Long non‐coding RNA TINCR suppresses metastatic melanoma dissemination by preventing ATF4 translation

Control of translation elongation in health and disease

(2020) John R. P. Knight et al.   Disease Models & Mechanisms

PRL3-DDX21 Transcriptional Control of Endolysosomal Genes Restricts Melanocyte Stem Cell Differentiation

(2020) Jeanette A. Johansson et al.   DEVELOPMENTAL CELL

Tuning Transcription Factor Availability through Acetylation-Mediated Genomic Redistribution

(2020) Pakavarin Louphrasitthiphol et al.   MOLECULAR CELL

Many ways to resistance: How melanoma cells evade targeted therapies

(2019) Ines Kozar et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

MITF—the first 25 years

(2019) Colin R. Goding et al.   GENES & DEVELOPMENT

Long Noncoding RNA and Epithelial Mesenchymal Transition in Cancer

(2019) Gugnoni et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Stem Cell-Derived Models of Neural Crest Are Essential to Understand Melanoma Progression and Therapy Resistance

(2019) Lionel Larribère et al.   Frontiers in Molecular Neuroscience

MITF controls the TCA cycle to modulate the melanoma hypoxia response

(2019) Pakavarin Louphrasitthiphol et al.   Pigment Cell & Melanoma Research

The X-Linked DDX3X RNA Helicase Dictates Translation Reprogramming and Metastasis in Melanoma

(2019) Bengt Phung et al.   Cell Reports

Melanoma plasticity and phenotypic diversity: therapeutic barriers and opportunities

(2019) Florian Rambow et al.   GENES & DEVELOPMENT

Lineage-Restricted Regulation of SCD and Fatty Acid Saturation by MITF Controls Melanoma Phenotypic Plasticity

(2019) Yurena Vivas-García et al.   MOLECULAR CELL

Translational reprogramming marks adaptation to asparagine restriction in cancer

(2019) Gaurav Pathria et al.   NATURE CELL BIOLOGY

The MITF-SOX10 regulated long non-coding RNA DIRC3 is a melanoma tumour suppressor

(2019) Elizabeth A. Coe et al.   PLoS Genetics

Mechanisms of resistance to immune checkpoint inhibitors

(2018) Russell W Jenkins et al.   BRITISH JOURNAL OF CANCER

Toward Minimal Residual Disease-Directed Therapy in Melanoma

(2018) Florian Rambow et al.   CELL

Cross-talk between protein synthesis, energy metabolism and autophagy in cancer

(2018) Lisa M Lindqvist et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

N 6 -Methyladenosine Guides mRNA Alternative Translation during Integrated Stress Response

(2018) Jun Zhou et al.   MOLECULAR CELL

Cooperative targeting of melanoma heterogeneity with an AXL antibody-drug conjugate and BRAF/MEK inhibitors

(2018) Julia Boshuizen et al.   NATURE MEDICINE

Regulation of translation initiation factor eIF2B at the hub of the integrated stress response

(2018) Graham D. Pavitt   Wiley Interdisciplinary Reviews-RNA

Melanoma

(2018) Dirk Schadendorf et al.   LANCET

Ribosome Profiling: Global Views of Translation

(2018) Nicholas T. Ingolia et al.   Cold Spring Harbor Perspectives in Biology

Starvation and Pseudo-Starvation as Drivers of Cancer Metastasis through Translation Reprogramming

(2018) Custodia García-Jiménez et al.   Cell Metabolism

Translation reprogramming is an evolutionarily conserved driver of phenotypic plasticity and therapeutic resistance in melanoma

(2017) Paola Falletta et al.   GENES & DEVELOPMENT

Surviving Stress: Modulation of ATF4-Mediated Stress Responses in Normal and Malignant Cells

(2017) Inge M.N. Wortel et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Microenvironment-derived factors driving metastatic plasticity in melanoma

(2017) Isabella S. Kim et al.   Nature Communications

Hypoxia-mediated translational activation of ITGB3 in breast cancer cells enhances TGF-β signaling and malignant features in vitro and in vivo

