingling Wang, Linsheng Song
Summary: CgBCL10, a homologue identified in Pacific oysters, plays a crucial role in regulating the expression of inflammatory cytokines by activating MAPK kinase, and nuclear translocation of NF-KB/Rel and AP-1 to defend against pathogens.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Medicine, Research & Experimental
Runyi Ye, Dongwei Liu, Hongyu Guan, NiJiati AiErken, Zeng Fang, Yawei Shi, Yunjian Zhang, Shenming Wang
Summary: The study showed that upregulation of AHNAK2 in thyroid carcinoma tissues, especially in metastatic ones, is associated with poor prognosis. Knockdown of AHNAK2 inhibited thyroid carcinoma migration, invasion, and metastasis by reducing activation of the NF-kappa B pathway. This provides a novel target for treating metastatic thyroid carcinoma.
Article
Oncology
Jian-Hong Fang, Jie-Ying Chen, Jia-Lin Zheng, Hui-Xian Zeng, Jun-Guang Chen, Chen-Hui Wu, Jia-Li Cai, Zhi-Yong Wang, Shi-Mei Zhuang
Summary: Angiogenesis plays a crucial role in tumor growth and metastasis, and emerging evidence suggests that metabolic reprogramming in endothelial cells can impact angiogenesis. This study identified multiple regulators in the fructose metabolism pathway that were upregulated in tumor endothelial cells from hepatocellular carcinoma (HCC). It was found that dietary fructose enhanced tumor angiogenesis, growth, and metastasis, which could be attenuated by an inhibitor of fructose transporter SLC2A5. Fructose treatment also promoted endothelial cell proliferation, migration, tube formation, and mitochondrial respiration, while inhibiting fructose metabolism significantly abolished fructose-induced tumor angiogenesis.
Article
Biochemistry & Molecular Biology
Danli Yang, Mingjie Yao, Ying Yan, Yanna Liu, Xiajie Wen, Xiangmei Chen, Fengmin Lu
Summary: The study showed that in patients with liver diseases and hepatocellular carcinoma, the expression of GP73 is positively correlated with total bile acid, and deoxycholic acid upregulates the expression and release of GP73 through activating the NF-kappa B pathway and disrupting the Golgi structure.
Review
Biochemistry & Molecular Biology
Tatiana Lopez, Maeva Wendremaire, Jimmy Lagarde, Oriane Duquet, Line Alibert, Brice Paquette, Carmen Garrido, Frederic Lirussi
Summary: This article provides an overview of the pivotal role of oxidative stress in both wound healing and metastasis, with a focus on the contribution of macrophages. Understanding the functions of ROS in wound healing and metastatic spread may lead to the development of innovative therapeutic strategies.
Article
Pharmacology & Pharmacy
Hexu Han, Ting Lin, Zhenyu Wang, Jingjing Song, Ziyi Fang, Jing Zhang, Xiaomin You, Yanping Du, Jun Ye, Guoxiong Zhou
Summary: The study investigated the role of RNA-binding motif 4 (RBM4) in angiogenesis in hepatocellular carcinoma (HCC). It was found that RBM4 expression was correlated with tumor microvessel density and the expression of proangiogenic factor VEGF-A. Mechanistically, RBM4 mediated its effects through the NF-kB signaling pathway. These findings suggest that RBM4 plays a crucial role in promoting angiogenesis in HCC.
PHARMACOLOGICAL RESEARCH
(2023)