Article
Plant Sciences
Fernanda Rodrigues Santana, Marilia Trindade de Santana Souza, Enilton Aparecido Camargo, Aparecido Camargo, James Almada da Silva
Summary: This study aimed to evaluate the antinociceptive and anti-inflammatory activities of the pectinolide-enriched fraction of Mesosphaerum pectinatum (PEF) in animal models. PEF was found to have significant anti-inflammatory effects and potential for cancer treatment. These findings suggest the importance of this plant species in the search for bioactive compounds.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Mokhtaria Yasmina Boufadi, Jalal Soubhye, Pierre Van Antwerpen
Summary: Propolis extract has anti-inflammatory effects, reducing edema and inflammation markers, restoring homeostasis, increasing enzyme activity, and enhancing total antioxidant levels. It can be used in industries for the prevention of inflammatory diseases and protection against oxidative stress-induced damage.
JOURNAL OF FOOD BIOCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Soo-Jin Park, Dong-Soon Im
Summary: 2-ARA-LPE has been shown to inhibit M1 macrophage polarization and reduce inflammation in mouse peritoneal macrophages, as well as suppress carrageenan-induced paw edema in vivo. This compound may have potential anti-inflammatory effects by modulating macrophage phenotypes and gene expression related to inflammation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Irem Mert, Ayhan Cetinkaya, Mujgan Gurler, Canan Akunal Turel, Humeyra Celik, Ibrahim Ethem Torun, Idris Turel
Summary: The present study aimed to investigate the anti-inflammatory actions of liraglutide in an acute peripheral inflammation model. The results showed that liraglutide significantly improved hypersensitivity, reduced edema and fever, and suppressed inflammatory signs compared to tramadol. Co-administration of liraglutide and tramadol further reduced sensitivity to mechanical and cold stimuli.
INFLAMMOPHARMACOLOGY
(2022)
Review
Immunology
Wenji Zhang, Hui Lin, Mingmin Zou, Qinghua Yuan, Zhenrui Huang, Xiaoying Pan, Wenjuan Zhang
Summary: Nicotine, as an anti-inflammatory alkaloid, has dual roles in treating diseases. It predominantly exhibits anti-inflammatory effects, especially in ulcerative colitis, arthritis, sepsis, and endotoxemia, but may promote and aggravate certain diseases such as periodontitis and gingivitis in oral inflammation. The molecular mechanism of nicotine in these inflammatory diseases involves regulating immune cells, immune factors, and the vagus and acetylcholinergic anti-inflammatory pathways, offering potential value for remedying acute and chronic inflammation in humans.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Nutrition & Dietetics
Yun Mi Lee, Eunjung Son, Seung-Hyung Kim, Dong-Seon Kim
Summary: This study aimed to investigate the effects of Schisandra chinensis leaf extracts (SCLE) on inflammation and pain in different animal models, and found that SCLE could effectively reduce inflammation and pain, making it a potential therapeutic candidate for osteoarthritis (OA).
Article
Engineering, Biomedical
Mariana de Souza Costa, Tarcisio Vieira de Brito, Saul Barbosa de Oliveira, Isabela de Souza Brauna, Jose Carlos Rapozo Mazulo Neto, Ramon Handerson Gomes Teles, Yago Medeiros Dutra, Diva de Aguiar Magalhaes, Stefany Guimaraes Sousa, Janyere Alexandrino de Sousa, Carlos Eduardo Rodrigues Castelo Branco, Fuad Ahmad Hazime, Andre Luiz dos Reis Barbosa, Daniel Fernando Pereira Vasconcelos, Jand Venes Rolim Medeiros, Marcelo de Carvalho Filgueiras
Summary: Photobiomodulation therapy (PBMT) is a non-thermal therapeutic procedure used in clinical practice for treating various inflammatory conditions with fewer adverse effects compared to conventional therapy. This study investigated the effects of two different doses of PBMT on experimental models of inflammation, showing that 1 J/cm(2) of PBMT improved paw edema and reduced histological scores induced by phlogistic agents. PBMT at 1 J/cm(2) also demonstrated beneficial effects on carrageenan-induced edema and inhibited neutrophil migration.
LASERS IN MEDICAL SCIENCE
(2022)
Article
Cell Biology
Emanuele P. Lima, Odinei H. Goncalves, Franciele Q. Ames, Lidiane V. Castro-Hoshino, Fernanda V. Leimann, Roberto K. N. Cuman, Jurandir F. Comar, Ciomar A. Bersani-Amado
Summary: The study found that nanoencapsulated curcuminoid preparations and free curcuminoids had similar anti-inflammatory effects in topical treatment, while oral administration of nanoencapsulated curcuminoid preparations had a higher anti-inflammatory effect than free curcuminoids. Additionally, nanoencapsulated curcuminoid preparations showed better bioavailability compared to free curcuminoids.
Review
Chemistry, Medicinal
Leticia Groli Lucca, Pedro Roosevelt Torres Romao, Marcia Vignoli-Silva, Valdir F. da Veiga-Junior, Leticia S. Koester
Summary: In recent years, there has been an increasing interest in finding new therapeutic strategies for inflammatory diseases. Natural products, particularly essential oils, are being explored as potential sources of new drugs due to their pharmacological properties. This review discusses the commonly used in vivo models to study acute inflammation and presents studies demonstrating the anti-inflammatory activity of essential oils in vivo. Various families of plants have been found to contain essential oils with anti-inflammatory properties, such as Apiaceae, Asteraceae, and Burseraceae.
MINI-REVIEWS IN MEDICINAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Marie-Albane Minati, Maxime Libert, Hajar Dahou, Patrick Jacquemin, Mohamad Assi
Summary: Pancreatitis, especially when combined with Kras mutations, is a main driver of pancreatic cancer. Treatment with thiol-containing compound N-acetylcysteine (NAC) can increase pancreatic glutathione levels, reduce oxidative damages, and inhibit the production of inflammatory and tumor-related factors.
Article
Plant Sciences
Dilani Rukshala, E. Dilip de Silva, B. V. Loshini R. Ranaweera, Narmada Fernando, Shiroma M. Handunnetti
Summary: The study investigated the anti-inflammatory activity of Vernonia zeylanica methanol/dichloromethane extract by assessing inhibition of rat paw edema, NO and superoxide production, and iNOS gene expression. The results demonstrated potent anti-inflammatory activity of the extract, emphasizing the need for further purification and isolation of bioactive compounds.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Malgorzata Krol, Patrycja Kupnicka, Mateusz Bosiacki, Dariusz Chlubek
Summary: Stretching is a popular element in physiotherapy and rehabilitation, which can help reduce the disabling effects of chronic health conditions. Recent studies have shown that stretching not only has systemic anti-inflammatory effects, but also local effects. This review summarizes the current knowledge on the anti-inflammatory properties of stretching and suggests that a better understanding of this may increase its importance in the treatment and recovery of diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Noelia Florez-Fernandez, Arianna Rodriguez-Coello, Thomas Latire, Nathalie Bourgougnon, M. Dolores Torres, Manuela Bujan, Alexandra Muinos, Antonio Muinos, Rosa Meijide-Failde, Francisco J. Blanco, Carlos Vaamonde-Garcia, Herminia Dominguez
Summary: Ulvans, sulfated polysaccharides found in green seaweeds, have interesting anti-inflammatory properties. However, their composition and properties vary greatly depending on seaweed species and processing conditions. This review emphasizes the importance of appropriate extraction, depolymerization, and purification techniques for reproducible and well-characterized products. Ulvans can modulate different signaling pathways to exert anti-inflammatory effects and have potential applications in various diseases.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Biochemistry & Molecular Biology
Shih-Chun Yang, Ahmed Alalaiwe, Zih-Chan Lin, Yu-Chih Lin, Ibrahim A. Aljuffali, Jia-You Fang
Summary: miRNA plays a critical role in regulating skin inflammation and has anti-inflammatory features. miRNA-based therapies could be potential candidates for treating skin inflammation.
Article
Chemistry, Medicinal
Kalu K. Asanka Sanjeewa, Kalahe H. I. N. M. Herath, Hye-Won Yang, Cheol Soo Choi, You-Jin Jeon
Summary: Fucoidans are sulfated heteropolysaccharides found in brown seaweeds and some marine invertebrates, with promising bioactive properties such as antioxidant, immunomodulatory, anti-inflammatory, antiobesity, antidiabetic, and anticancer properties. Controlled inflammatory responses are beneficial, but chronic inflammatory responses are often associated with the pathogenesis of various diseases.