Pharmacodynamic effects and molecular mechanisms of lignans from Schisandra chinensis Turcz. (Baill.), a current review
出版年份 2020 全文链接
标题
Pharmacodynamic effects and molecular mechanisms of lignans from Schisandra chinensis Turcz. (Baill.), a current review
作者
关键词
Lignans, S. chinensis, Antioxidation, Anti-inflammation, Neuroprotection
出版物
EUROPEAN JOURNAL OF PHARMACOLOGY
Volume 892, Issue -, Pages 173796
出版商
Elsevier BV
发表日期
2020-12-17
DOI
10.1016/j.ejphar.2020.173796
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Exploring the protective effects of schizandrol A in acute myocardial ischemia mice by comprehensive metabolomics profiling integrated with molecular mechanism studies
- (2020) Qiong Lai et al. ACTA PHARMACOLOGICA SINICA
- Evidence of anti-inflammatory activity of Schizandrin A in animal models of acute inflammation
- (2020) Likun Cui et al. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
- Schisandrin B suppresses liver fibrosis in rats by targeting miR-101-5p through the TGF-β signaling pathway
- (2020) Wang Cuiqiong et al. Artificial Cells Nanomedicine and Biotechnology
- Schisandrin B attenuates bleomycin-induced pulmonary fibrosis in mice through the wingless/integrase-1 signaling pathway
- (2020) Ying Wang et al. EXPERIMENTAL LUNG RESEARCH
- Schizandrin attenuates inflammation induced by avian pathogenic Escherichia coli in chicken type II pneumocytes
- (2020) Meng Yuan et al. INTERNATIONAL IMMUNOPHARMACOLOGY
- The effects of inhibiting the activation of hepatic stellate cells by lignan components from the fruits of Schisandra chinensis and the mechanism of schisanhenol
- (2020) Xiaoli He et al. Journal of Natural Medicines
- Schizandrin attenuates lung lesions induced by Avian pathogenic Escherichia coli in chickens
- (2020) Meng Yuan et al. MICROBIAL PATHOGENESIS
- Dysfunction of ABC transporters at the blood-brain barrier: Role in neurological disorders
- (2020) Eva Gil-Martins et al. PHARMACOLOGY & THERAPEUTICS
- Schisandrin C targets Keap1 and attenuates oxidative stress by activating Nrf2 pathway in Ang II-challenged vascular endothelium
- (2019) Jibo Han et al. PHYTOTHERAPY RESEARCH
- Schisandrin A Inhibits the IL-1β-Induced Inflammation and Cartilage Degradation via Suppression of MAPK and NF-κB Signal Pathways in Rat Chondrocytes
- (2019) Chang Tu et al. Frontiers in Pharmacology
- Potential of Schisandra chinensis (Turcz.) Baill. in Human Health and Nutrition: A Review of Current Knowledge and Therapeutic Perspectives
- (2019) Adriana Nowak et al. Nutrients
- Protective effect of Schisandra chinensis total lignans on acute alcoholic-induced liver injury related to inhibiting CYP2E1 activation and activating the Nrf2/ARE signaling pathway
- (2019) Lianlin Su et al. Revista Brasileira de Farmacognosia-Brazilian Journal of Pharmacognosy
- Systematically Characterize the Anti-Alzheimer's Disease Mechanism of Lignans from S. chinensis based on In-Vivo Ingredient Analysis and Target-Network Pharmacology Strategy by UHPLC–Q-TOF-MS
- (2019) Mengying Wei et al. MOLECULES
- Schizandrin protects H9c2 cells against lipopolysaccharide-induced injury by downregulating Smad3
- (2019) Xuehua Zhang et al. JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
- Schisandrin B ameliorates high glucose-induced vascular endothelial cells injury by regulating Noxa/Hsp27/NF-κB signaling pathway
- (2019) Qiu-Ning Lin et al. Biochemistry and Cell Biology
- Schisandrin A inhibits triple negative breast cancer cells by regulating Wnt/ER stress signaling pathway
- (2019) Xiaohong Xu et al. BIOMEDICINE & PHARMACOTHERAPY
- Schizandrin A enhances the efficacy of gefitinib by suppressing IKKβ/NF-κB signaling in non-small cell lung cancer
- (2019) Haibing Xian et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Characterization of the cold and hot natures of raw and processed Rehmanniae Radix by integrated metabolomics and network pharmacology
- (2019) Fangbo Xia et al. PHYTOMEDICINE
- Schizandrin B attenuates angiotensin II induced endothelial to mesenchymal transition in vascular endothelium by suppressing NF-κB activation
- (2019) Shengban You et al. PHYTOMEDICINE
- Gomisin M2 Inhibits Mast Cell-Mediated Allergic Inflammation via Attenuation of FcεRI-Mediated Lyn and Fyn Activation and Intracellular Calcium Levels
- (2019) Hima Dhakal et al. Frontiers in Pharmacology
- Gomisin M2 from Baizuan suppresses breast cancer stem cell proliferation in a zebrafish xenograft model
- (2019) Yeguo Yang et al. Aging-US
- Schisantherin A induces cell apoptosis through ROS/JNK signaling pathway in human gastric cancer cells
- (2019) Zishu Wang et al. BIOCHEMICAL PHARMACOLOGY
- Schisandrin A protects against lipopolysaccharide-induced mastitis through activating Nrf2 signaling pathway and inducing autophagy
- (2019) Dianwen Xu et al. INTERNATIONAL IMMUNOPHARMACOLOGY
- Schizandrin B Mitigates Rifampicin-Induced Liver Injury by Inhibiting Endoplasmic Reticulum Stress
- (2019) Ling Cheng et al. BIOLOGICAL & PHARMACEUTICAL BULLETIN
- The neuroprotective effect of schisandrol A on 6-OHDA-induced PD mice may be related to PI3K/AKT and IKK/IκBα/NF-κB pathway
- (2019) Tingxu Yan et al. EXPERIMENTAL GERONTOLOGY
- Effect of gomisin A on osteoblast differentiation in high glucose-mediated oxidative stress
- (2019) Jyoti Shrestha Takanche et al. PHYTOMEDICINE
- Gomisin A ameliorates metastatic melanoma by inhibiting AMPK and ERK/JNK-mediated cell survival and metastatic phenotypes
- (2019) Yo-Han Han et al. PHYTOMEDICINE
- Schisandrin B attenuates renal fibrosis via miR-30e-mediated inhibition of EMT
- (2019) Guangxu Cao et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- Schisandrin A protects intestinal epithelial cells from deoxynivalenol-induced cytotoxicity, oxidative damage and inflammation
- (2019) Murphy L. Y. Wan et al. Scientific Reports
- Schizandrin A Protects Human Retinal Pigment Epithelial Cell Line ARPE-19 against HG-Induced Cell Injury by Regulation of miR-145
- (2019) Yi Dong et al. Molecular Therapy-Nucleic Acids
- Schisandrin B alleviates acute oxidative stress via modulating Nrf2/Keap1-mediated antioxidant pathway
- (2018) Wu Ying et al. Applied Physiology Nutrition and Metabolism
- Schizandrin A enhances chemosensitivity of colon carcinoma cells to 5-fluorouracil through up-regulation of miR-195
- (2018) Dongfang Kong et al. BIOMEDICINE & PHARMACOTHERAPY
- An overview of neuroprotective and cognitive enhancement properties of lignans from Schisandra chinensis
- (2018) Kandhasamy Sowndhararajan et al. BIOMEDICINE & PHARMACOTHERAPY
- Gomisin G Suppresses the Growth of Colon Cancer Cells by Attenuation of AKT Phosphorylation and Arrest of Cell Cycle Progression
- (2018) Sony Maharjan et al. Biomolecules & Therapeutics
- Gomisin G Inhibits the Growth of Triple-Negative Breast Cancer Cells by Suppressing AKT Phosphorylation and Decreasing Cyclin D1
- (2018) Sony Maharjan et al. Biomolecules & Therapeutics
- Schisantherin A Attenuates Neuroinflammation in Activated Microglia: Role of Nrf2 Activation Through ERK Phosphorylation
- (2018) Chuwen Li et al. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
- New insights into TGF-β/Smad signaling in tissue fibrosis
- (2018) He-He Hu et al. CHEMICO-BIOLOGICAL INTERACTIONS
- Gomisin A modulates aging progress via mitochondrial biogenesis in human diploid fibroblast cells
- (2018) Jeong-Seok Kim et al. CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
- Synthesis and biological evaluation of Schizandrin derivatives as potential anti-cancer agents
- (2018) Devi Amujuri et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Schisandrol B promotes liver regeneration after partial hepatectomy in mice
- (2018) Xi Li et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Schisantherin A alleviated alcohol-induced liver injury by the regulation of alcohol metabolism and NF- kB pathway
- (2018) Bin LI et al. EXPERIMENTAL ANIMALS
- Protective Effects of Gomisin N against Hepatic Cannabinoid Type 1 Receptor-Induced Insulin Resistance and Gluconeogenesis
- (2018) Arulkumar Nagappan et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Fecal Metabolomics of Type 2 Diabetic Rats and Treatment with Gardenia jasminoides Ellis Based on Mass Spectrometry Technique
- (2018) Yuan Zhou et al. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
- Schisantherin A protects renal tubular epithelial cells from hypoxia/reoxygenation injury through the activation of PI3K/Akt signaling pathway
- (2018) Jiachuan Gong et al. JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
- Organ and tissue fibrosis: Molecular signals, cellular mechanisms and translational implications
- (2018) Ralf Weiskirchen et al. MOLECULAR ASPECTS OF MEDICINE
- Lignans from Schisandra chinensis rattan stems suppresses primary Aβ1-42-induced microglia activation via NF-κB/MAPK signaling pathway
- (2018) Bingyou Yang et al. NATURAL PRODUCT RESEARCH
- Schisandrin B ameliorated chondrocytes inflammation and osteoarthritis via suppression of NF-κB and MAPK signal pathways
- (2018) Jisheng Ran et al. Drug Design Development and Therapy
- Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries
- (2018) Freddie Bray et al. CA-A CANCER JOURNAL FOR CLINICIANS
- Schizandrin A Alleviates LPS-Induced Injury in Human Keratinocyte Cell Hacat Through a MicroRNA-127-Dependent Regulation
- (2018) Shujie Li et al. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
- Gomisin N Alleviates Ethanol-Induced Liver Injury through Ameliorating Lipid Metabolism and Oxidative Stress
- (2018) Arulkumar Nagappan et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Schisandrin B exhibits potent anticancer activity in triple negative breast cancer by inhibiting STAT3
- (2018) Xuanxuan Dai et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- Gomisin A Suppresses Colorectal Lung Metastasis by Inducing AMPK/p38-Mediated Apoptosis and Decreasing Metastatic Abilities of Colorectal Cancer Cells
- (2018) Ji-Ye Kee et al. Frontiers in Pharmacology
- Schisandra chinensis inhibiting TGFβ-induced activation of hepatic stellate cells
- (2018) Soon Young Shin et al. Applied Biological Chemistry
- Schisandrin B alleviates diabetic nephropathy through suppressing excessive inflammation and oxidative stress
- (2018) Zhenxin Mou et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Schisandrin B Attenuates Inflammation in LPS-Induced Sepsis Through miR-17-5p Downregulating TLR4
- (2018) Zhi-Rong Ji et al. INFLAMMATION
- Schisandrin B Improves the Renal Function of IgA Nephropathy Rats Through Inhibition of the NF-κB Signalling Pathway
- (2018) Jian-Hua Qin et al. INFLAMMATION
- Schisandra Chinensis Lignans Suppresses the Production of Inflammatory Mediators Regulated by NF-κB, AP-1, and IRF3 in Lipopolysaccharide-Stimulated RAW264.7 Cells
- (2018) Gan Luo et al. MOLECULES
- Schisandrin B attenuates epidural fibrosis in postlaminectomy rats by inhibiting proliferation and extracellular matrix production of fibroblasts
- (2018) Haiming Jin et al. PHYTOTHERAPY RESEARCH
- Schisandrin B protects against angiotensin II-induced endotheliocyte deficits by targeting Keap1 and activating Nrf2 pathway
- (2018) Jibo Han et al. Drug Design Development and Therapy
- Schisandrin B elicits the Keap1-Nrf2 defense system via carbene reactive metabolite which is less harmful to mice liver
- (2018) Shan Feng et al. Drug Design Development and Therapy
- Novel Gomisin B analogues as potential cytotoxic agents: Design, synthesis, biological evaluation and docking studies
- (2017) B. Poornima et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Alzheimer's disease
- (2017) C. A. Lane et al. EUROPEAN JOURNAL OF NEUROLOGY
- Schisandra Lignan Extract Protects against Carbon Tetrachloride-Induced Liver Injury in Mice by Inhibiting Oxidative Stress and Regulating the NF-κB and JNK Signaling Pathways
- (2017) Qingshan Chen et al. Evidence-based Complementary and Alternative Medicine
- Comparative Effects of Schisandrin A, B, and C on Acne-Related Inflammation
- (2017) Miaomiao Guo et al. INFLAMMATION
- Anti-Inflammatory Effects of Schisandrin B on LPS-Stimulated BV2 Microglia via Activating PPAR-γ
- (2017) Na Liu et al. INFLAMMATION
- Anti-inflammatory and antioxidant properties of Schisandrin C promote mitochondrial biogenesis in human dental pulp cells
- (2017) J. S. Takanche et al. INTERNATIONAL ENDODONTIC JOURNAL
- Protective effects of Schisandrin B on cigarette smoke-induced airway injury in mice through Nrf2 pathway
- (2017) Ruichun Jia et al. INTERNATIONAL IMMUNOPHARMACOLOGY
- Synergistic protection of Schizandrin B and Glycyrrhizic acid against bleomycin-induced pulmonary fibrosis by inhibiting TGF-β1/Smad2 pathways and overexpression of NOX4
- (2017) Di Zhang et al. INTERNATIONAL IMMUNOPHARMACOLOGY
- Attenuation of cyclosporine A induced nephrotoxicity by schisandrin B through suppression of oxidative stress, apoptosis and autophagy
- (2017) Qiao Lai et al. INTERNATIONAL IMMUNOPHARMACOLOGY
- Schisandrin B inhibits LPS-induced inflammatory response in human umbilical vein endothelial cells by activating Nrf2
- (2017) Qiuning Lin et al. INTERNATIONAL IMMUNOPHARMACOLOGY
- Schisantherin A protects against liver ischemia-reperfusion injury via inhibition of mitogen-activated protein kinase pathway
- (2017) Nanxin Zheng et al. INTERNATIONAL IMMUNOPHARMACOLOGY
- Gomisin N Inhibits Melanogenesis through Regulating the PI3K/Akt and MAPK/ERK Signaling Pathways in Melanocytes
- (2017) Jae Chae et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Schisandrin B attenuates the inflammatory response, oxidative stress and apoptosis induced by traumatic spinal cord injury via inhibition of p53 signaling in adult rats
- (2017) D.Q. Xin et al. Molecular Medicine Reports
- AMPK: guardian of metabolism and mitochondrial homeostasis
- (2017) Sébastien Herzig et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Schisandrin C enhances mitochondrial biogenesis and autophagy in C2C12 skeletal muscle cells: potential involvement of anti-oxidative mechanisms
- (2017) Jeong-Seok Kim et al. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
- Schisandrin B inhibits the proliferation and invasion of glioma cells by regulating the HOTAIR–micoRNA-125a–mTOR pathway
- (2017) Yan Jiang et al. NEUROREPORT
- AMPK as a Therapeutic Target for Treating Metabolic Diseases
- (2017) Emily A. Day et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- Schisandrin B attenuates CCl4-induced liver fibrosis in rats by regulation of Nrf2-ARE and TGF-β/Smad signaling pathways
- (2017) Qingshan Chen et al. Drug Design Development and Therapy
- Schisandrin B reverses doxorubicin resistance through inhibiting P-glycoprotein and promoting proteasome-mediated degradation of survivin
- (2017) Shengpeng Wang et al. Scientific Reports
- Transcriptional Regulation by Nrf2
- (2017) Claudia Tonelli et al. ANTIOXIDANTS & REDOX SIGNALING
- Schisandrol B protects against acetaminophen-induced acute hepatotoxicity in mice via activation of the NRF2/ARE signaling pathway
- (2016) Yi-ming Jiang et al. ACTA PHARMACOLOGICA SINICA
- Suppression of P2X7/NF-κB pathways by Schisandrin B contributes to attenuation of lipopolysaccharide-induced inflammatory responses in acute lung injury
- (2016) Zhiyong Cai et al. ARCHIVES OF PHARMACAL RESEARCH
- Schisandrin B inhibits the proliferation of airway smooth muscle cells via microRNA-135a suppressing the expression of transient receptor potential channel 1
- (2016) Xiao-yu Zhang et al. CELL BIOLOGY INTERNATIONAL
- Proliferation, survival and metabolism: the role of PI3K/AKT/mTOR signalling in pluripotency and cell fate determination
- (2016) Jason S. L. Yu et al. DEVELOPMENT
- Schisantherin A suppresses interleukin-1β-induced inflammation in human chondrocytes via inhibition of NF-κB and MAPKs activation
- (2016) Shiyao Liao et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Gomisin N Decreases Inflammatory Cytokine Production in Human Periodontal Ligament Cells
- (2016) Yoshitaka Hosokawa et al. INFLAMMATION
- Current knowledge of Schisandra chinensis (Turcz.) Baill. (Chinese magnolia vine) as a medicinal plant species: a review on the bioactive components, pharmacological properties, analytical and biotechnological studies
- (2016) Agnieszka Szopa et al. PHYTOCHEMISTRY REVIEWS
- Dissecting molecular cross-talk between Nrf2 and NF-κB response pathways
- (2015) Joanna D. Wardyn et al. BIOCHEMICAL SOCIETY TRANSACTIONS
- Schisandrin B induces an Nrf2-mediated thioredoxin expression and suppresses the activation of inflammasomein vitroandin vivo
- (2015) Pou Kuan Leong et al. BIOFACTORS
- Schisandrin B suppresses glioma cell metastasis mediated by inhibition of mTOR/MMP-9 signal pathway
- (2015) Yan Jiang et al. BIOMEDICINE & PHARMACOTHERAPY
- Hepato-protective effects of six schisandra lignans on acetaminophen-induced liver injury are partially associated with the inhibition of CYP-mediated bioactivation
- (2015) Yiming Jiang et al. CHEMICO-BIOLOGICAL INTERACTIONS
- Molecular basis of the Keap1–Nrf2 system
- (2015) Takafumi Suzuki et al. FREE RADICAL BIOLOGY AND MEDICINE
- Schizandrin inhibits fibrosis and epithelial–mesenchymal transition in transforming growth factor-β1-stimulated AML12 cells
- (2015) Ji-hyun Park et al. INTERNATIONAL IMMUNOPHARMACOLOGY
- Gomisin J Inhibits Oleic Acid-Induced Hepatic Lipogenesis by Activation of the AMPK-Dependent Pathway and Inhibition of the Hepatokine Fetuin-A in HepG2 Cells
- (2015) Myungsuk Kim et al. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
- Schisantherin A protects against 6-OHDA-induced dopaminergic neuron damage in zebrafish and cytotoxicity in SH-SY5Y cells through the ROS/NO and AKT/GSK3β pathways
- (2015) Lun Qing Zhang et al. JOURNAL OF ETHNOPHARMACOLOGY
- Schisandrin B protects PC12 cells against oxidative stress of neurodegenerative diseases
- (2015) En-Ping Jiang et al. NEUROREPORT
- Extracts and lignans of Schisandra chinensis fruit alter lipid and glucose metabolism in vivo and in vitro
- (2015) Haitao Liu et al. Journal of Functional Foods
- Reciprocal regulation of TGF-β and reactive oxygen species: A perverse cycle for fibrosis
- (2015) Rui-Ming Liu et al. Redox Biology
- P-glycoprotein inhibitors of natural origin as potential tumor chemo-sensitizers: A review
- (2015) Hossam M. Abdallah et al. Journal of Advanced Research
- Schisandrin B Prevents Doxorubicin Induced Cardiac Dysfunction by Modulation of DNA Damage, Oxidative Stress and Inflammation through Inhibition of MAPK/p53 Signaling
- (2015) Rajarajan A. Thandavarayan et al. PLoS One
- Schisandrin B Ameliorates ICV-Infused Amyloid β Induced Oxidative Stress and Neuronal Dysfunction through Inhibiting RAGE/NF-κB/MAPK and Up-Regulating HSP/Beclin Expression
- (2015) Vijayasree V. Giridharan et al. PLoS One
- PI3K/Akt-mediated regulation of p53 in cancer
- (2014) Aswin G. Abraham et al. BIOCHEMICAL SOCIETY TRANSACTIONS
- Regulation of NF-κB by ubiquitination
- (2013) Jueqi Chen et al. CURRENT OPINION IN IMMUNOLOGY
- TGF-β signaling in fibrosis
- (2011) Anna Biernacka et al. GROWTH FACTORS
- Pathological roles of MAPK signaling pathways in human diseases
- (2010) Eun Kyung Kim et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Crosstalk of reactive oxygen species and NF-κB signaling
- (2010) Michael J Morgan et al. CELL RESEARCH
- Increased levels of 4-hydroxynonenal and acrolein in the brain in preclinical Alzheimer disease
- (2010) M.A. Bradley et al. FREE RADICAL BIOLOGY AND MEDICINE
- Oxidative stress and glutathione in TGF-β-mediated fibrogenesis
- (2009) R.-M. Liu et al. FREE RADICAL BIOLOGY AND MEDICINE
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