(2017) Marta Sesé et al.   Oncotarget

Glucose availability controls ATF4-mediated MITF suppression to drive melanoma cell growth

(2017) Jennifer Ferguson et al.   Oncotarget

Genomic and Transcriptomic Features of Response to Anti-PD-1 Therapy in Metastatic Melanoma

(2016) Willy Hugo et al.   CELL

4E-BP1, a multifactor regulated multifunctional protein

(2016) Xiaoyu Qin et al.   CELL CYCLE

The integrated stress response

(2016) Karolina Pakos‐Zebrucka et al.   EMBO REPORTS

miR-214 protects erythroid cells against oxidative stress by targeting ATF4 and EZH2

(2016) Ming Gao et al.   FREE RADICAL BIOLOGY AND MEDICINE

Melanoma addiction to the long non-coding RNA SAMMSON

(2016) Eleonora Leucci et al.   NATURE

Single-cell RNA-seq supports a developmental hierarchy in human oligodendroglioma

(2016) Itay Tirosh et al.   NATURE

The emerging role of long non-coding RNAs in cutaneous melanoma

(2016) Eleonora Leucci et al.   Pigment Cell & Melanoma Research

Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq

(2016) I. Tirosh et al.   SCIENCE

SNHG5 promotes colorectal cancer cell survival by counteracting STAU1-mediated mRNA destabilization

(2016) Nkerorema Djodji Damas et al.   Nature Communications

Genome-wide assessment of differential translations with ribosome profiling data

(2016) Zhengtao Xiao et al.   Nature Communications

In Vivo Genetic Screens of Patient-Derived Tumors Revealed Unexpected Frailty of the Transformed Phenotype

(2016) D. Bossi et al.   Cancer Discovery

miRNA-1283 Regulates the PERK/ATF4 Pathway in Vascular Injury by Targeting ATF4

(2016) Ling He et al.   PLoS One

Regulation and roles of elongation factor 2 kinase

(2015) Christopher G. Proud   BIOCHEMICAL SOCIETY TRANSACTIONS

The race to decipher the top secrets of TOP mRNAs

(2015) Oded Meyuhas et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

CALML5 is a ZNF750- and TINCR-induced protein that binds stratifin to regulate epidermal differentiation

(2015) Bryan K. Sun et al.   GENES & DEVELOPMENT

The CASC15 Long Intergenic Noncoding RNA Locus Is Involved in Melanoma Progression and Phenotype Switching

(2015) Laurent Lessard et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

The emerging role of lncRNAs in cancer

(2015) Maite Huarte   NATURE MEDICINE

Detecting actively translated open reading frames in ribosome profiling data

(2015) Lorenzo Calviello et al.   NATURE METHODS

Decoding the regulatory landscape of melanoma reveals TEADS as regulators of the invasive cell state

(2015) Annelien Verfaillie et al.   Nature Communications

MITF and c-Jun antagonism interconnects melanoma dedifferentiation with pro-inflammatory cytokine responsiveness and myeloid cell recruitment

(2015) Stefanie Riesenberg et al.   Nature Communications

Transcription factor MITF and remodeller BRG1 define chromatin organisation at regulatory elements in melanoma cells

(2015) Patrick Laurette et al.   eLife

HTSeq--a Python framework to work with high-throughput sequencing data

(2014) S. Anders et al.   BIOINFORMATICS

Enhancer-targeted genome editing selectively blocks innate resistance to oncokinase inhibition

(2014) D. E. Webster et al.   GENOME RESEARCH

Primary Melanoma Tumors from CDKN2A Mutation Carriers Do Not Belong to a Distinct Molecular Subclass

(2014) Johan Staaf et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Ribosomal stress activates eEF2K–eEF2 pathway causing translation elongation inhibition and recruitment of Terminal Oligopyrimidine (TOP) mRNAs on polysomes

(2014) Angelo Gismondi et al.   NUCLEIC ACIDS RESEARCH

Single-cell gene expression signatures reveal melanoma cell heterogeneity

(2014) M Ennen et al.   ONCOGENE

Low MITF/AXL ratio predicts early resistance to multiple targeted drugs in melanoma

(2014) Judith Müller et al.   Nature Communications

A Melanoma Cell State Distinction Influences Sensitivity to MAPK Pathway Inhibitors

(2014) D. J. Konieczkowski et al.   Cancer Discovery

Reprogramming during epithelial to mesenchymal transition under the control of TGFβ

(2014) E-Jean Tan et al.   Cell Adhesion & Migration

Effects of Epithelial to Mesenchymal Transition on T Cell Targeting of Melanoma Cells

(2014) Katherine Woods et al.   Frontiers in Oncology

Melanoma Cells Revive an Embryonic Transcriptional Network to Dictate Phenotypic Heterogeneity

(2014) Niels Vandamme et al.   Frontiers in Oncology

Exome-based analysis for RNA epigenome sequencing data

(2013) Jia Meng et al.   BIOINFORMATICS

Hypoxia Contributes to Melanoma Heterogeneity by Triggering HIF1α-Dependent Phenotype Switching

(2013) Daniel S. Widmer et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death

(2013) Jaeseok Han et al.   NATURE CELL BIOLOGY

Melanoma metastasis: new concepts and evolving paradigms

(2013) W E Damsky et al.   ONCOGENE

Hypoxia Induces Phenotypic Plasticity and Therapy Resistance in Melanoma via the Tyrosine Kinase Receptors ROR1 and ROR2

(2013) M. P. O'Connell et al.   Cancer Discovery

TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions

(2013) Daehwan Kim et al.   GENOME BIOLOGY

RNA Binding Protein/RNA Element Interactions and the Control of Translation

(2012) Xavier Pichon et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

Melanomas resist T-cell therapy through inflammation-induced reversible dedifferentiation

(2012) Jennifer Landsberg et al.   NATURE

Control of somatic tissue differentiation by the long non-coding RNA TINCR

(2012) Markus Kretz et al.   NATURE

miR-214 targets ATF4 to inhibit bone formation

(2012) Xiaogang Wang et al.   NATURE MEDICINE

Human Cutaneous Melanomas Lacking MITF and Melanocyte Differentiation Antigens Express a Functional Axl Receptor Kinase

(2011) Marialuisa Sensi et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Mitf is the key molecular switch between mouse or human melanoma initiating cells and their differentiated progeny

(2011) Y Cheli et al.   ONCOGENE

ConsensusClusterPlus: a class discovery tool with confidence assessments and item tracking

(2010) Matthew D. Wilkerson et al.   BIOINFORMATICS

The GCN2-ATF4 pathway is critical for tumour cell survival and proliferation in response to nutrient deprivation

(2010) Jiangbin Ye et al.   EMBO JOURNAL

Cancer stem cells versus phenotype-switching in melanoma

(2010) Keith S. Hoek et al.   Pigment Cell & Melanoma Research

A proliferative melanoma cell phenotype is responsive to RAF/MEK inhibition independent of BRAF mutation status

(2010) Marie C. Zipser et al.   Pigment Cell & Melanoma Research

Differential expression analysis for sequence count data

(2010) Simon Anders et al.   GENOME BIOLOGY

Intravital Imaging Reveals Transient Changes in Pigment Production and Brn2 Expression during Metastatic Melanoma Dissemination

(2009) S. Pinner et al.   CANCER RESEARCH

ELDA: Extreme limiting dilution analysis for comparing depleted and enriched populations in stem cell and other assays

(2009) Yifang Hu et al.   JOURNAL OF IMMUNOLOGICAL METHODS

In vivo Switching of Human Melanoma Cells between Proliferative and Invasive States

(2008) K. S. Hoek et al.   CANCER RESEARCH

Brn-2 Represses Microphthalmia-Associated Transcription Factor Expression and Marks a Distinct Subpopulation of Microphthalmia-Associated Transcription Factor-Negative Melanoma Cells

(2008) J. Goodall et al.   CANCER RESEARCH