Translational reprogramming marks adaptation to asparagine restriction in cancer

METTL13 Methylation of eEF1A Increases Translational Output to Promote Tumorigenesis

(2019) Shuo Liu et al.   CELL

C57BL/6 congenic mouse NRAS Q61K melanoma cell lines are highly sensitive to the combination of Mek and Akt inhibitors in vitro and in vivo

(2019) Valérie Petit et al.   Pigment Cell & Melanoma Research

Oncogenic KRAS Regulates Amino Acid Homeostasis and Asparagine Biosynthesis via ATF4 and Alters Sensitivity to L-Asparaginase

(2018) Dana M. Gwinn et al.   CANCER CELL

As Extracellular Glutamine Levels Decline, Asparagine Becomes an Essential Amino Acid

(2018) Natalya N. Pavlova et al.   Cell Metabolism

Signaling Pathways Involved in the Regulation of mRNA Translation

(2018) Philippe P. Roux et al.   MOLECULAR AND CELLULAR BIOLOGY

Asparagine bioavailability governs metastasis in a model of breast cancer

(2018) Simon R. V. Knott et al.   NATURE

Role of eIF2α Kinases in Translational Control and Adaptation to Cellular Stress

(2018) Ronald C. Wek   Cold Spring Harbor Perspectives in Biology

Targeting the Warburg effect via LDHA inhibition engages ATF4 signaling for cancer cell survival

(2018) Gaurav Pathria et al.   EMBO JOURNAL

Inhibition of GCN2 sensitizes ASNS-low cancer cells to asparaginase by disrupting the amino acid response

(2018) Akito Nakamura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Translation reprogramming is an evolutionarily conserved driver of phenotypic plasticity and therapeutic resistance in melanoma

(2017) Paola Falletta et al.   GENES & DEVELOPMENT

A Unique ISR Program Determines Cellular Responses to Chronic Stress

(2017) Bo-Jhih Guan et al.   MOLECULAR CELL

Modulating the therapeutic response of tumours to dietary serine and glycine starvation

(2017) Oliver D. K. Maddocks et al.   NATURE

RAF proteins exert both specific and compensatory functions during tumour progression of NRAS-driven melanoma

(2017) Coralie Dorard et al.   Nature Communications

Functional Genomic Landscape of Human Breast Cancer Drivers, Vulnerabilities, and Resistance

(2016) Richard Marcotte et al.   CELL

A Landscape of Pharmacogenomic Interactions in Cancer

(2016) Francesco Iorio et al.   CELL

The Transcription Factor ATF5 Mediates a Mammalian Mitochondrial UPR

(2016) Christopher J. Fiorese et al.   CURRENT BIOLOGY

Upstream Open Reading Frames Differentially Regulate Gene-specific Translation in the Integrated Stress Response

(2016) Sara K. Young et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeting mitochondrial biogenesis to overcome drug resistance to MAPK inhibitors

(2016) Gao Zhang et al.   JOURNAL OF CLINICAL INVESTIGATION

Tuning Specific Translation in Cancer Metastasis and Synaptic Memory: Control at the MNK–eIF4E Axis

(2016) Clive R. Bramham et al.   TRENDS IN BIOCHEMICAL SCIENCES

Asparagine promotes cancer cell proliferation through use as an amino acid exchange factor

(2016) Abigail S. Krall et al.   Nature Communications

Polo-like kinase 1 induces epithelial-to-mesenchymal transition and promotes epithelial cell motility by activating CRAF/ERK signaling

(2016) Jianguo Wu et al.   eLife

The Role of Endoplasmic Reticulum Stress in Human Pathology

(2015) Scott A. Oakes et al.   Annual Review of Pathology-Mechanisms of Disease

cMyc-mediated activation of serine biosynthesis pathway is critical for cancer progression under nutrient deprivation conditions

(2015) Linchong Sun et al.   CELL RESEARCH

Co-clinical assessment identifies patterns of BRAF inhibitor resistance in melanoma

(2015) Lawrence N. Kwong et al.   JOURNAL OF CLINICAL INVESTIGATION

ERK2 Mediates Metabolic Stress Response to Regulate Cell Fate

(2015) Sejeong Shin et al.   MOLECULAR CELL

Comprehensive translational control of tyrosine kinase expression by upstream open reading frames

(2015) K Wethmar et al.   ONCOGENE

Asparagine Synthetase Expression and Phase I Study With L-Asparaginase Encapsulated in Red Blood Cells in Patients With Pancreatic Adenocarcinoma

(2015) Jean-Baptiste Bachet et al.   PANCREAS

Glutamate and asparagine cataplerosis underlie glutamine addiction in melanoma

(2015) Boris Ratnikov et al.   Oncotarget

BRAF Inhibitor Resistance Mechanisms in Metastatic Melanoma: Spectrum and Clinical Impact

(2014) H. Rizos et al.   CLINICAL CANCER RESEARCH

The general amino acid control pathway regulates mTOR and autophagy during serum/glutamine starvation

(2014) Rui Chen et al.   JOURNAL OF CELL BIOLOGY

Asparagine Plays a Critical Role in Regulating Cellular Adaptation to Glutamine Depletion

(2014) Ji Zhang et al.   MOLECULAR CELL

Polysome Fractionation and Analysis of Mammalian Translatomes on a Genome-wide Scale

(2014) Valentina Gandin et al.   Jove-Journal of Visualized Experiments

Endoplasmic Reticulum (ER) Stress and Hypoxia Response Pathways Interact to Potentiate Hypoxia-inducible Factor 1 (HIF-1) Transcriptional Activity on Targets Like Vascular Endothelial Growth Factor (VEGF)

(2013) Ethel R. Pereira et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Improving Breast Cancer Survival Analysis through Competition-Based Multidimensional Modeling

(2013) Erhan Bilal et al.   PLoS Computational Biology

Ribosome Profiling of Mouse Embryonic Stem Cells Reveals the Complexity and Dynamics of Mammalian Proteomes

(2011) Nicholas T. Ingolia et al.   CELL

Regulation of mTORC1 Signaling by pH

(2011) Aruna D. Balgi et al.   PLoS One

Essential Gene Profiles in Breast, Pancreatic, and Ovarian Cancer Cells

(2011) Richard Marcotte et al.   Cancer Discovery

L-asparaginase treatment in acute lymphoblastic leukemia

(2010) Rob Pieters et al.   CANCER

eIF4E phosphorylation promotes tumorigenesis and is associated with prostate cancer progression

(2010) L. Furic et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glutamine addiction: a new therapeutic target in cancer

(2010) David R. Wise et al.   TRENDS IN BIOCHEMICAL SCIENCES

Upstream open reading frames cause widespread reduction of protein expression and are polymorphic among humans

(2009) S. E. Calvo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ATF4-dependent transcription mediates signaling of amino acid limitation

(2009) Michael S. Kilberg et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

MEK Signaling Is Required for Phosphorylation of eIF2α following Amino Acid Limitation of HepG2 Human Hepatoma Cells

(2008) Michelle M. Thiaville et al.   JOURNAL OF BIOLOGICAL CHEMISTRY