Role of the DDX11 DNA Helicase in Warsaw Breakage Syndrome Etiology

Hit the brakes – a new perspective on the loop extrusion mechanism of cohesin and other SMC complexes

(2021) Avi Matityahu et al.   JOURNAL OF CELL SCIENCE

Genomic integrity and mitochondrial metabolism defects in Warsaw syndrome cells: a comparison with Fanconi anemia

(2021) Roberta Bottega et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Visualising G-quadruplex DNA dynamics in live cells by fluorescence lifetime imaging microscopy

(2021) Peter A. Summers et al.   Nature Communications

The regulation and functions of DNA and RNA G-quadruplexes

(2020) Dhaval Varshney et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Timeless couples G‐quadruplex detection with processing by DDX 11 helicase during DNA replication

(2020) Leticia K Lerner et al.   EMBO JOURNAL

Single-molecule visualization of DNA G-quadruplex formation in live cells

(2020) Marco Di Antonio et al.   Nature Chemistry

Cohesion is established during DNA replication utilising chromosome associated cohesin rings as well as those loaded de novo onto nascent DNAs

(2020) Madhusudhan Srinivasan et al.   eLife

DNA Helicases and Their Roles in Cancer

(2020) Srijita Dhar et al.   DNA REPAIR

Warsaw Breakage Syndrome associated DDX11 helicase resolves G-quadruplex structures to support sister chromatid cohesion

(2020) Janne J. M. van Schie et al.   Nature Communications

G-Quadruplex loops regulate PARP-1 enzymatic activation

(2020) Andrea D Edwards et al.   NUCLEIC ACIDS RESEARCH

Replication of G Quadruplex DNA

(2019) Leticia Koch Lerner et al.   Genes

DNA loop extrusion by human cohesin

(2019) Iain F. Davidson et al.   SCIENCE

Human cohesin compacts DNA by loop extrusion

(2019) Yoori Kim et al.   SCIENCE

Organization of Chromosomal DNA by SMC Complexes

(2019) Stanislau Yatskevich et al.   Annual Review of Genetics

Establishment of DNA-DNA Interactions by the Cohesin Ring

(2018) Yasuto Murayama et al.   CELL

MCM2–7-dependent cohesin loading during S phase promotes sister-chromatid cohesion

(2018) Ge Zheng et al.   eLife

Warsaw breakage syndrome: Further clinical and genetic delineation

(2018) Ebba Alkhunaizi et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Translation deregulation in human disease

(2018) Soroush Tahmasebi et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Warsaw breakage syndrome DDX11 helicase acts jointly with RAD17 in the repair of bulky lesions and replication through abasic sites

(2018) Takuya Abe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Keeping ribosomal DNA intact: a repeating challenge

(2018) Daniël O. Warmerdam et al.   CHROMOSOME RESEARCH

Interaction of the Warsaw breakage syndrome DNA helicase DDX11 with the replication fork-protection factor Timeless promotes sister chromatid cohesion

(2018) Giuseppe Cortone et al.   PLoS Genetics

DNA G-quadruplexes in the human genome: detection, functions and therapeutic potential

(2017) Robert Hänsel-Hertsch et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Ctf4 Links DNA Replication with Sister Chromatid Cohesion Establishment by Recruiting the Chl1 Helicase to the Replisome

(2016) Catarina P. Samora et al.   MOLECULAR CELL

Ctf4 Is a Hub in the Eukaryotic Replisome that Links Multiple CIP-Box Proteins to the CMG Helicase

(2016) Fabrizio Villa et al.   MOLECULAR CELL

G-quadruplexes and helicases

(2016) Oscar Mendoza et al.   NUCLEIC ACIDS RESEARCH

G-rich telomeric and ribosomal DNA sequences from the fission yeast genome form stable G-quadruplex DNA structuresin vitroand are unwound by the Pfh1 DNA helicase

(2016) Marcus Wallgren et al.   NUCLEIC ACIDS RESEARCH

The Warsaw breakage syndrome-related protein DDX11 is required for ribosomal RNA synthesis and embryonic development

(2015) Xinliang Sun et al.   HUMAN MOLECULAR GENETICS

A Distinct Triplex DNA Unwinding Activity of ChlR1 Helicase

(2015) Manhong Guo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Global transcriptional disturbances underlie Cornelia de Lange syndrome and related phenotypes

(2015) Bo Yuan et al.   JOURNAL OF CLINICAL INVESTIGATION

Timeless Interacts with PARP-1 to Promote Homologous Recombination Repair

(2015) Si Xie et al.   MOLECULAR CELL

Tim/Timeless, a member of the replication fork protection complex, operates with the Warsaw breakage syndrome DNA helicase DDX11 in the same fork recovery pathway

(2015) Federica Calì et al.   NUCLEIC ACIDS RESEARCH

TIMELESS Forms a Complex with PARP1 Distinct from Its Complex with TIPIN and Plays a Role in the DNA Damage Response

(2015) Lauren M. Young et al.   Cell Reports

Etiology and pathogenesis of the cohesinopathies

(2015) Musinu Zakari et al.   Wiley Interdisciplinary Reviews-Developmental Biology

