Metabolic reprogramming: A driver of cigarette smoke-induced inflammatory lung diseases

l-Arginine supplementation in severe asthma

(2020) Shu-Yi Liao et al.   JCI Insight

Pathophysiological Mechanisms of Asthma

(2019) Andrew Bush   Frontiers in Pediatrics

Pathobiological mechanisms underlying metabolic syndrome (MetS) in chronic obstructive pulmonary disease (COPD): clinical significance and therapeutic strategies

(2019) Stanley M.H. Chan et al.   PHARMACOLOGY & THERAPEUTICS

Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Lung Disease: The GOLD Science Committee Report 2019

(2019) Dave Singh et al.   EUROPEAN RESPIRATORY JOURNAL

Lipid metabolism in chronic obstructive pulmonary disease

(2019) Haipin Chen et al.   International Journal of Chronic Obstructive Pulmonary Disease

Involvement of cigarette smoke-induced epithelial cell ferroptosis in COPD pathogenesis

(2019) Masahiro Yoshida et al.   Nature Communications

Functional and metabolic impairment in cigarette smoke-exposed macrophages is tied to oxidative stress

(2019) Daniel S. Aridgides et al.   Scientific Reports

An Updated Overview of Metabolomic Profile Changes in Chronic Obstructive Pulmonary Disease

(2019) Nan Ran et al.   Metabolites

Tobacco Product Use and Cessation Indicators Among Adults — United States, 2018

(2019) MeLisa R. Creamer et al.   MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT

Current advances in research in treatment and recovery: Nicotine addiction

(2019) Judith J. Prochaska et al.   Science Advances

Hexokinase 2 couples glycolysis with the profibrotic actions of TGF-β

(2019) Xueqian Yin et al.   Science Signaling

Airway Epithelial Barrier Dysfunction in Chronic Obstructive Pulmonary Disease: Role of Cigarette Smoke Exposure

(2018) Mahyar Aghapour et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Angiotensin-(1-7) Attenuated Cigarette Smoking-related Pulmonary Fibrosis via Improving the Impaired Autophagy Caused by NOX4-dependent ROS

(2018) Miaoxia Pan et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Targeting Hypoxia-Inducible Factor-1α/Pyruvate Dehydrogenase Kinase 1 Axis by Dichloroacetate Suppresses Bleomycin-induced Pulmonary Fibrosis

(2018) Justin Goodwin et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Glutaminolysis Promotes Collagen Translation and Stability via α-Ketoglutarate–mediated mTOR Activation and Proline Hydroxylation

(2018) Jing Ge et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Genetic Ablation of p16(Ink4a) Does Not Protect Against Cellular Senescence in Mouse Models of COPD/Emphysema

(2018) Isaac K Sundar et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Targeting arginase and nitric oxide metabolism in chronic airway diseases and their co-morbidities

(2018) Mariska PM van den Berg et al.   CURRENT OPINION IN PHARMACOLOGY

MTOR Suppresses Cigarette Smoke–Induced Epithelial Cell Death and Airway Inflammation in Chronic Obstructive Pulmonary Disease

(2018) Yong Wang et al.   JOURNAL OF IMMUNOLOGY

Biomarkers in idiopathic pulmonary fibrosis

(2018) F. Drakopanagiotakis et al.   MATRIX BIOLOGY

Idiopathic Pulmonary Fibrosis

(2018) David J. Lederer et al.   NEW ENGLAND JOURNAL OF MEDICINE

Reactive Oxygen Species in Chronic Obstructive Pulmonary Disease

(2018) Samia Boukhenouna et al.   Oxidative Medicine and Cellular Longevity

Tobacco Smoke Induces and Alters Immune Responses in the Lung Triggering Inflammation, Allergy, Asthma and Other Lung Diseases: A Mechanistic Review

(2018) Agnieszka Strzelak et al.   International Journal of Environmental Research and Public Health

Type 2 immunity in asthma

(2018) Marco Caminati et al.   World Allergy Organization Journal

Comparison of the effects of e-cigarette vapor with cigarette smoke on lung function and inflammation in mice

