Astragaloside IV, a Natural PPARγ Agonist, Reduces Aβ Production in Alzheimer’s Disease Through Inhibition of BACE1

Long-Term Pioglitazone Treatment Improves Learning and Attenuates Pathological Markers in a Mouse Model of Alzheimer's Disease

(2018) James L. Searcy et al.   JOURNAL OF ALZHEIMERS DISEASE

Fluorimetric detection of the earliest events in amyloid β oligomerization and its inhibition by pharmacologically active liposomes

(2016) Luca Nardo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Astragaloside IV inhibits microglia activation via glucocorticoid receptor mediated signaling pathway

(2016) Hong-Shuai Liu et al.   Scientific Reports

Effect of pioglitazone medication on the incidence of dementia

(2015) Michael T. Heneka et al.   ANNALS OF NEUROLOGY

The peroxisome proliferators activated receptor-gamma agonists as therapeutics for the treatment of Alzheimer's disease and mild-to-moderate Alzheimer's disease: a meta-analysis

(2015) Huawei Cheng et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Ameliorating the Effect of Astragaloside IV on Learning and Memory Deficit after Chronic Cerebral Hypoperfusion in Rats

(2015) Sooyong Kim et al.   MOLECULES

APP intracellular domain derived from amyloidogenic β- and γ-secretase cleavage regulates neprilysin expression

(2015) Marcus O. W. Grimm et al.   Frontiers in Aging Neuroscience

The Resveratrol Trimer Miyabenol C Inhibits β-Secretase Activity and β-Amyloid Generation

(2015) Jin Hu et al.   PLoS One

Down-Regulation of PERK-ATF4-CHOP Pathway by Astragaloside IV is Associated with the Inhibition of Endoplasmic Reticulum Stress-Induced Podocyte Apoptosis in Diabetic Rats

(2014) Yifang Chen et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Astragaloside IV ameliorates diabetic nephropathy involving protection of podocytes in streptozotocin induced diabetic rats

(2014) Jianguo Chen et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Advanced glycation end products induce oxidative stress and mitochondrial dysfunction in SH-SY5Y cells

(2014) Xu Wang et al.   IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL

Protective Effects of Astragaloside IV against Amyloid Beta1-42 Neurotoxicity by Inhibiting the Mitochondrial Permeability Transition Pore Opening

(2014) Qinru Sun et al.   PLoS One

Trientine Reduces BACE1 Activity and Mitigates Amyloidosis via the AGE/RAGE/NF-κB Pathway in a Transgenic Mouse Model of Alzheimer's Disease

(2013) Chun-Yan Wang et al.   ANTIOXIDANTS & REDOX SIGNALING

Glimepiride attenuates Aβ production via suppressing BACE1 activity in cortical neurons

(2013) Feiyang Liu et al.   NEUROSCIENCE LETTERS

PPARγ Agonist Pioglitazone Reverses Memory Impairment and Biochemical Changes in a Mouse Model of Type 2 Diabetes Mellitus

(2012) Li-Ying Jiang et al.   CNS Neuroscience & Therapeutics

Protective effects of astragalosides on dexamethasone and Aβ25–35 induced learning and memory impairments due to decrease amyloid precursor protein expression in 12-month male rats

(2012) Wei-Zu Li et al.   FOOD AND CHEMICAL TOXICOLOGY

Mechanisms Underlying the Rapid Peroxisome Proliferator-Activated Receptor- -Mediated Amyloid Clearance and Reversal of Cognitive Deficits in a Murine Model of Alzheimer's Disease

(2012) S. Mandrekar-Colucci et al.   JOURNAL OF NEUROSCIENCE

Astragaloside IV prevents MPP+-induced SH-SY5Y cell death via the inhibition of Bax-mediated pathways and ROS production

(2012) Zhi-guo Zhang et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Ginsenoside Rg1 attenuates β-amyloid generation via suppressing PPARγ-regulated BACE1 activity in N2a-APP695 cells

(2011) Li-min Chen et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

BACE1 Gene Promoter Single-Nucleotide Polymorphisms in Alzheimer’s Disease

(2010) Weihui Zhou et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Insulin deficiency exacerbates cerebral amyloidosis and behavioral deficits in an Alzheimer transgenic mouse model

(2010) Xu Wang et al.   Molecular Neurodegeneration

Rosiglitazone Rescues Memory Impairment in Alzheimer's Transgenic Mice: Mechanisms Involving a Reduced Amyloid and Tau Pathology

(2010) Luis Escribano et al.   NEUROPSYCHOPHARMACOLOGY

The nuclear receptor PPARγ as a therapeutic target for cerebrovascular and brain dysfunction in Alzheimer's disease

(2010) Nektaria Nicolakakis   Frontiers in Aging Neuroscience

Antidiabetic drug metformin (GlucophageR) increases biogenesis of Alzheimer's amyloid peptides via up-regulating BACE1 transcription

(2009) Y. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reassessing the amyloid cascade hypothesis of Alzheimer's disease

(2008) Sanjay W. Pimplikar   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY