Reprogramming during epithelial to mesenchymal transition under the control of TGFβ

HMGA1 promotes metastatic processes in basal-like breast cancer regulating EMT and stemness

(2015) Silvia Pegoraro et al.   Oncotarget

TGFβ and matrix-regulated epithelial to mesenchymal transition

(2014) Aristidis Moustakas et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Oncofetal H19 RNA promotes tumor metastasis

(2014) Imad J. Matouk et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Disrupting the Interaction of BRD4 with Diacetylated Twist Suppresses Tumorigenesis in Basal-like Breast Cancer

(2014) Jian Shi et al.   CANCER CELL

TGF- -Induced Upregulation of malat1 Promotes Bladder Cancer Metastasis by Associating with suz12

(2014) Y. Fan et al.   CLINICAL CANCER RESEARCH

Blockade of Jagged/Notch Pathway Abrogates Transforming Growth Factor β2-Induced Epithelial-Mesenchymal Transition in Human Retinal Pigment Epithelium Cells

(2014) X. Chen et al.   CURRENT MOLECULAR MEDICINE

Sox4 Is a Master Regulator of Epithelial-Mesenchymal Transition by Controlling Ezh2 Expression and Epigenetic Reprogramming

(2013) Neha Tiwari et al.   CANCER CELL

FOXC2 Expression Links Epithelial-Mesenchymal Transition and Stem Cell Properties in Breast Cancer

(2013) B. G. Hollier et al.   CANCER RESEARCH

HMGA2 Is a Driver of Tumor Metastasis

(2013) A. Morishita et al.   CANCER RESEARCH

Targeting long non-coding RNAs in cancers: Progress and prospects

(2013) Chi Han Li et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Mechanisms that link the oncogenic epithelial–mesenchymal transition to suppression of anoikis

(2013) Steven M. Frisch et al.   JOURNAL OF CELL SCIENCE

Regulation of Heterochromatin Transcription by Snail1/LOXL2 during Epithelial-to-Mesenchymal Transition

(2013) Alba Millanes-Romero et al.   MOLECULAR CELL

Sequential introduction of reprogramming factors reveals a time-sensitive requirement for individual factors and a sequential EMT–MET mechanism for optimal reprogramming

(2013) Xiaopeng Liu et al.   NATURE CELL BIOLOGY

The epigenetics of epithelial-mesenchymal plasticity in cancer

(2013) Wai Leong Tam et al.   NATURE MEDICINE

MiR-155-mediated loss of C/EBPβ shifts the TGF-β response from growth inhibition to epithelial-mesenchymal transition, invasion and metastasis in breast cancer

(2013) J Johansson et al.   ONCOGENE

Dysregulation of PAD4-mediated citrullination of nuclear GSK3  activates TGF-  signaling and induces epithelial-to-mesenchymal transition in breast cancer cells

(2013) S. C. Stadler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Circulating Breast Tumor Cells Exhibit Dynamic Changes in Epithelial and Mesenchymal Composition

(2013) M. Yu et al.   SCIENCE

Brief Report: The lincRNA Hotair Is Required for Epithelial-to-Mesenchymal Transition and Stemness Maintenance of Cancer Cell Lines

(2013) Cleidson Pádua Alves et al.   STEM CELLS

TGF-β-Id1 Signaling Opposes Twist1 and Promotes Metastatic Colonization via a Mesenchymal-to-Epithelial Transition

(2013) Marko Stankic et al.   Cell Reports

Dynamic Chromatin Modification Sustains Epithelial-Mesenchymal Transition following Inducible Expression of Snail-1

(2013) Sarah Javaid et al.   Cell Reports

Architecture of epigenetic reprogramming following Twist1-mediated epithelial-mesenchymal transition

(2013) Gabriel G Malouf et al.   GENOME BIOLOGY

Spatiotemporal Regulation of Epithelial-Mesenchymal Transition Is Essential for Squamous Cell Carcinoma Metastasis

(2012) Jeff H. Tsai et al.   CANCER CELL

SOX4 Induces Epithelial-Mesenchymal Transition and Contributes to Breast Cancer Progression

(2012) J. Zhang et al.   CANCER RESEARCH

miR-34 and SNAIL form a double-negative feedback loop to regulate epithelial-mesenchymal transitions