(2018) Constantinos Glynos et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Supplementation with Qter® and Creatine improves functional performance in COPD patients on long term oxygen therapy

(2018) Fernando De Benedetto et al.   RESPIRATORY MEDICINE

Pro-inflammatory effects of e-cigarette vapour condensate on human alveolar macrophages

(2018) Aaron Scott et al.   THORAX

Cellular Metabolism in Lung Health and Disease

(2018) Gang Liu et al.   Annual Review of Physiology

Cigarette smoking aggravates bleomycin-induced experimental pulmonary fibrosis

(2018) Li-Ling Zhou et al.   TOXICOLOGY LETTERS

Idiopathic pulmonary fibrosis: lessons from clinical trials over the past 25 years

(2017) Ganesh Raghu   EUROPEAN RESPIRATORY JOURNAL

Glutaminolysis is required for transforming growth factor-β1–induced myofibroblast differentiation and activation

(2017) Karen Bernard et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metabolic regulation of inflammation

(2017) Timo Gaber et al.   Nature Reviews Rheumatology

Cellular senescence mediates fibrotic pulmonary disease

(2017) Marissa J. Schafer et al.   Nature Communications

Rejuvenating cellular respiration for optimizing respiratory function: targeting mitochondria

(2016) Anurag Agrawal et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Transforming Growth Factor-β: Master Regulator of the Respiratory System in Health and Disease

(2016) Yael Aschner et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Acute Impact of Tobacco vs Electronic Cigarette Smoking on Oxidative Stress and Vascular Function

(2016) Roberto Carnevale et al.   CHEST

Prevalence and incidence of COPD in smokers and non-smokers: the Rotterdam Study

(2016) Natalie Terzikhan et al.   EUROPEAN JOURNAL OF EPIDEMIOLOGY

Nicotine exposure induces bronchial epithelial cell apoptosis and senescence via ROS mediated autophagy-impairment

(2016) Manish Bodas et al.   FREE RADICAL BIOLOGY AND MEDICINE

Functional Effects of Cigarette Smoke-Induced Changes in Airway Smooth Muscle Mitochondrial Morphology

(2016) Bharathi Aravamudan et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Increased mitochondrial arginine metabolism supports bioenergetics in asthma

(2016) Weiling Xu et al.   JOURNAL OF CLINICAL INVESTIGATION

Metabolic Profiling Regarding Pathogenesis of Idiopathic Pulmonary Fibrosis

(2016) Yun Pyo Kang et al.   JOURNAL OF PROTEOME RESEARCH

Mitochondrial iron chelation ameliorates cigarette smoke–induced bronchitis and emphysema in mice

(2016) Suzanne M Cloonan et al.   NATURE MEDICINE

Chronic electronic cigarette exposure in mice induces features of COPD in a nicotine-dependent manner

(2016) Itsaso Garcia-Arcos et al.   THORAX

Public understanding of cigarette smoke constituents: three US surveys

(2016) Noel T Brewer et al.   TOBACCO CONTROL

Tissue-specific and convergent metabolic transformation of cancer correlates with metastatic potential and patient survival

(2016) Edoardo Gaude et al.   Nature Communications

Glycolytic Reprogramming in Myofibroblast Differentiation and Lung Fibrosis

(2015) Na Xie et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

PARK2-mediated mitophagy is involved in regulation of HBEC senescence in COPD pathogenesis

(2015) Saburo Ito et al.   Autophagy

Regulation of Cigarette Smoke Induction of IL-8 in Macrophages by AMP-activated Protein Kinase Signaling

(2015) Hsin-Kuo Ko et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Metabolomics analysis identifies novel plasma biomarkers of cystic fibrosis pulmonary exacerbation

