Timeless couples G‐quadruplex detection with processing by DDX 11 helicase during DNA replication

Cryo-EM Structure of the Fork Protection Complex Bound to CMG at a Replication Fork

(2020) Domagoj Baretić et al.   MOLECULAR CELL

Replication of G Quadruplex DNA

(2019) Leticia Koch Lerner et al.   Genes

Structural insights into the unique mechanism of transcription activation by Caulobacter crescentus GcrA

(2018) Xiaoxian Wu et al.   NUCLEIC ACIDS RESEARCH

Warsaw breakage syndrome: Further clinical and genetic delineation

(2018) Ebba Alkhunaizi et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Warsaw breakage syndrome DDX11 helicase acts jointly with RAD17 in the repair of bulky lesions and replication through abasic sites

(2018) Takuya Abe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The CMG Helicase Bypasses DNA-Protein Cross-Links to Facilitate Their Repair

(2018) Justin L. Sparks et al.   CELL

The role of fork stalling and DNA structures in causing chromosome fragility

(2018) Simran Kaushal et al.   GENES CHROMOSOMES & CANCER

Mrc1 and Tof1 prevent fragility and instability at long CAG repeats by their fork stabilizing function

(2018) Lionel Gellon et al.   NUCLEIC ACIDS RESEARCH

Interaction of the Warsaw breakage syndrome DNA helicase DDX11 with the replication fork-protection factor Timeless promotes sister chromatid cohesion

(2018) Giuseppe Cortone et al.   PLoS Genetics

The Effects of Replication Stress on S Phase Histone Management and Epigenetic Memory

(2017) Saša Šviković et al.   JOURNAL OF MOLECULAR BIOLOGY

How the Eukaryotic Replisome Achieves Rapid and Efficient DNA Replication

(2017) Joseph T.P. Yeeles et al.   MOLECULAR CELL

Local epigenetic reprogramming induced by G-quadruplex ligands

(2017) Guillaume Guilbaud et al.   Nature Chemistry

Crystal structure of the N-terminal domain of human Timeless and its interaction with Tipin

(2017) Sandro Holzer et al.   NUCLEIC ACIDS RESEARCH

The human CTF4-orthologue AND-1 interacts with DNA polymerase α/primase via its unique C-terminal HMG box

(2017) Mairi L. Kilkenny et al.   Open Biology

PrimPol Is Required for Replicative Tolerance of G Quadruplexes in Vertebrate Cells

(2016) Davide Schiavone et al.   MOLECULAR CELL

Phosphorylation of CMG helicase and Tof1 is required for programmed fork arrest

(2016) Deepak Bastia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chromatin determinants of the inner-centromere rely on replication factors with functions that impart cohesion

(2016) Takuya Abe et al.   Oncotarget

A Distinct Triplex DNA Unwinding Activity of ChlR1 Helicase

(2015) Manhong Guo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Timeless Interacts with PARP-1 to Promote Homologous Recombination Repair

(2015) Si Xie et al.   MOLECULAR CELL

The Replication Checkpoint Prevents Two Types of Fork Collapse without Regulating Replisome Stability

(2015) Huzefa Dungrawala et al.   MOLECULAR CELL

High-throughput sequencing of DNA G-quadruplex structures in the human genome

(2015) Vicki S Chambers et al.   NATURE BIOTECHNOLOGY

Tim/Timeless, a member of the replication fork protection complex, operates with the Warsaw breakage syndrome DNA helicase DDX11 in the same fork recovery pathway

(2015) Federica Calì et al.   NUCLEIC ACIDS RESEARCH

TIMELESS Forms a Complex with PARP1 Distinct from Its Complex with TIPIN and Plays a Role in the DNA Damage Response

(2015) Lauren M. Young et al.   Cell Reports

Nucleotide Pool Depletion Induces G-Quadruplex-Dependent Perturbation of Gene Expression

(2015) Charikleia Papadopoulou et al.   Cell Reports

Determinants of G quadruplex-induced epigenetic instability in REV1-deficient cells

(2014) D. Schiavone et al.   EMBO JOURNAL

Architecture and ssDNA interaction of the Timeless-Tipin-RPA complex

(2014) Justine Witosch et al.   NUCLEIC ACIDS RESEARCH

EBSeq: an empirical Bayes hierarchical model for inference in RNA-seq experiments

(2013) Ning Leng et al.   BIOINFORMATICS

Specialization among Iron-Sulfur Cluster Helicases to Resolve G-quadruplex DNA Structures That Threaten Genomic Stability

(2013) Sanjay Kumar Bharti et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genome engineering using the CRISPR-Cas9 system

(2013) F Ann Ran et al.   Nature Protocols

Human Tim-Tipin complex affects the biochemical properties of the replicative DNA helicase and DNA polymerases

(2013) W.-H. Cho et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Timeless preserves telomere length by promoting efficient DNA replication through human telomeres

(2012) Adam R. Leman et al.   CELL CYCLE

Mechanisms of replication fork protection: a safeguard for genome stability

(2012) Alessia Errico et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

The Q Motif of Fanconi Anemia Group J Protein (FANCJ) DNA Helicase Regulates Its Dimerization, DNA Binding, and DNA Repair Function

(2012) Yuliang Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Replication Fork Stalling and Checkpoint Activation by aPKD1Locus Mirror Repeat Polypurine-Polypyrimidine (Pu-Py) Tract

(2012) Guoqi Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Altered Replication in Human Cells Promotes DMPK (CTG)n {middle dot} (CAG)n Repeat Instability

(2012) G. Liu et al.   MOLECULAR AND CELLULAR BIOLOGY

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

Fast gapped-read alignment with Bowtie 2

(2012) Ben Langmead et al.   NATURE METHODS

RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome

(2011) Bo Li et al.   BMC BIOINFORMATICS

Biochemical Characterization of Warsaw Breakage Syndrome Helicase

(2011) Yuliang Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

FANCJ coordinates two pathways that maintain epigenetic stability at G-quadruplex DNA

(2011) Peter Sarkies et al.   NUCLEIC ACIDS RESEARCH

XDS

(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

BEDTools: a flexible suite of utilities for comparing genomic features

(2010) Aaron R. Quinlan et al.   BIOINFORMATICS

Interaction of human MCM2-7 proteins with TIM, TIPIN and Rb

(2010) Yuki Numata et al.   JOURNAL OF BIOCHEMISTRY

Fission Yeast Swi1-Swi3 Complex Facilitates DNA Binding of Mrc1

(2010) Taku Tanaka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human Timeless and Tipin stabilize replication forks and facilitate sister-chromatid cohesion

(2010) A. R. Leman et al.   JOURNAL OF CELL SCIENCE

Epigenetic Instability due to Defective Replication of Structured DNA

(2010) Peter Sarkies et al.   MOLECULAR CELL

Targeting the FANCJ–BRCA1 interaction promotes a switch from recombination to polη-dependent bypass

(2010) J Xie et al.   ONCOGENE

Mammalian TIMELESS Is Required for ATM-dependent CHK2 Activation and G2/M Checkpoint Control

(2009) Xiaoming Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TALOS+: a hybrid method for predicting protein backbone torsion angles from NMR chemical shifts

(2009) Yang Shen et al.   JOURNAL OF BIOMOLECULAR NMR

Replisome stalling and stabilization at CGG repeats, which are responsible for chromosomal fragility

(2009) Irina Voineagu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

First Evidence of a Functional Interaction between DNA Quadruplexes and Poly(ADP-ribose) Polymerase-1

(2008) V. A. Soldatenkov et al.   ACS Chemical Biology

Mutagenic Capacity of Endogenous G4 DNA Underlies Genome Instability in FANCJ-Defective C. elegans

(2008) Evelien Kruisselbrink et al.   CURRENT BIOLOGY

FANCJ Is a Structure-specific DNA Helicase Associated with the Maintenance of Genomic G/C Tracts

(2008) Timothy B. C. London et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Studies with the Human Cohesin Establishment Factor, ChlR1

(2008) Andrea Farina et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Novel Small Molecule That Alters Shelterin Integrity and Triggers a DNA-Damage Response at Telomeres

(2008) Raphaël Rodriguez et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

FANCJ Helicase Defective in Fanconia Anemia and Breast Cancer Unwinds G-Quadruplex DNA To Defend Genomic Stability

(2008) Y. Wu et al.   MOLECULAR AND CELLULAR BIOLOGY

Mrc1 and DNA Polymerase ɛ Function Together in Linking DNA Replication and the S Phase Checkpoint

(2008) Huiqiang Lou et al.   MOLECULAR CELL

Replication stalling at unstable inverted repeats: Interplay between DNA hairpins and fork stabilizing proteins

(2008) I. Voineagu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA