Teleological cooption of Mycobacterium tuberculosis PE/PPE proteins as porins: Role in molecular immigration and emigration

Pore-forming Esx proteins mediate toxin secretion by Mycobacterium tuberculosis

(2021) Uday Tak et al.   Nature Communications

Revisiting BCG to control tuberculosis: mucosal delivery and delipidation?

(2020) Javaid Ahmad Sheikh et al.   LANCET INFECTIOUS DISEASES

PE/PPE proteins mediate nutrient transport across the outer membrane of Mycobacterium tuberculosis

(2020) Qinglan Wang et al.   SCIENCE

Comprehensive analysis of iron utilization by Mycobacterium tuberculosis

(2020) Lei Zhang et al.   PLoS Pathogens

Homoplastic single nucleotide polymorphisms contributed to phenotypic diversity in Mycobacterium tuberculosis

(2020) Pornpen Tantivitayakul et al.   Scientific Reports

Intrinsic disorder in proteins: Relevance to protein assemblies, drug design and host-pathogen interactions

(2020) Tom L. Blundell et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Identification of autophagy inhibiting factors of Mycobacterium tuberculosis by high throughput loss of function screening

(2020) Emily J Strong et al.   INFECTION AND IMMUNITY

Optimization of secretion and surface localization of heterologous OVA protein in mycobacteria by using LipY as a carrier

(2019) Maroeska J. Burggraaf et al.   Microbial Cell Factories

A Mycobacterium tuberculosis surface protein recruits ubiquitin to trigger host xenophagy

(2019) Qiyao Chai et al.   Nature Communications

New insights into the mycobacterial PE and PPE proteins provide a framework for future research

(2019) Louis S. Ates   MOLECULAR MICROBIOLOGY

Architecture of the mycobacterial type VII secretion system

(2019) Nikolaos Famelis et al.   NATURE

Whole genome sequencing, analyses of drug resistance-conferring mutations, and correlation with transmission of Mycobacterium tuberculosis carrying katG-S315T in Hanoi, Vietnam

(2019) Nguyen Thi Le Hang et al.   Scientific Reports

Disorder‐to‐order transition in PE–PPE proteins of Mycobacterium tuberculosis augments the pro‐pathogen immune response

(2019) Javeed Ahmad et al.   FEBS Open Bio

WHO global progress report on tuberculosis elimination

(2019) Emilia Harding   Lancet Respiratory Medicine

Multidrug efflux pumps: structure, function and regulation

(2018) Dijun Du et al.   NATURE REVIEWS MICROBIOLOGY

Identification of genes required forMycobacterium abscessusgrowth in vivo with a prominent role of the ESX-4 locus

(2018) Laura Laencina et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RD5-mediated lack of PE_PGRS and PPE-MPTR export in BCG vaccine strains results in strong reduction of antigenic repertoire but little impact on protection

(2018) Louis S. Ates et al.   PLoS Pathogens

Mutations in ppe38 block PE_PGRS secretion and increase virulence of Mycobacterium tuberculosis

(2018) Louis S. Ates et al.   Nature Microbiology

Structural basis of the PE–PPE protein interaction inMycobacterium tuberculosis

(2017) Xin Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mycobacterial ESX-1 secretion system mediates host cell lysis through bacterium contact-dependent gross membrane disruptions

(2017) William H. Conrad et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Macrophage: A Disputed Fortress in the Battle against Mycobacterium tuberculosis

(2017) Christophe J. Queval et al.   Frontiers in Microbiology

Structure of the mycobacterial ESX-5 type VII secretion system membrane complex by single-particle analysis

(2017) Katherine S. H. Beckham et al.   Nature Microbiology

Mycobacterium tuberculosis PE_PGRS41 Enhances the Intracellular Survival of M. smegmatis within Macrophages Via Blocking Innate Immunity and Inhibition of Host Defense

(2017) Wanyan Deng et al.   Scientific Reports

Antibiotic resistance mechanisms in M. tuberculosis: an update

(2016) Liem Nguyen   ARCHIVES OF TOXICOLOGY

Phosphate starvation: a novel signal that triggers ESX-5 secretion inMycobacterium tuberculosis

(2016) Sarah R. Elliott et al.   MOLECULAR MICROBIOLOGY

TransportDB 2.0: a database for exploring membrane transporters in sequenced genomes from all domains of life

(2016) Liam D. H. Elbourne et al.   NUCLEIC ACIDS RESEARCH

Separable roles forMycobacterium tuberculosisESX-3 effectors in iron acquisition and virulence

(2016) JoAnn M. Tufariello et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural basis for haem piracy from host haemopexin by Haemophilus influenzae

(2016) Silvia Zambolin et al.   Nature Communications

Mycobacterium tuberculosis Co-operonic PE32/PPE65 Proteins Alter Host Immune Responses by Hampering Th1 Response

(2016) Mohd Khubaib et al.   Frontiers in Microbiology

Suppression of autophagy and antigen presentation by Mycobacterium tuberculosis PE_PGRS47

(2016) Neeraj K. Saini et al.   Nature Microbiology

PE11, a PE/PPE family protein of Mycobacterium tuberculosis is involved in cell wall remodeling and virulence

(2016) Parul Singh et al.   Scientific Reports

Substrates Control Multimerization and Activation of the Multi-Domain ATPase Motor of Type VII Secretion

(2015) Oren S. Rosenberg et al.   CELL

TheMycobacterium tuberculosisprotein pair PE9 (Rv1088)-PE10 (Rv1089) forms heterodimers and induces macrophage apoptosis through Toll-like receptor 4

(2015) Bhavana Tiwari et al.   CELLULAR MICROBIOLOGY

Mycobacterium tuberculosis Resists Stress by Regulating PE19 Expression

(2015) Pavithra Ramakrishnan et al.   INFECTION AND IMMUNITY

A Duplicated ESAT-6 Region of ESX-5 Is Involved in Protein Export and Virulence of Mycobacteria

(2015) Swati Shah et al.   INFECTION AND IMMUNITY

Phylogeny to function: PE/PPE protein evolution and impact onMycobacterium tuberculosispathogenicity

(2015) S. Fishbein et al.   MOLECULAR MICROBIOLOGY

Structure of EspB from the ESX-1 Type VII Secretion System and Insights into its Export Mechanism

(2015) Matthew Solomonson et al.   STRUCTURE

Essential Role of the ESX-5 Secretion System in Outer Membrane Permeability of Pathogenic Mycobacteria

(2015) Louis S. Ates et al.   PLoS Genetics

Gene cooption in Mycobacteria and search for virulence attributes: Comparative proteomic analyses of Mycobacterium tuberculosis, Mycobacterium indicus pranii and other mycobacteria

(2014) Yadvir Singh et al.   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

Increased Phagocytosis ofMycobacterium marinumMutants Defective in Lipooligosaccharide Production

(2014) Laeticia Alibaud et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MspA-Mycobacterium tuberculosis-transformant with reduced virulence: The “unbirthday paradigm”

(2014) Otmane Lamrabet et al.   MICROBIAL PATHOGENESIS

Structure of theMycobacterium tuberculosistype VII secretion system chaperone EspG5in complex with PE25-PPE41 dimer

(2014) Natalia Korotkova et al.   MOLECULAR MICROBIOLOGY

WXG100 Protein Superfamily Consists of Three Subfamilies and Exhibits an α-Helical C-Terminal Conserved Residue Pattern

(2014) Christian Poulsen et al.   PLoS One

Mycobacterium marinum MgtC Plays a Role in Phagocytosis but is Dispensable for Intracellular Multiplication

(2014) Claudine Belon et al.   PLoS One

Structure of a PE-PPE-EspG complex from Mycobacterium tuberculosis reveals molecular specificity of ESX protein secretion

(2014) D. C. Ekiert et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An outer membrane channel protein of Mycobacterium tuberculosis with exotoxin activity

(2014) O. Danilchanka et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

THE BIOLOGY OF MYCOBACTERIUM TUBERCULOSIS INFECTION.