(2015) Theresa A. Laguna et al.   PEDIATRIC PULMONOLOGY

Senescence-associated inflammatory responses: aging and cancer perspectives

(2015) Audrey Lasry et al.   TRENDS IN IMMUNOLOGY

Chronic obstructive pulmonary disease

(2015) Peter J. Barnes et al.   Nature Reviews Disease Primers

Asthma

(2015) Stephen T. Holgate et al.   Nature Reviews Disease Primers

Cigarette smoke-induced mitochondrial fragmentation and dysfunction in human airway smooth muscle

(2014) Bharathi Aravamudan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Untargeted Lipidomic Analysis in Chronic Obstructive Pulmonary Disease. Uncovering Sphingolipids

(2014) Eef D. Telenga et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The Changing Public Image of Smoking in the United States: 1964-2014

(2014) K. M. Cummings et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Mitophagy-dependent necroptosis contributes to the pathogenesis of COPD

(2014) Kenji Mizumura et al.   JOURNAL OF CLINICAL INVESTIGATION

The pivotal role of pyruvate dehydrogenase kinases in metabolic flexibility

(2014) Shuai Zhang et al.   Nutrition & Metabolism

Molecular Processes that Drive Cigarette Smoke–Induced Epithelial Cell Fate of the Lung

(2013) Toru Nyunoya et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Distribution of T-Cell Subsets in BAL Fluid of Patients With Mild to Moderate COPD Depends on Current Smoking Status and Not Airway Obstruction

(2013) Helena Forsslund et al.   CHEST

Heterogeneity of tumor-induced gene expression changes in the human metabolic network

(2013) Jie Hu et al.   NATURE BIOTECHNOLOGY

21st-Century Hazards of Smoking and Benefits of Cessation in the United States

(2013) Prabhat Jha et al.   NEW ENGLAND JOURNAL OF MEDICINE

Short-term cigarette smoke exposure induces reversible changes in energy metabolism and cellular redox status independent of inflammatory responses in mouse lungs

(2012) Amit R. Agarwal et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Insufficient autophagy in idiopathic pulmonary fibrosis

(2012) Jun Araya et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Acellular Normal and Fibrotic Human Lung Matrices as a Culture System forIn VitroInvestigation

(2012) Adam J. Booth et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Smoking and asthma: dangerous liaisons

(2012) Riccardo Polosa et al.   EUROPEAN RESPIRATORY JOURNAL

Pathogenesis of chronic obstructive pulmonary disease

(2012) Rubin M. Tuder et al.   JOURNAL OF CLINICAL INVESTIGATION

Prednisone, Azathioprine, andN-Acetylcysteine for Pulmonary Fibrosis

(2012)   NEW ENGLAND JOURNAL OF MEDICINE

The history of the discovery of the cigarette–lung cancer link: evidentiary traditions, corporate denial, global toll: Table 1

(2012) Robert N Proctor   TOBACCO CONTROL

Autophagy in the Cellular Energetic Balance

(2011) Rajat Singh et al.   Cell Metabolism

Cigarette Smoking and Inflammation

(2011) J. Lee et al.   JOURNAL OF DENTAL RESEARCH

NOX4/NADPH oxidase expression is increased in pulmonary fibroblasts from patients with idiopathic pulmonary fibrosis and mediates TGF 1-induced fibroblast differentiation into myofibroblasts

(2010) N. Amara et al.   THORAX

Arginase: a key enzyme in the pathophysiology of allergic asthma opening novel therapeutic perspectives

(2009) Harm Maarsingh et al.   BRITISH JOURNAL OF PHARMACOLOGY

Smoking-Dependent Reprogramming of Alveolar Macrophage Polarization: Implication for Pathogenesis of Chronic Obstructive Pulmonary Disease

(2009) R. Shaykhiev et al.   JOURNAL OF IMMUNOLOGY

Tobacco Smoke: Involvement of Reactive Oxygen Species and Stable Free Radicals in Mechanisms of Oxidative Damage, Carcinogenesis and Synergistic Effects with Other Respirable Particles

(2009) Athanasios Valavanidis et al.   International Journal of Environmental Research and Public Health

Animal models of chronic obstructive pulmonary disease

(2008) Joanne L. Wright et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY