Natural product discovery through microbial genome mining

Mining Symbionts of Spider-Transmitted Fungus Illuminates Uncharted Biosynthetic Pathways to Cytotoxic Benzolactones

(2020) Sarah P. Niehs et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Evolution-guided discovery of antibiotics that inhibit peptidoglycan remodelling

(2020) Elizabeth J. Culp et al.   NATURE

Genome mining of biosynthetic and chemotherapeutic gene clusters in Streptomyces bacteria

(2020) Kaitlyn C. Belknap et al.   Scientific Reports

ARTS 2.0: feature updates and expansion of the Antibiotic Resistant Target Seeker for comparative genome mining

(2020) Mehmet Direnç Mungan et al.   NUCLEIC ACIDS RESEARCH

A multiproducer microbiome generates chemical diversity in the marine sponge Mycale hentscheli

(2020) Michael Rust et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reconstitution of polythioamide antibiotic backbone formation reveals unusual thiotemplated assembly strategy

(2020) Kyle L. Dunbar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metagenomic Exploration of the Marine Sponge Mycale hentscheli Uncovers Multiple Polyketide-Producing Bacterial Symbionts

(2020) Mathew A. Storey et al.   mBio

CRISPR–Cas9, CRISPRi and CRISPR-BEST-mediated genetic manipulation in streptomycetes

(2020) Yaojun Tong et al.   Nature Protocols

Genome mining identifies cepacin as a plant-protective metabolite of the biopesticidal bacterium Burkholderia ambifaria

(2019) Alex J. Mullins et al.   Nature Microbiology

The antimicrobial potential of Streptomyces from insect microbiomes

(2019) Marc G. Chevrette et al.   Nature Communications

Enzyme-catalysed [6+4] cycloadditions in the biosynthesis of natural products

(2019) Bo Zhang et al.   NATURE

Biosynthesis and Ether-Bridge Formation in Nargenicin Macrolides

(2019) Sacha J. Pidot et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthetic Biology Tools for Novel Secondary Metabolite Discovery in Streptomyces

(2019) Namil Lee et al.   JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY

antiSMASH 5.0: updates to the secondary metabolite genome mining pipeline

(2019) Kai Blin et al.   NUCLEIC ACIDS RESEARCH

Localized production of defence chemicals by intracellular symbionts of Haliclona sponges

(2019) Ma. Diarey Tianero et al.   Nature Microbiology

Genome Mining Reveals Endopyrroles from a Nonribosomal Peptide Assembly Line Triggered in Fungal–Bacterial Symbiosis

(2019) Sarah P. Niehs et al.   ACS Chemical Biology

Bioactive Synthetic-Bioinformatic Natural Product Cyclic Peptides Inspired by Nonribosomal Peptide Synthetase Gene Clusters from the Human Microbiome

(2019) John Chu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Identification and Mobilization of a Cryptic Antibiotic Biosynthesis Gene Locus from a Human-Pathogenic Nocardia Isolate

(2019) Marion Herisse et al.   ACS Chemical Biology

Genomics-Driven Discovery of NO-Donating Diazeniumdiolate Siderophores in Diverse Plant-Associated Bacteria

(2019) Ron Hermenau et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A computational framework to explore large-scale biosynthetic diversity

(2019) Jorge C. Navarro-Muñoz et al.   Nature Chemical Biology

A metagenomic strategy for harnessing the chemical repertoire of the human microbiome

(2019) Yuki Sugimoto et al.   SCIENCE

Discovery, Biosynthesis, and Heterologous Production of Streptoseomycin, an Anti-Microaerophilic Bacteria Macrodilactone

(2018) Bo Zhang et al.   ORGANIC LETTERS

Discovery of recombinases enables genome mining of cryptic biosynthetic gene clusters in Burkholderiales species

(2018) Xue Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Self-resistance guided genome mining uncovers new topoisomerase inhibitors from myxobacteria

(2018) Fabian Panter et al.   Chemical Science

An Optimized Synthetic-Bioinformatic Natural Product Antibiotic Sterilizes Multidrug-Resistant Acinetobacter baumannii-Infected Wounds

(2018) Xavier Vila-Farres et al.   mSphere

Resistance-gene-directed discovery of a natural-product herbicide with a new mode of action

(2018) Yan Yan et al.   NATURE

Clone of plipastatin biosynthetic gene cluster by transformation-associated recombination technique and high efficient expression in model organism Bacillus subtilis

(2018) Yimin Hu et al.   JOURNAL OF BIOTECHNOLOGY

Atolypenes, Tricyclic Bacterial Sesterterpenes Discovered Using a Multiplexed In Vitro Cas9-TAR Gene Cluster Refactoring Approach

(2018) Seong-Hwan Kim et al.   ACS Synthetic Biology

Antimicrobials Inspired by Nonribosomal Peptide Synthetase Gene Clusters

(2017) Xavier Vila-Farres et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

PRISM 3: expanded prediction of natural product chemical structures from microbial genomes

(2017) Michael A. Skinnider et al.   NUCLEIC ACIDS RESEARCH

Discovery of MRSA active antibiotics using primary sequence from the human microbiome

(2016) John Chu et al.   Nature Chemical Biology

Detecting Sequence Homology at the Gene Cluster Level with MultiGeneBlast

(2013) Marnix H. Medema et al.   MOLECULAR BIOLOGY AND EVOLUTION

NRPSpredictor2—a web server for predicting NRPS adenylation domain specificity

(2011) Marc Röttig et al.   NUCLEIC ACIDS RESEARCH

antiSMASH: rapid identification, annotation and analysis of secondary metabolite biosynthesis gene clusters in bacterial and fungal genome sequences

(2011) Marnix H. Medema et al.   NUCLEIC ACIDS RESEARCH

CLUSEAN: A computer-based framework for the automated analysis of bacterial secondary metabolite biosynthetic gene clusters

(2009) T. Weber et al.   JOURNAL OF BIOTECHNOLOGY