The role of interleukin-1 family members in hyperuricemia and gout

Rare genetic variants in interleukin-37 link this anti-inflammatory cytokine to the pathogenesis and treatment of gout

(2020) Viola Klück et al.   ANNALS OF THE RHEUMATIC DISEASES

Soluble Uric Acid Promotes Atherosclerosis via AMPK (AMP-Activated Protein Kinase)-Mediated Inflammation

(2020) Yoshitaka Kimura et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

IL-33 Ameliorates the Development of MSU-Induced Inflammation Through Expanding MDSCs-Like Cells

(2019) Ke Shang et al.   Frontiers in Endocrinology

Interleukin-37 monomer is the active form for reducing innate immunity

(2019) Elan Z. Eisenmesser et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IL-36, IL-37, and IL-38 Cytokines in Skin and Joint Inflammation: A Comprehensive Review of Their Therapeutic Potential

(2019) Marie-Astrid Boutet et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

mTOR inhibition by metformin impacts monosodium urate crystal–induced inflammation and cell death in gout: a prelude to a new add-on therapy?

(2019) Nadia Vazirpanah et al.   ANNALS OF THE RHEUMATIC DISEASES

Sirt1 inhibits gouty arthritis via activating PPARγ

(2019) Juan Wang et al.   CLINICAL RHEUMATOLOGY

Residual inflammatory risk associated with interleukin-18 and interleukin-6 after successful interleukin-1β inhibition with canakinumab: further rationale for the development of targeted anti-cytokine therapies for the treatment of atherothrombosis

(2019) Paul M Ridker et al.   EUROPEAN HEART JOURNAL

Phosphoinositide‐3 kinase gamma regulates caspase‐1 activation and leukocyte recruitment in acute murine gout

(2019) Lívia D. Tavares et al.   JOURNAL OF LEUKOCYTE BIOLOGY

IL-1R3 blockade broadly attenuates the functions of six members of the IL-1 family, revealing their contribution to models of disease

(2019) Jesper Falkesgaard Højen et al.   NATURE IMMUNOLOGY

Short‐term interleukin‐37 treatment improves vascular endothelial function, endurance exercise capacity, and whole‐body glucose metabolism in old mice

(2019) Dov B. Ballak et al.   AGING CELL

Pharmacological Inhibitors of the NLRP3 Inflammasome

(2019) Ayesha Zahid et al.   Frontiers in Immunology

Asymptomatic hyperuricaemia: a silent activator of the innate immune system

(2019) Leo A. B. Joosten et al.   Nature Reviews Rheumatology

The enigmatic role of IL-38 in inflammatory diseases

(2018) Thomas Garraud et al.   CYTOKINE & GROWTH FACTOR REVIEWS

An update on the genetics of hyperuricaemia and gout

(2018) Tanya J. Major et al.   Nature Reviews Rheumatology

Relationship of Interleukin-1β Blockade With Incident Gout and Serum Uric Acid Levels

(2018) Daniel H. Solomon et al.   ANNALS OF INTERNAL MEDICINE

High-mobility group box 1 is responsible for monosodium urate crystal-induced inflammation in human U937 macrophages

(2018) Jung-Yoon Choe et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Expert opinion on emerging urate-lowering therapies

(2018) Lisa K Stamp et al.   EXPERT OPINION ON EMERGING DRUGS

Plasma interleukin-38 in patients with rheumatoid arthritis

(2018) Wang-Dong Xu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

15d-PGJ2-loaded nanocapsules ameliorate experimental gout arthritis by reducing pain and inflammation in a PPAR-gamma-sensitive manner in mice

(2018) Kenji W. Ruiz-Miyazawa et al.   Scientific Reports

Anakinra for the treatment of acute gout flares: a randomized, double-blind, placebo-controlled, active-comparator, non-inferiority trial

(2018) Carly A Janssen et al.   RHEUMATOLOGY

Suppression of inflammation and acquired immunity by IL-37

(2017) Giulio Cavalli et al.   IMMUNOLOGICAL REVIEWS

The family of the interleukin-1 receptors

(2017) Diana Boraschi et al.   IMMUNOLOGICAL REVIEWS

Overview of the IL-1 family in innate inflammation and acquired immunity

(2017) Charles A. Dinarello   IMMUNOLOGICAL REVIEWS

Uric acid priming in human monocytes is driven by the AKT–PRAS40 autophagy pathway

(2017) Tania O. Crişan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IL-33 and ST2 levels in chronic kidney disease: Associations with inflammation, vascular abnormalities, cardiovascular events, and survival

(2017) Ozkan Gungor et al.   PLoS One

The tyrosine kinase inhibitor imatinib mesylate suppresses uric acid crystal-induced acute gouty arthritis in mice

(2017) Laurent L. Reber et al.   PLoS One

2016 updated EULAR evidence-based recommendations for the management of gout

(2016) P Richette et al.   ANNALS OF THE RHEUMATIC DISEASES

Cytokine Profile in Gout: Inflammation Driven by IL-6 and IL-18?

(2016) Nara Gualberto Cavalcanti et al.   IMMUNOLOGICAL INVESTIGATIONS

Potential of IL-33 for Preventing the Kidney Injury via Regulating the Lipid Metabolism in Gout Patients

(2016) Lihua Duan et al.   Journal of Diabetes Research

Alpha-1-anti-trypsin-Fc fusion protein ameliorates gouty arthritis by reducing release and extracellular processing of IL-1β and by the induction of endogenous IL-1Ra

(2015) Leo A B Joosten et al.   ANNALS OF THE RHEUMATIC DISEASES

IL-37 inhibits the production of pro-inflammatory cytokines in MSU crystal-induced inflammatory response

(2015) Mei Zeng et al.   CLINICAL RHEUMATOLOGY

Proteolytic Processing of Interleukin-1 Family Cytokines: Variations on a Common Theme

(2015) Inna S. Afonina et al.   IMMUNITY

Selective interleukin-1 receptor–associated kinase 4 inhibitors for the treatment of autoimmune disorders and lymphoid malignancy

(2015) Priscilla N. Kelly et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Gout Is a Chronic Inflammatory Disease in Which High Levels of Interleukin-8 (CXCL8), Myeloid-Related Protein 8/Myeloid-Related Protein 14 Complex, and an Altered Proteome Are Associated With Diabetes Mellitus and Cardiovascular Disease

(2015) Laura B. E. Kienhorst et al.   Arthritis & Rheumatology

Airway Uric Acid Is a Sensor of Inhaled Protease Allergens and Initiates Type 2 Immune Responses in Respiratory Mucosa

(2014) K. Hara et al.   JOURNAL OF IMMUNOLOGY

Contribution of Mast Cell-Derived Interleukin-1β to Uric Acid Crystal-Induced Acute Arthritis in Mice

(2014) Laurent L. Reber et al.   Arthritis & Rheumatology

Caspase-1 Level in Synovial Fluid Is High in Patients with Spondyloarthropathy but Not in Patients with Gout

(2013) Chang-Nam Son et al.   JOURNAL OF KOREAN MEDICAL SCIENCE

Inflammasome Activators Induce Interleukin-1α Secretion via Distinct Pathways with Differential Requirement for the Protease Function of Caspase-1

(2012) Olaf Groß et al.   IMMUNITY

Prevalence of Contraindications and Prescription of Pharmacologic Therapies for Gout

(2011) Robert T. Keenan et al.   AMERICAN JOURNAL OF MEDICINE

Spontaneous resolution of acute gouty arthritis is associated with rapid induction of the anti-inflammatory factors TGF 1, IL-10 and soluble TNF receptors and the intracellular cytokine negative regulators CIS and SOCS3

(2011) Y.-H. Chen et al.   ANNALS OF THE RHEUMATIC DISEASES

P2Y6 Receptor Signaling Pathway Mediates Inflammatory Responses Induced by Monosodium Urate Crystals

(2011) H. Uratsuji et al.   JOURNAL OF IMMUNOLOGY

IL-1  and IL-1  Recruit Different Myeloid Cells and Promote Different Stages of Sterile Inflammation

(2011) P. Rider et al.   JOURNAL OF IMMUNOLOGY

Hyperalgesia, synovitis and multiple biomarkers of inflammation are suppressed by interleukin 1 inhibition in a novel animal model of gouty arthritis

(2009) R Torres et al.   ANNALS OF THE RHEUMATIC DISEASES

Inflammatory arthritis in caspase 1 gene–deficient mice: Contribution of proteinase 3 to caspase 1–independent production of bioactive interleukin-1β

(2009) Leo A. B. Joosten et al.   ARTHRITIS AND RHEUMATISM

Interleukin-18 Is a Strong Predictor of Cardiovascular Events in Elderly Men With the Metabolic Syndrome: Synergistic effect of inflammation and hyperglycemia

(2008) M. Troseid et al.   DIABETES CARE