Molecular functions and cellular roles of the ChlR1 (DDX11) helicase defective in the rare cohesinopathy Warsaw breakage syndrome

(2014) Sanjay Kumar Bharti et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The cohesin acetyltransferase Eco1 coordinates rDNA replication and transcription

(2014) S. Lu et al.   EMBO REPORTS

Cohesin embraces new phenotypes

(2014) Ian D Krantz   NATURE GENETICS

Mutations in SGOL1 cause a novel cohesinopathy affecting heart and gut rhythm

(2014) Philippe Chetaille et al.   NATURE GENETICS

Impact of Age-Associated Cyclopurine Lesions on DNA Repair Helicases

(2014) Irfan Khan et al.   PLoS One

Changes in vimentin, lamin A/C and mitofilin induce aberrant cell organization in fibroblasts from Fanconi anemia complementation group A (FA-A) patients

(2013) Cristina Capanni et al.   BIOCHIMIE

Mitochondrial respiratory chain Complex I defects in Fanconi anemia complementation group A

(2013) Silvia Ravera et al.   BIOCHIMIE

An Eco1-independent sister chromatid cohesion establishment pathway in S. cerevisiae

(2013) Vanessa Borges et al.   CHROMOSOMA

Roles of ChlR1 DNA helicase in replication recovery from DNA damage

(2013) Niyant Shah et al.   EXPERIMENTAL CELL RESEARCH

Specialization among Iron-Sulfur Cluster Helicases to Resolve G-quadruplex DNA Structures That Threaten Genomic Stability

(2013) Sanjay Kumar Bharti et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cohesion promotes nucleolar structure and function

(2013) Bethany Harris et al.   MOLECULAR BIOLOGY OF THE CELL

DHX9 helicase is involved in preventing genomic instability induced by alternatively structured DNA in human cells

(2013) A. Jain et al.   NUCLEIC ACIDS RESEARCH

Chl1 DNA Helicase Regulates Scc2 Deposition Specifically during DNA-Replication in Saccharomyces cerevisiae

(2013) Soumya Rudra et al.   PLoS One

Mitochondrial respiratory complex I defects in Fanconi anemia

(2013) Enrico Cappelli et al.   TRENDS IN MOLECULAR MEDICINE

Cohesinopathies of a Feather Flock Together

(2013) Robert V. Skibbens et al.   PLoS Genetics

Sister chromatid cohesion establishment occurs in concert with lagging strand synthesis

(2012) Soumya Rudra et al.   CELL CYCLE

The ENU-induced cetus mutation reveals an essential role of the DNA helicase DDX11 for mesoderm development during early mouse embryogenesis

(2012) Christina D. Cota et al.   DEVELOPMENTAL DYNAMICS

Identification and Biochemical Characterization of a Novel Mutation inDDX11Causing Warsaw Breakage Syndrome

(2012) José-Mario Capo-Chichi et al.   HUMAN MUTATION

DNA Repair and Replication Fork Helicases Are Differentially Affected by Alkyl Phosphotriester Lesion

(2012) Avvaru N. Suhasini et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DNA helicase and helicase-nuclease enzymes with a conserved iron-sulfur cluster

(2012) Y. Wu et al.   NUCLEIC ACIDS RESEARCH

Sister Chromatid Cohesion

(2012) J.-M. Peters et al.   Cold Spring Harbor Perspectives in Biology

Translational mechanisms at work in the cohesinopathies

(2012) Jennifer L. Gerton   Nucleus

Mammalian ChlR1 has a role in heterochromatin organization

(2011) Akira Inoue et al.   EXPERIMENTAL CELL RESEARCH

Biochemical Characterization of Warsaw Breakage Syndrome Helicase

(2011) Yuliang Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

G4 Resolvase 1 tightly binds and unwinds unimolecular G4-DNA

(2011) Banabihari Giri et al.   NUCLEIC ACIDS RESEARCH

Warsaw Breakage Syndrome, a Cohesinopathy Associated with Mutations in the XPD Helicase Family Member DDX11/ChlR1

(2010) Petra van der Lelij et al.   AMERICAN JOURNAL OF HUMAN GENETICS

DDX11L: a novel transcript family emerging from human subtelomeric regions

(2009) Valerio Costa et al.   BMC GENOMICS

Anticancer Activity of CX-3543: A Direct Inhibitor of rRNA Biogenesis

(2009) D. Drygin et al.   CANCER RESEARCH

FANCJ Uses Its Motor ATPase to Destabilize Protein-DNA Complexes, Unwind Triplexes, and Inhibit RAD51 Strand Exchange

(2009) Joshua A. Sommers et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cohesin and Human Disease

(2008) Jinglan Liu et al.   Annual Review of Genomics and Human Genetics

Studies with the Human Cohesin Establishment Factor, ChlR1

(2008) Andrea Farina et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The triple helix: 50 years later, the outcome

(2008) M. Duca et al.   NUCLEIC ACIDS RESEARCH

Inhibition of translation in living eukaryotic cells by an RNA G-quadruplex motif

(2008) A. Arora et al.   RNA