Human antiviral B cell responses: Emerging lessons from hepatitis B and COVID‐19

Immunological memory to SARS-CoV-2 assessed for up to 8 months after infection

(2021) Jennifer M. Dan et al.   SCIENCE

Hepatitis B core-specific memory B cell responses associate with clinical parameters in patients with chronic HBV

(2020) Thomas Vanwolleghem et al.   JOURNAL OF HEPATOLOGY

Spatiotemporal regulation of type I interferon expression determines the antiviral polarization of CD4+ T cells

(2020) Marco De Giovanni et al.   NATURE IMMUNOLOGY

Quantitative and Qualitative Analysis of Humoral Immunity Reveals Continued and Personalized Evolution in Chronic Viral Infection

(2020) Nike Julia Kräutler et al.   Cell Reports

Chronic Viral Infection Promotes Efficient Germinal Center B Cell Responses

(2020) Bénédict Fallet et al.   Cell Reports

Persistence and clearance of viral RNA in 2019 novel coronavirus disease rehabilitation patients

(2020) Yun Ling et al.   CHINESE MEDICAL JOURNAL

The Transcription Factor T-bet Resolves Memory B Cell Subsets with Distinct Tissue Distributions and Antibody Specificities in Mice and Humans

(2020) John L. Johnson et al.   IMMUNITY

Next-generation sequencing of the intrahepatic antibody repertoire delineates a unique B-cell response in HBV-associated acute liver failure

(2020) Zhaochun Chen et al.   JOURNAL OF VIRAL HEPATITIS

Human neutralizing antibodies elicited by SARS-CoV-2 infection

(2020) Bin Ju et al.   NATURE

Antibody responses to SARS-CoV-2 in patients with COVID-19

(2020) Quan-Xin Long et al.   NATURE MEDICINE

B Cell Activation and Response Regulation During Viral Infections

(2020) Jonathan H. Lam et al.   VIRAL IMMUNOLOGY

A Combination of Human Broadly Neutralizing Antibodies against Hepatitis B Virus HBsAg with Distinct Epitopes Suppresses Escape Mutations

(2020) Qiao Wang et al.   Cell Host & Microbe

Expansion of plasmablasts and loss of memory B cells in peripheral blood from COVID‐19 patients with pneumonia

(2020) Sara De Biasi et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Potent human broadly neutralizing antibodies to hepatitis B virus from natural controllers

(2020) Verena Hehle et al.   JOURNAL OF EXPERIMENTAL MEDICINE

CD11c+ T-bet+ B Cells Require IL-21 and IFN-γ from Type 1 T Follicular Helper Cells and Intrinsic Bcl-6 Expression but Develop Normally in the Absence of T-bet

(2020) Russell C. Levack et al.   JOURNAL OF IMMUNOLOGY

Convergent antibody responses to SARS-CoV-2 in convalescent individuals

(2020) Davide F. Robbiani et al.   NATURE

Humoral and circulating follicular helper T cell responses in recovered patients with COVID-19

(2020) Jennifer A. Juno et al.   NATURE MEDICINE

Deep immune profiling of COVID-19 patients reveals distinct immunotypes with therapeutic implications

(2020) Divij Mathew et al.   SCIENCE

Potent neutralizing antibodies from COVID-19 patients define multiple targets of vulnerability

(2020) Philip J. M. Brouwer et al.   SCIENCE

Early ART in Acute HIV-1 Infection: Impact on the B-Cell Compartment

(2020) Robert Badura et al.   Frontiers in Cellular and Infection Microbiology

Persistent Viral Presence Determines the Clinical Course of the Disease in COVID-19

(2020) De Chang et al.   Journal of Allergy and Clinical Immunology-In Practice

Loss of Bcl-6-Expressing T Follicular Helper Cells and Germinal Centers in COVID-19

(2020) Naoki Kaneko et al.   CELL

Extrafollicular B cell responses correlate with neutralizing antibodies and morbidity in COVID-19

(2020) Matthew C. Woodruff et al.   NATURE IMMUNOLOGY

Longitudinal observation and decline of neutralizing antibody responses in the three months following SARS-CoV-2 infection in humans

(2020) Jeffrey Seow et al.   Nature Microbiology

Functional SARS-CoV-2-Specific Immune Memory Persists after Mild COVID-19

(2020) Lauren B. Rodda et al.   CELL

SARS-CoV-2–specific antibody rearrangements in prepandemic immune repertoires of risk cohorts and patients with COVID-19

(2020) Lisa Paschold et al.   JOURNAL OF CLINICAL INVESTIGATION

Defining the features and duration of antibody responses to SARS-CoV-2 infection associated with disease severity and outcome

(2020) Katharina Röltgen et al.   Science Immunology

Type I interferon induces CXCL13 to support ectopic germinal center formation

(2019) Alice E. Denton et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The continuing story of T‐cell independent antibodies

(2019) David Allman et al.   IMMUNOLOGICAL REVIEWS

T‐bet + memory B cells: Generation, function, and fate

(2019) James J. Knox et al.   IMMUNOLOGICAL REVIEWS

FCRL5+ Memory B Cells Exhibit Robust Recall Responses

(2019) Charles C. Kim et al.   Cell Reports

Comparative characterization of B cells specific for HBV nucleocapsid and envelope proteins in patients with chronic hepatitis B

(2019) Nina Le Bert et al.   JOURNAL OF HEPATOLOGY

Epigenetic programming underpins B cell dysfunction in human SLE

(2019) Christopher D. Scharer et al.   NATURE IMMUNOLOGY

Restoring, releasing or replacing adaptive immunity in chronic hepatitis B

(2019) Mala K. Maini et al.   Nature Reviews Gastroenterology & Hepatology

Functional Characterization of CD11c+ Age-Associated B Cells as Memory B Cells

(2019) Samuel W. Du et al.   JOURNAL OF IMMUNOLOGY

Overexpression of T-bet in HIV infection is associated with accumulation of B cells outside germinal centers and poor affinity maturation

(2019) James W. Austin et al.   Science Translational Medicine

Circulating regulatory Tfh cells are enriched in patients with chronic hepatitis B infection and induce the differentiation of regulatory B cells

(2018) Rongxin Wang et al.   EXPERIMENTAL CELL RESEARCH

Dysregulated Response of Follicular Helper T Cells to Hepatitis B Surface Antigen Promotes HBV Persistence in Mice and Associates With Outcomes of Patients

(2018) Xiaowen Wang et al.   GASTROENTEROLOGY

Anti-HBV response to toll-like receptor 7 agonist GS-9620 is associated with intrahepatic aggregates of T cells and B cells

(2018) Li Li et al.   JOURNAL OF HEPATOLOGY

An OX40/OX40L interaction directs successful immunity to hepatitis B virus

(2018) Jean Publicover et al.   Science Translational Medicine

PD-1 blockade partially recovers dysfunctional virus–specific B cells in chronic hepatitis B infection

(2018) Loghman Salimzadeh et al.   JOURNAL OF CLINICAL INVESTIGATION

Circulating and intrahepatic antiviral B cells are defective in hepatitis B

(2018) Alice R. Burton et al.   JOURNAL OF CLINICAL INVESTIGATION

IgG3 regulates tissue-like memory B cells in HIV-infected individuals

(2018) Lela Kardava et al.   NATURE IMMUNOLOGY

HBV induces inhibitory FcRL receptor on B cells and dysregulates B cell-T follicular helper cell axis

(2018) Bhawna Poonia et al.   Scientific Reports

Distinct Effector B Cells Induced by Unregulated Toll-like Receptor 7 Contribute to Pathogenic Responses in Systemic Lupus Erythematosus

(2018) Scott A. Jenks et al.   IMMUNITY

The establishment of resident memory B cells in the lung requires local antigen encounter

(2018) S. Rameeza Allie et al.   NATURE IMMUNOLOGY

Role of humoral immunity against hepatitis B virus core antigen in the pathogenesis of acute liver failure

(2018) Zhaochun Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Plasmodium-specific atypical memory B cells are short-lived activated B cells

(2018) Damián Pérez-Mazliah et al.   eLife

Hepatitis B Reactivation Associated With Immune Suppressive and Biological Modifier Therapies: Current Concepts, Management Strategies, and Future Directions

(2017) Rohit Loomba et al.   GASTROENTEROLOGY

Age-Associated B Cells Express a Diverse Repertoire of VHand Vκ Genes with Somatic Hypermutation

(2017) Lisa M. Russell Knode et al.   JOURNAL OF IMMUNOLOGY

Plasma cell survival in the absence of B cell memory

(2017) Erika Hammarlund et al.   Nature Communications

Adaptive immunity in HBV infection

(2016) Antonio Bertoletti et al.   JOURNAL OF HEPATOLOGY

Cutting Edge: IL-4, IL-21, and IFN-γ Interact To Govern T-bet and CD11c Expression in TLR-Activated B Cells

(2016) Martin S. Naradikian et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: B Cell–Intrinsic T-bet Expression Is Required To Control Chronic Viral Infection

(2016) Burton E. Barnett et al.   JOURNAL OF IMMUNOLOGY

Defining antigen-specific plasmablast and memory B cell subsets in human blood after viral infection or vaccination

(2016) Ali H Ellebedy et al.   NATURE IMMUNOLOGY

Long-lived antigen-induced IgM plasma cells demonstrate somatic mutations and contribute to long-term protection

(2016) Caitlin Bohannon et al.   Nature Communications

Severe Malaria Infections Impair Germinal Center Responses by Inhibiting T Follicular Helper Cell Differentiation