(2012) Helge Siemens et al.   CELL CYCLE

TGF-β signaling and epithelial–mesenchymal transition in cancer progression

(2012) Yoko Katsuno et al.   CURRENT OPINION IN ONCOLOGY

Induction of palate epithelial mesenchymal transition by transforming growth factor β3 signaling

(2012) Azadeh Jalali et al.   DEVELOPMENT GROWTH & DIFFERENTIATION

Histone Demethylase KDM6B Promotes Epithelial-Mesenchymal Transition

(2012) Sivakumar Ramadoss et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of Transcription Factor Twist Expression by the DNA Architectural Protein High Mobility Group A2 during Epithelial-to-Mesenchymal Transition

(2012) E-Jean Tan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TGF- -induced activation of mTOR complex 2 drives epithelial-mesenchymal transition and cell invasion

(2012) S. Lamouille et al.   JOURNAL OF CELL SCIENCE

p53 regulates epithelial-mesenchymal transition induced by transforming growth factor β

(2012) Stefan Termén et al.   JOURNAL OF CELLULAR PHYSIOLOGY

G9a interacts with Snail and is critical for Snail-mediated E-cadherin repression in human breast cancer

(2012) Chenfang Dong et al.   JOURNAL OF CLINICAL INVESTIGATION

Effect of daily aspirin on risk of cancer metastasis: a study of incident cancers during randomised controlled trials

(2012) Peter M Rothwell et al.   LANCET

Effects of regular aspirin on long-term cancer incidence and metastasis: a systematic comparison of evidence from observational studies versus randomised trials

(2012) Annemijn M Algra et al.   LANCET ONCOLOGY

Targeting the TGFβ signalling pathway in disease

(2012) Rosemary J. Akhurst et al.   NATURE REVIEWS DRUG DISCOVERY

TGFβ signalling in context

(2012) Joan Massagué   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Role of the integrin-linked kinase (ILK)/Rictor complex in TGFβ-1-induced epithelial–mesenchymal transition (EMT)

(2012) I Serrano et al.   ONCOGENE

Specific interactions between Smad proteins and AP-1 components determine TGFβ-induced breast cancer cell invasion

(2012) A Sundqvist et al.   ONCOGENE

Targeting carbonic anhydrase IX depletes breast cancer stem cells within the hypoxic niche

(2012) F E Lock et al.   ONCOGENE

Interaction with Suv39H1 is critical for Snail-mediated E-cadherin repression in breast cancer

(2012) C Dong et al.   ONCOGENE

Induction of epithelial–mesenchymal transition by transforming growth factor β

(2012) Aristidis Moustakas et al.   SEMINARS IN CANCER BIOLOGY

Epigenetic reprogramming and post-transcriptional regulation during the epithelial–mesenchymal transition

(2012) Chung-Yin Wu et al.   TRENDS IN GENETICS

Akt/PKB-Mediated Phosphorylation of Twist1 Promotes Tumor Metastasis via Mediating Cross-Talk between PI3K/Akt and TGF-β Signaling Axes

(2012) Gongda Xue et al.   Cancer Discovery

EMT Inducers Catalyze Malignant Transformation of Mammary Epithelial Cells and Drive Tumorigenesis towards Claudin-Low Tumors in Transgenic Mice

(2012) Anne-Pierre Morel et al.   PLoS Genetics

The Ins and Outs of the Epithelial to Mesenchymal Transition in Health and Disease

(2011) M. Angela Nieto   Annual Review of Cell and Developmental Biology

Direct Signaling between Platelets and Cancer Cells Induces an Epithelial-Mesenchymal-Like Transition and Promotes Metastasis

(2011) Myriam Labelle et al.   CANCER CELL

The Hippo Transducer TAZ Confers Cancer Stem Cell-Related Traits on Breast Cancer Cells

(2011) Michelangelo Cordenonsi et al.   CELL

Control of the Embryonic Stem Cell State

(2011) Richard A. Young   CELL

Paracrine and Autocrine Signals Induce and Maintain Mesenchymal and Stem Cell States in the Breast

(2011) Christina Scheel et al.   CELL

Regulation of chromatin by histone modifications

(2011) Andrew J Bannister et al.   CELL RESEARCH

Endocardial cell epithelial-mesenchymal transformation requires Type III TGFβ receptor interaction with GIPC

(2011) Todd A. Townsend et al.   CELLULAR SIGNALLING

Epicardial-Derived Cell Epithelial-to-Mesenchymal Transition and Fate Specification Require PDGF Receptor Signaling

(2011) Christopher L. Smith et al.   CIRCULATION RESEARCH

SET8 promotes epithelial-mesenchymal transition and confers TWIST dual transcriptional activities

(2011) Fen Yang et al.   EMBO JOURNAL

Antagonistic regulation of EMT by TIF1γ and Smad4 in mammary epithelial cells

(2011) Cédric Hesling et al.   EMBO REPORTS

Functional Cooperation between Snail1 and Twist in the Regulation ofZEB1Expression during Epithelial to Mesenchymal Transition

(2011) Natàlia Dave et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A p53/miRNA-34 axis regulates Snail1-dependent cancer cell epithelial–mesenchymal transition

(2011) Nam Hee Kim et al.   JOURNAL OF CELL BIOLOGY

An autocrine TGF-β/ZEB/miR-200 signaling network regulates establishment and maintenance of epithelial-mesenchymal transition

(2011) Philip A. Gregory et al.   MOLECULAR BIOLOGY OF THE CELL

p53 regulates epithelial–mesenchymal transition and stem cell properties through modulating miRNAs

(2011) Chun-Ju Chang et al.   NATURE CELL BIOLOGY

Genome-scale epigenetic reprogramming during epithelial-to-mesenchymal transition

(2011) Oliver G McDonald et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Akt2 interacts with Snail1 in the E-cadherin promoter

(2011) P Villagrasa et al.   ONCOGENE

Twist2 contributes to breast cancer progression by promoting an epithelial–mesenchymal transition and cancer stem-like cell self-renewal

(2011) X Fang et al.   ONCOGENE

Hypoxia-induced Jagged2 promotes breast cancer metastasis and self-renewal of cancer stem-like cells

(2011) F Xing et al.   ONCOGENE

Comparative oncogenomics identifies breast tumors enriched in functional tumor-initiating cells

(2011) J. I. Herschkowitz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TRAF6 ubiquitinates TGFβ type I receptor to promote its cleavage and nuclear translocation in cancer

(2011) Yabing Mu et al.   Nature Communications

Smad Signaling Is Required to Maintain Epigenetic Silencing during Breast Cancer Progression

(2010) P. Papageorgis et al.   CANCER RESEARCH

Distinct Biological Roles for the Akt Family in Mammary Tumor Progression: Figure 1.

(2010) Rachelle L. Dillon et al.   CANCER RESEARCH

A Mesenchymal-to-Epithelial Transition Initiates and Is Required for the Nuclear Reprogramming of Mouse Fibroblasts

(2010) Ronghui Li et al.   Cell Stem Cell

Functional Genomics Reveals a BMP-Driven Mesenchymal-to-Epithelial Transition in the Initiation of Somatic Cell Reprogramming

(2010) Payman Samavarchi-Tehrani et al.   Cell Stem Cell

miR-200a Prevents Renal Fibrogenesis Through Repression of TGF- 2 Expression

(2010) B. Wang et al.   DIABETES

The SNAG domain of Snail1 functions as a molecular hook for recruiting lysine-specific demethylase 1

(2010) Yiwei Lin et al.   EMBO JOURNAL

Integration of a Notch-dependent mesenchymal gene program and Bmp2-driven cell invasiveness regulates murine cardiac valve formation

(2010) Luis Luna-Zurita et al.   JOURNAL OF CLINICAL INVESTIGATION

Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis

(2010) Rajnish A. Gupta et al.   NATURE

Nuclear reprogramming to a pluripotent state by three approaches

(2010) Shinya Yamanaka et al.   NATURE

Requirement of the histone demethylase LSD1 in Snai1-mediated transcriptional repression during epithelial-mesenchymal transition

(2010) T Lin et al.   ONCOGENE

Core epithelial-to-mesenchymal transition interactome gene-expression signature is associated with claudin-low and metaplastic breast cancer subtypes

(2010) J. H. Taube et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Akt1 and Akt2 Play Distinct Roles in the Initiation and Metastatic Phases of Mammary Tumor Progression

(2009) R. L. Dillon et al.   CANCER RESEARCH

Epithelial-Mesenchymal Transitions in Development and Disease

(2009) Jean Paul Thiery et al.   CELL

Ligand-specific function of transforming growth factor beta in epithelial-mesenchymal transition in heart development

(2009) Mohamad Azhar et al.   DEVELOPMENTAL DYNAMICS

Integrin α3β1–dependent β-catenin phosphorylation links epithelial Smad signaling to cell contacts

(2009) Young Kim et al.   JOURNAL OF CELL BIOLOGY

A SNAIL1–SMAD3/4 transcriptional repressor complex promotes TGF-β mediated epithelial–mesenchymal transition

(2009) Theresa Vincent et al.   NATURE CELL BIOLOGY

Many roads to maturity: microRNA biogenesis pathways and their regulation

(2009) Julia Winter et al.   NATURE CELL BIOLOGY

Linking DNA methylation and histone modification: patterns and paradigms

(2009) Howard Cedar et al.   NATURE REVIEWS GENETICS

MicroRNAs Differentially Regulated by Akt Isoforms Control EMT and Stem Cell Renewal in Cancer Cells

(2009) D. Iliopoulos et al.   Science Signaling

Induction of EMT by Twist Proteins as a Collateral Effect of Tumor-Promoting Inactivation of Premature Senescence

(2008) Stéphane Ansieau et al.   CANCER CELL

Stromal Transforming Growth Factor-  Signaling Mediates Prostatic Response to Androgen Ablation by Paracrine Wnt Activity

(2008) V. R. Placencio et al.   CANCER RESEARCH

A Double-Negative Feedback Loop between ZEB1-SIP1 and the microRNA-200 Family Regulates Epithelial-Mesenchymal Transition

(2008) C. P. Bracken et al.   CANCER RESEARCH

Transforming Growth Factor  : Tumor Suppressor or Promoter? Are Host Immune Cells the Answer?

(2008) L. Yang et al.   CANCER RESEARCH

The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells

(2008) Sendurai A. Mani et al.   CELL

MEKK3 Initiates Transforming Growth Factor β 2 –Dependent Epithelial-to-Mesenchymal Transition During Endocardial Cushion Morphogenesis

(2008) Mark V. Stevens et al.   CIRCULATION RESEARCH

A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells

(2008) Ulrike Burk et al.   EMBO REPORTS

Dynamic control of TGF-β signaling and its links to the cytoskeleton

(2008) Aristidis Moustakas et al.   FEBS LETTERS

Axin and GSK3- control Smad3 protein stability and modulate TGF- signaling

(2008) X. Guo et al.   GENES & DEVELOPMENT

The miR-200 Family Inhibits Epithelial-Mesenchymal Transition and Cancer Cell Migration by Direct Targeting of E-cadherin Transcriptional RepressorsZEB1andZEB2

(2008) Manav Korpal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HMGA2 and Smads Co-regulate SNAIL1 Expression during Induction of Epithelial-to-Mesenchymal Transition

(2008) Sylvie Thuault et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Snail is required for TGF -induced endothelial-mesenchymal transition of embryonic stem cell-derived endothelial cells

(2008) T. Kokudo et al.   JOURNAL OF CELL SCIENCE

MicroRNA-155 Is Regulated by the Transforming Growth Factor  /Smad Pathway and Contributes to Epithelial Cell Plasticity by Targeting RhoA

(2008) W. Kong et al.   MOLECULAR AND CELLULAR BIOLOGY

Polycomb Complex 2 Is Required for E-cadherin Repression by the Snail1 Transcription Factor

(2008) N. Herranz et al.   MOLECULAR AND CELLULAR BIOLOGY

Snail and Slug Promote Epithelial-Mesenchymal Transition through β-Catenin–T-Cell Factor-4-dependent Expression of Transforming Growth Factor-β3

(2008) Damian Medici et al.   MOLECULAR BIOLOGY OF THE CELL

The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1

(2008) Philip A. Gregory et al.   NATURE CELL BIOLOGY

A positive role for Myc in TGFβ-induced Snail transcription and epithelial-to-mesenchymal transition

(2008) A P Smith et al.   ONCOGENE

Generation of Breast Cancer Stem Cells through Epithelial-Mesenchymal Transition

(2008) Anne-Pierre Morel et al.   PLoS One

Sustained induction of epithelial to mesenchymal transition activates DNA methylation of genes silenced in basal-like breast cancers

(2008) N. Dumont et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA