Dual regulation of microglia and neurons by Astragaloside IV-mediated mTORC1 suppression promotes functional recovery after acute spinal cord injury

Astragaloside IV protects blood-brain barrier integrity from LPS-induced disruption via activating Nrf2 antioxidant signaling pathway in mice

(2018) Hongli Li et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Lysosomal damage after spinal cord injury causes accumulation of RIPK1 and RIPK3 proteins and potentiation of necroptosis

(2018) Shuo Liu et al.   Cell Death & Disease

Astragaloside IV Inhibits Triglyceride Accumulation in Insulin-Resistant HepG2 Cells via AMPK-Induced SREBP-1c Phosphorylation

(2018) Chunyi Wang et al.   Frontiers in Pharmacology

Astragaloside IV supplementation promotes a neuroprotective effect in experimental models of neurological disorders: a systematic review

(2018) Ianara Mendonça Costa et al.   Current Neuropharmacology

Astragaloside IV inhibits lung cancer progression and metastasis by modulating macrophage polarization through AMPK signaling

(2018) Fei Xu et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Regulation of Inflammatory Cytokines for Spinal Cord Injury Repair Through Local Delivery of Therapeutic Agents

(2018) Hao Ren et al.   Advanced Science

Peripherally derived macrophages modulate microglial function to reduce inflammation after CNS injury

(2018) Andrew D. Greenhalgh et al.   PLOS BIOLOGY

Local delivery of thyroid hormone enhances oligodendrogenesis and myelination after spinal cord injury

(2017) Robert B Shultz et al.   Journal of Neural Engineering

The mTOR Substrate S6 Kinase 1 (S6K1) Is a Negative Regulator of Axon Regeneration and a Potential Drug Target for Central Nervous System Injury

(2017) Hassan Al-Ali et al.   JOURNAL OF NEUROSCIENCE

Modulators of microglial activation and polarization after intracerebral haemorrhage

(2017) Xi Lan et al.   Nature Reviews Neurology

Astragaloside IV for Experimental Focal Cerebral Ischemia: Preclinical Evidence and Possible Mechanisms

(2017) Hui-Lin Wang et al.   Oxidative Medicine and Cellular Longevity

Rat models of spinal cord injury: from pathology to potential therapies

(2016) Jacob Kjell et al.   Disease Models & Mechanisms

Rapamycin suppresses microglial activation and reduces the development of neuropathic pain after spinal cord injury

(2016) Satoshi Tateda et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Metformin Improves Functional Recovery After Spinal Cord Injury via Autophagy Flux Stimulation

(2016) Di Zhang et al.   MOLECULAR NEUROBIOLOGY

The mTOR signalling cascade: paving new roads to cure neurological disease

(2016) Peter B. Crino   Nature Reviews Neurology

Autophagy induction stabilizes microtubules and promotes axon regeneration after spinal cord injury

(2016) Miao He et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functions and mechanisms of microglia/macrophages in neuroinflammation and neurogenesis after stroke

(2016) Xiao-Yi Xiong et al.   PROGRESS IN NEUROBIOLOGY

Function and Mechanisms of Autophagy in Brain and Spinal Cord Trauma

(2015) Marta M. Lipinski et al.   ANTIOXIDANTS & REDOX SIGNALING

Traumatic Spinal Cord Injury in the United States, 1993-2012

(2015) Nitin B. Jain et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Sustained dual drug delivery of anti-inhibitory molecules for treatment of spinal cord injury

(2015) Thomas S. Wilems et al.   JOURNAL OF CONTROLLED RELEASE

Rapamycin increases neuronal survival, reduces inflammation and astrocyte proliferation after spinal cord injury

(2015) Yona Goldshmit et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Global neurotrauma research challenges and opportunities

(2015) Andrés M. Rubiano et al.   NATURE

Stimulation of autophagy promotes functional recovery in diabetic rats with spinal cord injury

(2015) Kai-liang Zhou et al.   Scientific Reports

Repair of spinal cord injury by inhibition of astrocyte growth and inflammatory factor synthesis through local delivery of flavopiridol in PLGA nanoparticles

(2014) Hao Ren et al.   BIOMATERIALS

Rapamycin Plays a Neuroprotective Effect after Spinal Cord Injury via Anti-Inflammatory Effects

(2014) Yu Song et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

Genetic and Pharmacological Inhibition of Rheb1-mTORC1 Signaling Exerts Cardioprotection against Adverse Cardiac Remodeling in Mice

(2013) Xiangqi Wu et al.   AMERICAN JOURNAL OF PATHOLOGY

Astragaloside IV reduces cerebral edema post-ischemia/reperfusion correlating the suppression of MMP-9 and AQP4

(2013) Min Li et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Signal integration by mTORC1 coordinates nutrient input with biosynthetic output

(2013) Christian C. Dibble et al.   NATURE CELL BIOLOGY

The TSC-mTOR pathway regulates macrophage polarization

(2013) Vanessa Byles et al.   Nature Communications

The role of mTOR signaling pathway in spinal cord injury

(2012) Haruo Kanno et al.   CELL CYCLE

Regulation of TFEB and V-ATPases by mTORC1

(2011) Samuel Peña-Llopis et al.   EMBO JOURNAL

Synergistic protective effect of astragaloside IV–tetramethylpyrazine against cerebral ischemic-reperfusion injury induced by transient focal ischemia

(2011) Jiehong Yang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Rapamycin Promotes Autophagy and Reduces Neural Tissue Damage and Locomotor Impairment after Spinal Cord Injury in Mice

(2011) Akira Sekiguchi et al.   JOURNAL OF NEUROTRAUMA

Repertoire of microglial and macrophage responses after spinal cord injury

(2011) Samuel David et al.   NATURE REVIEWS NEUROSCIENCE

TFEB Links Autophagy to Lysosomal Biogenesis

(2011) C. Settembre et al.   SCIENCE

Protective Effect of Astragaloside on Focal Cerebral Ischemia/Reperfusion Injury in Rats

(2010) Yan-Yan Yin et al.   AMERICAN JOURNAL OF CHINESE MEDICINE

Astragaloside IV attenuates cerebral ischemia–reperfusion-induced increase in permeability of the blood-brain barrier in rats

(2009) You Zhi Qu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Autophagy Induction and Autophagosome Clearance in Neurons: Relationship to Autophagic Pathology in Alzheimer's Disease

(2008) B. Boland et al.   JOURNAL OF NEUROSCIENCE