(2016) Victoria Ryg-Cornejo et al.   Cell Reports

Altered Memory Circulating T Follicular Helper-B Cell Interaction in Early Acute HIV Infection

(2016) Roshell Muir et al.   PLoS Pathogens

Reversal of B-cell hyperactivation and functional impairment is associated with HBsAg seroconversion in chronic hepatitis B patients

(2015) Xiangsheng Xu et al.   Cellular & Molecular Immunology

Splenic extrafollicular reactions and BM plasma cells sustain IgM response associated with hypercholesterolemia

(2015) Lawrence Han Boon Khoo et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Salmonella Infection Drives Promiscuous B Cell Activation Followed by Extrafollicular Affinity Maturation

(2015) Roberto Di Niro et al.   IMMUNITY

Distinct germinal center selection at local sites shapes memory B cell response to viral escape

(2015) Yu Adachi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Control of Viremia Enables Acquisition of Resting Memory B Cells with Age and Normalization of Activated B Cell Phenotypes in HIV-Infected Children

(2015) Daniel M. Muema et al.   JOURNAL OF IMMUNOLOGY

CD11c-Expressing B Cells Are Located at the T Cell/B Cell Border in Spleen and Are Potent APCs

(2015) Anatoly V. Rubtsov et al.   JOURNAL OF IMMUNOLOGY

T- and B-cell responses and previous exposure to hepatitis B virus in ‘anti-HBc alone’ patients

(2015) Q. Wang et al.   JOURNAL OF VIRAL HEPATITIS

A Human Monoclonal Antibody against Hepatitis B Surface Antigen with Potent Neutralizing Activity

(2015) Antonella Cerino et al.   PLoS One

Malaria-associated atypical memory B cells exhibit markedly reduced B cell receptor signaling and effector function

(2015) Silvia Portugal et al.   eLife

Intrahepatic B-cell follicles of chronically hepatitis C virus-infected individuals lack signs of an ectopic germinal center reaction

(2014) Felicia A. Tucci et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

CD11c Expression Identifies a Population of Extrafollicular Antigen-Specific Splenic Plasmablasts Responsible for CD4 T-Independent Antibody Responses during Intracellular Bacterial Infection

(2014) R. Racine et al.   JOURNAL OF IMMUNOLOGY

Resting Human Memory B Cells Are Intrinsically Programmed for Enhanced Survival and Responsiveness to Diverse Stimuli Compared to Naive B Cells

(2014) K. L. Good et al.   JOURNAL OF IMMUNOLOGY

Inhibitory Phenotype of HBV-Specific CD4+ T-Cells Is Characterized by High PD-1 Expression but Absent Coregulation of Multiple Inhibitory Molecules

(2014) Bijan Raziorrouh et al.   PLoS One

Frequency and phenotype of B cell subpopulations in young and aged HIV-1 infected patients receiving ART

(2014) Sylvie Amu et al.   Retrovirology

Evolution of Broadly Cross-Reactive HIV-1-Neutralizing Activity: Therapy-Associated Decline, Positive Association with Detectable Viremia, and Partial Restoration of B-Cell Subpopulations

(2013) C. B. Ferreira et al.   JOURNAL OF VIROLOGY

The kinase mTOR modulates the antibody response to provide cross-protective immunity to lethal infection with influenza virus

(2013) Rachael Keating et al.   NATURE IMMUNOLOGY

Immunosuppression and HBV Reactivation

(2013) Oren Shibolet et al.   SEMINARS IN LIVER DISEASE

Decoupling activation and exhaustion of B cells in spontaneous controllers of HIV infection

(2012) Gaia Sciaranghella et al.   AIDS

Emergence of Exhausted B Cells in Asymptomatic HIV-1-Infected Patients Naïve for HAART is Related to Reduced Immune Surveillance

(2012) Manuela Fogli et al.   Clinical & Developmental Immunology

Memory B cells in the lung participate in protective humoral immune responses to pulmonary influenza virus reinfection

(2012) T. Onodera et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Complement receptor 2/CD21- human naive B cells contain mostly autoreactive unresponsive clones

(2010) I. Isnardi et al.   BLOOD

Enhanced B-cell differentiation and reduced proliferative capacity in chronic hepatitis C and chronic hepatitis B virus infections

(2010) Barbara Oliviero et al.   JOURNAL OF HEPATOLOGY

B-cell depletion reveals a role for antibodies in the control of chronic HIV-1 infection

(2010) Kuan-Hsiang G. Huang et al.   Nature Communications

Evidence for HIV-associated B cell exhaustion in a dysfunctional memory B cell compartment in HIV-infected viremic individuals

(2008) Susan Moir et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Properties of Subviral Particles of Hepatitis B Virus

(2008) N. Chai et al.   JOURNAL OF VIROLOGY

Enhancing SIV-specific immunity in vivo by PD-1 blockade

(2008) Vijayakumar Velu et al.   NATURE