IL-1R3 blockade broadly attenuates the functions of six members of the IL-1 family, revealing their contribution to models of disease

Psoriasis pathogenesis and the development of novel targeted immune therapies

(2017) Jason E. Hawkes et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Effect of interleukin-1β inhibition with canakinumab on incident lung cancer in patients with atherosclerosis: exploratory results from a randomised, double-blind, placebo-controlled trial

(2017) Paul M Ridker et al.   LANCET

Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease

(2017) Paul M Ridker et al.   NEW ENGLAND JOURNAL OF MEDICINE

Host and Environmental Factors Influencing Individual Human Cytokine Responses

(2016) Rob ter Horst et al.   CELL

HMGB1, IL-1α, IL-33 and S100 proteins: dual-function alarmins

(2016) Damien Bertheloot et al.   Cellular & Molecular Immunology

Imiquimod Treatment Causes Systemic Disease in Mice Resembling Generalized Pustular Psoriasis in an IL-1 and IL-36 Dependent Manner

(2016) Pilar Alvarez et al.   MEDIATORS OF INFLAMMATION

GWAS of longitudinal amyloid accumulation on18F-florbetapir PET in Alzheimer’s disease implicates microglial activation geneIL1RAP

(2015) Vijay K Ramanan et al.   BRAIN

IMQ-induced skin inflammation in mice is dependent on IL-1R1 and MyD88 signaling but independent of the NLRP3 inflammasome

(2015) Hanitriniaina Rabeony et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Proteolytic Processing of Interleukin-1 Family Cytokines: Variations on a Common Theme

(2015) Inna S. Afonina et al.   IMMUNITY

Human mast cells are major IL-22 producers in patients with psoriasis and atopic dermatitis

(2015) Shunya Mashiko et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Poly(inosinic-cytidylic) Acid–Triggered Exacerbation of Experimental Asthma Depends on IL-17A Produced by NK Cells

(2015) Lars P. Lunding et al.   JOURNAL OF IMMUNOLOGY

MyD88 dependence of beryllium-induced dendritic cell trafficking and CD4+ T-cell priming

(2015) A S McKee et al.   Mucosal Immunology

Hemolysis Exacerbates Hyperfibrinolysis, Whereas Platelolysis Shuts Down Fibrinolysis

(2015) Hunter B. Moore et al.   SHOCK

Current concepts in the diagnosis and management of cytokine release syndrome

(2014) D. W. Lee et al.   BLOOD

IL-33 stimulates CXCL8/IL-8 secretion in goblet cells but not normally differentiated airway cells

(2014) T. Tanabe et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Blockade of IL-33/ST2 ameliorates airway inflammation in a murine model of allergic asthma

(2014) Hea Yon Lee et al.   EXPERIMENTAL LUNG RESEARCH

TLRs to cytokines: Mechanistic insights from the imiquimod mouse model of psoriasis

(2013) Barry Flutter et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The Interleukin-1 Family: Back to the Future

(2013) Cecilia Garlanda et al.   IMMUNITY

Effects of altered FcγR binding on antibody pharmacokinetics in cynomolgus monkeys

(2013) Maya K Leabman et al.   mAbs

First Clinical Description of an Infant With Interleukin-36-Receptor Antagonist Deficiency Successfully Treated With Anakinra

(2013) L. Rossi-Semerano et al.   PEDIATRICS

The interleukin-1 receptor family

(2013) Diana Boraschi et al.   SEMINARS IN IMMUNOLOGY

Eosinophilic Inflammation in Allergic Asthma

(2013) Samantha S. Possa et al.   Frontiers in Pharmacology

Inflammation in Atherosclerosis

(2012) Peter Libby   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Intraperitoneal influx of neutrophils in response to IL-33 is mast cell-dependent

(2012) M. Enoksson et al.   BLOOD

IL-36 in psoriasis

(2012) JE Towne et al.   CURRENT OPINION IN PHARMACOLOGY

Psoriasiform dermatitis is driven by IL-36–mediated DC-keratinocyte crosstalk

(2012) Luigi Tortola et al.   JOURNAL OF CLINICAL INVESTIGATION

IL-33 induces skin inflammation with mast cell and neutrophil activation

(2011) Axel J. Hueber et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Interleukin-36–Receptor Antagonist Deficiency and Generalized Pustular Psoriasis

(2011) Slaheddine Marrakchi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Engagement of fatty acids with toll-like receptor 2 drives interleukin-1β production via the ASC/caspase 1 pathway in monosodium urate monohydrate crystal-induced gouty arthritis

(2010) Leo A. B. Joosten et al.   ARTHRITIS AND RHEUMATISM

Immunity, Inflammation, and Cancer

(2010) Sergei I. Grivennikov et al.   CELL

Averting inflammation by targeting the cytokine environment

(2010) Manfred Kopf et al.   NATURE REVIEWS DRUG DISCOVERY

The safety and side effects of monoclonal antibodies

(2010) Trevor T. Hansel et al.   NATURE REVIEWS DRUG DISCOVERY

Isolation and killing of candidate chronic myeloid leukemia stem cells by antibody targeting of IL-1 receptor accessory protein

(2010) M. Jaras et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanisms of inflammation in gout

(2010) Nathalie Busso et al.   ARTHRITIS RESEARCH & THERAPY

Caspase 1–independent activation of interleukin-1β in neutrophil-predominant inflammation

(2009) Monica Guma et al.   ARTHRITIS AND RHEUMATISM

Increased Expression of IL-33 in Severe Asthma: Evidence of Expression by Airway Smooth Muscle Cells

(2009) D. Prefontaine et al.   JOURNAL OF IMMUNOLOGY