(2014) Giovanni Delogu et al.   Mediterranean Journal of Hematology and Infectious Diseases

Take five — Type VII secretion systems of Mycobacteria

(2013) Edith N.G. Houben et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Pfam: the protein families database

(2013) Robert D. Finn et al.   NUCLEIC ACIDS RESEARCH

The ESX-3 Secretion System Is Necessary for Iron and Zinc Homeostasis in Mycobacterium tuberculosis

(2013) Agnese Serafini et al.   PLoS One

Virulence factors of theMycobacterium tuberculosiscomplex

(2013) Marina A. Forrellad et al.   Virulence

Strong Immunogenicity and Cross-Reactivity of Mycobacterium tuberculosis ESX-5 Type VII Secretion -Encoded PE-PPE Proteins Predicts Vaccine Potential

(2012) Fadel Sayes et al.   Cell Host & Microbe

Both Phthiocerol Dimycocerosates and Phenolic Glycolipids Are Required for Virulence of Mycobacterium marinum

(2012) Jia Yu et al.   INFECTION AND IMMUNITY

Mycobacterium tuberculosis Requires Phosphate-Responsive Gene Regulation To Resist Host Immunity

(2012) Anna D. Tischler et al.   INFECTION AND IMMUNITY

Comparative genomic and proteomic analyses of PE/PPE multigene family of Mycobacterium tuberculosis H37Rv and H37Ra reveal novel and interesting differences with implications in virulence

(2012) Sakshi Kohli et al.   NUCLEIC ACIDS RESEARCH

General secretion signal for the mycobacterial type VII secretion pathway

(2012) M. H. Daleke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The PE/PPE multigene family codes for virulence factors and is a possible source of mycobacterial antigenic variation: Perhaps more?

(2011) Yusuf Akhter et al.   BIOCHIMIE

PE_PGRS30 is required for the full virulence of Mycobacterium tuberculosis

(2011) Raffaella Iantomasi et al.   CELLULAR MICROBIOLOGY

Mycobacterial PE/PPE Proteins at the Host-Pathogen Interface

(2011) Samantha L. Sampson   Clinical & Developmental Immunology

Bacterial Virulence in the Moonlight: Multitasking Bacterial Moonlighting Proteins Are Virulence Determinants in Infectious Disease

(2011) Brian Henderson et al.   INFECTION AND IMMUNITY

Conserved Pro-Glu (PE) and Pro-Pro-Glu (PPE) Protein Domains Target LipY Lipases of Pathogenic Mycobacteria to the Cell Surface via the ESX-5 Pathway

(2011) Maria H. Daleke et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ESAT-6 Secretion-Independent Impact of ESX-1 Genes espF and espG1 on Virulence of Mycobacterium tuberculosis

(2011) Daria Bottai et al.   JOURNAL OF INFECTIOUS DISEASES

Mycobacterial outer membranes: in search of proteins

(2010) Michael Niederweis et al.   TRENDS IN MICROBIOLOGY

Multiple moonlighting functions of mycobacterial molecular chaperones

(2010) Brian Henderson et al.   TUBERCULOSIS

Mycobacteriophage Lysin B is a novel mycolylarabinogalactan esterase

(2009) Kimberly Payne et al.   MOLECULAR MICROBIOLOGY

Mycobacterial PE, PPE and ESX clusters: novel insights into the secretion of these most unusual protein families

(2009) Daria Bottai et al.   MOLECULAR MICROBIOLOGY

PPE and PE_PGRS proteins ofMycobacterium marinumare transported via the type VII secretion system ESX-5

(2009) Abdallah M. Abdallah et al.   MOLECULAR MICROBIOLOGY

Mycobacterial Esx-3 is required for mycobactin-mediated iron acquisition

(2009) M. S. Siegrist et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Systematic Genetic Nomenclature for Type VII Secretion Systems

(2009) Wilbert Bitter et al.   PLoS Pathogens

Rv1698 ofMycobacterium tuberculosisRepresents a New Class of Channel-forming Outer Membrane Proteins

(2008) Axel Siroy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genomic fluidity and pathogenic bacteria: applications in diagnostics, epidemiology and intervention

(2008) Niyaz Ahmed et al.   NATURE REVIEWS MICROBIOLOGY

The porin and the permeating antibiotic: a selective diffusion barrier in Gram-negative bacteria

(2008) Jean-Marie Pagès et al.   NATURE REVIEWS MICROBIOLOGY

Identification of outer membrane proteins of Mycobacterium tuberculosis

(2008) Houhui Song et al.   TUBERCULOSIS