Schisandrin A Inhibits the IL-1β-Induced Inflammation and Cartilage Degradation via Suppression of MAPK and NF-κB Signal Pathways in Rat Chondrocytes

Histone deacetylase-4 and histone deacetylase-8 regulate interleukin-1β-induced cartilage catabolic degradation through MAPK/JNK and ERK pathways

(2018) Pengcheng Wang et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Osteoarthritis year in review 2017: biology

(2018) C.T. Appleton   OSTEOARTHRITIS AND CARTILAGE

Osteoarthritis year in review 2017: clinical

(2018) A.E. Nelson   OSTEOARTHRITIS AND CARTILAGE

Schisandrin B ameliorated chondrocytes inflammation and osteoarthritis via suppression of NF-κB and MAPK signal pathways

(2018) Jisheng Ran et al.   Drug Design Development and Therapy

Schizandrin A Alleviates LPS-Induced Injury in Human Keratinocyte Cell Hacat Through a MicroRNA-127-Dependent Regulation

(2018) Shujie Li et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Comparative Effects of Schisandrin A, B, and C on Acne-Related Inflammation

(2017) Miaomiao Guo et al.   INFLAMMATION

Schisandrin A suppresses lipopolysaccharide-induced inflammation and oxidative stress in RAW 264.7 macrophages by suppressing the NF-κB, MAPKs and PI3K/Akt pathways and activating Nrf2/HO-1 signaling

(2017) Da Kwon et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment

(2017) Ok Hee Jeon et al.   NATURE MEDICINE

Knee osteoarthritis has doubled in prevalence since the mid-20th century

(2017) Ian J. Wallace et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biochanin-A antagonizes the interleukin-1β-induced catabolic inflammation through the modulation of NFκB cellular signaling in primary rat chondrocytes

(2016) Ji-Su Oh et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Schizandrin A Inhibits Microglia-Mediated Neuroninflammation through Inhibiting TRAF6-NF-κB and Jak2-Stat3 Signaling Pathways

(2016) Fangjiao Song et al.   PLoS One

Differential Action between Schisandrin A and Schisandrin B in Eliciting an Anti-Inflammatory Action: The Depletion of Reduced Glutathione and the Induction of an Antioxidant Response

(2016) Pou Kuan Leong et al.   PLoS One

Arthropod steroid hormone (20-Hydroxyecdysone) suppresses IL-1β- induced catabolic gene expression in cartilage

(2015) Shiow-Yunn Sheu et al.   BMC Complementary and Alternative Medicine

Osteoarthritis

(2015) S Glyn-Jones et al.   LANCET

Schisandrin A and B affect subventricular zone neurogenesis in mouse

(2014) Yi-Xue Sun et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Development and reliability of a multi-modality scoring system for evaluation of disease progression in pre-clinical models of osteoarthritis: celecoxib may possess disease-modifying properties

(2014) A. Panahifar et al.   OSTEOARTHRITIS AND CARTILAGE

Celecoxib exerts protective effects on extracellular matrix metabolism of mandibular condylar chondrocytes under excessive mechanical stress

(2014) S.-C. Su et al.   OSTEOARTHRITIS AND CARTILAGE

The protective mechanism of schisandrin A ind-galactosamine-induced acute liver injury through activation of autophagy

(2014) Ye Lu et al.   PHARMACEUTICAL BIOLOGY

Structure and bioactivity of triterpenoids from the stems of Schisandra sphenanthera

(2013) Cheng-Qin Liang et al.   ARCHIVES OF PHARMACAL RESEARCH

The NF-κB signalling pathway in osteoarthritis

(2013) Stella Rigoglou et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Protective Role of Deoxyschizandrin and Schisantherin A against Myocardial Ischemia–Reperfusion Injury in Rats

(2013) Ruimiao Chang et al.   PLoS One

MAPKs are essential upstream signaling pathways in proteolytic cartilage degradation – divergence in pathways leading to aggrecanase and MMP-mediated articular cartilage degradation

(2009) B.-C. Sondergaard et al.   OSTEOARTHRITIS AND CARTILAGE