Article
Plant Sciences
Jing Zhao, Kaixin Ding, Manting Hou, Yuanhua Li, Xiaorong Hou, Wenzhang Dai, Zhiyong Li, Jun Zhao, Wenlong Liu, Zhaofang Bai
Summary: This study demonstrated that Schisandra chinensis essential oil has protective effects against acetaminophen-induced liver injury in mice, suggesting its potential as a therapeutic option for liver diseases.
PHARMACEUTICAL BIOLOGY
(2022)
Article
Food Science & Technology
Zhou Si, Haoxiang Chen, Chensi Gu, Tingting Wang, Ziluan Fan
Summary: Schisandra chinensis extract (SCE) has significant anti-fatigue effects in mice by prolonging swimming time, increasing levels of hepatic and muscular glycogen, reducing levels of lactic acid, blood urea nitrogen, and malondialdehyde, enhancing activities of antioxidant enzymes, and activating the AMPK/PGC-1 alpha signaling pathway.
Review
Biochemistry & Molecular Biology
Dalia M. Kopustinskiene, Jurga Bernatoniene
Summary: Schisandra chinensis fruits, their extracts, and bioactive compounds have potent antioxidant and mitoprotective effects, exerting anti-inflammatory, antiviral, anticancer, and anti-aging properties. The polyphenolic compounds in S. chinensis are responsible for its antioxidant activities, which play a significant role in protecting cells under normal and pathological conditions.
Article
Chemistry, Medicinal
Tingxu Yan, Nizhi Wang, Bing Liu, Bo Wu, Feng Xiao, Bosai He, Ying Jia
Summary: The study found that lignans in Schisandra chinensis are effective in ameliorating depressive disorders by inhibiting inflammation and regulating gut microbiota balance.
PHYTOTHERAPY RESEARCH
(2021)
Article
Multidisciplinary Sciences
Linye Zhang, Qihong Jiang, Xiuming Wang, Amit Jaisi, Opeyemi Joshua Olatunji
Summary: This study evaluated the cardioprotective effects of Boesenbergia rotunda extract (BrE) against doxorubicin (DOX)-induced cardiotoxicity. The results demonstrated that BrE attenuated DOX-induced body and cardiac weight loss, prevented cardiac injury by mitigating histopathological alterations and reducing serum cardiac function enzymes. Furthermore, BrE alleviated cardiotoxicity by reducing oxidative stress, inflammation, and apoptosis in cardiac tissues.
SCIENTIFIC REPORTS
(2023)
Article
Environmental Sciences
Yu Wang, Hongjing Zhao, Yachen Liu, Jingyan Li, Xiaopan Nie, Puyi Huang, Mingwei Xing
Summary: This study revealed the therapeutic effect of Lycopene (LYC) on sulfamethoxazole (SMZ)-induced intestinal injury in grass carp, showing that LYC can suppress intestinal damage, oxidative stress, inflammation, and apoptosis, as well as reduce autophagy activation caused by SMZ.
ENVIRONMENTAL POLLUTION
(2021)
Article
Nutrition & Dietetics
Yun Mi Lee, Eunjung Son, Seung-Hyung Kim, Dong-Seon Kim
Summary: This study aimed to investigate the effects of Schisandra chinensis leaf extracts (SCLE) on inflammation and pain in different animal models, and found that SCLE could effectively reduce inflammation and pain, making it a potential therapeutic candidate for osteoarthritis (OA).
Review
Biochemistry & Molecular Biology
Darcy Wear, Caleb Vegh, Jagdeep K. Sandhu, Marianna Sikorska, Jerome Cohen, Siyaram Pandey
Summary: The search for effective therapies for progressive neurodegenerative diseases like Alzheimer's and Parkinson's continues, with a focus on redox therapies such as coenzyme-Q(10). A water-soluble formulation called Ubisol-Q(10) has shown promising results in providing neuroprotection, antioxidant effects, anti-inflammatory properties, and mitochondrial stabilization in in vitro and in vivo models.
Article
Chemistry, Medicinal
Xu Wang, Wenzhuang Shi, Kang Wang, Zifan Ye, Runying Wang, Hui Wang, Huaixin Yang, Zeping Xie, Haining Yu, Yipeng Wang
Summary: In this study, a nonapeptide named PWH was screened and found to have antioxidant activity, promote the secretion of type 1 collagen, and repair damaged skin. PWH could alleviate UV-A-induced oxidative stress, restrain pro-inflammatory cytokine production, protect mitochondrial function, and maintain autophagy activity. In addition, inhibiting the PI3K/AKT/mTOR signaling pathway and restoration of autophagy activity were found to delay the photoaging process in skin cells. Topical applications of PWH showed significant protection against full-wavelength UV-induced skin aging in mice models, both in prophylaxis and treatment. With good stability and no toxicity or anaphylaxis, PWH holds promise as a candidate for cosmetics and pharmaceuticals.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Su Jin Lee, Ji Eun Kim, Yun Ju Choi, Jeong Eun Gong, You Jeong Jin, Da Woon Lee, Young Whan Choi, Dae Youn Hwang
Summary: Alpha-cubebenol isolated from Schisandra chinensis shows novel roles as a lipogenesis inhibitor, lipolysis and beta-oxidation stimulator, and inflammasome suppressor in MDI-stimulated 3T3-L1 adipocytes, without significant cytotoxic effects.
Review
Pharmacology & Pharmacy
Yuan Zhou, Lihui Men, Yunxia Sun, Mengying Wei, Xiang Fan
Summary: Schisandra chinensis, a traditional herbal medicine, is commonly used in the treatment of liver and neurological diseases. Modern research has highlighted lignans as its main active ingredients, showing antioxidant, anti-inflammatory, and neuroprotective properties, as well as potential effects in cancer and fibrosis.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Food Science & Technology
Jae-Hoon Lee, Yun-Yeol Lee, Jangho Lee, Young-Jin Jang, Hae-Won Jang
Summary: The study investigated the chemical composition and antioxidant anti-inflammatory activity of essential oil from Schisandra chinensis fruits, confirming its significant inhibitory effects on ROS and NO production. OMEO, containing compounds like α-pinene and nerolidol, showed excellent potential as a functional food ingredient with antioxidant and anti-inflammatory properties.
Article
Forestry
Dan Sun, Xilin Zhao, Jun Ai, Zhenxing Wang, Guangli Shi, Yumeng Liu, Xiang Li, Chengcheng Zhao
Summary: This study aimed to determine a suitable growing medium and appropriate root hormone type, concentration, and treatment time for the cutting propagation of Schisandra chinensis. The optimal treatment resulted in a rooting rate of 60% with 225 ppm ABT and 75 ppm NAA for 2.5 h. The vermiculite/perlite = 1:1 (urea+potassium) substrate promoted adventitious root formation, reaching 79%. The timing of enzyme activity and hormone concentration was affected by the treatments. High endogenous IAA concentration promoted early adventitious root formation, while lower endogenous IAA and GA(3) concentrations promoted root elongation and growth in the later stages. Low ABA and ZR concentrations facilitated adventitious root formation and elongation. Developing an efficient cutting propagation system would enable mass propagation of S. chinensis seedlings.
Article
Multidisciplinary Sciences
Alvar J. Alonso-Lavin, Djordje Bajic, Juan F. Poyatos
Summary: This research focuses on the impact of redox couple imbalances on cellular function, particularly in yeast. By using a computational model of metabolism, the study shows that redox disequilibrium can lead to metabolic syndromes similar to those seen in cancer cells. The findings also highlight the importance of certain metabolites in helping to regulate redox imbalances, which can in turn influence lifespan and potential anti-aging interventions.
Article
Immunology
You-Suk Lee, Sung-Min Kim, Eun-Jung Park, Hae-Jeung Lee
Summary: The present study investigated the therapeutic effects of Schisandra chinensis (SC) extract on osteoarthritis symptoms and the underlying mechanisms in a rat model. The results showed that SC extract alleviated pain behavior, bone erosion, and cartilage degradation, reduced levels of matrix metalloproteinases and pro-inflammatory cytokines, reversed the levels of biomarkers in cartilage tissue, and inhibited the phosphorylation levels of nuclear factor kappa B (NF-kappa B). These findings suggest that SC extract may be a potential therapeutic agent for osteoarthritis.
INFLAMMOPHARMACOLOGY
(2022)